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All Journal JURNAL PENGABDIAN KEPADA MASYARAKAT INDONESIAN JOURNAL OF PHARMACY Berkala Kedokteran Jurnal Berkala Kesehatan Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education International Journal of Humanities, Management, and Social Science (IJ-HuMaSS) Journal of Public Health Research and Community Health Development (JPH RECODE) Jurnal Ners Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Ilmu Kesehatan Masyarakat Homeostasis: Jurnal Mahasiswa Pendidikan Dokter Cermin Dunia Kedokteran
Mohammad Bakhriansyah
Departemen Farmakologi, Fakultas Kedokteran, Universitas Lambung Mangkurat Banjarmasin
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Berkala Kedokteran

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The Risk of Adverse Drug-Drug Interactions for Stable Angina Pectoris Patients with Heart Failure Complication Prescribed Polypharmacy Fadillah, Ahmad Aldi; Bakhriansyah, Mohammad; Yustikasari, Intan; Nurikhwan, Pandji Winata; Adiputro, Dwi Laksono
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17404

Abstract

Stable angina pectoris (SAP) is an imbalance that occurs when myocardial oxygen need increases disproportionally, causing complaints of chest pain. Uncontrolled SAP can lead to a complication of heart failure (HF). Polypharmacy treatment frequently given to SAP patients with HF complications can be potentially detrimental for them. This study aims to determine the risk of adverse drug-drug interactions in SAP patients with HF complications prescribed polypharmacy. This was an analytic observational study with a cross-sectional approach using retrospective data from medical record data from 2020-2021 among hospitalized patients in cardiology ward Ulin General Hospital, Banjarmasin. Potential drug-drug interactions were determined using the Lexicomp tool from the UpToDate® site. Prevalence Odds Ratio (POR) and 95% Confidence Interval (95%CI) were determined using the Logistic Regression test at the 95% level of confidence. Twenty-four SAP patients with HF were recruited. According to its potential interactions, the most interactions were under category C (82.6%), followed by category B (11.3%) and category D (6.0%). Based on its level of severity, the most common was moderate (77.4%), followed by minor (13.0%) and major (9.5%). SAP patients with HF who were not prescribed polypharmacy had a lower risk of adverse drug-drug interactions by 64.7% compared to polypharmacy users, although it was not statistically difference (crude POR 0.353, 95% CI; 0.360-3.421; p-value = 0.369). This study shows that there is a tendency of lower risk of adverse drug-drug interactions in SAP patients with HF complication prescribed polypharmacy compared to those without polypharmacy, but the association is not statistically significant.
Co-Authors Achyar Nawi Husein Adeliana Hardinawati Agung Biworo Agung Biworo Alfanie, Iwan Andini Octaviana Putri Annisa Avicenna, Annisa Ardik Lahdimawan, Ardik Asnawati Asnawati Aswin Febria Defiyanti Rahmah Desi Amalia Desi Ramayanti Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Diauddin Divae Sandrainy Dona Marisa, Dona Dwi Laksono Adiputro, Dwi Laksono Dyah Ayu Kusumawarddhani, Dyah Ayu Dyah Septy Tri Christanty Eko Suhartono Fadillah, Ahmad Aldi Faishal Muhammad Arrosyad Fakhriyah Fakhriyah Fakhrurrazy Fakhrurrazy Farsya, Aqila Layyina Fauzan Muttaqien Fauzan Muttaqien Fauzie Rahman Ferina Fernanda, Ferina Firani, Dewi Firda Wirasari, Firda Fujianti, Annisa Hadrianti H. D. Lasari Haryati Haryati Hikmat, Ramadhan Maulana Huldani Huldani Husnul Fatimah Ica Pratiwi Islah, Anida Istiana Istiana Istiana Iwan Aflanie Jayadi, Yusef Dwi Jordy Aditya Raharjo Lia Anggraini Lia Yulia Budiarti Limantara, Sherly Meilani, Elma Meitria Syahadatina Noor Millenia Bella Putri Syafrina Mohammad Isa Mohammad Rudiansyah Muhammad Abdan Shadiqi Muhammad Annahri Mushoffa Muhammad Hendy Arizal, Muhammad Hendy Muhammad Welly Dafif Muhammad Welly Dafif Munirah, Nida Mutaqqien, Fauzan Nanang Miftah Fajari Nelly Al Audhah Nia Kania Nita Pujianti Nurhayati Nurhayati NURUL HIDAYAH Pagan Pambudi Pagan Pambudi Pandji Winata Nurikhwan Pratama, Muhammad Noor Aditya Riana Sari, Ayu Rizky, Nabilla Sari A, Ayu Riana Shadiqi , Muhammad Abdan Shinta Kartika Nur Aisah, Shinta Kartika Sidnan Naufa Sulaiman Sonya Esti Kholifa Triawanti Triawanti Vina Yulia Anhar Wiwit Agung Sri Nur Cahyawati Yustikasari, Intan Zoelkarnain, Izaak