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All Journal Jurnal Kedokteran JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Ners Jurnal Medika Hutama Majalah Biomorfologi (Biomorphology Journal) Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Indian Journal of Forensic Medicine & Toxicology Jurnal Yoga Dan Kesehatan Indonesian Nursing Journal of Education and Clinic (Jurnal Pendidikan dan Praktik Keperawatan Indonesia) Physical Therapy Journal of Indonesia GEMBIRA (Pengabdian Kepada Masyarakat) Folia Medica Indonesiana
Mohammad Fathul Qorib
Airlangga University
Religion Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Pengaruh Jus Buah Delima (Punica granatum) sebagai Agen Antioksidan pada Tikus Putih (Rattus norvegicus) yang Diinduksi Larutan Complete Freund’s Adjuvant (CFA) melalui Jalur Penurunan Kadar Malondialdehid (MDA) Shayla Kokomi Rishardy; Nurmawati Fatimah; Gadis Meinar Sari; Mohammad Fathul Qorib
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.51842

Abstract

Inflamasi kronis berkontribusi pada berbagai penyakit degeneratif, sehingga diperlukan terapi alternatif berbasis antioksidan alami. Buah delima (Punica granatum) kaya akan polifenol, flavonoid, dan tanin yang memiliki potensi antioksidan dan antiinflamasi. Penelitian ini bertujuan untuk mengevaluasi pengaruh jus buah delima terhadap kadar malondialdehid (MDA) sebagai penanda stres oksidatif pada tikus Wistar jantan yang diinduksi Complete Freund’s Adjuvant (CFA). Penelitian eksperimental menggunakan rancangan post-test only control group design dengan empat kelompok: kontrol negatif (K–), kontrol positif (K+), serta dua kelompok perlakuan (P1: 16,7% jus delima; P2: 33,3% jus delima). Jus diberikan secara oral selama 28 hari. Analisis data menggunakan uji Shapiro-Wilk dan Levene untuk uji normalitas dan homogenitas, dilanjutkan dengan ANOVA satu arah dan uji post hoc LSD atau uji non-parametrik Kruskal-Wallis dan Mann-Whitney U jika data tidak normal. Hasil menunjukkan bahwa kadar MDA tertinggi terjadi pada K+, sedangkan P1 dan P2 mengalami penurunan signifikan (p<0,05). Temuan ini mengindikasikan bahwa jus delima efektif menurunkan stres oksidatif melalui penghambatan peroksidasi lipid, mendukung potensinya sebagai agen terapeutik alami dalam manajemen inflamasi.
Pengaruh Jus Buah Delima (Punica granatum) sebagai Agen Anti-inflmasi pada Tikus Putih (Rattus norvegicus) yang Diinduksi Larutan Complete Freund’s Adjuvant (CFA) melalui Jalur Penurunan Kadar Sitokin Pro-inflamasi TNF-α Muhammad Axel Arsyad; Nurmawati Fatimah; Gadis Meinar Sari; Mohammad Fathul Qorib
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52488

Abstract

Reaksi alami tubuh terhadap kerusakan atau penyakit adalah peradangan, yang ditandai dengan peningkatan mediator pro-inflamasi seperti TNF-α. Karena Complete Freund's Adjuvant (CFA) dapat menimbulkan peradangan kronis dan respons imunologis seluler, zat ini sering digunakan sebagai model induksi peradangan. Punicalagin, asam ellagic, dan flavonoid yang terdapat dalam buah delima (Punica granatum) memiliki sifat anti-inflamasi dan antioksidan yang dapat mengurangi respons inflamasi. Dalam eksperimen laboratorium ini, digunakan lima kelompok tikus jantan putih (Rattus norvegicus) dengan desain kelompok kontrol pasca-tes saja. Kelompok-kelompok tersebut meliputi kelompok kontrol negatif, kelompok kontrol positif (CFA), kelompok vitamin C, dan dua kelompok perlakuan yang menerima dosis oral jus delima yang bervariasi selama 28 hari. Jus delima secara signifikan (p<0.05) menurunkan kadar TNF-α pada tikus yang diinduksi CFA dibandingkan dengan kelompok kontrol positif, dengan penurunan terbesar terjadi pada dosis tertinggi, menurut data. Oleh karena itu, telah dibuktikan bahwa jus delima memiliki sifat antiinflamasi dengan menurunkan kadar sitokin pro-inflamasi TNF-α.
The Potential of Ethanol Extract of Dutch Eggplant (Solanum betaceum) against caspase-3 Expression in the Kidneys of Mice (Mus musculus) Exposed to Lead Acetate Rifatus Solicha; Rahaju, Anny Setijo; Qorib, Mohammad Fathul; I’tishom, Reny; Arfian, Nur
Majalah Biomorfologi 2026: MAJALAH BIOMORFOLOGI (IN PRESS)
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Lead (Pb) exposure remains an environmental health concern due to its toxicity, particularly to the kidneys, where it can cause nephrotoxicity. The accumulation of lead acetate induces oxidative stress through elevated reactive oxygen species (ROS) levels, which subsequently activate the apoptosis pathway characterized by increased caspase-3 expression. Caspase-3 serves as the primary executor enzyme in apoptosis and functions as a key indicator of kidney cell injury. Natural antioxidants, such as the ethanol extract of Dutch eggplant (Solanum betaceum), are rich in flavonoids and can protect kidney tissue by neutralizing free radicals and inhibiting apoptosis. Given these properties, Solanum betaceum has emerged as a candidate for protecting the kidneys against damage caused by heavy metals. Objective: This study investigated whether ethanol-extracted Dutch eggplant could protect the kidneys of mice (Mus musculus) exposed to lead acetate by looking at its effect on caspase-3 expression. The research also examined whether the extract’s protective effect depended on the dose given. Materials and Methods: This experimental research employed a post-test control group design. The authors classified the mice into five groups (K0, K1, P1, P2, and P3). The treatment groups received Dutch eggplant extract at varying doses administered concurrently with lead acetate exposure. Caspase-3 expression was evaluated using immunohistochemistry (IHC) and assessed using an H-score, followed by statistical analysis with SPSS. Results: Lead acetate increased caspase-3 expression compared to the negative control group (K1: 122.00 vs. K0: 71.00). Administration of Dutch eggplant extract reduced caspase-3 expression in a dose-dependent manner. Conclusion: The ethanol extract of Dutch eggplant has demonstrated potential nephroprotective effects against lead acetate-induced kidney damage by reducing caspase-3 expression.
The relationship between backpack load, shoulder muscle strength, and shoulder pain in elementary school students Harzat; Sari, Gadis Meinar; Qorib, Mohammad Fathul; Putri, Eka Arum Cahyaning
Physical Therapy Journal of Indonesia Vol. 7 No. 1 (2026): Inpress January-June 2026
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v7i1.345

Abstract

Background: Carrying school backpacks exceeding 10% of body weight is linked to shoulder discomfort in primary school students. This study aimed to analyse whether factors such as shoulder muscle strength, carrying duration, flexibility, blood lactate levels, and age contribute to shoulder pain beyond backpack load. Methods: This analytical observational study used a cross-sectional design involving 66 male students aged 7–10 years from SDI Maryam Surabaya, Indonesia. Standardised measurements were conducted, including shoulder pain (Wong–Baker Faces Scale), body and backpack weight (digital scale), backpack carrying duration (stopwatch), shoulder strength (dynamometer), flexibility (goniometer), and blood lactate levels (Accutrend Plus). Associations between variables were analysed using Spearman’s rho correlation test. Results: Backpack load percentage (p = 0.020), carrying duration (right p = 0.010; left p = 0.006), age (right p = 0.000; left p = 0.001), and shoulder muscle strength push (p = 0.000) and pull (left p = 0.004) were significantly associated with shoulder pain, while shoulder flexibility and blood lactate showed no significant relationships (p > 0.05). Conclusion: Shoulder pain in primary school students was influenced by backpack load and key physiological factors, particularly shoulder muscle strength, carrying duration, and age. These findings highlighted the importance of preventive measures such as postural education and muscle-strengthening programs to reduce musculoskeletal discomfort from daily backpack use.
ANALYSIS OF NURSING STUDENTS NEEDS FOR CHILD DEVELOPMENT SCREENING LEARNING THROUGH CASE-BASED VIRTUAL SIMUALTION Lestari, Nur Eni; Istiani, Hari Ghanesia; Martinez, Oscar Fidel Antunez; Qorib, Mohammad Fathul
INDONESIAN NURSING JOURNAL OF EDUCATION AND CLINIC (INJEC) Vol 11, No 1 (2026): INJEC
Publisher : Asosiasi Institusi Pendidikan Ners Indonesia (AIPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24990/injec.v11i1.1054

Abstract

Introduction: Nursing education requires innovative approaches to overcome limitations in clinical practice, particularly in child development screening. Case-based virtual simulation has become a promising alternative for enhancing nursing students' skills in handling real clinical situations.Methods: This study aims to analyze the needs of nursing students regarding child development screening learning using case-based virtual simulation. The research method used was descriptive quantitative research, with data collected through questionnaires distributed to 84 nursing students. The questionnaire covered five leading indicators: the availability and limitations of clinical practice, difficulties in understanding child development concepts, the need for digital learning media, preferences for interactive and case-based media, and responses to the use of technology in learning.Results: The results showed that students experienced limitations in gaining direct practical experience in field-based child development screening (average scores 3.5–3.7) and in understanding child development concepts without illustrations or real case examples (average score 3.5). Students also expressed a strong need for flexible, interactive digital learning media (average score: 3.9). Moreover, students preferred case-based learning that supports clinical decision-making (average score: 3.6).Conclusion: The study concluded that the development of case-based virtual simulations can overcome the limitations of clinical practice and provide a more applicable learning experience. Technology-based learning media can be integrated into nursing education to improve students' clinical preparedness in conducting child development screening.
Profile of Analgesics in Toddler Patients Undergoing Surgery at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, January 2021-December 2021 Devin Hernando; Maulydia Maulydia; Mohammad Fathul Qorib; Kohar Hari Santoso
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 17 No. 1 (2026): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V17I12026.7-13

Abstract

Highlights: Pain is the most common complaint in every medical procedure. Pain management in toddlers requires special attention due to the need to consider various factors.   Abstract Introduction: Pain is the most frequent complaint in all medical procedures. Managing procedures in toddlers requires special attention due to various influencing factors. The 19th century witnessed significant advancements in analgesics. Analgesics help manage pain that may arise from procedures performed on toddlers. Methods: This study identified the analgesic profile in toddlers undergoing surgery at the Integrated Surgery Center (GBPT) of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January to December 2021. It was a retrospective descriptive study using medical records. The sample included toddlers who underwent surgery and received analgesics at Dr. Soetomo General Academic Hospital in Surabaya, Indonesia. The sampling technique used was total sampling. Results: During January to December 2021, a total of 451 pediatric patients underwent surgery at Dr. Soetomo General Academic Hospital in Surabaya, Indonesia. A total of 232 patients were excluded due to incomplete medical records. A total of 219 patients met the criteria. The majority were 1-year-old (32.42%), with male patients being predominant (58.9%). Most toddlers had a normal body mass index (BMI). The majority of surgeries lasted 1-3 hours (64.38%). The most common procedures were debridement and wound dressing (11.87%). Opioids were the most frequently used analgesics (41%), with fentanyl being the most common (71.85%), while paracetamol was the primary non-opioid analgesic (43.33%). The most common pain intensity before and after surgery was no pain. Conclusion: Analgesics help manage procedural pain in toddlers. Opioids were the most frequently used, with fentanyl being the most common.
Co-Authors , Retnaningsih Achmad Yarziq Mubarak Salis Salamy Alphania Rahniayu Annette d’Arqom, Annette Anny Setijo Rahaju, Anny Setijo Ardana, Arin Aurilia Arlia Ayu Damayanti Ayu Imamatun Nisa Baarid Luqman Hamidi Constantia Lidwina Targanski Damayanti, Arlia Ayu David Setyo Budi Devin Hernando Fatimah, Nurmawati Filhi Rihmayuwainilla Hamidi, Baarid Luqman Harzat HERAWATI, LILIK I'tishom, Reny Indiastuti , Danti Nur Indiastuti, Danti Nur Irmi Syafa'ah Istiani, Hari Ghanesia I’tishom, Reny Jeffri Nagasastra Junaidah Yusof Kusuma Eko Purwantari Lucky Prasetiowati Machin, Abdulloh ManikRetno Wahyunitisari Martinez, Oscar Fidel Antunez Maulydia Maulydia Mhd Zamal Nasution Mohamed, Moh Nahar Azmi Muhammad Axel Arsyad Mujahiddin, M. Izzul Nagasastra, Jeffri Nisa, Ayu Imamatun Nur Arfian, Nur Nur Eni Lestari Nurina Hasanatuludhhiyah Praba, Venansya Maulina Primitasari, Yulia Puteri, Fira Adilah Putri, Eka Arum Cahyaning Ramadhan, Ain Darojah Siddiq Ramadhan Retnaningsih Rifatus Solicha Rizky Darmawan, Rizky Rozalina Loebis, Rozalina Salamun Salamun Salamy, Ahmed Zaiyan Nahel Salamy, M. Fath Alhaqqi Sanis Santoso, Kohar Hari Santoso Hari Sari, Gadis Meinar Shayla Kokomi Rishardy Wilda Mahdani Wiwin Retnowati Yuani Setiawati