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All Journal Ilmiah Manajemen Bisnis Nusantara Medical Science Journal Jurnal Biomedika Sasambo Journal of Pharmacy Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Majalah Ilmiah Inspiratif Bandung Conference Series: Accountancy Gunung Djati Conference Series Indonesian Journal of Pharmacy and Natural Product Neraca Manajemen, Akuntansi, dan Ekonomi Bilangan: Jurnal Ilmiah Matematika, Kebumian dan Angkasa Algoritma: Jurnal Matematika, Ilmu Pengetahuan Alam, Kebumian dan Angkasa
Arif Santoso
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Religion Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Potensi Antioksidan Biji Pepaya terhadap Parameter Oksidatif Jantung pada Tikus Jantan Model Diet Tinggi Lemak: Antioxidant Potential of Papaya Seeds on Cardiac Oxidative Parameters in Male Rats with High Fat Diet Model Arif Santoso; Choirul Huda; Sulastri; Pera Amelia; Rissa Laila Vifta; Melati Aprilliana Ramadhani; Eka Noviya Fuzianingsih
Indonesian Journal of Pharmacy and Natural Product Vol. 8 No. 01 (2025): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v8i01.3836

Abstract

An imbalance between the body's antioxidant system capacity and free radical production can lead to oxidative stress, which ultimately causes the lipid peroxidation process. This phenomenon is commonly identified by increased superoxide dismutase (SOD) activity and reduced malondialdehyde (MDA) concentrations. The objective of this study was to assess the efficacy of ethanolic papaya seed (Carica papaya L.) extract in modulating SOD and MDA levels in the heart tissue of male Sprague-Dawley rats subjected to a high-fat diet over 17 days. A total of 30 rats were used and allocated into six groups: a positive control (K+), a negative control (K−), a standard control (KN), and three treatment arms receiving oral doses of 150 mg/kgBW (P1), 250 mg/kgBW (P2), and 350 mg/kgBW (P3). The extraction process employed 70% ethanol through maceration. The lowest MDA average was recorded in the P3 group (3.50±1.65), whereas the K-group exhibited the highest level (24.45±4.71). In terms of SOD, the K+ group had the highest mean (65.46±5.93), and the K− group the lowest (36.34±7.57). Statistical analysis using Tukey’s test showed that administration of 350 mg/kg body weight extract yielded results closely resembling those of the positive control. However, the observed differences did not reach statistical significance (p > 0.05). The conclusion is that administration of papaya seed extract at a dose of 350 mg/kgBW has the potential to reduce MDA levels and increase SOD levels, with effects similar to positive controls.   ABSTRAK Tidak seimbangnya antara kapasitas sistem antioksidan tubuh dan produksi radikal bebas dapat mengakibatkan kearah stres oksidatif, yang pada akhirnya menyebabkan proses peroksidasi lipid. Keadaan ini ditandai oleh aktivitas enzim superoxide dismutase (SOD) yang meningkat dan konsentrasi malondialdehida (MDA) yang menurun. Penelitian ini bertujuan mengevaluasi potensi ekstrak etanol biji pepaya (Carica papaya L.) dalam memodulasi kadar SOD dan MDA pada jaringan jantung tikus jantan galur Sprague Dawley yang diberi diet tinggi lemak pada rentang waktu 17 hari. Penelitian ini memakai desain eksperimental dengan melibatkan 30 ekor tikus, yang dikelompokkan menjadi enam: kelompok kontrol positif (K+), kontrol negatif (K−), kontrol normal (KN), serta tiga kelompok perlakuan dengan dosis bertingkat yaitu 150 mg/kgBB (P1), 250 mg/kgBB (P2), dan 350 mg/kgBB (P3). Ekstrak diperoleh melalui metode maserasi menggunakan pelarut etanol 70%. Hasil analisis menyatakan bahwa kadar MDA terendah ditemukan pada kelompok P3 (3,50±1,65), sedangkan kadar tertinggi terdapat pada kelompok K− (24,45±4,71). Sebaliknya, kadar SOD tertinggi dicatat pada kelompok K+ (65,46±5,93) dan terendah pada kelompok K− (36,34±7,57). Berdasarkan uji lanjut Tukey, pemberian ekstrak biji pepaya dosis 350 mg/kgBB (P3) memberikan hasil yang secara statistik mendekati kelompok kontrol positif, meskipun belum menyatakan perbedaan bermakna (p > 0,05). Kesimpulannya adalah pemberian ekstrak biji pepaya dosis 350 mg/kgBB memiliki potensi pada penurunan kadar MDA dan meningkatkan kadar SOD, dengan efek yang menyerupai kontrol positif.
Upaya Meningkatkan Motivasi Belajar Peserta Didik Pada Mata Pelajaran Matematika Melalui Pembelajaran Berdiferensiasi Berdasarkan Konten Di Kelas Xi TFLM-3 SMK Negeri 5 Surabaya Nada Haristiani Barida; Fatkul Anam; Arif Santoso
Bilangan : Jurnal Ilmiah Matematika, Kebumian dan Angkasa Vol. 2 No. 3 (2024): Bilangan : Jurnal Ilmiah Matematika, Kebumian dan Angkasa
Publisher : Asosiasi Riset Ilmu Matematika dan Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/bilangan.v2i3.91

Abstract

In learning activities, motivation is an encouragement or process to direct students in achieving learning goals. The research was motivated by the very diverse problem of students' learning motivation in mathematics subjects in class XI TFLM-3 SMK Negeri 5 Surabaya. This can be seen from the results of the researcher's observations, where when they are about to start learning activities, many students still think that mathematics is less interesting and boring so that students are always less ready to start learning mathematics and the learning that was usually carried out by previous mathematics teachers was just learning. just lectures and assignments. This research aims to determine the increase in students' learning motivation in mathematics subjects through differentiated learning based on content. This research uses a type of Classroom Action Research (PTK) which consists of two cycles using data collection techniques in the form of questionnaires and observation. This questionnaire is used to determine learning satisfaction that motivates students after carrying out learning strategy treatment. The results of research using differentiated learning based on content show an increase in students' learning motivation from pre-cycle activities 63,8% to 73,1% in cycle I, then continued with cycle II. It shows that the presentation average of students' learning motivation in mathematics subjects is 83,2% From the results of this research it can be concluded that using differentiated learning based on content is successful in increasing students' learning motivation in mathematics subjects in class XI TFLM-3 SMK Negeri 5 Surabaya.
Penerapan Pembelajaran Berdiferensiasi Dalam Upaya Meningkatkan Hasil Belajar Matematika Pada Materi Analisis Regresi Linear Sederhana Kelas XI TITL (Teknik Instalasi Tenaga Listrik) 2 SMK N 5 Surabaya Tahun Ajaran 2023/2024 Nur Layli Indah Puspita; Fatkul Anam; Arif Santoso
Algoritma : Jurnal Matematika, Ilmu pengetahuan Alam, Kebumian dan Angkasa Vol. 2 No. 4 (2024): Algoritma : Jurnal Matematika, Ilmu pengetahuan Alam, Kebumian dan Angkasa
Publisher : Asosiasi Riset Ilmu Matematika dan Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/algoritma.v2i4.94

Abstract

The research was conducted based on the problem of students in class XI TITL 2 SMK N 5 Surabaya This research aims to improve student learning outcomes by using differentiated learning based on student learning styles with differentiated content aspects. This research uses the PTK (Classroom Action Research) method with a quantitative approach and data collection techniques using diagnostic assessments (prestest) and summative assessments (posttest). The results of research using differentiated learning based on students' learning styles with differentiated content aspects show that there is an increase in learning outcomes which can be seen from pre-cycle activities with the percentage of learning completeness increasing from 18% to 43% in cycle I, then increasing to 78% in cycle II. From these results it can be concluded that research using differentiated learning based on students' learning styles based on differentiated content aspects has succeeded in improving the learning outcomes of class XI TITL 2 SMK N 5 Surabaya in mathematics lessons simple linear regression analysis material.
EVALUASI TOKSISITAS EKSTRAK KULIT BATANG MAJAPAHIT (Crescentia cujete) TERHADAP Artemia Sallina LEACH DAN IDENTIFIKASI SENYAWA MENGGUNAKAN LC-MS ELEN VIKELAVIANIS; ARIF SANTOSO; RAHMA DIYAN MARTHA
Gunung Djati Conference Series Vol. 58 (2025): Seminar Nasional Kimia Tahun 2025
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Terapi kimia untuk kanker dapat menimbulkan efek samping yang merugikan. Berdasarkan beberapa penelitian, tanaman obat Crescentia cujete memiliki aktivitas antikanker. Tujuan dari penelitian ini adalah untuk mengetahui potensi antikanker dari kulit batang Majapahit terhadap mortalitas larva Artemia salina Leach menggunakan metode BSLT (Brine Shrimp Lethality Test). Infusa kulit batang Majapahit dianalisis kandungan senyawa kimianya menggunakan LCMS (Liquid Chromatography Mass Spectrometry), dan analisis toksisitas dilakukan dengan memberikan infusa kulit batang pada konsentrasi 100 ppm hingga 1000 ppm terhadap larva udang yang telah menetas dan diamati selama 24 jam. Mortalitas larva dihitung dalam bentuk nilai probit. Data kemudian dimasukkan ke dalam Excel untuk memperoleh nilai LC50 yang menunjukkan potensi antikanker. Hasil identifikasi senyawa dengan analisis LCMS menemukan empat senyawa kimia dengan puncak tertinggi yaitu kaempferol-3-O-rhamnosida, hesperidin, asam galat, dan rutin. Hasil uji toksisitas akut infusa kulit batang Majapahit terhadap mortalitas Artemia salina Leach menunjukkan aktivitas antikanker dengan nilai LC50 < 1000 ppm, yaitu sebesar 324,339 ppm. Konsentrasi 400 ppm menunjukkan efek toksik yang dapat mewakili nilai LC50.
Co-Authors A. Kaisar Adiwijaya Putra Akrom, Akrom Andi Alfian Zainuddin Annisah Mahanani Choirul Huda Dianawaty Amiruddin Edward Pandu Wiriyansyah Elen Vikelavianis Fatkul Anam Firdaus Hamid Fuzianingsih, Eka Noviya Harun Iskandar Hasan Nyambe Iman Kadarman Is Fadhillah Laela Hayu Nurani Meiliani Meiliani Melati Aprilliana Ramadhani Muh Ilyas Mulkan Teguh Sutrisno Nada Haristiani Barida Nasrawati Basir Nur Ahmad Tabri Nur Layli Indah Puspita Nurjanah, Mutia Hariani Nurleli Pera Amelia Rahma Diyan Martha Ramadhani, Melati Apriliana Rizalinda Sjahril Sriyanty Sadsyam SULASTRI Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati vifta, rissa laila Yulia Yusrini Djabir