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All Journal E-Jurnal Medika Udayana Damianus Journal of Medicine Jurnal Biomedika dan Kesehatan Medica Hospitalia Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan JURNAL Al-AZHAR INDONESIA SERI SAINS DAN TEKNOLOGI Jurnal EnviScience (Environment Science) Bali Dermatology and Venereology Journal Indonesian Journal of Pharmaceutical and Clinical Research Pena Medika : Jurnal Kesehatan Journal of Holistic and Traditional Medicine (JHTM) Insights in Public Health Journal NUCLEUS: Jurnal Sains dan Teknologi International Islamic Medical Journal Cermin Dunia Kedokteran Jurnal Ilmu Medis Indonesia GENIUS JOURNAL (General Nursing Science Journal) Journal of Pharmaceutical Care and Sciences Indonesian Journal of Advanced Research (IJAR) Jurnal Sains, Teknologi dan Kesehatan ASSYIFA: Jurnal Ilmu Kesehatan Jurnal Ilmiah Ilmu Kesehatan ACTIVE: Journal of Physical Education, Sport, Health and Recreation Jurnal Olahraga Nasional
Reqgi First Trasia
Dept. Of Parasitology, Faculty Of Medicine, Sultan Ageng Tirtayasa University, Cilegon, Banten, Indonesia
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P PENGOBATAN TERKINI DAN PROFILAKSIS PRIMER PADA TOKSOPLASMOSIS Reqgi First Trasia
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 2 (2021): Journal Pharmaceutical Care and Sciences
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v2i1.73

Abstract

Background: Toxoplasmosis is still a health problem in the world. This parasite is found cosmopolitan in humans and animals. In Indonesia, the prevalence of positive anti-Toxoplasma gondii substances in humans ranges from 2-63%, but there are still few comprehensive studies on current treatment and prophylaxis to treat it. Objective: This article will provide an in-depth review of current treatment and primary prophylaxis in toxoplasmosis. Methods: Searching the latest literature, obtained 10 relevant journals. Results: Initial therapy Pyrimethamine 200 mg was given for 6 weeks. Maintenance therapy (suppressive, secondary prophylaxis) is given for life if immune reconstitution does not occur. Primary prophylaxis against toxoplasmic encephalitis is given to patients who are seropositive for Toxoplasma. Conclusion: Initial therapy, maintenance, and primary prophylaxis can be useful to prevent worsening of the prognosis of toxoplasmosis disease.
P Pengobatan Terkini Alergi, Reaksi Toksik, Dan Penyakit Akibat Artropoda Reqgi First Trasia
Jurnal Pelayanan Kefarmasian dan Sains Vol 2 No 1 (2021): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v2i1.122

Abstract

Abstract Background: The presence of erusism and lepidopterism cases in Indonesia is influenced by butterfly species, regional conditions and community habits as farmers or garden workers. In addition, the population of house dust mites depends on several factors that are still being studied. Parasitological reviews of current treatments for insect disease are still poorly understood. Purpose: This article aims to review current treatments for allergies, toxic reactions, and insect-borne diseases. Methods: Recent literature search, obtained 11 relevant articles for review. Results: Local treatment due to contact with insects can be given a solution of iodine, corticosteroids and antihistamines. In severe cases, the drug can be given orally or parenterally. Conclusion: Based on the results of the review, it can be concluded that to treat airway attacks due to mite allergy, bronchodilators and corticosteroids can be given.
Pilihan Pengobatan Mikosis Superfisialis dan Profunda di Indonesia Reqgi First Trasia
Jurnal Pelayanan Kefarmasian dan Sains Vol 2 No 2 (2022): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v2i2.151

Abstract

Background: Fungal infectious diseases are found cosmopolitan, especially in hot climates. In Indonesia, the frequency of superficial mycoses is still quite high. However, the parasitological review of the current treatment of superficial and deep fungal diseases is still poorly understood. Purpose: This article aims to review the current treatment of superficial and deep mycoses in Indonesia. Methods: Recent literature search, obtained 13 relevant articles for review. Results: In minor superficial mycoses, local (topical) treatment with salicyl, imidazole derivatives, isoconazole, terbinafine cream, cyclopyrox solution and tolnaphthate tincture or ointment may be given. In deep mycoses, itraconazole can be given. Conclusion: Based on the results of the review, it can be concluded that to treat the symptoms caused by superficial mycoses, topical treatment with imidazole derivatives is given, while in deep mycoses, tablets or injections such as amphotericin are given. Keywords: treatment, fungus, mycosis, infection.
Prevalence of Pediculosis Capitis in Indonesia Reqgi First Trasia
Insights in Public Health Journal Vol 3 No 1 (2022): Insights in Public Health Journal
Publisher : Public Health Department, Faculty of Health Sciences, Jenderal Soedirman University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.iphj.2022.3.1.4936

Abstract

Head lice infestation is still a health problem in Indonesia. Currently, there has been a lot of research on the incidence of pediculosis capitis. However, there are still few articles that systematically review the incidence of head lice infestation. The purpose of writing this article is to examine cases of pediculosis capitis in several regions in Indonesia in order to obtain systematic and comprehensive prevalence data. A literature search was carried out in October 2021 through Google Scholar and obtained 13 relevant articles. Based on the above review, it can be concluded that the highest incidence of pediculosis capitis is in Islamic boarding schools, attacking elementary school-aged children, with a prevalence range of 29.3%-88.9% and can occur throughout Indonesia. This condition can be caused by a lack of personal hygiene, so that it can continue to be a source of infestation for children around it.
Scabies in Indonesia: Epidemiology and Prevention Reqgi First Trasia
Insights in Public Health Journal Vol 1 No 2 (2020): Insights in Public Health Journal
Publisher : Public Health Department, Faculty of Health Sciences, Jenderal Soedirman University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.iphj.2020.1.2.3071

Abstract

Scabies is still a health problem in the world, including Indonesia. The World Health Organization (WHO) in 2017 stated that scabies is included in the Neglected Tropical Disease (NTD) which requires large-scale control. In Indonesia, according to data from the Ministry of Health Republic of Indonesia the prevalence of scabies in 2017 is 6% of the total population in Indonesia. Discussion on the incidence and prevention of scabies from various regions in Indonesia so far is still not comprehensive. This review will provide an overview related to epidemiology and preventive measures against scabies so that scabies cases in Indonesia can be controlled properly
EPIDEMIOLOGY UPDATE OF HELMINTHIASIS IN INDONESIA Reqgi First Trasia
Insights in Public Health Journal Vol 2 No 1 (2021): Insights in Public Health Journal
Publisher : Public Health Department, Faculty of Health Sciences, Jenderal Soedirman University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.iphj.2021.2.1.4283

Abstract

Helminthiasis are still a health problem in Indonesia. Although not deadly, helminth infections will slowly affect children's health and productivity through a decrease in nutritional status. The chronic clinical course and tend to be asymptomatic causes helminthiasis to be classified as a neglected tropical disease. Research on the epidemiology of helminthiasis has been carried out in several regions in Indonesia. However, there has not been a comprehensive review to see the epidemiology aspects of helminthiasis. This article will discuss in detail how helminth infections influence the host to increase the incidence of malnutrition and its impact on children's health. Although this is not an emergency and a condition, the risk factors will lead the child to a state of chronic helminthiasis and transmission to other children which will have a negative impact on public health.
TARGET MOLEKULER UNTUK DESAIN PENGOBATAN PRURITUS NOKTURNAL PADA PASIEN SKABIES: Molecular Target for Treatment Design of Nocturnal Pruritus in Scabies Patients Reqgi First Trasia; Samsul Mustofa; Endang Purwaningsih; Sri Wahyu Herlinawati
ASSYIFA : Jurnal Ilmu Kesehatan Vol. 2 No. 2 (2024)
Publisher : Forind Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62085/ajk.v2i2.76

Abstract

Pruritus is one of the factors that contributes to reduced quality of life in patients with scabies, along with disease severity and sleep disturbances. So far not much is known about the molecular targets in scabies treatment. The aim of this article is to examine the potential of molecular targets for the design of treatment for nocturnal pruritus as the main symptom of scabies. Evidence in various literature correlates the incidence of scabies with a number of targets found in the skin, such as NK1R, JAK, TRPV1 and TRPA1 channels, because the expression of these receptors is very high in the skin lesions of patients suffering from nocturnal pruritus, when compared with skin that does not have lesions. . Results from comparing three molecular targets and considering the development of new therapeutic strategies with structure-based design, NK1R seems to be the most promising due to recent findings of its crystallographic structure.
Covid-19 dan Koinfeksi Penyakit Parasit Trasia, Reqgi First
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1A (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (284.078 KB) | DOI: 10.36408/mhjcm.v7i1A.471

Abstract

LATAR BELAKANG: Kondisi pandemi, kasus Covid-19 semakin meningkat, manifestasi klinis seperti demam, batuk, diare, muntah, sakit kepala, mialgia dan kelelahan, mungkin sulit untuk membedakan COVID-19 dari spektrum penyakit dengan manifestasi serupa, seperti malaria dan cacingan, terutama di daerah endemik. Di Indonesia belum ada artikel yang membahas Covid-19 dengan koinfeksi malaria dan cacing. TUJUAN: Tujuan penulisan ini adalah menelaah dampak klinis infeksi Covid-19 dengan komorbid infeksi parasit yaitu malaria dan kecacingan. METODE: Penelusuran kepustakaan 154 jurnal, terdapat 4 jurnal yang relevan. DISKUSI: Manifestasi klinis malaria yang parah terjadi karena respon proinflamasi yang meningkat, hal yang sama terjadi dalam banyak kasus COVID-19. Koinfeksi Malaria dan COVID-19 dapat menyebabkan respons pro-inflamasi yang berlebihan, manifestasi klinis lebih parah dan prognosis buruk. Berdasarkan imunopatogenitas dari infeksi cacing di daerah endemis, dikhawatirkan hal tersebut akan meningkatkan keparahan gejala Covid-19 pada pasien dengan koinfeksi cacing. KESIMPULAN: Pada kasus Covid-19 yang diikuti dengan koinfeksi malaria menunjukkan keparahan manifestasi klinis akibat peningkatan respon inflamasi. Diduga bahwa respon imun hospes terhadap cacing akan memberikan dampak klinis yang lebih berat pada kasus Covid-19. Kata kunci: Covid-19, koinfeksi, malaria, cacingan, penyakit parasit BACKGROUND: The condition of the Covid-19 pandemic where the number of cases is increasing. Clinical manifestations such as fever, cough, diarrhea, vomiting, headache, myalgia and fatigue, it may be difficult to distinguish COVID-19 from the spectrum of diseases with similar manifestations, such as malaria and intestinal worms, especially in endemic areas. Indonesia there are no articles discussing Covid-19 with malaria and worm coinfection. OBJECTIVE: The purpose this article is to review the clinical impact of Covid-19 infection with comorbid parasitic infections, in this case malaria and worms. METHOD: Search the literature of 154 journals, there are 4 journals that are relevant DISCUSSION: The severe manifestations of malaria occur because of an increased proinflammatory response, the same thing happens in many cases of COVID-19. Malaria coinfection and COVID-19 can then cause excessive pro-inflammatory responses, severe manifestations and a poor prognosis. In addition, based on immunopathogenicity from worm infections in endemic areas, it is feared that this will increase the severity of Covid-19 symptoms in patients with worm co-infection. CONCLUSION: In the case of Covid-19 followed by co-infection with malaria, it shows the severity of clinical manifestations due to increased inflammatory response. Tobe assumed that the host's immune response to worms will have a more severe clinical impact in the Covid-19 case. Keywords: Covid-19, coinfection, malaria, intestinal worms, parasitic diseases
Host Immune Response to Malaria Trasia, Reqgi First
Jurnal Medis Islam Internasional Vol 2 No 2 (2021): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v2i2.1681

Abstract

Malaria is still a health threat, especially for children and pregnant women in endemic areas. The World Health Organization (WHO) reports 228 million cases of malaria occur worldwide and an estimated 405,000 deaths from malaria globally in 2018. A series of malaria control efforts according to WHO recommendations have been carried out widely. However, these programs face obstacles. Therefore, the existence of an effective malaria vaccine is absolutely necessary in a series of malaria control strategies. Development of a malaria vaccine requires a basic concept regarding the host's immune response to malaria. Unfortunately, only a few in Indonesia have reviewed how the immune response is. This article will present an understanding of how the human immune system responds to Plasmodium falciparum.
House Dust Mite Exposure: Can It Be A Severe COVID-19 Prevention? Trasia, Reqgi First
Jurnal Medis Islam Internasional Vol 4 No 1 (2022): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v4i1.3817

Abstract

Background: In the midst of the ongoing COVID-19 pandemic, many studies are looking for treatment  to suppress viral replication and prevention through vaccination. However, to this day the number of incidences and deaths due to COVID-19 is still increasing. Objective: The purpose of this article is to review theoretically the alleged increase in eosinophils in house dust mite exposure can prevent the severity of COVID-19 symptoms. Methods: This article was compiled through a literature search in reputable international journals by the time 2020-2021. Result: The severity of symptoms that arise due to COVID-19 infection is one of them caused by eosinophenia. On the other hand, the host immune response to house dust mite exposure can increase the number of eosinophils through stimulation of IL-6, IL-8, GM-CSF, IL-5 and IL-33. These eosinophils will then express TLR-7 on the cell surface which makes them able to recognize SARS-CoV-2. Stimulation of this eosinophil receptor triggers the production of cytokines, degranulation, superoxide, and nitric oxide (NO) through NO synthase which has a direct antiviral effect. EDN and ECP of human eosinophils can decrease viral infectivity through a ribonuclease-dependent mechanism. Eosinophils are capable of producing extracellular traps composed of eosinophilic granule proteins bound to mitochondrial DNA in response to viral infection in vitro, especially in an oxidative lung tissue environment. Eosinophils also rapidly mobilize granules of Th1 cytokines, including IL-12 and IFN-g which are important for antiviral immune responses. Conclusion: Although available data are still limited, there are indications that eosinophils have a protective effect during SARS-CoV-2 infection. Therefore, biological agents such as exposure to house dust mites targeting eosinophils may be useful to help clarify the role of eosinophils in their antiviral response.
Co-Authors Akmaluddin, Muhammad Anggraeni, Inggrid Dwi Aryatama, Aslam Desyana, Rizqia Meta Fairuz Dua, Muhammad Yugo Hario Sakti Endang Purwaningsih Endang Purwaningsih Faruqi, Azzam Fitriani, Nabilla Hakyanto, Eka Hawa, Farahdhiya Millati Ika Puspa Sari Irawati, Nur Bebi Ulfah Kamila, Muthia Dwifitri Keumala Dewi, Intan Masnur Ali Muhammad Tola, Sakura Panjaitan, Samuel Nicolas Agustinus Pratama, Adito Joyo Ari Putra, Novitrian Eka Putri, Haura Firlanti Putu Aryani Qory Jumrotul Aqobah Rawina Winita Robiatul Adawiyah Sa'diyah, Salma Safitri, Dina Lutfia Samsul Mustofa Samsul Mustofa Sasmita, Guruh Nata Sri Wahyu Herlinawati Sri Wahyu Herlinawati Yenny Djuardi Zenia Maulivia Fadila