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Protein Tungau Sarcoptes Scabiei Sebagai Penyebab Stres Oksidatif Pada Kulit yang Terinvestasi Parasit Trasia, Reqgi First; Mustofa, Samsul; Purwaningsih, Endang; Herlinawati, Sri Wahyu
Pena Medika : Jurnal Kesehatan Vol. 15 No. 1 (2025): PENA MEDIKA: JURNAL KESEHATAN
Publisher : Universitas Pekalongan

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Abstract

S. scabiei infestation triggers many reactions including allergic reactions, inflammation, innate immune reactions, and activation of immune components in the skin accompanied by oxidative stress stages. This article aims to examine the genetic characterization of S. scabiei and gain a better understanding of host-parasite interactions with particular emphasis on skin oxidative stress parameters such as oxidant/antioxidant balance, stress parameters, and immune responses. This article is compiled as a systematic review by examining a number of relevant publications. Based on this search, it was found that to determine the effect of S. scabiei infestation on the oxidant/antioxidant balance in serum, oxidative stress markers such as total antioxidant activity (T-AOC), total nitric oxide concentration (TNO), lipid peroxide levels, and malonyldialdehyde (MDA) were used, as well as antioxidant enzyme levels; superoxide dismutase (SOD), glutathione-S-transferase (GSH) and catalase. Oxidative stress has been shown to be involved in the pathogenesis of several parasitic infectious diseases including scabies. Host cell metabolism produces ROS and RNS. At low to moderate levels, they are involved in several physiological functions including cell signaling and immune function. Conversely, at high levels, they cause damage to molecules including lipids, proteins, lipoproteins, and nucleic acids starting from a chain reaction of free radical formation leading to a condition known as oxidative stress. This article recommends a meta-analysis study to obtain more in-depth review results for further research..
Rational Use of Medicine in the Treatment of Helminth Infection : A Mini Review Trasia, Reqgi First
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 1 (2021): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i1.5375

Abstract

Indonesia still has health problem, especially soil transmitted helminth. These helminths can cause deteriorate health, nutrition, intelligence and productivity of patients so causes a lot of losses economically. The aim of this article is to review the rational treatment of helminth infection. Albendazole, mebendazole, and pyrantel pamoate are the drugs recommended by the WHO. However, the uses of the three are different, especially for mass treatment or selective medicine. This review conclude that the three drugs are used according to the target patient's age with dosages and preparations that must be adjusted.
Development of Muscle Explosive Power Tests on Upper Body Aqobah, Qory Jumrotul; Trasia, Reqgi First; Ali, Masnur; Pratama, Adito Joyo Ari
ACTIVE: Journal of Physical Education, Sport, Health and Recreation Vol. 13 No. 3 (2024)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/peshr.v13i3.13667

Abstract

Tests and measurements in the field of sports are important to reach the peak of achievement. With advances in technology in the field of sports can help make it easier to carry out tests and measurements. Upper muscle explosive power (upper body) is one important component to achieve achievement in each sport. The results of observations in the field, tests and measurement of upper muscle explosive power are still using manuals not digitally, such as push up Ball uses a measuring instrument in the form of a long ruler or meter. The method used in this study is the Research & Development (R&D) method that refers to the 4D model of the development of Thiagaradjan & Semmel with steps  including Define, Design, Develop, and Disseminate. The research subjects are athletes who will compete in the 2024 National Sports Week (PON) Banten Province and its surroundings. Data collection methods are carried out using media and material validation questionnaires. Data analysis techniques use descriptive statistics that refer to the guide of Mardapi (2018), namely by converting score data on the questionnaire sheet into a qualitative form, calculating the average score of the total filling of the questionnaire sheet, and changing the average score into a qualitative value. The results show that it is very practical as indicated by the results of the questionnaire and has good effectiveness on training results.
Association between HIV Clinical Stage and The Incidence of Opportunistic Infections among HIV/AIDS Patients at Banten Regional Hospital in 2020-2024 Trasia, Reqgi First; Safitri, Dina Lutfia; Irawati, Nur Bebi Ulfah
Jurnal Medis Islam Internasional Vol 7 No 2 (2025): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v7i2.7105

Abstract

Introduction: Untreated HIV conditions can progress to AIDS, which is the terminal phase of HIV infection, making the body more susceptible to other infections called opportunistic infections. Opportunistic infections are generally not dangerous for healthy people but can be fatal if they affect people with immunosuppression, such as HIV/AIDS patients. Objective: This study aims to determine the relationship between HIV clinical stage and the incidence of opportunistic infections among HIV/AIDS patients at Banten Regional Hospital in 2020–2024. Methods: This study is retrospective with a cross-sectional design. The sampling technique used was consecutive sampling, and the sample size calculation used the two-proportion comparison formula. The research data were analyzed univariate and bivariate using SPSS 26.0 Program. The research hypothesis was tested using the Chi-square statistical test and the Mantel-Haenszel Common Odds Ratio Estimate. Results: The respondents in this study were 242 HIV/AIDS patients. The results of the analysis showed that the prevalence of HIV/AIDS at Banten Regional Hospital in 2020-2024 was 0.06%, with the highest proportion being stage I (50.83%), stage III (26.45%), stage IV (14.88%), and stage II (7.85%). The prevalence of opportunistic infections was 45.45%. Of the 110 patients identified as having opportunistic infections, 141 infections were obtained. Some patients had one type of opportunistic infection (81.82%), two types of opportunistic infections (11.82%), and ≥ three types of opportunistic infections (6.36%). The proportion of opportunistic infections based on etiology was dominated by bacterial infections (73.76%), parasitic infections (13.48%), fungal infections (6.38%), and viral infections (6.38%). The most common opportunistic infections suffered by HIV/AIDS patients at Banten Regional Hospital were tuberculosis (44,68%) and toxoplasmosis (9,93%). Conclusions: Based on bivariate analysis, there was a significant relationship between the clinical stage of HIV and the incidence of opportunistic infections among HIV/AIDS patients at Banten Regional Hospital in 2020–2024.
Mikrobiota Pada Atlet Berdasarkan Kapasitas Aerobik Maksimal Reqgi First Trasia; Zenia Maulivia Fadila
Jurnal Olahraga Nasional Vol. 2 No. 1 (2025): Jurnal Olahraga Nasional
Publisher : Universitas Nahdlatul Ulama Cirebon

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Abstract

Peran utama kolonisasi mikroorganisme pada olahragawan dijalankan oleh mikrobiota saluran pencernaan. komposisi mikrobiota juga dapat dipengaruhi oleh aktivitas fisik atau diet . Namun, masih sedikit artikel di Indonesia yang meninjau microbiota pada atlet. Oleh karena itu, tinjauan ini bertujuan untuk mengulas korelasi antara komposisi mikrobiota aktivitas fisik pada atlet, yang dapat meningkatkan kinerja olahraga mereka. Penelitian ini menggunakan metode narrative literature review dengan menyusun sebuah tinjauan atau rangkuman dari hasil-hasil penelitian yang telah dilakukan sebelumnya yaitu dari literasi atau jurnal yang mendukung dengan topik mengenai microbiota pada atlet berdasarkan kapasitas aerobic maksimal. Bakteri probiotik adalah strain bakteri hidup yang bila diberikan dalam jumlah tepat, akan bermanfaat bagi organisme inang . Sebagian besar data literatur menunjukkan sejumlah besar bakteri Clostridiales, seperti Bacteroides, Lactobacillus, Bifidobacterium, atau Veillonella. Namun, masih belum ada jawaban yang jelas spesies mana yang dominan mengkolonisasi saluran cerna atlet. Diversifikasi mikrobiota usus juga berubah tergantung pola makan yang dikonsumsi. Pola makan tinggi serat meningkatkan jumlah bakteri dari genera Lactobacillus dan Bifido bacterium, namun protein masih menjadi bahan pembangun massa otot yang paling penting