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All Journal E-Jurnal Medika Udayana Damianus Journal of Medicine Jurnal Biomedika dan Kesehatan Medica Hospitalia Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan JURNAL Al-AZHAR INDONESIA SERI SAINS DAN TEKNOLOGI Jurnal EnviScience (Environment Science) Bali Dermatology and Venereology Journal Indonesian Journal of Pharmaceutical and Clinical Research Pena Medika : Jurnal Kesehatan Journal of Holistic and Traditional Medicine (JHTM) Insights in Public Health Journal NUCLEUS: Jurnal Sains dan Teknologi International Islamic Medical Journal Cermin Dunia Kedokteran Jurnal Ilmu Medis Indonesia GENIUS JOURNAL (General Nursing Science Journal) Journal of Pharmaceutical Care and Sciences Journal of Hospital Management Indonesian Journal of Advanced Research (IJAR) Jurnal Sains, Teknologi dan Kesehatan ASSYIFA: Jurnal Ilmu Kesehatan Jurnal Ilmiah Ilmu Kesehatan ACTIVE: Journal of Physical Education, Sport, Health and Recreation Jurnal Olahraga Nasional
Reqgi First Trasia
Dept. Of Parasitology, Faculty Of Medicine, Sultan Ageng Tirtayasa University, Cilegon, Banten, Indonesia
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DAMPAK OBESITAS TERHADAP KEJADIAN INFLUENZA DAN COVID-19 Trasia, Reqgi First
Jurnal Ilmiah Ilmu Kesehatan Vol. 1 No. 2 (2023): Volume 1 Nomor 2 Tahun 2023
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jiik.v1i2.3160

Abstract

Latar Belakang: SARS-CoV-2 dengan cepat menyebar ke seluruh dunia dan membahayakan kesehatan manusia. COVID-19 memperlihatkan dirinya melalui spektrum yang luas dari gejala yang dapat berkembang menjadi sesuatu yang lebih parah seperti pneumonia dan beberapa komplikasi non-pernapasan. Peningkatan terhadap pasien rawat inap COVID-19 dan kematian dengan komorbiditas. Demikian pula dengan individu yang memiliki obesitas lebih berisiko untuk mengembangkan komplikasi klinis dan memiliki prognosis yang buruk seperti radang paru-paru. Metode: Penelusuran kepustakaan dilakukan pada Pubmed dan didapatkan artikel yang relevan. Hasil: Disfungsi pada imun dan metabolisme kelebihan berat badan dapat dikaitkan dengan kerentanan terhadap infeksi influenza, peradangan, gangguan sistem kekebalan tubuh, endokrin, dan risiko kardiovaskular. Kondisi obesitas yang sudah ada sebelumnya ini dapat mendukung persistensi virologi, memperkuat respon imunopatologi dan memperburuk kestabilan hemodinamik pada saat terpapar COVID-19. Kesimpulan: Dalam ulasan ini dapat disimpulkan bahwa faktor utama dan keadaan saat ini tentang obesitas sebagai faktor risiko influenza dan pasien rawat inap COVID-19, pernapasan berat manifestasi, komplikasi ekstrapulmoner dan bahkan kematian. Akhirnya, imunoregulasi mekanisme pneumonia influenza akut yang terjadi pada individu penderita obesitas dibahas sebagai kemungkinan faktor yang terlibat dalam patofisiologi COVID-19.
Respon imun hospes terhadap Sarcoptes scabiei Reqgi First Trasia; Ika Puspa Sari
Jurnal Biomedika dan Kesehatan Vol 3 No 4 (2020)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2020.v3.183-192

Abstract

Skabies, penyakit kulit yang disebabkan oleh infestasi dan sensitisasi terhadap tungau Sarcoptes scabiei var. hominis dan produknya, masih menjadi masalah kesehatan di dunia, termasuk Indonesia. World Health Organization (WHO) atau Organisasi Kesehatan Dunia pada tahun 2017 menyatakan bahwa skabies termasuk dalam Neglected Tropical Disease (NTD) yang memerlukan pengontrolan skala besar. S. scabiei spesifik terhadap hospes dan hal tersebut akibat perbedaan fisiologis tungau dan variabel hospes seperti diet, bau, respon imun, dan faktor-faktor fisik. Manifestasi klinis pada manusia berupa inflamasi kulit akan timbul lebih dari 4 minggu setelah terinfestasi. Lambatnya respon imun itu adalah efek dari kemampuan S.scabiei dalam memodulasi berbagai aspek respon imun dan inflamasi hospes. Telur, feses, ekskreta, saliva, dan tubuh S.scabiei yang mati juga menstimulasi respon imun. S.scabiei mendorong keluarnya anti-inflammatory cytokine interleukin-1 receptor antagonist (IL-1ra) dari sel fibroblas manusia. IL-1ra menginhibisi sitokin proinflamasi IL-1 dengan mengikat reseptor IL-1 yang ada dalam sel limfosit T, sel limfosit B, natural killer cell, makrofag dan neutrofil. Berdasarkan patogenesis skabies, antigen tungau merangsang respon imun adaptif pada manusia agar muncul produksi imunoglobulin. Pengetahuan mengenai respon imun hospes terhadap Sarcoptes scabiei ini dapat dijadikan dasar untuk pengembangan metode serodiagnostik dalam rangka menegakkan diagnosis skabies, sehingga membantu eliminasi skabies di Indonesia.
Analisis Faktor yang Berhubungan dengan Perdarahan Postpartum RSUD Banten Tahun 2019-2023 Trasia, Reqgi First; Anggraeni, Inggrid Dwi; Putra, Novitrian Eka
Jurnal Ilmu Medis Indonesia Vol. 4 No. 2 (2025): Maret
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/jimi.v4i2.4408

Abstract

Purpose: This study aimed to analyze the factors associated with postpartum hemorrhage (PPH) among postpartum mothers at RSUD Banten from 2019 to 2023, focusing on both causal and predisposing factors.. Methodology/approach: An observational analytic study with a cross-sectional and retrospective design was conducted using secondary data from medical records in the Obstetrics and Gynecology department. Independent variables included causal factors (uterine atony, retained placenta, lacerations, inversion, coagulopathy, rupture, and retained tissue) and predisposing factors (age, parity, prolonged labor, birth interval, and anemia). Data analysis was performed using SPSS 26.0 with chi-square, Fisher’s exact test, and logistic regression. Results/findings: Bivariate analysis showed significant associations between PPH and birth canal tears (p = 0.011; odds ratio [OR] = 2.594) and prolonged labor (p = 0.043; OR = 0.470). Other factors, such as uterine atony, placental retention, inversion, coagulopathy, age, parity, birth spacing, and anemia, were not significant. Multivariate analysis identified birth canal tear as the most dominant factor (p = 0.003; OR = 3.766; 95% CI: 1.558–9.102), emphasizing the need for better trauma prevention and labor management. Conclusions: Limitations include the cross-sectional design, which restricts causal interpretation, and the use of secondary data from a single hospital, which potentially affects accuracy and generalizability. Contribution: This study contributes to maternal health research by identifying the key risk factors for PPH. The findings can guide clinical practices, inform preventive strategies, and serve as a reference for future research on maternal morbidity and mortality.
Dampak Lingkungan Terhadap Kejadian Infeksi Parasit Trasia, Reqgi First
Jurnal EnviScience (Environment Science) Vol. 5 No. 1 (2021)
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/jev.v5i1.244

Abstract

Penyakit infeksi parasit masih menjadi masalah kesehatan di Indonesia dan di dunia. Pada tahun 2017, World Health Organization (WHO) memasukkan beberapa penyakit parasit ke dalam Neglected Tropical Disease (NTD). Penyakit parasit tidak dapat lepas dari kondisi lingkungan, suhu, kelembaban, iklim, dll. Di Indonesia, masih sedikit artikel yang meninjau dampak lingkungan terhadap insiden infeksi parasit. Tujuan dari penulisan artikel ini adalah untuk membahas bagaimana suhu, kelembaban dan cuaca dapat memengaruhi angka prevalensi penyakit akibat parasit.
Pengaruh Lingkungan Terhadap Transmisi Infeksi Protozoa Trasia, Reqgi First
Jurnal EnviScience (Environment Science) Vol. 5 No. 2 (2021): Implementing the Quality of Environmental Health as a 2030 Sustainable Developm
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/jev.v5i2.276

Abstract

Amebiasis and other protozoal infectious diseases occur worldwide. The highest prevalence is especially in the tropics and subtropics, especially in countries with poor environmental sanitation conditions. In Indonesia, colonic amebiasis is found in endemic conditions with a prevalence of about 18%. Epidemiological research shows that lack of hygiene is a factor that influences the occurrence of infection. In free-living amoeba, the spread can be through fresh water, soil, and feces because this amoeba is thermophilic. The amoeba is commonly found in water contaminated with E.coli. Several other types of protozoa were found to be cosmopolitan, so one form of prevention is by chlorinating drinking water sources using the coagulation-sedimentation-filtration method. In addition, environmental temperature also plays a role in the life cycle of the protozoa. Outside their habitat, protozoa can die at a temperature of 50 C, but can live for 5 days at a temperature of 0 C. Protozoa can also die in culture at a pH of less than 4.9 and cannot live in an aerobic environment. In parasites belonging to sporozoa, oocysts die at a temperature of 45-55 C or when dried and mixed with formalin, ammonia, and iodine solution.
Peran Lingkungan Terhadap Daur Hidup dan Perilaku Nyamuk Sebagai Vektor Penyakit Trasia, Reqgi First
Jurnal EnviScience (Environment Science) Vol. 6 No. 2 (2022)
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/jev.v6i2.295

Abstract

Prevalensi penyakit tular vektor berbeda antar wilayah endemi, seperti malaria dan filariasis yang sangat tergantung pada perilaku nyamuk. Sementara Ae.aegypti dapat tersebar luas di seluruh Indonesia. Kejadian tersebut terjadi akibat kurangnya perhatian terhadap pengaturan air dan saluran irigasi. Perilaku nyamuk sebagai vektor akan menentukan penyebarluasan penyakit dan munculnya wilayah endemi. Tujuan dari penulisan artikel ini adalah untuk meninjau peran lingkungan terhadap daur hidup dan perilaku nyamuk sebagai vektor penyakit. Sifat zoofilik dan antropofilik serta panjangnya usia nyamuk dapat meningkatkan jumlah sumber infeksi, sehingga dapat mengembangkan pertumbuhan larva mencapai stadium infektif untuk ditularkan. Berdasarkan tinjauan di atas, dapat disimpulkan bahwa perlu dilakukan pemberantasan penyakit tular vektor melalui pengobatan penderita malaria, filariasis, dan demam dengue, serta mengupayakan agar tidak ada kontak antara manusia dan nyamuk dengan cara menggunakan kawat kasa di jendela rumah, kelambu atau pemakaian repellent. Penting juga dilakukan penyuluhan mengenai sanitasi lingkungan dan pendidikan kesehatan masyarakat dalam upaya memusnahkan tempat perindukan nyamuk di rumah-rumah penduduk.
Anemia Gravis Caused by Chronic Multiple Infection of Helminthiasis on Geriatric: An Evidence-Based Case Report Trasia, Reqgi First; Dua, Muhammad Yugo Hario Sakti; Desyana, Rizqia Meta Fairuz; Akmaluddin, Muhammad; Kamila, Muthia Dwifitri
Jurnal Medis Islam Internasional Vol 7 No 1 (2025): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v7i1.6629

Abstract

Introduction: Soil-transmitted helminth (STH) infections remain the most prevalent parasitic diseases globally. In elderly individuals, such infections can lead to significant morbidity, including anemia, fatigue, decreased activity levels, cognitive impairment, nutritional deficiencies, and gastrointestinal disturbances. This case report aims to highlight a rare instance of severe anemia caused by worm infestation in an elderly patient. Case: A 57-year-old male presented with a 7-day history of fatigue, dizziness, and marked pallor, accompanied by worsening abdominal pain over the past 5 days. Physical examination revealed moderate illness with pale conjunctiva, a mildly distended abdomen, and hyperactive bowel sounds. Laboratory tests showed a significant drop in hemoglobin, hematocrit, erythrocyte count, serum iron, TIBC, and ferritin levels. Endoscopic evaluation revealed esophagitis, a Forrest III gastric ulcer, and multiple worms in the duodenum, later identified macroscopically as Ascaris lumbricoides. Discussion: Worm infection is the most recent known diagnosis. The patient has undergone a complete stool analysis, but no worm eggs were found microscopically. This condition is very likely a false negative due to various factors, such as a less fresh stool sample (not examined immediately within 30 minutes) and human error by the analyst. The diagnosis was made after an endoscopic examination and multiple worms were found in the duodenum. When viewed from the large number of worms, it is likely that the patient has a severe and chronic worm infection. This is what causes the patient to suffer from anemia gravis with Hb 5.9. Conclusions: Initial clinical and laboratory assessments led to a diagnosis of anemia gravis. The patient received three units of packed red cells. Further investigations confirmed microcytic hypochromic anemia due to iron deficiency and chronic inflammation, with parasitic infection as the underlying cause. Treatment with a single 400 mg dose of albendazole resulted in clinical improvement, allowing for safe discharge.
Analisis Kondisi Lingkungan Sebagai Faktor Risiko Infeksi Kecacingan pada Siswa Madrasah Ibtida’iyah di Kecamatan Banjarsari, Kabupaten Lebak Trasia, Reqgi First; Sasmita, Guruh Nata; Irawati, Nur Bebi Ulfah
Jurnal EnviScience (Environment Science) Vol. 9 No. 02 (2025): Environmental Health and Sanitation Issues
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/jev.v9i02.818

Abstract

The level of helminth infection in Banten Province reached 60.7%, with the highest case being in Lebak District, which is around 63.4%. This study is an analytic observational study using a cross-sectional study design and the sampling technique used is consecutive sampling. In this study, it was found that the proportion of Madrasah Ibtida'iyah students in Banjarsari Subdistrict, Lebak Regency who were at high risk of Soil Transmitted Helminths (STH) infection was 50.5%, the proportion of Madrasah Ibtida'iyah students in Banjarsari Subdistrict, Lebak Regency with poor nail hygiene was 14.7%, the habit of wearing footwear was 13.7%, and the socioeconomic status of the lower middle class was 81.1%. The proportion of Madrasah Ibtida'iyah students in Banjarsari Subdistrict, Lebak Regency who are at high risk of Soil Transmitted Helminths (STH) infection is 50.5%, the proportion of Madrasah Ibtida'iyah students in Banjarsari Subdistrict, Lebak Regency with poor personal hygiene between nail hygiene and the habit of wearing footwear, namely, poor nail hygiene is 14.7%, the habit of wearing footwear is 13.7%, the proportion of Madrasah Ibtida'iyah students in Banjarsari Subdistrict, Lebak Regency with lower-middle socioeconomic status as much as 81.1%, and a significant relationship was found between the habit of wearing footwear with a high risk of STH infection (p-value 0.000), but no significant relationship was found between nail hygiene with the risk of infection in Madrasah Ibtida'iyah students in Banjarsari District, Lebak Regency (p-value 0.090), and there was a significant relationship between the socioeconomic status of students with a high risk of STH infection (pvalue 0.000).
Protein Tungau Sarcoptes Scabiei Sebagai Penyebab Stres Oksidatif Pada Kulit yang Terinvestasi Parasit Trasia, Reqgi First; Mustofa, Samsul; Purwaningsih, Endang; Herlinawati, Sri Wahyu
Pena Medika : Jurnal Kesehatan Vol. 15 No. 1 (2025): PENA MEDIKA: JURNAL KESEHATAN
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

S. scabiei infestation triggers many reactions including allergic reactions, inflammation, innate immune reactions, and activation of immune components in the skin accompanied by oxidative stress stages. This article aims to examine the genetic characterization of S. scabiei and gain a better understanding of host-parasite interactions with particular emphasis on skin oxidative stress parameters such as oxidant/antioxidant balance, stress parameters, and immune responses. This article is compiled as a systematic review by examining a number of relevant publications. Based on this search, it was found that to determine the effect of S. scabiei infestation on the oxidant/antioxidant balance in serum, oxidative stress markers such as total antioxidant activity (T-AOC), total nitric oxide concentration (TNO), lipid peroxide levels, and malonyldialdehyde (MDA) were used, as well as antioxidant enzyme levels; superoxide dismutase (SOD), glutathione-S-transferase (GSH) and catalase. Oxidative stress has been shown to be involved in the pathogenesis of several parasitic infectious diseases including scabies. Host cell metabolism produces ROS and RNS. At low to moderate levels, they are involved in several physiological functions including cell signaling and immune function. Conversely, at high levels, they cause damage to molecules including lipids, proteins, lipoproteins, and nucleic acids starting from a chain reaction of free radical formation leading to a condition known as oxidative stress. This article recommends a meta-analysis study to obtain more in-depth review results for further research..
Rational Use of Medicine in the Treatment of Helminth Infection : A Mini Review Trasia, Reqgi First
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 1 (2021): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i1.5375

Abstract

Indonesia still has health problem, especially soil transmitted helminth. These helminths can cause deteriorate health, nutrition, intelligence and productivity of patients so causes a lot of losses economically. The aim of this article is to review the rational treatment of helminth infection. Albendazole, mebendazole, and pyrantel pamoate are the drugs recommended by the WHO. However, the uses of the three are different, especially for mass treatment or selective medicine. This review conclude that the three drugs are used according to the target patient's age with dosages and preparations that must be adjusted.
Co-Authors Adito Joyo Ari Pratama Akmaluddin, Muhammad Anggraeni, Inggrid Dwi Aslam Aryatama Desyana, Rizqia Meta Fairuz Dua, Muhammad Yugo Hario Sakti Endang Purwaningsih Endang Purwaningsih Endang Purwaningsih Fadila, Zenia Maulivia Farahdhiya Millati Hawa Faruqi, Azzam Fitriani, Nabilla Hakyanto, Eka Haura Firlanti Putri Ika Puspa Sari Irawati, Nur Bebi Ulfah Kamila, Muthia Dwifitri Keumala Dewi, Intan Masnur Ali Muhammad Tola, Sakura Putra, Novitrian Eka Putu Aryani Qory Jumrotul Aqobah Rawina Winita Robiatul Adawiyah Sa'diyah, Salma Safitri, Dina Lutfia Samsul Mustofa Samsul Mustofa Samsul Mustofa Samuel Nicolas Agustinus Panjaitan Sasmita, Guruh Nata Sri Wahyu Herlinawati Sri Wahyu Herlinawati Sri Wahyu Herlinawati Yenny Djuardi