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All Journal Tropical Medicine Journal Biospecies Biosfer: Jurnal Tadris Biologi Tadris: Jurnal keguruan dan Ilmu Tarbiyah Bioedukasi: Jurnal Pendidikan Biologi Biota Biology, Medicine, & Natural Product Chemistry Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Bio Ilmi: Jurnal Pendidikan Agriprima : Journal of Applied Agricultural Sciences BIOEDUSCIENCE JMM (Jurnal Masyarakat Mandiri) Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati BIOSFER : Jurnal Biologi dan Pendidikan Biologi AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Jurnal Pembelajaran dan Biologi Nukleus Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Seminar Nasional Peningkatan Mutu Pendidikan Jurnal EduHealth Inornatus: Biology Education Journal Jurnal Pemberdayaan Masyarakat Gunung Djati Conference Series Organisms: Journal of Biosciences Riwayat: Educational Journal of History and Humanities Journal Fatmawati Laboratory & Medical Science Jurnal Bioteknologi & Biosains Indonesia (JBBI) IJIS Edu : Indonesian Journal of Integrated Science Education Jurnal Bioteknologi & Biosains Indonesia
Marlina Kamelia
Universitas Islam Negeri Raden Intan Lampung
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Journal : Tropical Medicine Journal

 1 
Study on Chloroquine Resistance Transporter (pfcrt) Gene Polymorphism of Plasmodium falciparum in Malaria Patients in Lampung Marlina Kamelia; Supargiyono -; Mahardika Agus Wijayanti
Tropical Medicine Journal Vol 1, No 1 (2011): Tropical Medicine Journal
Publisher : Pusat Kedokteran Tropis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/tmj.4567

Abstract

Introduction: The prevalence of malaria in Lampung Province was increased in the last few years. One of the factors contributes to the increased rate is the widespread of the Plasmodium falciparum resistance to antimalarial drugs. Mutation on the gene encoding Pfcrt protein has been reported to be correlated with this resistance.Objectives: To fi nd out the frequency and distribution of the pfcrt gene polymorphism among Plasmodium falciparum in malaria patients in endemic area at Bandar Lampung and Lampung Selatan, LampungProvince.Methods: Blood samples were collected from malaria falciparum patients in Bandar Lampung and Lampung Selatan by active and passive case detections. Two to three mL of venous blood were collected in tubes with EDTA, and kept in the temperature of -200C before DNA extraction. DNA from each sample was extracted using Guanidine isothiocyanate and Chelex 100 methods. Genes encoding Pfcrt protein were amplifi ed by Nested PCR using TCRP and TCRD primers. The polymorphism of the pfcrt gene was identified by cutting the PCR product using Apo1 restriction enzymes to produce 100bp and 34bp fragments.Results: Forty six samples from P. falciparum-infected patients were collected from the two areas. The genes encoding the Pfcrt protein were succesfully amplifi ed, all 46 PCR products showed 100bp and 34bpfragments after incubation with Apo1 restriction enzyme. It indicated that pfcrt polymorphism was 100%.Conclusion: The frequency of pfcrt gene polymorphisms in patients with malaria falciparum in Bandar Lampung and Lampung Selatan was 100%.Keywords: malaria falciparum, pfcrt, chloroquine, polymorphism
Co-Authors Ade Lenty Hoya Adistyaningrum, Nurul Ahmad Ahmad Ahmad Ahmad Ahmad Fauzi Rosnadi Almayda, Lika Dini Anam, M. Khairul Andri Jaya Kesuma Ari Hermawan Asa Izati Aulia Novitasari Aulia Ulmillah Aulia Ulmillah Ayu Febriyani, Vicca Badrul Kamil Baika, Febta Dwi Bambang Sri Anggoro Deffi Novitasari Dian Nur Chomsyah Dina Maulina Dwijowati Aji Saputri Dwijowati Asih Saputri Farida, Farida Faridah, Indah Fathurohman Fathurohman Fathurohman Fathurohman, Fathurohman FNU Supriyadi Franciska Anes Rianti Hendras Restuti, Ayesha Utari Hening, Jeni Latri Indah Faridah Irbah, Istiana Irma Sari Irma, Putri Irwandani Irwandani Khairul Anam Khairul Anam Kurnia, Aniza Mahardika Agus Wijayanti Mahmud Rudini Maylinda, Vera Meirina Meirina Meirina, Meirina Muhammad Fahmi Erlangga Netriwati Nita Ayu Agustin Novita Nurhasanah Novitasari, Deffi Novitasari, Yeni Novitasari, Yeni Nurhaida Widiani Nurhaida Widiani Oktaviyani, Sari Ovi Prasetya Winandari Ovi Prasetya Winandari, Ovi Prasetya Puji Nurrohmah Putri Irma Rani Yosilia Rasuane Noor Reza Fahlida Rina Budi Satiyarti Rina Budi Satiyarti, Rina Budi Riyanti, Franciska Anes Rizki, Erika Puspita Ruhban Maskur Sa'adah, Farida Putri Saadah, Farida Putri Satitiningrum, Yuni Shinta Almayra Shinta Anisya Siti Fatayati Suci Ristawati Suci Wulan Pawhestri Suci Wulan Pawhestri Suci Wulan Pawhestri Suharno Zein Suharno Zein Suharno Zein, Suharno Suharno Zen Supargiyono - Supriyadi Supriyadi Supriyadi Supriyadi Suri, Intan Mulia Tantri Subo Marmanik Triawan Alkausar Umillah, Aulia Veny Endarhadi A Winda Isti Utami Yeni Novitasari Yessy Velina Zackia Irina Zahra Zahra, Zackia Irina