Article Per Year (5 Year)
p-Index From 2020 - 2025
1.728
P-Index
This Author published in this journals
All Journal Pharmaciana: Jurnal Kefarmasian Research Journal of Life Science Journal of Mathematical and Fundamental Sciences JURNAL PHARMASCIENCE Pharmascience Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASI GALENIKA Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Indonesian Journal of Global Health research Mattawang: Jurnal Pengabdian Masyarakat Media Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan
Asmiyenti Djaliasrin Djalil
Universitas Muhammadiyah Purwokerto
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

Published : 21 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Jurnal Ilmu Kefarmasian Indonesia

 1 
Optimasi Fast Disintegrating Tablet Difenhidramin HCl Menggunakan Modifikasi Pati Pisang Kepok Kuning, Crospovidone, dan Microcrystalline Cellulose Rahmawati, Tias Eka; Siswanto, Agus; Djalil, Asmiyenti Djaliasrin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1406

Abstract

Diphenhydramine HCl is an antihistamine drug that is available in conventional tablet form. This study aimed to produce the optimum formula for a diphenhydramine fast disintegrating tablet (FDT) using a modification of starch, crospovidone, and microcrystalline cellulose (MCC) to produce quality tablets that meet the tablet's physical requirements and tablet dissolution. Starch modification was made using a two-step method of starch cross-link, then continued with silica coprecipitation. FDT was prepared by the direct compression method. Optimisation with the simplex lattice design (SLD) model uses three components: co-process starch crosslink-silica, crospovidone, and MCC, which obtained 14 formula designs. The hardness, wetting time, disintegration time, and percent dissolution are optimisation parameters. Equations, contour plots, and desirability values were determined as the optimum formula. Based on the research results, an optimum formula was obtained with the proportion of co-process cross-link starch-silica was 56.185 mg, crospovidone at 6 mg, and MCC at 45.815 mg. The result of hardness was 5 kg, wetting time 51.061 seconds, disintegration time 63.129 seconds, and dissolution was 100.972%. The interaction of the three components reduces hardness and increases disintegration time, wetting time, and percent dissolution.
Co-Authors Aditya Hanif Evridianto Agus Siswanto Alwani Hamad Alwani Hamad Andestia Sinaga, Risda Yunita Andestia Sinaga, Risda Yunita Andry Nur Hidayat Anna Nurlativah Arba, Muhammad Arinda Nur Cahyani Arry Yanuar Ayu Mulyani Azzahra, Ratu Bayu Satria Nugroho Putra Daryono Hadi Tjahjono Dhanti, Kurnia Ritma Dwi Hartanti Dwi Hartanti Dwi Hartanti Dwi Hartanti Eka Yuliani Saputri Eli Nurlaeli, Eli Fadhilah Zahra Nadia Fadlilah, Intan Nur Genatrika, Erza Hartanti, Dwi Hasnita Ika Diandana Yulia Asmara Ika Yuni Astuti Ika Yuni Astuti Ivani, Adhika Rifki Kumala, Rosa Muhammad Sulaiman Zubair Mulyani, Ayu Nur Yulianingsih Nurul Fadhilah Deni Saputri Nurul Fadhilah Deni Saputri, Nurul Fadhilah Deni Pradani, Dea Yulinestria Pri Iswati Utami Rahmawati, Tias Eka Retno Sulistiyowati Retno Wahyuningrum Risda Yunita Andestia Sinaga Sanang Nur Safitri Siti Musyarofah Subagio, Resita Suparman Suparman Suparman Susanti Susanti Syah Putri, Tina Tina Syah Putri Wahyu Utaminingrum Widyowati, Ulfi Wiranti Sri Rahayu Yulianingsih, Nur Zainur Rahman Hakim