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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Ilmu Perairan (Aquatic Science) Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Indonesian Journal of Pharmaceutical Science and Technology INDONESIAN JOURNAL OF PHARMACY Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis JOPS (Journal Of Pharmacy and Science) JURNAL EDUCATION AND DEVELOPMENT JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Majalah Kedokteran Andalas Jurnal Farmasi Higea Menara Ilmu Jurnal Penelitian Farmasi dan Herbal Journal of Pharmaceutical and Health Research Jurnal Zona REACTOR : Journal of Research On Chemistry And Engineering Pharmaceutical And Biomedical Sciences Journal (PBSJ) Biodiversitas Journal of Biological Diversity
Akmal Djamaan
Fakultas Farmasi Universitas Andalas Padang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Karaktersasi Bakteri Pengurai Plastik Sintetis Polipropilen dari Sampel Air Laut Studi Kasus dan Potensi Lingkungan Muhammad Diki Juliandi; Akmal Djamaan; Dewi Yudiana Shinta; Anthoni Agustien
Jurnal Zona Vol 8, No 1 (2024)
Publisher : Pelantar Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52364/zona.v8i1.113

Abstract

The increase in the number of waste piles in Indonesia has reached 175,000 tons/day or the equivalent of 64 million tons/year. In the health sector, synthetic plastics are used as materials for making packaged medicine bottles and infusion bottles. Polypropylene synthetic plastics are very slow to degrade, making them a major problem in environmental pollution. This study aims to determine the type of bacteria and the ability of bacterial isolates to degrade polypropylene plastics. The research methods used include characterization of bacterial isolates macroscopicly, microscopicly, biochemical tests, then polypropylene synthetic plastic biodegradation tests were carried out during the incubation period of 1 week, 2 weeks, 3 weeks, and 4 weeks using an incubator shaker device. The results of this study obtained 4 bacterial isolates that can decompose polypropylene plastic from seawater samples in Padang City. The results of the isolation of polypropylene plastic bacteria from seawater samples in Padang City ILT-14 bacterial isolate based on macroscopic characteristics. and molecular identification was carried out in the LIPI biotechnology testing laboratory by the 16S rRNA gene deritimization method obtained polypropylene plastic scavenging bacterial species, namely: ILT-14 has similarities with Stenotropomonas Maltophilia. With a 30-day polypropylene plastic decomposer percentage of 10.8%. The difference in FTIR analysis was in the percentage value of carbon group transmission, and the aromatic group decreased. When compared to plastic before it was degraded and there was a decrease in percent. Microscopy Electron Scanning (SEM) Analysis of ILR-14 polypropylene plastic isolate of bacteria isolated is able to break down complex polymers into monomer forms
The Cytotoxic Activity of Marine Sponge-Derived Fungus Aspergillus nomius NC06 Against HT29 Colon Cancer Cells: Cytotoxic Activity of A. nomius NC06 Against HT29 Cancer Cells Artasasta, Muh. Ade; Djamaan, Akmal; Yanwirasti, Yanwirasti; Taher, Muhammad; Djamaludin, Heder; Siswanto, Siswanto; Handayani, Dian
Journal of Tropical Life Science Vol. 14 No. 1 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.01.05

Abstract

The study of natural products from marine-derived fungi has been interesting tense to researchers as drug discovery sources. Marine fungus from West Sumatera, Indonesia repeatedly showed their potential for cytotoxic and antimicrobial activities.  This study aims to determine the cytotoxic activity against HT29 colon cancer cells of each fraction of ethyl acetate extracts from Aspergillus nomius NC06 derived from marine sponge Neopetrosia chaliniformis. A. nomius was cultivated with rice as a growth medium and extracted with ethyl acetate solvent and evaporated in vacuo to obtain ethyl acetate extract. Furthermore, the compounds of ethyl acetate extract were separated with the VLC (Vacuum Liquide Chromatography) method. Five fractions were obtained, which further investigated their cytotoxic activity against HT29 colon cancer cells by using an MTT assay. The result showed that fractions I and III were categorized as potential fractions due to their IC50 value of 13.12 ± 0.39 μg/mL and 2.59 ± 0.19 μg/mL, respectively. It was also supported by ANOVA to measure the effect of each concentration (0.1; 1; 10; 100 μg/mL) of each fraction on the viability percentage of HT29 cells with p < 0.005.
Growth Curve and Antibacterial Activity Test of Endophytic Bacteria Isolates 1 (IBE1) from Labu Koteka (Lagenaria siceraria) Against Escherochoa coli, Pseudomonas aeruginosa and MRSA Putri, Silvy Rizka; Djamaan, Akmal; Agustien, Anthoni
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8506

Abstract

The rising incidence of antibiotic-resistant bacteria presents a considerable global health threat, requiring the immediate creation of new antimicrobial drugs. A possible strategy involves investigating antibiotics sourced from endophytic bacteria, which are microorganisms that inhabit plant tissues symbiotically. This research is to assess the inhibitory efficacy of endophytic bacteria derived from Lagenaria sicerari against, Escherichia coli, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus (MRSA). The identified endophytic bacteria were cultivated in a fermentation medium to synthesize antibiotics, and their growth curves were examined. Subsequently, antibacterial activity assays were performed against the three harmful bacteria, measuring the sizes of the clear inhibitory zones. The results indicated that Isolated Bacteria Endophytic (IBE) 1 attained optimal inoculum levels at 24 hours and sustained the stationary phase from 24 to 36 hours. The isolates exhibited optimum fermentation on a medium utilizing glucose as the carbon source, with a carbon-to-nitrogen ratio of 5. IBE 1 had the most effective antibacterial action against P. aeruginosa, with a moderate inhibition characterized by clear zone widths of 10.80 mm. The findings indicate that endophytic bacteria from Lagenaria siceraria may serve as promising sources of new antimicrobial drugs, especially against Pseudomonas aeruginosa.
The Cytotoxic Activity of Marine Sponge-Derived Fungus Aspergillus nomius NC06 Against HT29 Colon Cancer Cells: Cytotoxic Activity of A. nomius NC06 Against HT29 Cancer Cells Artasasta, Muh. Ade; Djamaan, Akmal; Yanwirasti, Yanwirasti; Taher, Muhammad; Djamaludin, Heder; Siswanto, Siswanto; Handayani, Dian
Journal of Tropical Life Science Vol. 14 No. 1 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.01.05

Abstract

The study of natural products from marine-derived fungi has been interesting tense to researchers as drug discovery sources. Marine fungus from West Sumatera, Indonesia repeatedly showed their potential for cytotoxic and antimicrobial activities.  This study aims to determine the cytotoxic activity against HT29 colon cancer cells of each fraction of ethyl acetate extracts from Aspergillus nomius NC06 derived from marine sponge Neopetrosia chaliniformis. A. nomius was cultivated with rice as a growth medium and extracted with ethyl acetate solvent and evaporated in vacuo to obtain ethyl acetate extract. Furthermore, the compounds of ethyl acetate extract were separated with the VLC (Vacuum Liquide Chromatography) method. Five fractions were obtained, which further investigated their cytotoxic activity against HT29 colon cancer cells by using an MTT assay. The result showed that fractions I and III were categorized as potential fractions due to their IC50 value of 13.12 ± 0.39 μg/mL and 2.59 ± 0.19 μg/mL, respectively. It was also supported by ANOVA to measure the effect of each concentration (0.1; 1; 10; 100 μg/mL) of each fraction on the viability percentage of HT29 cells with p < 0.005.
The Potential of Bacillus spp. In Green Biosynthesis of Zinc Oxide Nanoparticles Alviche, Lola; Agustien, Anthoni; Djamaan, Akmal
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Supplementary July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i5.p818-835.2023

Abstract

Nanopartikel yang dihasilkan melalui metode Green biosintesis berpotensi untuk diterapkan pada dunis medis dan farmasi. Penelitian ini menggunakan senyawa metabolit yang dihasilkan isolat Bacillus spp untuk mereduksi zink sulfat menjadi nanopartikel zink oksida. Berdasarkan hasil pengukuran spetrofotometri UV-Vis panjang gelombang optimum koloid nanopartikel yang dihasilkan dari proses Green biosintesis isolate BES 6A dengan penambahan zink sulfat sebanyak 0,2 g/ml yaitu pada 366 nm. Adapun gugus fungsi Zn-O berdasarkan pengukuran FTIR terbaca pada panjang puncak gelombang 438 dan 530 cm-1. Bentuk kristal yang dihasilkan yaitu heksagonal dengan puncak 2Ɵ yang terdeteksi yaitu 31,82°; 34,33°; 36,49°; 47,56°; 57,16°; 63,20°; 66,76°; dan 68,99° yang menandakan kehadiran nanopartikel zink oksida berdasarkan referensi ICDD 00-001-1136. Ukuran nanopartikel yang dihasilkan yaitu 30 – 47 nm.
SKRINING BAKTERI PENGHASIL POLI(3-HIDROKSIBUTIRAT) P(3HB) DARI SAMPEL IKAN KEMBUNG (Rastrelliger sp.) Inayati Rahmi; Anthoni Agustien; Akmal Djamaan
Jurnal Penelitian Pendidikan IPA Vol 9 No 10 (2023): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i10.5262

Abstract

Bioplastic P(3HB) is a plastic that can be decomposed by decomposing microorganisms. Bacteria can produce P(3HB) in conditions of low nutrition and high carbon sources accumulated in cells as energy reserves. Isolation of bacteria-producing bioplastic P(3HB) was carried out in mackerel fish's gills and intestines, allowing direct contact with polluted waters. This research aimed to determine the presence of P(3HB) bioplastic-producing bacteria in mackerel fish samples and to screen for P(3HB) bioplastic-producing bacteria. The stages of the research were the isolation of P(3HB) producing bacteria from the gills and intestines of mackerel fish, screening of P(3HB) bioplastic-producing bacteria by using Nile Blue A staining, and molecular identification of bioplastic-producing bacteria using 16S rRNA gene. The results of bacterial isolation in the gills and intestines of mackerel obtained 10 bacterial isolates. P(3HB) screening found 1 bacterium showing orange fluorescence, namely IKE-1 isolate which was isolated from the gills of mackerel fish and included in the Gram-negative group with a monobacilli cell shape. Molecular identification of bacteria by using the 16S rRNA gene that isolate IKE-1 is Enterobacter roggenkampii. These results indicate that Enterobacter roggenkampii can produce P(3HB) which was confirmed by the screening results
Sintesis Precipitate Calsium Carbonat Sebagai Filler Pada Plastik Ramah Lingkungan Sri Elfina; Novesar Jamarun; Akmal Djamaan
REACTOR: Journal of Research on Chemistry and Engineering Vol. 1 No. 1 (2020)
Publisher : Politeknik ATI Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52759/reactor.v1i1.4

Abstract

Limestone is a mineral which is very abundant in Indonesia, especially in West Sumatra. Limestone is synthesized for making Precipitate Calcium Carbonate as a filler in plastics. The results of studies conducted on Precipitate Calcium Carbonate fillers from limestone based on X-RD, FTIR and SEMEDX analysis results, it can be concluded that the compound synthesized from limestone CaO is Precipitate Calcium Carbonate with aragonite and calcite crystal types. While the BET test showed a specific surface area of Precipitate Calcium Carbonate with a value of 7.315 m2 / g. Environmentally friendly plastic surfaces with the addition of Precipitate Calcium Carbonate filler were characterized using AFM obtained Rq value of 0.43 µm.
MSC Secretome's Antibacterial Activity on P. aeruginosa Isolated from Diabetic Ulcer Patient Dini Assyfa; Marlina Marlina; Akmal Djamaan
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4717

Abstract

The study aims to determine the antibacterial activity of adipose tissue-derived Mesenchymal Stem Cell (MSC) secretome against P. aeruginosa bacteria isolated from diabetic ulcer patients. Bacteria were isolated from specimens obtained from diabetic ulcer patient and identified using MacConkey and Blood Agar media followed by Polymerase Chain Reaction (PCR) molecular identification. Confirmed P. aeruginosa bacteria were used to evaluate the MSC secretome's antibacterial activity via the Kirby-Bauer method. Isolated bacteria grew on MacConkey media as gram-negative, non-lactose-fermenting bacteria, showing hemolytic capabilities on Blood Agar media. PCR identification yielded positive results for P. aeruginosa. In antibacterial activity testing against isolated bacteria, MSC secretome at concentrations of 1.25%, 2.5%, 5%, and 10% exhibited efficacy with average inhibitory zones measuring 8.17 mm, 8.23 mm, 8.52 mm, and 9.30 mm, respectively. The MSC secretome demonstrates antibacterial activity against P. aeruginosa bacteria isolated from diabetic ulcer patients.
Computational Screening of Functional Monomers for Esculetin Recognition Using a Semiempirical Tight-Binding Approach Dia Indah Azhari; Akmal Djamaan; Aiyi Asnawi; Purnawan Pontana Putra
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.61-69.2026

Abstract

Esculetin is a bioactive coumarin derivative with reported antioxidant, anti-inflammatory, and anticancer activities. Despite its pharmacological relevance, achieving selective molecular recognition of esculetin in complex systems remains challenging. Computational screening of functional monomers offers a rational strategy to identify candidates capable of forming stable noncovalent interactions with the target molecule. In this study, 21 monomers were evaluated using a semiempirical extended tight-binding (xTB) approach. Initial screening was performed through automated interaction site screening (aISS) to estimate interaction energies. The aISS results identified 4-vinylbenzeneboronic acid as having the most favorable interaction energy (-312.87 kcal/mol), followed by 2-Acrylamido-2-methyl-1-propanesulfonic acid (-25.34 kcal/mol), p-vinylbenzoic acid (-24.71 kcal/mol), trans-3-(3-pyridyl)acrylic acid (-23.04 kcal/mol), and 9-vinylcarbazole (-22.17 kcal/mol). To evaluate dynamic stability, selected complexes were subjected to molecular dynamics simulations. The results showed that 2-Acrylamido-2-methyl-1-propanesulfonic acid exhibited the lowest average energy (-76.301 kcal/mol), followed by p-vinylbenzoic acid (-70.03 kcal/mol) and 4-vinylbenzeneboronic acid (-69.70 kcal/mol). Metadynamics simulations further confirmed this trend, with total energy (Etot) values of -76.23 kcal/mol, -69.96 kcal/mol, and -69.64 kcal/mol for the same monomers, respectively. The consistency between molecular dynamics and metadynamics analyses indicates that 2-Acrylamido-2-methyl-1-propanesulfonic acid forms the most energetically stable complex with esculetin under simulated conditions. This study provides a computational basis for selecting functional monomers for esculetin recognition systems and supports further experimental validation.
Formation of Silver Nanoparticles Using Phyllantus buxifolius Leaf Extract and Its Antioxidant Activity Dini Hanifa; Purnawan Pontana Putra; Akmal Djamaan; Marta Aulia Zahra; Maharani Auliasanrah Siregar
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 8 No. 1 (2026)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v8i1.50647

Abstract

Green synthesis is an approach for producing silver nanoparticles (AgNPs) that more popular because the use of bioreductor, making it safer and more eco-friendly. The use of Phyllanthus buxifolius as a source of reducing and stabilizing agents in the formation of AgNPs and its contribution to antioxidant activity is still limited. Therefore, this study aims to synthesize AgNPs using P. buxifolius leaf extract and evaluate its antioxidant activity. The leaves of P. buxifolius were extracted using ethanol in a 1:10 ratio through maceration, then followed by solvent evaporation using a rotary evaporator. AgNO3 was mixed with a 10% P. buxifolius leaf extract solution. The UV-Vis spectrum was analyzed at wavelengths ranging from 400 to 800 nm. Particle size, morphology, functional groups, and crystal structure of AgNPs were characterized. Antioxidant activity was assessed using the DPPH method to determine the IC50, with ascorbic acid as the reference standard. To confirmed the formation of silver nanoparticles, a color change from colorless to brown were observed. These nanoparticles exhibited a Surface Plasmon Resonance (SPR) peak at 420 nm, were non-spherical with the particle size around 50 nm, and showed a crystalline structure. Additionally, the silver nanoparticles synthesized with P. buxifolius extract demonstrated comparable antioxidant activity to standard ascorbic acid, indicating their potential to be developed as antioxidant agents for health and therapeutic uses.
Co-Authors -, Salman Agusri Boestari Aiyi Asnawi Alviche, Lola Andani Eka Putra Andre Prima Rahmadhana Anthoni Agustien Arfiandi Arfiandi Asia Asia Asiska Permata Dewi Asiska Permata Dewi Asiska Permatadewi Atika Melati Bakhtra, Dwi Dinni Aulia Bilqis Nurganiyu Densi Selpia Sopianti Densi Selpia Sopianti Desma Yuni Dia Indah Azhari Dian Handayani Dian Handayani Dini Assyfa Dini Hanifa Djamaludin, Heder Edtyva Monicha Elmi Sariani Hasibuan Erizal Zaini Fatimah Saidah Gustina &#039; Haliatur Rahma, Haliatur Hari, Dewi Gulyla Ifan Aulia Candra Irfan Mustafa Krisyanella Krisyanella Kustiasih Lestari Laura Syahrul Liswarni, Yenny Lola Alviche Maharani Auliasanrah Siregar Mahrani Napitupulu Majid, Mohammed Isa Abdul Maria Ulfa Marlina . Marlina Marlina Marlina Marlina Marta Aulia Zahra Melati, Atika Melzi Octaviani Mimi Susanti Mohamed Isa Abd. Majid Mohd. Azizan Mohd. Noor Muh Ade Artasasta Muhammad Diki Juliandi Muslim Suardi Musyirna Rahmah Nst Netty Suharti Netty Suharty Noor, Mohd. Azizan Mohd. Novesar Jamarun Nurbailis Purnawan Pontana Putra Putri, Silvy Rizka Rahmi Inayati Refilda Refilda Rendowaty, Agnes Rezki Amelia Rezki Amelia Rina Wahyuni Rini Agustin Rusmana Wijaya Setia Ningrat Rustini Rustini Rustini Rustini S Siswanto Salman - Sarina, Gemmy Shinta, Dewi Yudiana SILVA DIKA RAHAYU Sri Elfina Sri Elfina Syamsuardi Syamsuardi Syukria Ikhsan Zam Taher, Muhammad Witra Aulia Witra Aulia Wiwik Handayani Yanwirasti Yanwirasti Yohannes Alen Yufri Aldi Yulmira Yanti Yutra Noka Zurai Resti