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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Riset Kesehatan Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Journal of Indonesian Dental Association Seminar Nasional Lahan Suboptimal JITEKGI Jurnal Ilmiah dan Teknologi Kedokteran Gigi E-Prodenta Journal of Dentistry JPP Jurnal Kesehatan Poltekkes Palembang Jurnal 'Aisyiyah Medika MDJ (Makassar Dental Journal) Jurnal Kesehatan Gigi dan Mulut (JKGM) Cerdika: Jurnal Ilmiah Indonesia Cakradonya Dental Journal Electrician : Jurnal Rekayasa dan Teknologi Elektro Odonto dental journal Jurnal INFOTEL
Siti Rusdiana Puspa Dewi
Department Of Biomedical Science, Dentistry Study Programme, Faculty Of Medicine, Universitas Sriwijaya, Palembang, South Sumatra
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Oral Pseudomembrane Kandidiasis in Nasopharynx Cancer - A Case Report Dewi, Siti Rusdiana Puspa; Maulina, Shania Tri
Journal of Indonesian Dental Association Vol 8 No 1 (2025): May
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v8i1.1222

Abstract

Introduction. Nasopharyngeal cancer (NPC) is a malignant condition of the nasopharynx. The cancer therapy given is usually radiotherapy (RT), chemotherapy (CT), or a combination of RT and CT. Cancer therapy and poor oral hygiene can lead to susceptibility to fungal infections, one of which is pseudomembranous kandidiasis (thrush). The aim of this report was to present oral pseudomembrane kandidiasis patient with nasopharynx cancer. Case report. A 52-year-old female patient was referred to the hospital's dental clinic with complaints of a white coating on the inside of her cheeks, roof of the mouth, and tongue since ± 1 week ago. The patient feels pain when swallowing and discomfort when opening the mouth. The results of clinical and supporting examinations showed that the patient was diagnosed with oral pseudomembranous kandidiasis. The patient was treated using nystatin drop and chlorhexidine gluconate 0.2% Conclusion. The NPC patient in this case was diagnosed with pseudomembranous kandidiasis (thrush) caused by Candida albicans. Early management of cases of pseudomembranous kandidiasis in NPC patients was very important so that the lesion would not disrupt the general condition of the patient as a whole. Collaboration and coordination from various specialist divisions were needed.
3D Dentobox (Dental Explosion Box 3D) as education media for children caries prevention Dewi, Siti Rusdiana Puspa; Utami AF, Deratih Putri; Octantia, Indah; Ifadah, Nurul
Padjadjaran Journal of Dentistry Vol 29, No 2 (2017): July 2017
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (195.232 KB) | DOI: 10.24198/pjd.vol29no2.13604

Abstract

Introduction: The most common dental and oral health problem in the world is dental caries. In Indonesia, as many as 89% of children under 12 years old suffered from dental and oral disease. Lack of dental knowledge and awareness can be overcome by conducting intensive dental and health education to the community. 3D Dentobox is a simple three-dimensional game designed to deliver dental and oral health messages, including dental hygiene, ways to overcome dental health problems and some dental games. 3D Dentobox is an educational media prevention of caries in children. Methods: The method used was Quasi experiment with the type of pretest and posttest control group design. The sample of this study was 30 children aged 9-12 years old. The research subjects filled out a questionnaire containing information on the level of knowledge, attitudes, and actions in caries prevention efforts followed by outreaching to the media and 3D props Dentobox and was given back the same questionnaire to be filled. Data were collected and evaluated using Guttman scale and was analyzed by paired T test. Results: The results showed that the average level of knowledge, changing attitudes, and actions before and after use 3D Dentobox increased significantly (p<0.05). Conclusion: 3D Dentobox can be used as a media of education to prevent dental caries in children.
PENGARUH KOMBINASI EKSTRAK KULIT BUAH DURIAN DAN ITRACONAZOLE DALAM MENGHAMBAT PERTUMBUHAN Candida albicans Puspa Dewi, Siti Rusdiana; Sukmawan, Ahdiyat; Farianty, Lizzana
Cakradonya Dental Journal Vol 11, No 2 (2019): Agustus 2019
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v11i2.12643

Abstract

Itraconazole merupakan salah satu obat sintetik yang memiliki keterbatasan dalam menghambat pertumbuhan Candida albicans (C. albicans). Kulit buah durian (Durio zibethinus L.) merupakan salah satu tanaman yang memiliki efek antifungal karena mengandung senyawa organik seperti flavonoid, tannin, dan saponin yang mampu menghambat pertumbuhan C. albicans. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh kombinasi ekstrak kulit buah durian dan itraconazole dalam menghambat pertumbuhan C. albicans. Penelitian ini menggunakan metode checkerboard dengan 6 jenis konsentrasi ekstrak kulit buah durian dan 5 jenis konsentrasi itraconazole dalam menentukan KHM kombinasi. KHM kombinasi diuji pada media SDA untuk mengetahui pengaruh kombinasi terhadap C. albicans melalui zona hambat yang dibandingkan dengan itraconazole, ekstrak kulit buah durian, dan akuades. Hasil dari penelitian didapatkan bahwa KHM kombinasi adalah ekstrak kulit buah durian 25% dan itraconazole 4 g/ml. Semakin meningkatan konsentrasi kulit buah durian dan dosis itraconazole, maka semakin meningkat pula daya hambat terhadap pertumbuhan C. albicans. Kesimpulan dari penelitian ini adalah kombinasi ekstrak kulit buah durian dengan itraconazole meningkatkan kemampuan dalam menghambat pertumbuhan C. albicans.
PENATALAKSANAAN MUKOBIOADHESIF EKSTRAK GAMBIR (Uncaria gambir) TERHADAP LESI ULSERASI RONGGA MULUT Puspa Dewi, Siti Rusdiana; Handayani, Pudji; Tyas, Hestiningsih; Destriarum, Destriarum; Sari, Adelina Putri
Cakradonya Dental Journal Vol 13, No 2 (2021): Agustus 2021
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v13i2.19279

Abstract

Lesi ulserasi merupakan penyakit jaringan lunak mulut yang banyak dijumpai. Pendekatan perawatan terhadap lesi ulserasi dengan menggunakan bioadhesif bertujuan untuk mendapatkan efek terapi maksimal dari suatu zat aktif. Tanaman gambir (Uncaria gambir) adalah suatu jenis tanaman yang banyak dikembangkan sebagai obat herbal karena memiliki senyawa aktif seperti katekin. Tujuan dari penelitian ini adalah untuk mengevaluasi efek mukobioadhesif ekstrak gambir terhadap lesi ulserasi rongga mulut. Penelitianini menggunakan metode pretest-posttestcontrol group. 24 sampel dibagi menjadi dua kelompok, kelompok yang diberi mukobioadhesif ekstrak gambir dan kelompok yang diberi mukobioadhesif plasebo selama 7 hari dengan aturan pakai 3 kali sehari. Tingkat keparahan rasa sakit yang diukur dengan skala VAS, luas lesi ulserasi, dan durasi penyembuhan dievaluasi dan dianalisis dengan SPSS ver. 22. Hasil penelitian menunjukkan bahwa penggunaan mukobiadhesif ekstrak gambir mampu mengurangi rasa sakit dan luas lesi, serta mampu menurunkan durasi penyembuhan secara signifikan dibandingkan dengan plasebo. Dapat disimpulkan bahwa penatalaksanaan mukobioadhesif ekstrak gambir berpotensi dalam mengurangi rasa sakit dan mempercepat penyembuhan lesi ulserasi rongga mulut.
A Combination of 10% Gambier Extract and 0.0048% Fluoride Toothpaste as An Alternative Antifungal Therapy Handayani, Pudji; Denhari Aflah, Muhammad Naufal; Puspa Dewi, Siti Rusdiana
Cerdika: Jurnal Ilmiah Indonesia Vol. 2 No. 7 (2022): Cerdika: Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v2i7.412

Abstract

Poor oral hygiene might lead to Candida albicans infection. Since long term used of synthetics antifungal therapy could lead to fungal resistance, an alternative of antifungal therapy was needed. It has been reported that Gambier (Uncaria gambir ROXB) contains catechins and tannins which have antifungal effects invitro, but research using Gambier extract as a toothpaste for daily oral hygiene maintenance has not established. This study was done to determine the antifungal effect and the synergy of the combination of 10% gambier and fluorides in toothpaste preparation against Candida albicans. A true experimental laboratory study with a post-test-only design group was established. Three groups namely 10% gambier extract toothpaste, the combination of 10% gambier extract and 0.0048% fluorides toothpaste, lastly the 0.0048% fluoride toothpaste were tested. Gambier extract was obtained using the soxhletation method and the separation of the solvent from the extract was carried out by the distillation method. Agar Well method antifungal test was used to measure the inhibition zone value of tested groups. Data were analyzed using one-way Anova. Inhibition test of tested groups showed that only combination of gambier and fluorides toothpaste was effective in inhibiting Candida albicans with an average inhibition zone value of 8.35 mm. Toothpaste preparation of 10% Gambier extract and 0.0048% fluorides combination produce a synergistic therapeutic effect in antifungal therapy.
Pembelajaran Ensemble Voting Tertimbang dari Arsitektur CNN untuk Klasifikasi Retinopati Diabetik Desiani, Anita; Primartha, Rifkie; Hanum, Herlina; Dewi, Siti Rusdiana Puspa; Suprihatin, Bambang; Al-Filambany, Muhammad Gibran; Suedarmin, Muhammad
JURNAL INFOTEL Vol 16 No 1 (2024): February 2024
Publisher : LPPM INSTITUT TEKNOLOGI TELKOM PURWOKERTO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20895/infotel.v16i1.999

Abstract

Diabetic Retinopathy (DR) is a diabetes disease that attacks the retina of the eye and can be recognized through retinal images. The process of assisting retinal images can be done by applying deep learning-based methods, one of which is the Convolutional Neural Network (CNN). CNN has many architectures that can perform image classification processes, namely ResNet-50, MobileNet, and EfficientNet. Weaknesses of each architecture can be overcome through ensemble learning methods that can add up the performance results of each classification method. The study applies the ensemble learning method to improve the performance of the ResNet-50, MobileNet, and EfficientNet architectures in paying for DR disease on the retina by weighted voting. The data used are the APTOS and EyePACS datasets. The method in this research is data collection, training, testing, and evaluation of each architecture and ensemble learning. The results of the superior ensemble learning performance in the value of accuracy, F1-Score, and Cohens Kappa were obtained respectively 93.3%, 93.42%, and 0.866. The best specificity value was obtained by Resnet-50 at 99.78% and the highest sensitivity value was obtained by EfficientNet at 96.2%. Based on the classification results of each architectural and ensemble learning, it can be interpreted that the proposed ensemble learning method is excellent to perform image classification for Diabetic Retinopathy.
DUKU (Lansium domesticum) STEM BARK GEL PROMOTES HEALING OF ORAL ULCERS IN WISTAR RATS: AN IN VIVO STUDY Siti Rusdiana Puspa Dewi; Pudji Handayani; Jessi Miranda; Shanty Chairani; Rahmatullah Irfani
Jurnal Kesehatan Gigi dan Mulut (JKGM) Vol 8 No 1 (2026): Jurnal Kesehatan Gigi dan Mulut (JKGM)
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkgm.v8i1.3799

Abstract

Background: Oral ulcers are common and usually managed with topical medications; however, prolonged use of these medications may lead to various side effects. Duku (Lansium domesticum) stem bark contains flavonoids, saponins, alkaloids, and Triterpenes that may promote healing. This study investigated the impact of duku stem bark extract gel on the healing of oral ulcers in Wistar rats. Methods: An experimental study was done with 25 wistar strain rats and were divided into 5 tested groups, namely negative control, positive control (0,1% triamcinolone acetonide), and the experimental group with three different concentrations (5%, 10%, and 20%) duku stem bark extracts gel. Oral ulcers were induced on the lower lip mucosa of rats. Extract gels were applied three times daily for 14 days. Diameter of ulcer was measured on day 0, 3, 5, 7, 9, 11, 13, and 14. Kruskal Wallis and Pairwise Comparison test were used to analyze the data. Results: At day 13th, the 20% duku stem bark extract gel had significant lower ulcer diameters compared to another group (p <0,05). Conclusion: Duku (Lansium domesticum) stem bark extract gels could accelerate oral ulcer healing and could be used as an alternative natural topical drug for oral ulcer.
Oral Pseudomembrane Kandidiasis in Nasopharynx Cancer - A Case Report Siti Rusdiana Puspa Dewi; Shania Tri Maulina
Journal of Indonesian Dental Association Vol. 8 No. 1 (2025): April
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v8i1.1222

Abstract

Introduction. Nasopharyngeal cancer (NPC) is a malignant condition of the nasopharynx. The cancer therapy given is usually radiotherapy (RT), chemotherapy (CT), or a combination of RT and CT. Cancer therapy and poor oral hygiene can lead to susceptibility to fungal infections, one of which is pseudomembranous kandidiasis (thrush). The aim of this report was to present oral pseudomembrane kandidiasis patient with nasopharynx cancer. Case report. A 52-year-old female patient was referred to the hospital's dental clinic with complaints of a white coating on the inside of her cheeks, roof of the mouth, and tongue since ± 1 week ago. The patient feels pain when swallowing and discomfort when opening the mouth. The results of clinical and supporting examinations showed that the patient was diagnosed with oral pseudomembranous kandidiasis. The patient was treated using nystatin drop and chlorhexidine gluconate 0.2% Conclusion. The NPC patient in this case was diagnosed with pseudomembranous kandidiasis (thrush) caused by Candida albicans. Early management of cases of pseudomembranous kandidiasis in NPC patients was very important so that the lesion would not disrupt the general condition of the patient as a whole. Collaboration and coordination from various specialist divisions were needed.
Biomolecular and bioinformatics characterization of salivary matrix metalloproteinase-9 as oral cancer potential targeted therapy Dewi, Siti Rusdiana Puspa; Saleh, Muhammad Irsan; Murti, Krisna; Parisa, Nita; Rosdah, Ayeshah Augusta; Subandrate, Subandrate; Kumar, Arun
Padjadjaran Journal of Dentistry Vol 38, No 2 (2026): July 2026
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol38no2.70464

Abstract

Introduction: Oral cancer is the 11th most common cancer worldwide. Previous studies have reported that saliva contains biomarkers for oral cancer. MMP-9, found in saliva, is a marker that indicates and facilitates tumor development. However, comprehensive biomolecular and bioinformatics characterization of salivary MMP-9 remains limited. This study aimed to analyze the biomolecular and bioinformatics characteristics of salivary MMP-9 as an oral cancer biomarker and a potential target for therapy because it plays an important role in tumor development and management. Methods: The features of MMP-9 were obtained from the NCBI database (www.ncbi.nlm.nih.gov). Protein analyses were performed using Protparam site, PROTSCALE, TMM application, PEPTIDE CUTTER, NETNGLYC and TARGETTP. The protein model and structure of MMP-9 were evaluated using SWISSMODEL. Results: Based on the study, it showed that MMP-9 is located on 20q13.12. It is involved in extracellular matrix breakdown, and this enzyme degrades type IV and V collagens. Based on the instability index (II), the protein was found to be unstable. The hydrophobicity range of the MMP-9 protein was 0–7654. Among the 20 amino acids analyzed, the hydrophobicity of arginine was -4.500, while isoleucine was 4.500. Transmembrane helix analysis indicated the MMP-9 protein isoform is predominantly located outside of the cell. The predicted N-glycosylation site was at the 28th amino acid. The structural model analysis indicated that the protein model was of good quality. Conclusion: Biomolecular and bioinformatics characterization of salivary MMP-9 demonstrates strong potential as an oral cancer biomarker. The biomolecular and bioinformatics characteristics identified in this study support the potential utility of MMP-9 as an oral cancer biomarker and provide a foundation for future studies investigating its therapeutic relevance.
The effect of toothpaste containing gambier (Uncaria gambir Roxb.) 10% extract on decreasing dental plaque index Tuzzahra, Aquila Haya; Puspa Dewi, Siti Rusdiana; Meiliyanawaty, Rina
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 38, No 1 (2026): April 2026
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v38i1.63633

Abstract

Introduction: Dental plaque is a major etiological factor in various oral diseases, including dental caries and periodontitis, which are highly prevalent in Indonesia. Toothbrushing can reduce dental plaque accumulation through mechanical and chemical mechanisms. Gambier (Uncaria gambir Roxb.) has potential as an antibacterial agent in toothpaste because it contains catechins and tannins, which exhibit bacteriolytic and bacteriostatic activities. This study aimed to determine the effect of toothpaste containing 10% gambier (Uncaria gambir Roxb.) extract on the dental plaque index. Methods: This experimental study employed a pretest-posttest control group design and was conducted from January to March 2023. Sixty dental students from Sriwijaya University participated. The subjects were divided into two groups: a gambier toothpaste group and a fluoride toothpaste control group, with 30 subjects in each group. The subjects underwent a 21-day toothbrushing adaptation period using the Bass technique, after which the pretest plaque index was measured. Subjects then brushed their teeth for 2 minutes with either gambier toothpaste or fluoride toothpaste and fasted for 4 hours before the posttest plaque index was measured. The plaque index was assessed using the Turesky modification of the Quigley-Hein Plaque Index. We analyzed the data using paired and independent t-tests. Result: Both groups showed a significant reduction in the dental plaque index (p < 0.05). The mean difference between the pretest and posttest plaque indices was 0.677 in the 10% gambier extract toothpaste group and 0.270 in the fluoride toothpaste control group. The reduction in the dental plaque index was significantly greater in the gambier toothpaste group than in the fluoride toothpaste control group (p < 0.05). Conclusion: Toothpaste containing 10% gambier (Uncaria gambir Roxb.) extract significantly reduced the dental plaque index and demonstrated greater plaque-reducing effectiveness than the fluoride toothpaste used as the control.Efek penggunaan pasta gigi ekstrak Gambir (Uncaria gambir Roxb.) 10% terhadap penurunan indeks plak gigi: studi eksperimentalPendahuluan: Plak gigi merupakan penyebab utama berbagai penyakit rongga mulut, seperti karies dan periodontitis, yang merupakan penyakit rongga mulut dengan prevalensi tertinggi di Indonesia. Menyikat gigi dengan pasta gigi dapat mengurangi akumulasi plak gigi melalui metode mekanis dan kimiawi. Gambir (Uncaria gambir Roxb.) berpotensi sebagai antibakteri pada pasta gigi karena memiliki kandungan utama katekin dan tanin, yang bersifat bakteriolisis dan bakteriostatik. Penelitian ini bertujuan untuk menganalisis efek penggunaan pasta gigi ekstrak gambir (Uncaria gambir Roxb.) 10% terhadap penurunan indeks plak gigi. Metode: Penelitian eksperimental dengan desain pretest-postest with control group, dilaksanakan bulan Januari – Maret 2023, dengan subjek sebanyak 60 orang mahasiswa Kedokteran Gigi Universitas Sriwijaya. Subjek dibagi menjadi 2 kelompok, yaitu kelompok pasta gigi gambir dan kelompok kontrol fluoride, dengan subjek sebanyak 30 orang untuk tiap kelompok. Subjek melakukan adaptasi cara menyikat gigi menggunakan teknik Bass selama 21 hari, lalu dilakukan pengukuran skor indeks plak pretest. Subjek menyikat gigi selama 2 menit menggunakan pasta gigi ekstrak gambir 10% atau fluoride, lalu berpuasa selama 4 jam sebelum dilakukan pengukuran skor indeks plak posttest. Skor indeks plak diukur menggunakan indeks plak Turesky-Glimore-Glickman modifikasi Quigley-Hein, dengan analisis data menggunakan uji t-test berpasangan & tidak berpasangan Hasil: Terdapat penurunan indeks plak gigi (p<0,05) pada kedua kelompok, dengan rerata penurunan 0,677 untuk kelompok pasta gigi gambir, dan 0,27 untuk kelompok pasta gigi kontrol fluoride. Penurunan indeks plak gigi pada kelompok pasta gigi gambir lebih besar dibandingkan dengan kelompok kontrol fluoride. Simpulan: Pasta gigi ekstrak gambir (Uncaria gambir Roxb.) 10% dapat menurunkan indeks plak gigi.
Co-Authors Abda Abda Abu Bakar Lutfi Adelina Putri Sari Ahdiyat Sukmawan Ahmad Rama Biran Al-Filambany, Muhammad Gibran Amarel, Fahma Alfarizqy Angraini, Mona Rizki Anin Esta Rauna Anita Desiani Anna Pratiwi Arya Prasetya Beumaputra Arya Prasetya Beumaputra Ayeshah A Rosdah Bambang Suprihatin Billy Sujatmiko Budi Santoso Debby Handayani Harahap Denhari Aflah, Muhammad Naufal Deratih Putri Utami AF, Deratih Putri Destriarum Destriarum Destriarum, Destriarum Dina Oktaviani Marlamsya Dwi Budi Santoso Endang Sri Kresnawati Fahma Alfarizqy Amarel Farianty, Lizzana Ferdinan, Muhammad Handayani, Pudji Harahap, Debby Handayani Herlina Hanum, Herlina Hestiningsih, Tyas Hutami, Rizka Adianti Indah Marsya Fitadea Indah Octantia, Indah Indira, Tissa Irfannuddin Irfannuddin Jessi Miranda Krisna Murti Kumar, Arun Lasma Evi Lany Legiran Legiran Lidya Astri Lizzana Farianty Lutfi, Abu Bakar Maulina, Shania Tri Maya Hudiyati Mayang Pramudya Sari Meiliyanawaty, Rina Mozartha, Martha Nita Parisa Nurul Ifadah, Nurul Pudji Handayani Pudji Handayani Rahmatullah Irfani Rifkie Primartha Rindit Pambayun Rindit Pambayun Rini Bikarindrasari Rini Bikarindrasari Rini Bikarindrasari, Rini Rosada Sintya Dwi Saleh, Muhammad Irsan Sari, Adelina Putri Shania Tri Maulina Sherly Septhimoranie Sri Wahyuningsih Rais Sri Wahyuningsih Rais Subandrate Suedarmin, Muhammad Sujatmiko, Billy Sukmawan, Ahdiyat SULISTIANI Suryadi Muchzal Teodorus Teodorus Theodorus Theodorus Tiara Samapta Dewi Tissa Indira Tri Wardani Widowati Trisnawaty K Tuzzahra, Aquila Haya Tyas Hestiningsih Tyas, Hestiningsih Veronita Veronita Veronita, Veronita Yeza Safitri Yuli Andriani