Article Per Year (5 Year)
p-Index From 2021 - 2026
3.495
P-Index
This Author published in this journals
All Journal VALENSI Science and Technology Indonesia ALCHEMY Jurnal Penelitian Kimia JURNAL PENDIDIKAN TAMBUSAI Journal of Midwifery and Nursing Jurnal Penelitian Farmasi dan Herbal JURNAL INOVASI KESEHTAN MASYARAKAT Jurnal Farmanesia Jurnal Pengabdian Masyarakat Putri Hijau Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Jurnal Natural Jurnal Kedokteran Hewan Herbal Medicine Journal Journal of Pharmaceutical and Sciences. Molekul: Jurnal Ilmiah Kimia
Nerdy, Nerdy
Universitas Tjut Nyak Dhien
Religion Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

Published : 34 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : Science and Technology Indonesia

 1 
Tablet Formulation with Galactomannan Binding Agent and Acute Toxicity Test from Terminalia catappa L. Nilsya Febrika Zebua; Tandra Alexandro; Virda Widya Pratiwi; Syarifah Nadia; Supran Hidayat; Muflihah Fujiko; Muharni Saputri; Tedy Kurniawan Bakri; Nerdy
Science and Technology Indonesia Vol. 8 No. 1 (2023): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.1.129-136

Abstract

Ketapang is one of the many medicinal plant species that grow in Indonesia and is used to treat various diseases. Ketapang leaves contain flavonoids, tannins, saponins, and terpenoids that have anti-inflammatory, antioxidant, antiviral, and antimicrobial properties. This study aimed to determine the LD50 and histopathology of Liver and kidney damage before the formulation of tablets containing galactomannan-binding agents. The toxicity determination method was carried out in vivo in experimental animals at doses of 4g/kg BW, 8g/kg BW and 16g/kg BW, and Liver and kidney histopathology was carried out before formulation into tablet preparations using the wet granulation method with various concentrations of binders and disintegrants, namely F1(8:0), F2(0:8), F3(4:4), F4(2:6), and F5(6:2). The results of the toxicity test showed an LD50 of 15.9959, liver damage at a dose of 4 g/kg BW hepatocyte karyorrhexis cells, central vein constriction, sinusoidal dilatation, a dose of 8 g/kg BW hepatocyte karyorrhexis, significant venous congestion, sinusoidal dilatation, a dose of 16 g/kg BW hepatocyte cells, karyolysis, dilated central veins, and dilated sinusoids. The results of the tablet mass preformulation test meet the requirements: the flow time test was 1.48-2.14 g/second, the angle of repose test was 24.60°-30.60°, and the tab index test was 5.33%-9.33%. The results of the tablet evaluation test were as follows: the tablet hardness test was 3.8-8.6 kg, the tablet friability test was 0.167-0.64%, and the tablet disintegration time test was 29.06-107.51 minutes.
Development and Validation of Fast and Simple Fourier Transform Infrared Spectrophotometric Method for Analysis of Thiamphenicol in Capsule Dosage Form Nerdy Nerdy; Linda Margata; Nilsya Febrika Zebua; Puji Lestari; Tedy Kurniawan Bakri; Faisal Yusuf; Vonna Aulianshah
Science and Technology Indonesia Vol. 8 No. 3 (2023): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.3.344-352

Abstract

The development of a method for identification and determination of thiamphenicol by Fourier Transform Infrared will provide convenience to developers because it is fast and easy for analysis. The research was carried out by utilizing the solubility of thiamphenicol in methanol with three stages, namely method development, sample analysis, and method validation. The method development stage showed that the specific peak of thiamphenicol was at a peak with a wavenumber of 1694.1 cm−1; this specific peak of thiamphenicol was used for qualitative analysis and quantitative analysis of thiamphenicol in the capsule dosage form. The sample analysis showed that all analyzed thiamphenicol in capsule dosage form showed good results both qualitatively and quantitatively. Qualitatively all the samples analyzed showed a specific peak at specific positions and specific wavenumbers. These results meet the requirements for containing thiamphenicol in the dosage form. Quantitatively all the samples analyzed ranged from 97.97% to 102.24% by peak height and peak area. These results meet the requirements for active substance levels in general preparations within 90.0% to 110.0%. The method validation for peak height and peak area showed that the accuracy parameter had a recovery percentage of 100.28% and 100.41% (between 98.0% to 102.0%), the precision parameter with a relative standard deviation of 0.31% and 0.37% (not more than 2.0%), and the linearity parameter with a correlation coefficient of 0.9999 and 0.9997 (not less than 0.99). The limit of detection value was 0.2971 mg/mL and 0.5338 mg/mL, the limit of quantitation value was 0.9004 mg/mL and 1.6176 mg/mL, the range for both was 80% to 120%, and the specificity for both met the requirement. The Fourier Transform Infrared method has been successfully developed, applied, and validated for qualitative analysis and quantitative analysis of thiamphenicol in capsule dosage form.
Co-Authors Abdi Wira Septama Ariani, Peny Atika Mulyati Bahtera Bin David Purba BAKRI, TEDY KURNIAWAN Barus, Bunga Rimta Bunga Mari Sembiring Bunga Rimta Barus Christivo Tambusai Dachi, Kanne Dhita Millenia Br. Tarigan Dian Ika Perbina Meliala Effendy De Lux Putra, Effendy De Lux Elysa Elysa Evalina Manurung Faisal Yusuf Faisal, Yusuf Febia, Ananda Dwina Ferry Handika Firdaus Fahdi Firdaus, Fahdi Fitri, Rizka Ramadhani Fujiko, Muflihah GINTING, SELAMAT Hulu, Titi Kurniawati Ika Julianti Tambunan JIHAN SAFIRA Kanne Dachi Kesaktian Manurung Linda Margata Linda Margata Linda Margatha Linta Meliala Linta Meliala Manurung, Kesaktian MAYA KUSUMA Meliala, Linta Mierza, Vriezka Muflihah Fujiko Muflihah Fujiko Muharni Saputri Nadia, Syarifah NILSYA FEBRIKA ZEBUA Nilsya Febrika Zebua, Nilsya Febrika Ningrum, Adelia Puspita Retno Ningrum, Siti Rahmi Nurfazillah, Nurfazillah Nurul karima Oppie Meisya Tanjung Palas Tarigan Pravil Mistriyanto Puji Lestari PUJI LESTARI Puji Lestari Puji, Lestari RANI FARAH BUTSAINAH TANJUNG Razali Razali Razali, Mariany Refi Bahrainur Rifoni Simbolon Rusdi Andreas Sembiring Saiful Batubara SATRIYAS ILYAS Selamat Ginting Siagian, Nurul Siagian, Nurul Aini Silmi Hayati Siti Nurmalisa Siti Rahmi Ningrum Sitohang, Nikasia Gabriela Supran Hidayat SURBAKTI, CHRISTICA ILSANNA Suryani , Monica Syarifah Nadia Tandra Alexandro Tedy Kurniawan Bakri Tedy Kurniawan Bakri Tedy Kurniawan Bakri Tedy Kurniawan Bakri TJUT XENA Virda Widya Pratiwi Vivi Sofia Vonna Aulianshah Vriezka Mierza Zuhairiah Nasution, Zuhairiah