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Journal : Jurnal Natural

Antidiabetic Activity of Leaves Ethanol Extract Chromolaena odorata (L.) R.M. King on Induced Male Mice with Alloxan Monohydrate Marianne Marianne; Dwi Lestari; Elin Yulinah Sukandar; Neng Fisheri Kurniati; Rosnani Nasution
Jurnal Natural Volume 14, Number 1, March 2014
Publisher : Universitas Syiah Kuala

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Abstract

Chromolaena odorata or Tekelan has been used traditionally to cope with diabetes mellitus, but the scientific evidence as antidiabetic agent has not been previously reported. Therefore, it is necessary to test the antidiabetic activity using ethanol extract of the tekelan leaves in male mice induced by alloxan. Mice were induced intravenously by alloxan dose of 55 mg/kg bw. After 7 days, mice were diabetic ( KGD 200 mg/dL ) and were grouped into 6 groups: negative control group (only treated with CMC - Na) , positive control group (glibenclamide 0.45 mg/kg bw) and the 4 other groups were given ethanol extract of Tekelan leaves at doses of 5 , 25 , 125 and 250 mg/kg bw. Dosage administered for 28 days and blood glucose levels was checked every 7 days using a glucotest. Data were analyzed by one-way analysis of variation at 95% confidence level. Ethanol extract of tekelan’s leaves  at doses of 5 , 25 , 125 and 250 mg/kg bw can lower blood levels  from day 7 to day 28 and was significantly different compared to the negative control group ( p 0.05). Ethanol extract of tekelan’s leaves at doses of 5 , 25 , 125 and 250 mg/kg bw showed antidiabetic activity in alloxan-induced mice.
Co-Authors . Endarti . Patonah Afifah B. Sutjiatmo Afifah Bambang Sutjiatmo, Afifah Bambang Afrillia Nuryanti Garmana Afrillia Nuryanti Garmana Agung Yuwono Aisyah, Salmanda Ame Suciati Setiawan Anam, M. Khairul Ardiansyah, Muhamad Asep Abdul Rahman Asep Gana Suganda Asep Gana Suganda Asri Wulandari Astuti, Niken Juni Attifah Zahra Shafira Atun Qowiyyah Cahyono, Nur Sidik Candra candra Christanti, Yohanna Daryono Hadi Tjahjono Dwi Lestari Evi Sovia Faizal Hermanto Goeswin Agoes Hartini, Sri Hernandi, Baso Hikmat Permana Hubbi Nashrullah Muhammad I Ketut Adnyana Irawan, Wira Irda Fidrianny Irianti Bahana Maulida Reyaan Iwang Soediro Joseph I. Sigit Joseph Iskendiarso Sigit Joseph Iskendiarso Sigit Komar Ruslan Wirasutisna Kosasih Padmawinata Kuatrina, Kuatrina Kusmaningati, Suswini Kusmaningati, Suswini L Broto S Kardono Leni Herliani Afrianti Lucy Dewi N. Sasongko Marianne Marianne Maulita Cut Nuria Muhamad Insanu Muna Anom Fitri Narvikasari, Suci Neng Fisheri Kurniati Neng Fisheri Kurniati Nova Suliska Primal Sudjana Puput Ayu Perdana, Puput Ayu Putra , Erwin Ekadharma Putri, Mareta Ananda Raras Adinindya Putri Redya Hernawati, Redya Rini Syafriani Rini Syafriani Ririn Sinaga, Ririn Rizkita, Putri Rosnani Nasution RR. Ella Evrita Hestiandari Setiani, Nur Asni Setiawan, Finna Sheba, Shiane Hanako Siftiani, Nindy Dwi Siti Nur Aeni, Siti Nur Slamet Ibrahim - Soediro Soetarno Solihah, Puspa Sari Dewi Suci Nar Vikasari, Suci Nar Suganda, Asep Gana Sujiatmo, Afifah Bambang Sukrasno Sukrasno Sumartin, Yunita Sumintir, Sumintir Suryani Suryani Sylvia Sylvia Teti Indrawati Tommy Apriantono Vanessa Claudia Wiharja Vidya Finanda Yani Mulyani Yeyet Cahyati Sumirtapura Yulia Ratnawati, Yulia Yuliet Yuliet