Articles
<![CDATA[The Difference of Zinc And Matrix Levels of Metalloproteinase-9 Serum Between Premature Rupture Of Membrane Aterm And Normal Pregnancy ]]>
<![CDATA[Lisa Ernita]]>;
<![CDATA[Ellyza Nasrul]]>;
<![CDATA[Andi Friadi]]>
<![CDATA[ Journal of Midwifery Vol 4, No 1 (2019): Published on June 2019 ]]>
Publisher : <![CDATA[Universitas Andalas ]]>
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DOI: 10.25077/jom.4.1.40-50.2019
<![CDATA[Premature rupture of membranes (PROM) is one of the common problems in the obstetric field, ranging from 8-10% of term pregnancies will experience PROM. The increase in MMP-9 also has an impact on the degradation of the extracellular matrix and the apoptotic process of amniotic epithelial cells which ultimately leads to membrane rupture. The purpose of this study was to determine the differences in serum zinc and MMP-9 levels between premature rupture of membranes and normal pregnancies.This research is quantitative observational with the cross-sectional design carried out in Independent Practice Midwives for research samples of term premature rupture of normal and amniotic pregnancies, and Biomedical Laboratory of the Medical Faculty of Andalas University in March 2018 to March 2019. The research sample amounted to 35 respondents using consecutive sampling. Zinc and MMP-9 levels were examined by the Human ELISA Kit. Data analysis using the unpaired t-test.The results showed a mean serum zinc level of 13608 ± 1128.976µg / ml in Aterm KPD and 13799,111 ± 1254,335 µg / ml in normal pregnancies with p> 0.05. The mean serum MMP-9 levels were 1682.412 ± 320,398 ng / ml in Aterm PROM and 1807,667 ± 484,735 ng / ml in normal pregnancies with p <0.05.This study concludes that there is no difference in serum zinc levels in premature rupture of membranes and normal pregnancies; there is a difference in MMP-9 levels in premature rupture of membranes and normal pregnancy. ]]>
<![CDATA[CORRELATION OF LIPID PROFILE WITH INTERLEUKIN-12 IN TYPE 2 DIABETES MELLITUS ]]>
<![CDATA[Meri Ponda Sari]]>;
<![CDATA[Hanifah Maani]]>;
<![CDATA[Ellyza Nasrul]]>;
<![CDATA[Dia Rofinda]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v25i1.1486
<![CDATA[Dyslipidemia is one of the common disorders in the diabetes mellitus (DM) patients causes cardiovascular disorders. Interleukin-12 (IL-12) is an important inflammation cytokine and elevated in type 2 DM (T2DM) which may contribute to inflammation of atherosclerotic plaque formation. Hyperglycemia, hyperlipidemia, hyperinsulinemia and oxidative stress that lead to endothelial dysfunction of atherosclerotic. The aim of this study to determine the correlation of lipid profile with IL-12 in T2DM. This study was an analytical study with cross-sectional design in 30 patients T2DM meet the inclusion and exclusion criteria and conduct blood tests at the Central Laboratory Installation of Dr. M. Djamil Hospital Padang in September 2016-August 2017. Level of lipid profile performed by the enzymatic colorimetric method. Sandwich ELISA used to measure the level of IL-12 in Biomedical Laboratory Medical Faculty of Andalas University. Spearman correlation was used, significant if p<0,05. The mean levels of total cholesterol, high-density lipoprotein, (HDL), triglycerides and low-density lipoprotein (LDL) in T2DM were 204.2 ± 42.8 mg/dL; 46.8 ± 9.3 mg/dL; 57 ± 53.4 mg/dL; 132.97 ± 41.0 mg/dL. The mean level of IL-12 in T2DM is 160.15 ± 99.05 pg/mL. Spearman correlation test of total cholesterol, (HDL), triglycerides and (LDL) with IL-12 are r= 0.228 (p=0.225); r= -0.234 (p=0.212); r= 0.415 (p=0.031); r= 0,215 (p=0.291) and analysis linear regression showed a moderate correlation between the levels triglycerides and Il-12 with r=0,512 and p<0,05. There is a moderate positive correlation between triglycerides, weak between total cholesterol and LDL with IL-12 and negative correlation between HDL with IL-12 in T2DM.]]>
<![CDATA[DIFFERENCE IN GLICATED HEMOGLOBIN LEVEL BETWEEN BORONATE AFFINITY METHOD AND ION EXCHANGE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD IN TYPE 2 DIABETES MELLITUS ]]>
<![CDATA[Tuti Asryani]]>;
<![CDATA[Ellyza Nasrul]]>;
<![CDATA[Rikarni Rikarni]]>;
<![CDATA[Tutty Prihandani]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 2 (2019) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v25i2.1466
<![CDATA[Background: Glycated Hb (HbA1c) test is needed to control glycemic in high prevalence type 2 diabetes mellitus (DM) patients. Hemoglobin fraction separated and chemical reaction are two main concepts in HbA1c test. Ion exchange-high performance liquid chromatography (HPLC) and boronate affinity use first concept. Ion exchange-HPLC is reference method in most of clinical laboratorium. Point of care testing (POCT) with boronate affinity method that has been standardized by international institution is available. The aim of this study was to compare boronate affinity POCT method and ion exchange-HPLC method.Method: This cross sectional study was conducted to 22 type 2 DM patients those fullfill inclusion and exclusion criteria in January 2017 to February 2018. Level of HbA1c was assayed with boronate affinity POCT and ion exchange-HPLC method. T-test was used to analyse data and no significance difference if p>0.005Results: Subjects of this study are women (59.1%) more than men (40.9%) with age mean 59.23 years old (8.1). Uncontroled type 2 DM (77.3%) more than controled type 2 DM (22.7%).Mean of HbA1 level was 8.0% (1.7) in boronate affinity POCT and 8.3% (1.8) in ion exchange-HPLC. T-test showed no significance difference between those two HbA1C assay methods (p>0.005).Conclusion: There was no difference HbA1c level between boronate affinity POCT method and ion exchange-HPLC method.]]>
<![CDATA[Effect of ethanol extract of myrmecodia pendens on TGF-?1 expression and osteoblast cells after tooth extraction (experimental research on cavia cobaya) ]]>
<![CDATA[Efa Ismardianita]]>;
<![CDATA[Ellyza Nasrul]]>;
<![CDATA[Yanwirasti Yanwirasti]]>;
<![CDATA[Mieke Hemiawati]]>
<![CDATA[ Journal of Dentomaxillofacial Science Vol. 2 No. 3 (2017): (Available online: 1 December 2017) ]]>
Publisher : <![CDATA[DiscoverSys Inc. ]]>
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DOI: 10.15562/jdmfs.v2i3.608
<![CDATA[Objective: Myrmecodia pendens is often used as a traditional medicine to treat various disease. A previous study, ethanol extract of sarang semut plant (Hypnophytum furmicarum jack) 4.65 mg was effective in fastening establishment of socket granulation tissue after tooth extraction, the Myrmecodia pendens 3% too fasten healing soft tissue of wound after tooth extraction. The aim of this study to determine the effect of ethanol extract of Myrmecodia pendens to the expression of TGF-β1, and the number of osteoblasts after tooth extraction.Material and Methods: this study using 24 male marmoots were divided into 2 groups. The entire groups had extract done 1st left incisor mandibula, into the socket control group applied 0,1 ml of 0.5% CMC and treatment group was given 0,1 ml of ethanol extract Myrmecodia pendens 10% dissolved with CMC 0.5%. On day 3,7,14 and 21, marmoots were decapitated and histopathologic preparations then observed the expression of TGF-β1, and the number of osteoblast cell. Data analyzed by Kruskall-wallis test with probability p<0.05 and Mann-Whitney to determine differences in effectiveness between variables.Results: Based on the Kruskal-wallis test, there is a significant difference the TGF-β1 expression and the number of osteoblast cell which had giving ethanol extract of Myrmecodia pendens between of control group and group treatment (p<0.05), further test with Mann-Whitney for TGF-β1 with days of observation shown a significant difference meanwhile osteoblast with days of observation showed no significant difference.Conclusion: the ethanol extract Myrmecodia pendans can assist the wound healing process after tooth extraction by increasing the expression of TGF-β1, and osteoblast cells number]]>
<![CDATA[Pengaruh Dispersi Padat Irbesartan-Poloxamer 188 Terhadap Tekanan Darah dan Kadar Nitric Oxide (NO) Pada Tikus Putih Jantan Hipertensi ]]>
<![CDATA[Fifi Harmely]]>;
<![CDATA[Ellyza Nasrul]]>;
<![CDATA[Salman Umar]]>;
<![CDATA[Erizal Zaini]]>;
<![CDATA[Yufri Aldi]]>
<![CDATA[ Jurnal Sains Farmasi & Klinis Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018 ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Andalas ]]>
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DOI: 10.25077/jsfk.5.2.88-93.2018
<![CDATA[A research on formulation of edible film from basil leaves extract as mouth freshener has been done. The extract of basil leaves were used in various concentrations which are 2.5%, 5% and 7.5%. The products were evaluated for some parameters such as organoleptic, friability, drying shrinkage, pH, thickness, flavonoid contents and respondents preference. The results of evaluation showed that edible filmsfrom basil leaves extract meet requirements as required by Standard Nasional Indonesia (SNI) and have such quality as product in the market. Statistical analysis using Kruskal Wallis test showed that respondents preferred for the F0 formulation in term of their appearance and taste while as mouth freshener, respondents preferred the F3 formulation.]]>
<![CDATA[Perbedaan Rerata Kadar Albumin Serum Berdasarkan Klasifikasi Child Turcotte Pugh pada Pasien Sirosis Hepatis di RSUP Dr. M. Djamil Padang ]]>
<![CDATA[Fadila Esmeralda Ilmi]]>;
<![CDATA[Ellyza Nasrul]]>;
<![CDATA[Rina Gustia]]>
<![CDATA[ Jurnal Ilmu Kesehatan Indonesia Vol 1 No 3 (2020): November 2020 ]]>
Publisher : <![CDATA[Fakultas Kedokteran, Universitas Andalas ]]>
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DOI: 10.25077/jikesi.v1i3.172
<![CDATA[Sirosis hepatis termasuk 10 penyakit penyebab kematian di US. Penyakit ini terjadi akibat adanya inflamasi kronik di hati. Sirosis hepatis di Indonesia paling banyak disebabkan oleh virus hepatitis B dan C. Pada sirosis hepatis stadium lanjut dapat terjadi hipoalbuminemia karena penurunan sintesis albumin. Tingkat keparahan sirosis hepatis dapat dinilai dari klasifikasi Child Turcotte Pugh (CTP). Penelitian ini bertujuan untuk mengetahui apakah terdapat perbedaan rerata kadar albumin serum berdasarkan klasifikasi CTP. Metode penelitian analitik retrospektif dilakukan dengan mengambil rekam medik di RSUP Dr. M. Djamil Padang dari 1 Januari 2018 – 31 Desember 2018. Pengambilan sampel diakukan dengan Purposive Sampling dan didapatkan 80 sampel yang memenuhi kriteria inklusi dan eksklusi. Analisis data perbedaan rerata kadar albumin serum berdasarkan klasifikasi CTP dilakukan dengan uji t. Pada penelitian ini didapatkan paling banyak pasien sirosis hepatis pada kelompok umur 51 – 60 (35%) dan jenis kelamin laki-laki (66,3%). Penelitian ini mendapatkan 30 pasien sirosis hepatis dengan CTP B dan 50 pasien CTP C. Didapatkan rerata kadar albumin serum pada CTP B sebesar 2,73 g/dL dan pada CTP C sebesar 2,16 g/dL. Analisis dari perbedaan rerata kadar albumin serum berdasarkan klasifikasi CTP yang dilakukan didapatkan nilai p < 0,001. Berdasarkan analisis yang dilakukan pada penelitian ini, disimpulkan terdapat perbedaan rerata kadar albumin serum pada klasifikasi CTP B dan CTP C. Pada klasifikasi CTP B rerata kadar albumin serum lebih tinggi dari CTP C.]]>
<![CDATA[Efek Pemberian Kalsium dan Berjemur Terhadap Kadar D-Dimer pada Penderita Diabetes Mellitus Tipe 2 di Sumatera Barat ]]>
<![CDATA[Dwi Yulia]]>;
<![CDATA[Rikarni Rikarni]]>;
<![CDATA[Ellyza Nasrul]]>
<![CDATA[ Health and Medical Journal Vol 5, No 1 (2023): HEME January 2023 ]]>
Publisher : <![CDATA[Universitas Baiturrahmah ]]>
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DOI: 10.33854/heme.v5i1.1081
<![CDATA[Tujuan: Penelitian ini bertujuan untuk menganalisis pengaruh berjemur dan pemberian tablet kalsium terhadap kadar D-dimer pada penderita Diabetes Mellitus tipe 2 yang terkontrol. Berjemur adalah memanfaatkan sarana alam sinar matahari yang tersedia sesuai standar operasional waktu yang terukur, dan pemberian tablet Kalsium 500 mg tiap hari dapat menurunkan kadar D-dimer yang berisiko terjadinya obstruksi pada pembuluh darah dan berpotensi munculnya kerusakan endotel pembuluh darah. Dengan menggunakan faktor alam terapi berjemur dapat membantu memperbaiki penyakit dan merencanakan terapi. Metode: Rancangan penelitian ini adalah studi kohort prospektif dengan jumlah sampel sebanyak 20 data pasien yang terdiagnosis sebagai penderita Diabetes Mellitus tipe 2 di RSUD Prof Dr. Ali Hanafiah SM Batusangkar selama periode 2019-2020. Data yang dianalisis adalah kadar D-dimer sebelum dilakukan perlakuan berjemur dengan waktu yang terukur, serta pemberian tablet kalsium sebagai suplemen yang dapat mempengaruhi proses koagulasi dalam pembuluh darah. Kasus Diabetes mellitus tipe 2 dipilih kasus Diabetes yang terkontrol dengan pemeriksaan HBA1c dibawah 6.5%. Selajutnya, setelah dilakukan proses berjemur dan pemberian suplemen Kalsium selama 1 bulan, dilakukan kembali pemeriksaan D-dimer. Analisis data penelitian dilakukan pada derajat kepercayaan 95% CI (α=0.05), apabila hasil yang didapatkan diperoleh nilai p<0.05 maka terdapat hubungan yang bermakna. Pengolahan dan analisis data dilakukan dengan program SPSS 25. Hasil: Dua puluh pasien Diabetes Mellitus tipe 2 dilakukan pemerisaan D-dimer didapatkan rerata d-dimer 582 ±806 ng/mL. Selanjutnya dilakukan perlakuan berjemur sesuai protokol berjemur selama 30 hari dan pemberian suplemen tablet kalsium 500 mg, setelah itu dilakukan kembali pemeriksaan kadar D-dimer, didapatkan rerata d-dimer 401 ±390 ng/mL Terdapat kecenderungan penurunan kadar D-dimer setelah perlakuan berjemur dan pemberian tablet kalsium dengan hubungan yang bermakna antara kadar D-dimer sebelum dan sesudah perlakuan berjemur dan pemberian tablet kalsium pada penderita Diabetes Mellitus tipe 2. Simpulan: Pada penelitian ini ditemukan penurunan kadar D-dimer pada pasien Diabetes Mellitus tipe 2 setelah dilakukan perlakuan berjemur dan pemberian tablet kalsium. Namun, tidak diketahui apakah peran kombinasi berjemur dengan pemberian tablet kalsium atau ada peran dari masing masing variabel.]]>
<![CDATA[Perbedaan Rerata Indeks Fibrosis-4 Antara Manifestasi Klinis Berat Dan Kritis Pada Pasien COVID-19. ]]>
<![CDATA[Umar Syarif]]>;
<![CDATA[Ellyza Nasrul]]>;
<![CDATA[Dwi Yulia]]>
<![CDATA[ Majalah Kedokteran Andalas Vol 46, No 4 (2023): Online Juli 2023 ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Andalas ]]>
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DOI: 10.25077/mka.v46.i4.p680-685.2023
<![CDATA[Latar Belakang: Coronavirus disease 2019 (COVID-19) adalah penyakit menular baru yang disebabkan SARS-CoV-2. Indeks Fibrosis-4 (FIB-4) saat ini digunakan sebagai prediktor awal menilai derajat berat dan perburukan COVID-19. Tujuan: Mengetahui perbedaan rerata indeks FIB-4 antara manifestasi klinis berat dan kritis pada pasien COVID-19. Metode: Penelitian analitik dengan rancangan potong lintang dilakukan terhadap 100 pasien COVID-19 dengan manifestasi klinis berat dan kritis di RSUP Dr. M. Djamil Padang sejak Juli 2022 hingga Februari 2023. Indeks FIB-4 dihitung dengan rumus umur × SGOT dibagi jumlah trombosit × √SGPT. Data dianalisis dengan uji T tidak berpasangan, bermakna jika p <0,05. Hasil: Subjek penelitian sebagian besar laki-laki (62%). Rerata umur subjek penelitian 57 tahun, rentang 38-80 tahun. Rerata indeks FIB-4 seluruh subjek penelitian 4,24 (1,72-8,66). Rerata indeks FIB-4 dengan manifestasi klinis berat 2,83 dan manifestasi klinis kritis 5,65 bermakna (p=0,001). Pembahasan: Terdapat peningkatan indeks FIB-4 yang lebih tinggi pada pasien manifestasi klinis kritis dibandingkan dengan manifestasi klinis berat, sehingga pasien dengan manifestasi klinis kritis sudah terjadi fibrosis hati. Keterbatasan pada penelitian ini adalah tidak dilakukannya fibroscan sebagai konfirmasi fibrosis hati. Simpulan:Terdapat peningkatan indeks FIB-4 yang lebih tinggi pada manifestasi klinis kritis dibandingkan dengan manifestasi klinis berat pada pasien COVID-19. ]]>
<![CDATA[Korelasi Mean Platelet Volume dengan Child-Pugh Score pada Pasien Sirosis Hepatis Stadium Dekompensata ]]>
<![CDATA[Fhany El Shara]]>;
<![CDATA[Ellyza Nasrul]]>;
<![CDATA[Dwi Yulia]]>
<![CDATA[ Majalah Kedokteran Andalas Vol 46, No 4 (2023): Online Juli 2023 ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Andalas ]]>
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DOI: 10.25077/mka.v46.i4.p633-638.2023
<![CDATA[Tujuan : Sirosis hepatis stadium dekompensata memiliki angka ketahanan hidup yang lebih rendah. Child-Pugh Score secara klinis banyak digunakan untuk menentukan derajat penyakit sirosis hepatis. Relevansi nilai mean platelet volume (MPV) dengan Child-Pugh Score menggambarkan kondisi inflamasi kronis pada sirosis hepatis. Tujuan penelitian ini untuk mengetahui korelasi nilai MPV dengan Child-Pugh Score pada pasien sirosis hepatis stadium dekompensata; Metode : Penelitian analitik dengan pendekatan retrospektif dilakukan terhadap 54 pasien sirosis hepatis stadium dekompensata dengan etiologi infeksi virus hepatitis B dan C di RSUP Dr. M. Djamil Padang sejak Mei hingga Agustus 2022. Nilai MPV dan Child-Pugh Score diperoleh dari observasi data rekam medis. Data dianalisis dengan uji korelasi Spearman, bermakna jika p<0,05; Hasil : Subjek penelitian sebagian besar laki-laki (75,9%) dengan rerata usia 53,3 (10,87) tahun. Rerata nilai MPV didapatkan 10,49 (0,13) fL. Median Child-Pugh Score adalah 11 (7–15). Uji korelasi Spearman menunjukkan terdapat korelasi positif lemah antara nilai MPV dengan Child-Pugh Score (r=0,29) dan bermakna secara statistik (p=0,03); Kesimpulan : Terdapat korelasi positif lemah antara nilai MPV dengan Child-Pugh Score pada pasien sirosis hepatis stadium dekompensata di RSUP Dr. M. Djamil Padang]]>
<![CDATA[DIFFERENCE IN HbA1c LEVEL BETWEEN BORONATE AFFINITY AND ION EXCHANGE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD IN DIABETIC PATIENT ]]>
<![CDATA[Tuti Asryani]]>;
<![CDATA[Ellyza Nasrul]]>;
<![CDATA[Rikarni Rikarni]]>;
<![CDATA[Tutty Prihandani]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 25 No. 2 (2019) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v25i2.1466
<![CDATA[Glycated Hb (HbA1c) test is needed to control glycemic in high prevalence type 2 Diabetes Mellitus (DM) patients. Hemoglobin fraction separated and chemical reaction is two main concepts in the HbA1c test. Ion exchange-high performance liquid chromatography (HPLC) and boronate affinity use the first concept. Ion exchange-HPLC is a reference method in most of the clinical laboratory. Point of care testing (POCT) with boronate affinity method that has been standardized by the international institution is available. This study aimed to compare the boronate affinity POCT method and ion exchange-HPLC method. This cross-sectional study was conducted to 22 types 2 DM patients those fulfilled inclusion and exclusion criteria in January 2017 to February 2018. Level of HbA1c was assayed with boronate affinity POCT and ion exchange-HPLC method. A t-test was used to analyze data and no significant difference if p>0.005. Subjects of this study are females (59.1%) more than males (40.9%) with age mean 59.23 years old (8.1). Uncontrolled type 2 DM (77.3%) more than controlled type 2 DM (22.7%).Mean of HbA1 level was 8.0% (1.7) in boronate affinity POCT and 8.3% (1.8) in ion exchange-HPLC. T-test showed no significant difference between those two HbA1C assay methods (p>0.005). There was no difference HbA1c level between boronate affinity POCT method and ion exchange-HPLC method.]]>
