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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Research Journal of Life Science MNJ (Malang Neurology Journal) Paediatrica Indonesiana Majalah Kesehatan FKUB Medical Laboratory Technology Journal Jurnal Ilmiah Bidan Indonesian Journal of Medicine International Journal of Community Service Learning Jurnal Riset Kesehatan Poltekkes Depkes Bandung Journal of Issues in Midwifery Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Indonesian Archives of Biomedical Research (InABR) Journal of Global Pharma Technology Media Penelitian dan Pengembangan Kesehatan
Agustina Tri Endharti
Departemen Parasitologi, Fakultas Kedokteran Universitas Brawijaya Malang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Menurunkan Angka Kejadian dan Mencegah Kekambuhan COVID-19, Lupus, Reumatik, dan Alergi Melalui Pembentukan Desa Binaan Dewi, Elvira Sari; Wahono, Cesarius Singgih; Barlianto, Wisnu; Handono, Kusworini; Sari, Tita Luthfia; Hasanah, Dian; Rahman, Perdana Aditya; Anshory, Muhammad; Wulandari, Desy; Sari, Dewi Purnama; Endharti, Agustina Tri; Nurdiana, Nurdiana; Kalsum, Umi; Susianti, Hani; Kalim, Handono
International Journal of Community Service Learning Vol. 5 No. 1 (2021): February 2021
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (189.075 KB) | DOI: 10.23887/ijcsl.v5i1.30161

Abstract

Kurangnya pengetahuan masyarakat tentang COVID-19, lupus, reumatik, dan alergi mempengaruhi keberhasilan terapi, penurunan angka kejadian, dan pencegahan kekambuhan. Tujuan pengabdian masyarakat adalah membangun desa-desa binaan tanggap COVID-19, lupus, reumatik, dan alergi di Malang oleh Tim Kelompok Kajian Lupus, Autoimun, Reumatik, dan Alergi (LAURA) Universitas Brawijaya. Warga desa binaan diberikan penyuluhan berupa seminar awam dan pelatihan tentang pertolongan awal pada penyakit COVID-19, lupus, reumatik, dan alergi, kemudian diminta mengisi kuesioner posttest untuk mengukur pemahaman. Desa-desa binaan diberikan thermo-gun dan wastafel untuk menerapkan protokol kesehatan. Satu bulan kemudian dievaluasi adanya kejadian COVID-19, lupus, reumatik, dan alergi di desa binaan. Hasil evaluasi menunjukkan rata-rata warga desa binaan memahami 78,3% materi yang diberikan dan menerapkan protokol kesehatan sesuai yang diajarkan saat penyuluhan. Dilaporkan tidak ada kejadian COVID-19 serta kekambuhan lupus, reumatik, dan alergi dalam satu bulan terakhir kegiatan. Kesimpulan: pembangunan desa-desa binaan di Malang meningkatkan tanggap warga terhadap COVID-19, lupus, reumatik, dan alergi.
PREDICTION OF MADECASSOSIDE (CENTELLA ASIATIACA) AFFINITY AS ANTIPARKINSON DRUG ON DOPAMINE RECEPTOR D1: MOLECULAR DOCKING ANALYSIS Shinta Kusumawati; Khotimah, Husnul; Endharti, Agustina Tri; Balafif, Farhad; Zakiyah, Rima
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.03

Abstract

Background: Parkinson's disease results from the gradual degeneration of dopamine neurons in the brain's substantia nigra pars compacta. The Dopamin receptor D1 (DRD1), which controls nerve growth and behavior, is the most prevalent dopamine receptor in the human nervous system. Objective: To determine the affinity of madecassoside on dopamine D1 receptors as a potential for anti-Parkinson's medications. Methods: The RSCB PDB database provided the chosen target protein's three-dimensional structure. namely DRD1. The PubChem database provided the 3D structure of the Madecassoside sample (CID: 45356919) and the PDB ligand control Rotigotine (CID: 59227). Autodock Vina, which was integrated with Pyrx v.1, was used for docking. Results: The madecassoside has a lower binding energy than the PDB control in the form of Rotigotine. The docking results showed that  madecassoside compounds formed more hydrogen bonds than Rotigotine. It was predicted that madecassoside and the dopamin receptor 1 receptor would create a stability complex. Conclusion: Madecassoside was predicted create a stability complex with DRD1.
Chemical Compounds and Antibacterial Activity of Thymus Vulgaris Leaves’ Ethanolic Extract Against Salmonella typhimurium: Thymus vulgaris Against Salmonella typhimurium Abousouh, Emad Khaleefah; Endharti, Agustina Tri; Santoso, Sanarto; Santosaningsih, Dewi
Journal of Tropical Life Science Vol. 14 No. 1 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.01.09

Abstract

Invasive non-typhoidal Salmonella is an important pathogen that causes life-threatening bloodstream infections. Antibiotic resistance in non-typhoidal Salmonella has emerged as a result of the increasing use of antibiotics; therefore, an alternative source of therapeutic agents is required. This study aimed to investigate the active compound and antibacterial activity of Thymus vulgaris leaves’ ethanolic extract against Salmonella typhimurium. Thin-layer chromatography was performed to identify the active compound in the ethanolic extract of T. vulgaris leaves. The antibiotic effect of the extract was carried out by agar dilution assay using the following concentrations: 0%, 2.5%, 5.0%, 7.5%, 10.0%, 12.5%, and 15.0% (w/v). Thymol and carvacrol were detected in the thin-layer chromatography. The minimum inhibitory concentration of the extract was 10.0% (w/v). In conclusion, T. vulgaris leaves’ ethanolic extract demonstrated antimicrobial activity against S. typhimurium. Further investigation is required to analyze the role of thymol and carvacrol as active compounds against S. typhimurium.
COMBINATION THERAPY OF CISPLATIN AND NANOCURCUMIN REDUCES PI3K EXPRESSION AND PROLIFERATION OF HeLa CELLS Subandi, Subandi; Febriana, Romadhinniar; Taqiyya, Nadia; Endharti, Agustina Tri
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 17 No 2 (2025): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v17i2.2912

Abstract

Kanker serviks merupakan salah satu penyebab utama kematian akibat kanker pada wanita, terutama di negara berkembang. Cisplatin adalah obat kemoterapi yang umum digunakan, tetapi penggunaannya dalam dosis tinggi sering menyebabkan efek samping toksik seperti kerusakan ginjal (nefrotoksisitas), yang dapat terjadi pada 25–33% pasien pada dosis 75–100 mg/m². Untuk mengurangi toksisitas dan meningkatkan efektivitas terapi, kombinasi cisplatin dengan senyawa alami seperti nanokurkumin mulai dikembangkan. Penelitian ini bertujuan untuk mengevaluasi potensi kombinasi cisplatin dan nanokurkumin dalam menghambat proliferasi dan menurunkan ekspresi PI3K pada sel kanker serviks HeLa. Penelitian ini menggunakan desain eksperimental dengan post-test only control group. Sel HeLa diberi perlakuan cisplatin (2,5 dan 5 µg/mL), nanokurkumin (100 µg/mL), serta kombinasi cisplatin 2,5 µg/mL dengan nanokurkumin (25, 50, dan 100 µg/mL). Evaluasi mencakup morfologi sel, uji viabilitas menggunakan CCK-8, dan analisis ekspresi PI3K menggunakan flow cytometry. Analisis statistik dilakukan dengan uji Kruskal-Wallis, dilanjutkan uji post hoc Dunn, dengan nilai signifikansi p < 0,05. Hasil menunjukkan bahwa kombinasi cisplatin 2,5 µg/mL dan nanokurkumin 100 µg/mL secara signifikan menurunkan viabilitas sel dibandingkan cisplatin 2,5 µg/mL saja (p = 0,035), serta memiliki efektivitas yang sebanding dengan cisplatin 5 µg/mL (p = 0,553). Penurunan ekspresi PI3K juga signifikan dibandingkan kontrol negatif (p = 0,000), cisplatin 2,5 µg/mL (p = 0,006), dan cisplatin 5 µg/mL (p = 0,010). Hasil ini menunjukkan bahwa kombinasi cisplatin dan nanokurkumin berpotensi sebagai terapi kanker serviks yang efektif.
SYNERGISTIC EFFECTS OF NANOCURCUMIN AND CISPLATIN COMBINATION THERAPY ON APOPTOSIS AND PROTEIN KINASE B (AKT) IN CERVICAL CANCER Subandi, Subandi; Taqiyya, Nadia; Febriana, Romadhinniar; Endharti, Agustina Tri
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 3 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i3.3169

Abstract

Kanker serviks merupakan salah satu jenis kanker yang sering dijumpai pada wanita dan penyebab utama kematian di negara berkembang, termasuk Indonesia. Kemoterapi berbasis cisplatin merupakan terapi standar, namun penggunaannya dibatasi oleh toksisitas yang bergantung pada dosis, seperti nefrotoksisitas, neurotoksisitas, dan  kardiotoksisitas. Penelitian ini bertujuan untuk mengevaluasi efek sinergis kombinasi nanokurkumin dan cisplatin terhadap tingkat apoptosis dan ekspresi Protein Kinase B (AKT) pada sel HeLa. Metode yang digunakan adalah eksperimen dengan desain post-test only control group, dengan kelompok kontrol negative (media standar), kontrol positif monoterapi cisplatin (5 dan 2,5 µg/mL), nanokurkumin (100 µg/mL), serta kombinasi cisplatin 2,5 µg/mL dan nanokurkumin berbagai dosis (25, 50, dan 100 µg/mL). Uji flow cytometry digunakan untuk menganalisis tingkat apoptosis dan ekspresi AKT setelah 48 jam inkubasi. Hasil penelitian menunjukkan bahwa kombinasi cisplatin 2,5 µg/mL dan nanokurkumin 100 µg/mL menyebabkan apoptosis (75,23%) pada sel HeLa yang sebanding (p<0.05) dengan efek cisplatin tunggal 5 µg/mL (76,15%) serta secara signifikan (p<0,05) menurunkan ekspresi AKT pada sel HeLa (76,53%) dibanding cisplatin 5 µg/mL (97,18%) serta cisplatin 2,5 µg/mL (97,24%). Peningkatan apoptosis dan penurunan ekspresi AKT menunjukkan potensi terapi kombinasi ini dalam mengurangi dosis cisplatin yang diperlukan dengan harapan dapat menurunkan toksisitas.
Potency of bioactive compounds in Minasarua traditional beverage from Indonesia as an antioxidant and anti-inflammatory: A review Maramy, Neyla Vista; Widyaningsih, Tri Dewanti; Martati, Erryana; Endharti, Agustina Tri
Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Vol 8, No 3 (2025)
Publisher : Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.afssaae.2025.008.03.2

Abstract

Minasarua is a traditional beverage believed by the local community in Bima, Indonesia, to have perceived health benefits. This review explores the potential of bioactive compounds in Minasarua as antioxidants and anti-inflammatories. The product is made from ingredients such as ginger (Zingiber officinale), turmeric (Curcuma longa), Javanese chilli pepper (Piper retrofractum Vahl), pepper (Piper nigrum), and fermented black glutinous rice, each of which contributes key bioactive compounds, including gingerol, shogaol, curcumin, piperine, and anthocyanins. These compounds are known for their ability to neutralize free radicals and inhibit the expression of pro-inflammatory cytokines. Although individual components have been studied extensively, the potential synergistic effects of these compounds when combined in Minasarua remain underexplored. This review highlights the promising role of Minasarua as a functional beverage, suggesting that the interaction among its major compounds may enhance their collective antioxidant and anti-inflammatory activities. These findings offer a foundation for future research into the development of Minasarua as a health-promoting traditional drink.
A Comparison Study of the Influence of Caffeic Acid Phenethyl Ester and Mitoxantrone in Experimental Autoimmune Encephalomyelitis Balb/C Mice Model: Comparison Effect Cape and Mitoxantrone Alnawajha, Amin; Endharti, Agustina Tri; Santoso, Sunarto; Santosaningsih , Dewi; Satriotomo , Irawan
Journal of Tropical Life Science Vol. 13 No. 3 (2023)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.13.03.03

Abstract

A common neurodegenerative condition that still presents clinical challenges is Multiple Sclerosis (MS). Effective multiple sclerosis treatments are sorely needed in clinical settings. Experimental Autoimmune Encephalomyelitis (EAE) is an animal model of multiple sclerosis, a T-cell-mediated disease. Active T-cells differentiate into the Th9 and Th17 subsets, which are controlled by NF-kB and produce the proinflammatory cytokines IL9 and IL17. Because these cytokines are crucial to the pathophysiology of EAE, they have been used as targets for MS therapy. Caffeic acid phenethyl ester (CAPE) is an active ingredient of propolis that has been shown to have immunomodulatory and anti-inflammatory activities. Mitoxantrone is a synthetic antineoplastic agent and cytotoxic immunosuppressive effect used to treat MS. The study aimed to determine whether the two medications have superior efficacy and effect in the treatment of EAE mouse model MS compared to the other. After inducing EAE in mice, CAPE and mitoxantrone were administered to evaluate this therapeutic effectiveness. ELISA was used to measure IL9, IL17 levels and the activity of NF-kBp56. H&E was used to evaluate cell infiltration T lymphocytes for histopathology of spinal cord tissue. Molecular docking was performed to predict the interaction between CAPE and a cytokine. We found that CAPE has a sufficient effect of reducing the level of IL9, IL17, active NF-kBp56, and inflammatory cell infiltration T-lymphocytes in all groups of mice EAE treated with CAPE. In contrast, mitoxantrone reduced cytokines and cell infiltration, so EAE mice treated with both compounds were observed more improvement than other groups. Based on our findings, two medications demonstrated the same efficacy and effect in EAE mice model MS., whereas CAPE did not statistically reach a significant value. While the combination of two medications has the optimal effect.
Co-Authors A.A. Santi Dewi Abd. Rasyid Syamsuri Abousouh, Emad Khaleefah Alnawajha, Amin Ambar Dwi Retnoningrum Andre William Tulle Anggie Diniayuningrum Ari Yunanto Arifin, Mochammad Samsul Aris Widodo Bagus Hermansyah Balafif, Farhad Bambang Rahardjo Burhan, Niniek Daniel Happy Putra desy wulandari Dewi Purnama Sari Dewi Santosaningsih Dian Hasanah Didi Candradikusuma Didi Candradikusuma Dinda Oktia Maghfiroh Dwi Yuni Nur Hidayati Elvira Sari Dewi Erma Sulistyaningsih Erryana Martati Ery Olivianto Febriana, Romadhinniar Handono Kalim Hani Susianti Hidayat Sujuti Hittoh Fattory, Hittoh HMS Chandra Kusuma Indriati Dwi Rahayu Irma Hamdayani Pasaribu Josef Sem Berth Tuda Krisni Subandiyah Kusumawati, Shinta Kusworini Handono Loeki Enggar Fitri Maramy, Neyla Vista Muhammad Anshory, Muhammad Muhammad Rivai Nikmatul Ulya, Nikmatul Niniek Burhan Nuning Winaris Nurdiana Nurdiana Nurdiana Nurdiana Perdana Aditya Rahman Prawiro, Sumarno Reto R Setyohadi, R Rahmad Rahmad Rima Zakiyah Samsul Arifin Sanarto Santoso Santosaningsih , Dewi Santoso, Sunarto Sari, Tita Luthfia Satriotomo , Irawan Soeyati Poejiani Solly Aryza Sri Andarini Subandi Subandi Sumarno . Sumarno Reto Prawiro Sumarno Sumarno Sutrisno Sutrisno Taqiyya, Nadia Tatit Nurseta Tri Dewanti Widyaningsih Tuda, Josef Sem Berth Umar Zein Vanji Budi Himawan, Vanji Budi Wahono, Cesarius Singgih Wahyono, Tikto Wardhani, Ratih Kusuma Wening Prastowo Wisnu Barlianto Zahra Ahmed