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Journal : Riset Informasi Kesehatan

Effect of non-adherence to ARV therapy on 3-year life of HIV/AIDS patients: a cohort retrospective study Hendra Dhermawan Sitanggang; Tri Yunis Miko Wahyono; Ira Marti Ayu
Riset Informasi Kesehatan Vol 12 No 1 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i1.692

Abstract

Background: Antiretroviral drug Therapy (ART) has dramatically reduced the morbidity and mortality of People Living with HIV/AIDS (PLWHA). However, adherence to antiretroviral therapy has become a challenge due to a lifetime of therapy. Adherence to antiretroviral therapy is one determining factor in the success of treatment. Method: This study aimed to determine the influence of medication non-adherence on the 3-year survival of patients with HIV/AIDS. The study design used a retrospective cohort and calculated survival estimates using Cox regression. All HIV/AIDS patients in the RSPI-SS from 2010 – April 2012, totaling 164 patients, were obtained from medical records, a summary of treatment and ART (follow-up), pharmacy data, and ARV therapy monitoring books at the RSPI-SS. Data analysis using cox regression. Results: The cumulative survival probability of patients with HIV/AIDS at RSPI Prof. dr. Sulianti Saroso in the second year (24th month) was 95.6% and in the third year (in the 36th) was 91%. Multivariate analysis with Cox regression showed the factors that affected the 3-year survival of patients with HIV/AIDS are non-adherence to ART after being controlled by initial CD4 count (aHR = 7.608; 95% CI: 1.664 to 34.790) and non-compliance appointments after controlled by opportunistic infection, age and initial CD4 count (aHR = 2.456; 95% CI: 0.802 to 7.518). Among patients' non-adherence to ART, non-compliance appointments affected the 3-year survival of patients with HIV/AIDS after controlled by initial CD4 count, sex, CPT, modes of HIV transmission, WHO clinical stage, opportunistic infection, and age (aHR = 4.517; 95%CI: 0.729 to 27.987). Conclusion: Non-adherence to ART may cause a failure to suppress HIV viral, thus increasing the possibility of HIV mutations that can lead to drug-resistant and ultimately increase the risk of death. Patients who do not adhere to medication and do not adhere to their medication appointments show a higher risk of dying than those who adhere to HIV/AIDS. Non-adherence to taking medication in the first year can be used as a marker to monitor medication adherence and the patient's health condition in the future. Therefore, it is essential to monitor adherence to taking the medication regularly through ARV therapy surveillance activities.
Co-Authors Ade Heryana Ade Heryana Ade Heryana Adella Dwi Ayu Ningsih Adinda Putri Syahrani Ahmad Irfandi Ahmad Irfandi Amelia Amelia Andi Shalsabila Putri Andi Shalsabila Putri Anfrew Leoranz Purba Anggun Sella Safitri Asari Asari Azzahra Putri Indarg Br Perangin, Br Perangin Br Sembiring, Elsye Meilinda Briandanu Bintoro Clara Elnisa Woro Hanadi Cri Sajjana Prajna Wekadigunawan Cut Alia Keumala Cut Alia Keumala Muda Cut Alia Keumala Muda David Martua Sehat Nababan Deasy Febriyanty Deasy Febriyanty Decy Situngkir Desyawati Utami Devi Angeliana Kusumaningtiar Deybi Julianti Napitu Dwi Apriliawati Eka Cempaka Putri Eka Cempaka Putri Elsha Palupi, Elsha Palupi Erlina Puspitaloka Mahadewi Erlina Puspitaloka Mahadewi Erna Veronika Farhan Hakiki Febriyanty, Deasy Fitrotul Hasanah Fransisco, Indra Gisely Vionalita Harahap, Mitha Aulia Hendra Dhermawan Sitanggang Heryana, Ade Indasari, Riska Intan Silviana Irfandi, Ahmad Izzah, Widya Nur Laosma Sipahutar Lawalata, Omri Ebo Junior Luh Ayu Krisdayanti M Rafi Favianto Marito Elisha Hofman Panjaitan Mayumi Nitami Mirta Dwi Rahmah Rusdy Mirta Dwi Rahmah Rusdy Misalsalina, Frisella Muda, Cut Alia Keumala Mugi Wahidin Murti, Christinauli Eka Mustikawati, Intan Silviana Nada Mutiara Sanni Nadiyah Nadiyah Nadiyah Nadiyah Namira W Sangadji Namira Wadjir Sangadji Ni'matul Hidayah, Ummu Rohmah Ning Setianti Ning Setianti Novita, Olga Olga Novita Putri Handayani PUTRI HANDAYANI Rahmawati Rahmawati Raihan Muhammad Dzulkarnaen Rini Handayani Rini Handayani Rosita Rosita Sangadji, Namira W Sangadji, Namira Wadjir Shafira Azuraa Shofi Jasmine Shorayasari, Susi Simanjuntak, Acnes Cristina soraya, Una Sumayya, Siti Susi Shorayasari Tri Yunis Miko Wahyono Veronika, Erna Veza Azteria Wiraatmadja, Jesica Zulfa Rindy Al Fitry