Garuda - Garba Rujukan Digital

SAGO STARCH AND SODIUM ALGINATE AS NATURAL CROSSLINKING FOR CAPSULE ALTERNATIVES Harimurti, Sabtanti; Mulyanti, Amelia Nur'afni; Kusnindyasita, Anisa; Widada, Hari; Febriansah, Rifki; Suwanda, Totok; Muhtadi, Muhtadi
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.8856

Capsule shells are generally made from gelatin. The gelatin that is spread in the world is commonly derived from pigs. This animal is forbidden to be consumed by Muslims. This issue is due to the halal aspect. Sago starch and sodium alginate are halal materials that are capable of gelatinizing. This property made it able to be molded as a capsule. This research aims to determine the formula of sago and sodium alginate as a capsule and the evaluation. Three formulas were made with the ratio of sago and sodium alginate 100%: 0% (formula 1), 50%: 50% (formula 2), and 0%: 100% (formula 3). The capsule was manually molded using a food-grade stainless steel capsule mold. The size of the capsule, weight uniformity, swelling, and disintegration time were determined for a physical evaluation. SLD was used to determine the best formula, and the validation was done using One-sample T-test. The evaluations of the capsule shell were found ranged as follows: the size specifications were 21-22 mm, the body diameter was 6.1-7.2 mm, the cap diameter was 13.6-13.8 mm, weight uniformity was 0.10-0.26 gram, the swelling test was 433-1583%, and the disintegration time was 10.20-14.43 minutes. The best formula based on the SLD of the experiment was formula 3, which are two parameters that met the requirements, i.e., swelling and disintegration time. The sago and sodium alginate were crosslinked, and the capsule was made. However, the performance dislike of gelatin capsules. Continued research shall be done to find the optimum formula and its characteristics for alternative material on halal capsules.

Acute toxicity of the intranasal administration of Anredera cordifolia extract in Wistar Rats Widuri, Asti; Febriansah, Rifki
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28249

Anredera cordifolia (AC) known as binahong plant in Indonesia is commonly used for traditional medicine since ancients. AC contains of secondary metabolites such as flavonoids that have anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties. Many flavonoids compound that has anti-inflammatory activity were potential for treatment of nasal inflammatory such as allergic rhinitis. This study aims to evaluate the preclinical safety of acute intranasal administration of AC extract in laboratory wistar rats. Acute toxicity using the intranasal route of administration of AC extract was evaluated on 30 female wistar rats, divided five rats for control, and each five of doses 5%, 10%, 25%, 50% and 75%. Observation during 14 days for the incidence of mortality and signs of toxicity. The AC extract intranasal administration doses at 5%, 10%, 25%, 50% and 75% did not show mortality or treatment related adverse events and did not showed significantly changes on blood profile. The AC extract was found safe until 75% for nasal administration in wistar rats.

Ursolic Acid and Polydatin in Melinjo Seeds Inhibit AKT1 and GAPDH Protein and HTB-179 Cells Migration Febriansah, Rifki; Julita, Irna
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.88227

The incidence of lung cancer in Indonesia by 2020 has reached 34.783 cases. Melinjo contains ursolic acid and polydatin, which can suppress cell proliferation and induce cell apoptosis, respectively. This study aims to determine the Melinjo seed ethyl acetate fraction (MSEAF) ability to inhibit lung cancer proliferation and migration towards HTB-179 cells using in vitro and in silico methods. Melinjo seed powder was macerated using 70% ethanol and fractionated with ethyl acetate. The fraction obtained was then analyzed using HPLC to detect the active compounds. The compounds obtained were further analyzed using bioinformatics to determine the target proteins. The docking method was performed between ursolic acid and polydatin compounds with each target protein to determine the binding affinity. The in vitro test was done using the MTT cytotoxicity assay and scratch wound healing assay methods. The results showed that MSEAF contains ursolic acid and polydatin with retention times of 12,475 minutes and 16,564 minutes, respectively. Ursolic acid protein targets were TP53 and AKT1 with docking scores of -6,3 kcal/mol and -7,4 kcal/mol, while polydatin target proteins were GAPDH and VEGFA with docking scores of -8,8 kcal/mol and -5,5 kcal/mol. The results of the MTT assay showed an IC50 value of 35,539 g/mL, and MSEAF inhibited the migration of HTB-179 cells by slowing the migration rate. This study suggested that the MSEAF contained ursolic acid and polydatin, which exhibited the ability to prevent the growth and migration of HTB-179 lung cancer, supported by the prediction of their ability to bind to TP53 and AKT1 proteins.

Ethnomedicine Study on Medicinal Plants in Nanggulan District, Kulon Progo Regency Kintoko, Kintoko; Saputri, Ginanjar Zukhruf; Novitasari, Putri Rachma; Desmayanti, Astri; Witasari, Hardi Astuti; Ranti, Imaniar; Yulianto, Yulianto; Febriansah, Rifki; Widyaningrum, Rachmawati; Utami, Febri; Setiyawati, Fitri Indah
Journal of Food and Pharmaceutical Sciences Vol 13, No 1 (2025): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.14189

Despite the advancements in conventional medicine, medicinal plants continue to play an important role in treating different human ailments, particularly in developing nations. This is based on locals' knowledge of medicinal plants for treating various ailments. Ethnomedicine is a branch of research investigating society's local wisdom for maintaining its health. According to diverse field studies, 40 different varieties of plants have been discovered that the native inhabitants of Kulon Progo Regency think are medicinal. The purpose of this research was to identify therapeutic herbs used by the Kulon Progo population. Traditional healers and members of the Kulon Progo village were interviewed as part of this study. The ethnomedicine data was analyzed using Use Value (UV), Frequency of Citation (FC), and Plant Part Value (PPV). The analytical results suggest that turmeric (0.78), galangal (0.67), and ginger (0.67) are the most important plants to society. Rhizomes (38.10%) and leaves (34.52) are the most commonly employed plant parts for medicinal purposes. Boiling it (47.06%) produces herbal medication from the plant extract.

Ethnomedicine Study on Medicinal Plants in Nanggulan District, Kulon Progo Regency Kintoko, Kintoko; Saputri, Ginanjar Zukhruf; Novitasari, Putri Rachma; Desmayanti, Astri; Witasari, Hardi Astuti; Ranti, Imaniar; Yulianto, Yulianto; Febriansah, Rifki; Widyaningrum, Rachmawati; Utami, Febri; Setiyawati, Fitri Indah
Journal of Food and Pharmaceutical Sciences Vol 13, No 1 (2025): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.14189

Despite the advancements in conventional medicine, medicinal plants continue to play an important role in treating different human ailments, particularly in developing nations. This is based on locals' knowledge of medicinal plants for treating various ailments. Ethnomedicine is a branch of research investigating society's local wisdom for maintaining its health. According to diverse field studies, 40 different varieties of plants have been discovered that the native inhabitants of Kulon Progo Regency think are medicinal. The purpose of this research was to identify therapeutic herbs used by the Kulon Progo population. Traditional healers and members of the Kulon Progo village were interviewed as part of this study. The ethnomedicine data was analyzed using Use Value (UV), Frequency of Citation (FC), and Plant Part Value (PPV). The analytical results suggest that turmeric (0.78), galangal (0.67), and ginger (0.67) are the most important plants to society. Rhizomes (38.10%) and leaves (34.52) are the most commonly employed plant parts for medicinal purposes. Boiling it (47.06%) produces herbal medication from the plant extract.

Title

Found 15 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 15 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 15 Documents
Search