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All Journal HAYATI Journal of Biosciences Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Mutiara Medika: Jurnal Kedokteran dan Kesehatan Majalah Obat Tradisional Jurnal Farmasi Sains dan Komunitas Acta Pharmaciae Indonesia : Acta Pharm Indo BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks Acta Biochimica Indonesiana Menara Perkebunan Journal of Fundamental and Applied Pharmaceutical Science Universitas Muhammadiyah Yogyakarta Undergraduate Conference Proceeding Prosiding Seminar Nasional Program Pengabdian Masyarakat Pharmacy Reports Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Journal of Food and Pharmaceutical Sciences
Rifki Febriansah
School Of Pharmacy, Faculty Of Medicine And Health Sciences, Universitas Muhammadiyah Yogyakarta, Yogyakarta 55183, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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PENINGKATAN KUALITAS KESEHATAN MELAUI EDUKASI PENGGUNAAN OBAT DAN HERBAL BAGI BINAAN RUMAH ZAKAT Aji Winanta; Hari Widada; Rifki Febriansah; Muhammad Arif Rizqi
Prosiding Seminar Nasional Program Pengabdian Masyarakat 2021: 1. Peningkatan Kapasitas Kelembagaan Publik
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (577.292 KB) | DOI: 10.18196/ppm.41.865

Abstract

Informasi pengunaan obat-obat alternatif yang dapat berkhasiat untuk mengobati covid-19 yang tidak pasti membuat kepanikan di masyarakat. Pemanfaatan obat tradisional di era pandemi Covid-19 sangat bermanfaat sebagai pencegahan yaitu untuk meningkatkan daya tahan tubuh, atau sebagai pelengkap (komplemen) obat konvesional yang diberikan pada pasien Covid-19 sehingga daya tahan tubuh seseorang menjadi semakin bagus. Rumah zakat yang merupakan lembaga filantropi yang mengelola zakat, infak sedekah, serta dana sosial lainnya melalui program Senyum Sehat (kesehatan) berupaya dapat bermanfaat di bidang kesehatan. Program pengabdian masyarakat yang akan dilakukan bertujuan untuk meningkatkan kualitas kesehatan melalui edukasi penggunaan obat dan herbal yang benar bagi binaan rumah RUMAH ZAKAT Sleman, DIY. Metode pelaksanaan program didahului dengan observasi lingkungan, kemudian pelaksanaan program menggunakan metode ceramah/diskusi. Pelaksanaan ceramah/diskusi tentang penggunaan obat dengan metode CBIA (Cara Belajar Insan Aktif) yang dilaksanakan secara luring dan daring sebanyak 3 kali pertemuan. Selain ceramah juga dilaksanakan praktek budidaya tanaman herbal dan pemanfaatannya. Diakhir pelaksanaan dilakukan evaluasi terkait pelaksanaan program. Khalayak sasaran untuk kegiatan ini yaitu remaja dan orang tua binaan rumah zakat Sleman, Yogyakarta. Luaran yang akan dicapai diharapkan dapat memberikan pengetahuan dan bekal bagi binaan rumah zakat mengenai penggunaan obat yang benar serta pemanfaat budidaya tanaman herbal. Hasil program pengabdian menunjukan peningkatan pemahaman masyarakat tentang penggunaan obat yang ditunjukkan dengan peningkatan nilai pada tahap post-test. Pemberian edukasi dapat meberikan efek positif terkait kualitas kesehatan masyarakat. Hasil kegiatan ini juga akan dimuat dalam suatu artikel ilmiah yang akan dipublikasikan dalam jurnal ber ISSN.
Uji molecular docking dan bioinformatika terhadap meniran (Phyllanthus niruri L.) sebagai antivirus SARS-CoV-2 dan antikanker serviks Nuha Haifa ARIFIN; Rifki FEBRIANSAH
E-Journal Menara Perkebunan Vol 90, No 1 (2022): April, 2022
Publisher : INDONESIAN RESEARCH INSTITUTE FOR BIOTECHNOLOGY AND BIOINDUSTRY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/iribb.jur.mp.v90i1.477

Abstract

Abstract     The SARS-CoV-2 virus is a virus that emerged in late 2019 and has yet to find a cure. On the other hand, the incidence of cervical cancer in women continues to increase along with the emergence of cases of COVID-19 caused by SARS-CoV-2. Based on WHO data in 2020 stated that there were 107 per 72,314 cancer patients infected with SARS-CoV-2. Meniran (Phyllanthus niruri L.) is a herbaceous plant in Indonesia that has secondary metabolites derived from the tannin group, such as corilagin. This compound has the potential to be developed as an antiviral and anticancer agent. Thus, the purpose of this study was to determine the potential of corilagin in meniran herbs to act as an antiviral SARS-CoV-2 and cervical anticancer compared to the drug compounds molnupiravir and paclitaxel through the STITCH & STRING bioinformatics in silico test and molecular docking method. The results of the bioinformatics test of corilagin against the SARS-CoV-2 virus showed predictions of high protein binding to AGTR2 and ENPEP with a docking score of -10.9 and -9.9 kcal/mol, respectively. Meanwhile, cervical cancer cells showed the highest predicted protein binding to IL-10 and MAPK3 with a docking score of -10.5 and -10.8 kcal/mol. The docking score of molnupiravir against the COVID-19 virus protein, AGTR2, and ENPEP were -7.4 and -7.2 kcal/mol, respectively. The docking scores of paclitaxel for IL10 and MAPK3 were -8.2 and -8.9 kcal/mol, respectively. These values indicate that the activity of corilagin with proteins AGTR2, ENPEP, IL10, and MAPK3 has stronger affinity energy than the comparison drugs molnupiravir and paclitaxel. Thus, the corilagin compound from the tannin group in meniran (Phyllanthus niruri L.) has the potential to be developed and formulated as a treatment and prevention of SARS-CoV-2 antiviral and cervical anticancer.[Keywords: corilagin, cervical cancer, Phyllanthus niruri L., SARS-CoV-2] Abstrak      Virus SARS-CoV-2 merupakan virus yang muncul di akhir tahun 2019 dan belum ditemukan pengobatannya. Di sisi lain, terjadinya kasus kanker serviks pada wanita masih terus meningkat beriringan dengan munculnya kasus COVID-19 yang disebabkan oleh SARS-CoV-2. Berdasarkan data studi WHO tahun 2020 menyatakan bahwa terdapat 107 per 72.314 pasien kanker yang terinfeksi SARS-CoV-2. Meniran (Phyllanthus niruri L.) merupakan tanaman herba di Indonesia yang memiliki senyawa metabolit sekunder yang berasal dari golongan tannin seperti corilagin. Senyawa ini memiliki potensi untuk dikembangkan sebagai agen antivirus dan antikanker. Penelitian ini bertujuan untuk mengetahui potensi corilagin yang terkandung pada herba meniran sebagai antivirus SARS-CoV-2 dan antikanker serviks yang dibandingkan dengan senyawa obat molnupiravir dan paclitaxel melalui uji in silico bioinformatika STITCH & STRING serta metode molecular docking. Hasil uji bioinformatika corilagin terhadap virus SARS-CoV-2 menunjukkan prediksi pengikatan protein yang tinggi pada AGTR2 dan ENPEP dengan docking score -10,9 dan -9,9 kcal/mol. Sedangkan pada sel kanker serviks menunjukkan prediksi pengikatan protein tertinggi pada IL-10 dan MAPK3 dengan docking score -10,5 dan -10,8 kcal/mol. Docking score molnupiravir terhadap protein virus Covid-19, AGTR2 dan ENPEP adalah -7,4 dan -7,2 kcal/mol. Docking score paclitaxel terhadap IL10 dan MAPK3 adalah -8,2 dan -8,9 kcal/mol. Nilai tersebut menunjukkan aktivitas corilagin dengan protein AGTR2, ENPEP, IL10, dan MAPK3 memiliki energi afinitas yang lebih kuat dibandingkan senyawa obat pembanding molnupiravir dan paclitaxel. Sehingga, senyawa corilagin dari golongan tannin pada meniran (Phyllanthus niruri L.) memiliki potensi untuk dikembangkan dan diformulasikan sebagai pengobatan serta pencegahan antivirus SARS-CoV-2 dan antikanker serviks.[Kata kunci:   corilagin, kanker serviks, Phyllanthus niruri L., SARS-CoV-2]
The Chemopreventive Effects of The Combination Between Tea Leaf and Mandarine Peel Extract on Breast Cancer Cell Ega Hida Prabowo; Rifki Febriansah
Journal of Fundamental and Applied Pharmaceutical Science Vol 1, No 1 (2020): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.010101

Abstract

The number of breast cancer patients is increasing high in the world. This study aims to determine the chemopreventive effect of a combination of ethanolic extracts of tea leaves and mandarin peel in silico and in vitro on T47D breast cancer cells. Extraction by the maceration method used ethanol solvent 70%. The research is an in silico molecular docking utilized software of Autodock Vina to determine the binding affinity of tangeretin compounds and Epigallocatechin gallate (EGCG) on HER-2 protein. The antioxidant test used the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method to determine the antioxidant activity of the combination of tea leaf and mandarine peel (CTM) extract. The in vitro test used the method of 3-(4,5-dimethyltiazol-2-il) -2,5-diphenyltetrazolium bromide (MTT) to determine the value of IC50 fromCTM on T47D breast cancer cells. The result of this study showed that CTM had a vigorous antioxidant activity with an IC50 value of 83 μg/ml. CTM had a weak cytotoxic activity with an IC50 value of 1889 μg/ml. Molecular tethering results of tangeretin and EGCG compounds produced a docking score of -6.6 and -5.0 kcal/mol with docking score proportion consisting of -4.9 kcal/mol of original ligand, -6.1 kcal/mol of doxorubicin and -4.5 kcal/mol of 5-fluorouracil. CTM had potential as a chemopreventive agent based on the robust antioxidant activity data on T47D breast cancer cells and molecular docking on the HER-2 protein.
Pembimbingan Pemasaran Online Kelompok Usaha Telur Asin dan Pepes Ikan di Dusun Ngentak Turi Aji Winanta; Rifki Febriansah; Ramdhani Saifulloh; Aldi Ihza Mahendra
Prosiding Seminar Nasional Program Pengabdian Masyarakat 2022: 4. Kapasitas Daya Saing Usaha Mikro, Kecil, dan Menengah (UMKM) dan Badan Usaha Milik Desa (BU
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/ppm.54.964

Abstract

Teknologi yang semakin berkembang membuat perilaku jual-beli produk di masyarakat juga berubah. Konsumen lebih menyukai membeli produk secara daring atau online melalui media internet. Kelebihan kegiatan jual-beli dengan menggunaan internet yaitu lebih mudah, cepat, serta dapat diakses kapan saja dan dimana saja tanpa terikat ruang dan waktu. Model pemasaran dengan menggunakan internet atau online diprediksi akan menjadi sebuah nilai tambah bagi produk atau jasa di masa mendatang. Tujuan dari program KKN-PPM UMY adalah untuk meningkatkan kemampuan dari khalayak dusun mitra yaitu usaha telur asin dan pepes ikan di dusun Ngentak, Turi, Sleman, Yogyakarta dalam memasarkan secara online. Mitra secara teknis diajarkan bagaimana cara mendaftarkan profil bisnis di mesin pencari Google serta toko-toko online yang ada di Indonesia. Selain itu, mitra juga diajarkan bagaimana cara beriklan secara online. Hal ini diharapkan akan meningkatan pendapatan mitra. Upaya yang dilakukan untuk mencapai tujuan tersebut antara lain adalah penyuluhan mengenai pemasaran daring (online marketing), mendaftarkan produk atau jasa yang ditawarkan ke mesin pencari Google dan toko online, serta penyuluhan mengenai model pemasaran secara online. Program hibah kemitraan KKN-PPM oleh LP3M UMY ini pada akhirnya dapat membantu meningkatkan kemampuan mitra dalam bidang pemasaran secara online, dan mengetahui cara melakukan promosi melalui internet atau online, sehingga dapat mengenalkan usaha mereka pada tingkat yang lebih luas dan meningkatkan pendapatan
Antioxidant, Cytotoxic Activity and Protein Target Inhibition of Ethyl Acetate Fraction Melinjo Seed (Gnetum gnemon L.) by In Vitro and In Silico Studies on HeLa Cervical Cancer Cells Rawi Ingra Savitri; Nuha Haifa Arifin; Rifki Febriansah
HAYATI Journal of Biosciences Vol. 30 No. 5 (2023): September 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.5.864-873

Abstract

Cervical cancer is one of the most common cancer suffered in women. Chemotherapy usage often causes physical and psychological side effects in patients. This study aims to determine the antioxidant and cytotoxic effects of the ethyl acetate fraction of melinjo seeds (Gnetum gnemon L.) on HeLa cervical cancer cells through in vitro and in silico assays. Melinjo seed was extracted by maceration using ethanol 70% and fractionated with ethyl acetate to obtain the Ethyl Acetate Fraction of Melinjo Seed (EAFMS). The identification of the active compounds group was done using Thin Layer Chromatography (TLC) method. In vitro studies were conducted on antioxidant tests using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and cytotoxic activity test using 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) Assay. In silico test for molecular docking analyzed by Autodock Vina method. The TLC analysis of EAFMS showed the presence of the stilbenoid compounds group. The antioxidant activity of EAFMS is weak, with an IC50 value of 175.8 g/ml. Cytotoxic activity of EAFMS is categorized as toxic to HeLa cancer cells with an IC50 value of 21.69 g/ml, while EAFMS has a synergistic effect combined with doxorubicin as a standard drug with a combination index (CI) value of 0.24-0.80. A molecular docking test of gnetin C with VHR receptor found a strong and stable bond with a docking score of -8.3 kcal/mol. Thus, EAFMS has the potential to be used as a chemopreventive agent for cervical cancer and can be combined with doxorubicin.
Evaluasi Tingkat Pengetahuan Perawatan Kesehatan Gigi dan Mulut Anak TK YM Nomporejo Nisriina Yusan Nindy Azzahra; Siti Nahdiyatul Ummah; Mustafid Amna; Devanola Pitaloka Aninda Matsna Aziza; Cika Fathunissa; Johan Agung Dermawan; Anggi Sabaya; Rifki Febriansah
Prosiding Seminar Nasional Program Pengabdian Masyarakat Vol. 6 No. 1 (2023): Semnas PPM 6 Tahun 2023
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/ppm.61.1164

Abstract

Pemeliharaan kebersihan gigi dan mulut merupakan salah satu upaya meningkatkan kesehatan. Masalah kesehatan gigi dan mulut merupakan hal yang dapat dihindari dengan melakukan perawatan sejak dini. Hasil survei yang dilakukan di TK YM Nomporejo menunjukkan bahwa anak-anak memiliki kebiasaan mengonsumsi minuman dingin dan makanan manis yang menyebabkan kerusakan gigi pada anak usia dini, sehingga perlu dilakukan kegiatan pengabdian terkait perawatan kesehatan gigi dan mulut. Tujuan pengabdian ini yaitu untuk mengevaluasi tingkat pengetahuan perawatan kesehatan gigi dan mulut pada anak-anak TK YM Nomporejo. Metode pengabdian yang digunakan yaitu survei dan observasi, penyuluhan, serta monitoring dan evaluasi. Hasil pengabdian yang telah dilakukan yaitu terjadi peningkatan pengetahuan perawatan kesehatan gigi dan mulut pada anak TK YM Nomporejo sebesar 54,5%. Hal tersebut menunjukkan bahwa penyuluhan yang dilakukan di TK YM Nomporejo Padukuhan Pandowan, Kalurahan Nomporejo, Kapanewon Galur, Kabupaten Kulon Progo dapat meningkatkan pengetahuan tentang perawatan kesehtan gigi dan mulut pada anak-anak.
Potency Of Andrographolide, L-Mimosine And Asiaticoside Compound As Antiviral For Covid-19 Based On In Silico Method Ningrum, Dhecella; Aini, Dita; Juniananda, Melisa; Febriansah, Rifki
Proceedings of Universitas Muhammadiyah Yogyakarta Graduate Conference Vol. 2 No. 2 (2023): Strengthening Youth Potential for Sustainable Innovation
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/umygrace.v2i2.418

Abstract

Introduction - COVID-19 is an infectious disease that is a global challenge, making it necessary for innovation and the development of antiviral agents in prevention and treatment efforts. Indonesia is known as a country rich in potential plants as medicine, a potential antiviral plant among them Andrographis paniculata , Mimosa pudica and Centella asiatica. The compound that have antiviral activity in each of these plants are andrographolide (Andrographis paniculata), L-mimosine (Mimosa pudica) and asiaticoside (Centella asiatica). The purpose of this study is to identify the potential of the andrographolide, l-mimosine and asiaticoside to inhibit SARS COV-2 protein and to predict the molecular drug profile which refers to lipinski's rule of 5. Purpose - The purpose of this study was to determine the potential of Andrographis paniculata , Mimosa pudica and Centella asiatica compounds in inhibiting the SARS CoV-2 protein and to determine the prediction of drug profiles such as molecules referring to Lipinski's rule of 5. Methodology - The methods used in this research by molecular docking and lipinski's Ro5 using PKCSM. The control compounds used are favipiravir and remdesivir. Results - The results of the affinity of target protein bonds using molecular docking obtained the best results in NSP3 proteins with An Asiaticoside docking score of -10.1 kcal / mol stronger than favipiravir -5.3 kcal/mol and remdesivir -8.6 kcal/mol. As for the compounds L-mimosine -6.1 kcal / mol and Andrographolide -7.7 kcal / mol. The compounds of andrographolide and L-mimosine showed good results and met the 5 aspects of Lipinski's Ro5, but asiaticoside compounds did not good enough. . Conclusion - The Research has concluded that the compound of the Andrographis paniculata , Mimosa pudica and Centella asiatica have a good potential in inhibiting SARS cov2 protein that is stronger than favipiravir and almost the same with remdesivir activity.
Investigation of Moringa Leaf Compounds as Colon Anticancer Agents Using Bioinformatics and Molecular Docking Methods Saputri, Dwi; Kusumaningtyas, Triana; Setiadi, Prismo; Febriansah, Rifki
Proceedings of Universitas Muhammadiyah Yogyakarta Graduate Conference Vol. 2 No. 2 (2023): Strengthening Youth Potential for Sustainable Innovation
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/umygrace.v2i2.421

Abstract

Introduction - Colon cancer is a disease that has a high mortality rate. Cancer treatments such as chemotherapy can cause severe side effects. So, it is necessary to do research on herbal plants to minimize these side effects. The bioactive compounds in Moringa leaves (Moringa oleifera L.) are known to have antioxidant and anticancer activity, so they have the potential to be used as cancer treatment. Purpose – . This study aims to determine the potential of Moringa leaves as an anticancer agent in silico. Methodology/Approach – The in silico test used is STITCH-STRING bioinformatics and molecular docking. STITCH-STRING bioinformatics was used to determine the target protein of the test compound, and molecular docking was used to determine the binding affinity between the test compound and cancer protein. Findings – In the STITCH-STRING bioinformatics test, the potential targets for kaempferol and quercetin were TP53-ESR1 and STAT3-EGFR, respectively.test Molecular docking on cancer protein showed that quercetin compound in EGFR protein had the best binding with a docking score of -9.2 kcal/mol. This shows good results because the docking score obtained is lower than the comparison drug (Fluorouracil) which has a docking score of -4.2 kcal/mol. These results indicate that compounds in Moringa leaves (Moringa oleifera L.) have the potential to be used as anticancer agents. Originality/ Value/ Implication – Moringa leaf research using bioinformatics and molecular docking methods is still rarely done, so this research can be used as further knowledge related to the search for moringa leaf compounds that have the potential for anticancer using bioinformatics and molecular docking methods
Screening the Activity of Epigallocatechin Gallate as a Colorectal Anticancer Agent: In Silico and ADMET/Pharmacokinetic Studies Setiadi, Prismo Bagas; Alamsyah, Maura Shavira; Ningsih, Tria; Fajriyah, Qatrunada; Febriansah, Rifki
Proceedings of Universitas Muhammadiyah Yogyakarta Graduate Conference Vol. 3 No. 2 (2024): Crafting Innovation for Global Benefit
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/umygrace.v3i2.602

Abstract

Introduction - Colorectal cancer is one of the third ranked cancers in Indonesia and has a high level of malignancy. The bioactive compound Epigallocatechin Gallate (EGCG) is known to have antioxidant and cytotoxic activity, so it has the potential to be developed as an anticancer agent. Purpose - This study aims to determine the potential of EGCG compounds as anticancer in silico. Methodology/Approach - The in-silico tests used are molecular docking and ADMET/Pharmacokinetic profiles using biosig pkcsm.Finding - The results of the respective binding affinities formed from EGCG compounds with the target protein affinities of COX-2 and Caspace-3 are -9.2 and -5.4 which are better links between EGCG and Caspace. The Lipinski rule show that the epigallocatecin compound has strength to absorb is 47%. This indicates that EGCG has the potential as a candidate for colorectal anticancer drugs with poor absorption. Originality/Value/Implications – In Silico, many studies have been carried out, but it is still rare to combine molecular docking methods with pKCSM to determine the solubility properties of compounds. The prospect of this research can become a basic or key for developing ECGC compounds into preparations because they have low bioavailability and can be continued in in vitro and in vivo research.
Exploration of date palm (Phoenix dactylifera) bioactivity as anti-SARS-CoV-2: in silico study Arifin, Nuha Haifa; Febriansah, Rifki
Pharmacy Reports Vol. 2 No. 3 (2022): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.50

Abstract

The COVID-19 pandemic has highlighted the need for innovation and the development of antiviral agents. One plant with potential antiviral properties is the date palm (Phoenix dactylifera). However, research on the antiviral activity of dates against SARS-CoV-2 is limited. This study aims to assess the antiviral potential of compounds found in date palm fruit using a molecular docking method. Specifically, we compare these compounds to the antiviral drugs ritonavir and nirmatrelvir in their ability to inhibit SARS-CoV-2 proteins. The molecular docking analysis was conducted using various tools and software, including Autodock Vina, DS Visualizer, Autodock Tools, Python, and Marvin Sketch. The results of the study indicate that compounds such as apigenin, diosmetin, and luteolin have strong potential as antiviral agents. The binding affinity of apigenin in date fruit with various SARS-CoV-2 proteins is as follows: -7.6 kcal/mol for 3CL-Pro, -8.7 kcal/mol for Nsp3, -5.7 kcal/mol for PD-ACE-2, and -7.0 kcal/mol for RBD-S. Diosmetin exhibits similar binding affinities with these proteins: -6.7 kcal/mol, -8.5 kcal/mol, -5.6 kcal/mol, and -7.2 kcal/mol, respectively. Luteolin also shows strong binding affinities: -7.9 kcal/mol, -8.6 kcal/mol, -5.7 kcal/mol, and -7.3 kcal/mol. In comparison, nirmatrelvir achieved docking scores of -7.2 kcal/mol, -7.5 kcal/mol, -5.1 kcal/mol, and -6.3 kcal/mol with the same proteins, while ritonavir scored -7.0 kcal/mol, -8.2 kcal/mol, -5.6 kcal/mol, and -6.7 kcal/mol, respectively. Apigenin, diosmetin, and luteolin demonstrate stronger potential than nirmatrelvir and ritonavir, as evidenced by their lower docking scores when compared to these drugs.
Co-Authors Adi Hermawansyah Aditya Fitriasari Aini, Dita Aji Winanta Aji Winanta Aji Winanta Alamsyah, Maura Shavira Aldi Ihza Mahendra Amaliyah, Alfiah Anggi Sabaya Anggraini, Chaessy Yori Arifin, Nuha Haifa Arsito, Puguh Novi Asti Widuri, Asti Cika Fathunissa Desmayanti, Astri Desy Bintang, Desy Devanola Pitaloka Aninda Matsna Aziza Devi Rahmawati, Devi Dita Prabaningrum, Dita Dita Sozianty Dwi Susilo Hardika, Dwi Susilo Dyaningtyas Dewi P. Putri Dzilqi Bustanul Hadi, Dzilqi Bustanul Ega Hida Prabowo Endah Puspitasari Fajriyah, Qatrunada Fatma Sari Masitha Hanik, Linta Sabila Hardi Astuti Witasari Hari Widada Hari Widada, Hari Hidayaturahmah, Rizky Ikfini, Hayu Iwan Dewanto, Iwan Johan Agung Dermawan Julita, Irna Juniananda, Melisa Kenyori, Ivana Kinanti Kintoko Kintoko Krisridwany, Annisa Kusnindyasita, Anisa Kusumaningtyas, Triana Arum Masitha, Fatma Sari Muhammad Arif Rizqi Muhammad Salman Fareza Muhtadi Muhtadi Mulyanti, Amelia Nur'afni Mustafid Amna Nazariah Putri Ningrum, Dhecella Ningrum, Dhecella Winy Cintya Ningsih, Tria Nisriina Yusan Nindy Azzahra Novitasari, Putri Rachma Noviyanti, Vidia Nuha Haifa ARIFIN Nuha Haifa Arifin Nur Ismiyati Nur Oktafiyani, Nur Octavia, Melany Ayu Ramdhani Saifulloh Ranti, Imaniar Rawi Ingra Savitri Sabtanti Harimurti, Sabtanti Saputri, Dwi Saputri, Ginanjar Zukhruf Sarmoko Sarmoko Setiadi, Prismo Setiadi, Prismo Bagas Setiyawati, Fitri Indah Siska Febdian Nitami Siti Nahdiyatul Ummah Sri Tasminatun Totok Suwanda Triana Kusumaningtyas, Triana Utami, Febri Widyaningrum, Rachmawati Yulianto Yulianto