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All Journal JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Medical Journal of Indonesia Jurnal Keolahragaan Journal of Biomedicine and Translational Research The Indonesian Biomedical Journal Paediatrica Indonesiana JOURNAL SPORT AREA Media Medika Muda Journal of Dedicators Community Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Cendana Medical Journal

Nyoman Suci Widyastiti

Department Of Clinical Pathology, Faculty Of Medicine, Diponegoro University, Semarang

Author-ID : 2668173

Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

Published : 29 Documents Claim Missing Document

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Melatonin menurunkan berat badan tetapi tidak menurunkan kadar TNF-Î± pada tikus wistar jantan yang diberi minyak jelantah selama 28 hari Novianti, Anugrah; Dharmana, Edi; Widyastiti, Nyoman Suci
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 5, No 2 (2017)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Backgound: Non Alcoholic Fatty Liver Disease (NAFLD) occurs when the intake and free fatty acid synthesis occurs more frequently than its oxidation and resecretion in the blood. Melatonin is a powerful antioxidant that can boost the synthesis of endogenous antioxidants in the body, suppress the inflammatory response and inhibit the formation of steatosis.Objective: To analyze the effect of melatonin supplementation in reducing body weight andTNF-Î± levels in male Wistar rats were fed by waste cooking oil.Methods: True experimental studyusing post-test only control group design. This study was done on 18 male wistar rats were divided into 3 groups : the positive control group (P0) was administrated waste cooking oil, the treated group 1 (P1) was administrated waste cooking oil and 5mg/kgBW melatonin, and the treated group 2 (P2) was administrated waste cooking oil and 10mg/kgBW melatonin for 28 days.Data analysis using One Way ANOVA test and followed by Tukey test to determine the most effective dose of melatonin.Results: There was significant difference in body weightbetween P2group and K0 group (p=0,019) with the mean body weight difference was 19,167g lower than K0 group. There was no difference in TNF-Î± levels between the three groups (p=0,155). Conclusion: Melatonin dose of 10mg/kgBWloses body weight male Wistar rats have given by waste cooking oil for 28 days, but does not reduce TNF-Î± levels.

Pengaruh suplementasi vitamin e (Î±-tokoferol) terhadap kadar gamma glutamil transferase (ggt) dan kadar nitric oxide (no) pada tikus (Studi pada tikus rattus novergicus strain wistar jantan terpapar inhalasi uap benzene) Roziana, Roziana; Subagio, Hertanto Wahyu; Suhartono, Suhartono; Widyastiti, Nyoman Suci
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 3, No 2 (2015)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Latar Belakang : Paparan benzene dapat menyebabkan stres oksidatif, diantaranya ditandai dengan peningkatan kadar GGT dan kadar NO. Vitamin E dapat mengurangi dan mencegah produksi radikal bebas. Reaktivitas hidrogen fenolik pada kelompok hidroksil Î±-tokoferol akan menstabilkan elektron tidak berpasangan pada radikal bebas.Tujuan : Membuktikan pengaruh suplementasi vitamin E terhadap kadar GGT dan kadar NO pada tikus jantan terpapar uap benzene.Metode : Penelitian ini adalah penelitian eksperimen pada binatang coba dengan rancangan post test only controlled group design. Sampel 35 ekor tikus strain wistar jantan dibagi secara random dalam enam kelompok yaitu kontrol negatif, kontrol positif dan empat kelompok perlakuan suplementasi vitamin E dosis bertingkat (X1 = 1,8 IU;Â X2 = 3,6 IU; X3 = 7,2 IU; dan X4 = 14,4 IU per hari untuk setiap 200 gram berat badan tikus). Setiap kelompok kecuali kontrol negatif dipapar 300 ppm uap benzene selama 2 minggu (6 hari/minggu, 6 jam/hari). Pengukuran kadar GGT menggunakan metoda Kinetik Colorimetric dan kadar NO menggunakan metoda Colorimetric Gries dilakukan pada setiap kelompok. Hasil : Suplementasi vitamin E berpengaruh menurunkanÂ kadar GGT (p=0,0001). Pengaruh paparan benzene terhadap peningkatan kadar GGT dapat dicegah dengan baik pada dosis suplementasi vitamin E 14,4 IU/200gr BB tikus/hari. Suplementasi vitamin E tidak berpengaruh terhadap kadar NO.Simpulan : Ada pengaruh suplementasi vitamin E terhadap penurunan kadar GGT danÂ tidak ada pengaruh suplementasi vitamin E terhadap penurunan kadar NO.

Pengaruh pemberian minuman lidah buaya terhadap kadar antioksidan total dan persentase lemak tubuh pada sindrom metabolik Silitonga, Marisi Elizabeth R.; Nugroho HS, K. Heri; Tjahjono, Kusmiyati; Widyastiti, Nyoman Suci; Afifah, Diana Nur
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 7, No 1 (2018)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background: Metabolic syndrome is related to glucose metabolism disturbance (hyperglycemia), lipid (dyslipidemia), high blood pressure, and central obesity. Metabolic syndrome implicates to heart attack, diabetes mellitus, hypertension, and death. Aloe vera, well known rich of polyphenol and vitamin, has a pharmacological effect to improve insulin resistance, chronic inflammation, and oxidative stress.Objective: To prove the effect of Aloe vera-based drink toward total antioxidant concentration improvement and body fat percentage reduction in metabolic syndrome subjects.Methods: Thus study was pre-post randomized true experimental study with control group design. The subjects were divided by 2 groups, treatment group (n=19) and control group (n=19). Treatment group was given 165 g/d Aloe vera-based drink for 30 days. Both of groups were given nutrition education about metabolic syndrome management. Total antioxidant concentration and body fat percentage were assessed pre-post-test by ABTS and BIA respectively, while food intake and activity were assessed by 24-h recall and GPAQ respectively. Independent t-test and Mann Whitney test were used to compare before and after treatment between control and treatment group.Results: Total antioxidant concentration significantly improved (p=0.00) in treatment group from 1.2 to 2.0 mmol/L, while total antioxidant concentration decreased from 1.4 to 1.3 mmol/L (p=0.074) in this control group. Moreover, there was significant difference of total antioxidant between treatment and control groups in the end of study (p=0.00). Furthermore, body fat percentage was reduced significantly from 32.8 to 32,4 mmol/L (p=0.005) in treatment group, while the reduction of body fat percentage in control group was not significant from 33.1 to 33,4 mmol/L (p=0.100). There was no difference of body fat percentage between two groups after intervention (p=0.358).Conclusion: Aloe vera-based drink improved total antioxidant concentration in metabolic syndrome subjects.

Pengaruh suplementasi Î²-carotene terhadap kadar glukosa darah dan kadar malondialdehida pada tikus sprague dawley yang diinduksi Streptozotocin Soviana, Elida; Rachmawati, Banundari; Widyastiti, Nyoman Suci
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 2, No 2 (2014)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background : Hyperglycemia on diabetes mellitus can cause increasing of free radicals production. Free radicals caused lipid peroxidation reaction by forming malondialdehyde (MDA). Î²-carotene has antioxidant activity may inhibit the formation of ROS.Objective : To prove the effect of multilevel doses Î²-carotene 1 mg/kg BW, 20 mg/kg BW and 20 mg/kg BW on alternate days within 30 days orally supplementation on blood glucose level and MDA level on Sprague Dawley male rats induced by streptozotocin (STZ). Methods : Thirty rats were randomly divided into 5 groups: X1=Negative control/diabetic, X2 (STZ 40 mg/kg BW + BC 1 mg/kg BW), X3 (STZ 40 mg/kg BW + BC 10mg/kg BW), X4 (STZ 40 mg/kg BW + BC 20 mg/kg BW), X5 (technic control/non diabetic). Î²-Carotene supplementation was given by nasogastric tube on alternate days within thirty days. Blood glucose level was measured by GOD-PAP and MDA level by ELISA with TBARS methods. Data was analized using paired t-test, wilcoxon, one way anova and post hoc bonferroni. Results : there was a significant difference of blood glucose level (p = 0,0001) and MDA level (p = 0,0001) after suplementation Î²-carotene on alternate days within 30 days orally. Î²-carotene 10 mg/kg BW was the most effective and efficient dose to lowering blood glucose, while 20 mg/kg BW to lowering MDA level. Conclusion : The multilevel doses Î²-carotene (1 mg/kg BW, 10 mg/kg BW and 20 mg/kg BW) on alternate days within 30 days orally supplementation can decrease blood glucose and MDA level. Î²-carotene 10 mg/kg BW is the most effecetive and efficient to decrease blood glucose and Î²-carotene 20 mg/kg BW to decrease MDA level.

Efek suplementasi Î²-carotene terhadap kolesterol total, trigliserida dan malondialdehid pada tikus sprague dawley yang diabet Ermawati, Devi; Rachmawati, Banundari; Widyastiti, Nyoman Suci
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 2, No 2 (2014)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Background : diabetes mellitus (DM) is associated with increased total cholesterol and triglyceride, also well characterized by increased malondialdehyde production. Î²-carotene has antioxidant activity, glycemic and lipid control. Objective : to analyze the effect of Î²-carotene on total cholesterol, triglyceride and MDA on diabetic Rattus norvegicus sprague dawley. Methods : thirty rats were randomly divided into 5 groups : 1 (STZ), 2 (STZ+Î²-carotene 1 mg/kg BW), 3 (STZ+Î²-carotene 10 mg/kg BW), 4 (STZ+Î²-carotene 20 mg/kg BW), 5 (normal). Streptozotocin induced intraperitoneal 40 mg/kg BW. Î²-carotene was given by nasogastric tube on alternate days within thirty days. Blood glucose level was measured by GOD-PAP, total cholesterol by CHOD-PAP, triglyceride by GPO and MDA by ELISA with TBARS methods. Hypothesis test used one way anova then followed by post hoc bonferroni to analyze the efficient dose effect. Results : there was a significant difference of total cholesterol (p=0.002) after Î²-carotene 10 mg/kg BW supplementation on alternate days within 30 days orally. Î²-carotene 10 mg/kg BW was the most efficient dose to lowering total cholesterol. There were significant differences of triglyceride (p=0.0001) and MDA (p=0.0001) after Î²-carotene 1, mg/kg BW, 10 mg/kg BW and 20 mg/kg BW supplementation on alternate days within 30 days orally. Î²-carotene 10 mg/kg BW was the most efficient dose to lowering triglyceride, while 20 mg/kg BW to lowering MDA. Conclusion : Î²-carotene 10 mg/kg BW is the most efficient dose to lowering total cholesterol and triglyceride. Î²-carotene 20 mg/kg BW is the most efficient dose to lowering MDA.

Co-Authors Abd. Rasyid Syamsuri Adieba Warda Hayya Afriana, Rizky Dyas Agus Fitrianto Ainun Najib Amelia, Sesa Anies Anies Ardhea Jaludamascena Ariosta Ariosta Arulita Ika Fibriana Astika Widy Utomo, Astika Widy Azizah, Arfianty Nur Banundari Rachmawati Budhi Setianto Dea Amanda Caressa Devi Ermawati Diana Nur Afifah, Diana Nur Djuara P Lubis Dwi Retnoningrum Edi Dharmana Edi Dharmana Edward Kurnia Setiawan Edward Kurnia Setiawan Limijadi Ekowati, Liana Elida Soviana Elsa Naviati Erna Mirani Etika Ratna Noer Fathur Nur Kholis Galang Bela Nusa Hadian Hadian Hardhono Susanto Hardhono Susanto Henna Rya Abdurachmin Hertanto Wahyu Subagio I Made Miarta Yasa Ima Arum Lestarini Imam Budiwiyono Indranila Kustarini Samsuria K. Heri Nugroho HS, K. Heri Kurniawan, Muhammad Farhan Kusmiyati DK Kusmiyati Tjahjono Mabruratussania Maherdika Mahalul Azam Maria Mexitalia Martha Irene Kartasurya Meira Erawati Meita Hendrianingtyas Moedrik Tamam Moedrik Tamam Muji Rahayu Mulya Agustina Mulyono Mulyono Muniroh, Muflihatul Najma Khairani Harahap Naufal, Haidar Satya Novianti, Anugrah Nugroho, Trilaksana Partiwi, Rina Purwanto Adipireno Purwanto AP R. Lindeman Ratih Budinastiti Retnoningrum, Dwi Rina Pratiwi Roziana Roziana, Roziana Rr. Sri Ratna Rahayu Ruth Hanna Kristina Saputra, Taufik Setianingrum, Elisabeth Levina Sari Silitonga, Marisi Elizabeth R. Suhartono Suhartono, Suhartono Susanti Lestari Thijs Eijsvogels Tri Indah Winarni Udin Bahrudin Umi S Intansari Widyastuti, Trioni Yanuarita Tursinawati Yanuarius Alvin Pratama Budianto Yetty Movieta Nancy Yetty Movieta Nency Yetty Movieta Nency Yetty Movieta Nency, Yetty Movieta Yuliana Yuliana Zetta, Adelia Paradya

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