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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Klinik Indonesia JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Majalah Obat Tradisional Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan INDONESIAN JOURNAL OF PHARMACY JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Ilmiah Manuntung JFIOnline Jurnal Farmasi Jurnal Kefarmasian Indonesia
Achmad Fudholi
Fakultas Farmasi UGM
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : Jurnal Ilmiah Manuntung

 1 
FORMULASI TABLET EKSTRAK ANGKAK (RED YEAST RICE) DENGAN VARIASI CROSCARMELLOSE SODIUM SEBAGAI PENGHANCUR DAN LAKTOSA SEBAGAI PENGISI Resti, Adestria; Kusuma, Aris Perdana; Fudholi, Achmad
Jurnal Ilmiah Manuntung Vol 3 No 1 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (180.856 KB) | DOI: 10.51352/jim.v3i1.95

Abstract

Angkak or better known as Red yeast rice is fermentation rice using a mold Monascus purpureus. Some studies of red yeast rice can lower cholesterol levels in the body because it contains monoakolin K or similliar with lovastatin compound. Generally in community consumption of red yeast rice only with pour in the boilling water so it can causing inconvenience for its customers. This study aims to make a formulation tablet of red yeast rice extract which varied with the levels of croscarmellose sodium 5% -1% (32mg, 26mg, 19,5mg, 13mg, 6,5mg) and lactose (75,75mg, 82.25 mg, 88,75mg , 95,25mg, 101,75mg) in order to get a best physical properties of the tablet including friability and disintegration time. Angkak extract was made by remaseration method using ethanol 75% and the manufacture of tablets using wet granulation method. Stastical test tablet extract angkak using One Way ANOVA with 95% confidence level. Optimum formula obtained by using the Simplex Lattice Design (SLD) using Design Expert version 8.0.7.1 program and statistically tested using one-sample t-test. The results from test showed the proportion of croscarmellose sodium 6.5mg and 101.75mg lactose produces tablets with the best of physical properties of red yeast rice extract.The result is indicate that the combination of croscarmellose sodium and lactose may affect response the physical properties of red yeast rice extract tablets.
Co-Authors . Sismindari A. Kharis Nugroho, A. Kharis Abdul Rohman Agus Siswanto Akhmad Kharis Nugroho Amrullah, Hafizh Anitawati, Enggar Ardiningtyas, Bondan Aris Perdana Kusuma, Aris Perdana Basu Swastha Dharmmesta Carolien, Ivonie Daulay, Eliza Hanum Devi, Andika Purnama Dinaryanti, Pratiwi Drastiana, Friska Eka Deddy Irawan Erlianti, Karina Fithria Dyah Ayu Suryanegara, Fithria Dyah Ayu Gede Bayu Suparta Gozali, Mu’min Gunawan Pamudji Widodo Hari Kusnanto Hartati Hartati Herri S. Sastramihardja Heru Sasongko Ika Ratna Hidayati Iwan Dwiprahasto Kencanasari, Tiekha Lannie Hadisoewignyo Lolok, Nike Herpianti Marchaban Marchaban, Marchaban Meilanda, Rastria Muhammad Ridwan Ni Made Dharma Shantini Suena Ningsih, Andriyani Ningsih, Andryani Nining Sugihartini Nugroho, Edy Prasetyo Nurmainah Nurmainah Nurniswati Nurniswati Oviani, Gusti Ayu P., I Gusti Ngurah Agung Windra W. Parina, Ana Bella Purnamasari, Vina Puspandari, Dyah Ayu Puung, Florensia Kurnia R., Wirdah Wati Resti, Adestria Resti, Adestria Rizellia, Rizellia S, Hilda S., Hilda Sahlani, Suci Paramitasari Sampurno Sampurno Samsubar Saleh Saputri, Laras Tri Sarie, Lamlay Sarifudin, Barbara Azalya Satibi Satibi Sirait, Septilina Melati Sismindari . Siti Aisiyah Siti Aminah Sudibyo Martono Sumarni Sumarni Suwaldi . Suwendar Suwendar Suwidjiyo Pramono Swastiandari, Gabriela Larasati T.N. Saifullah Sulaiman, T.N. Saifullah Tri Murti Andayani Trisnawati, Komang Tuko, Eirene Copalcanty Wahyono Wahyono Wawang Anwarudin Zubaydah, Wa Ode Sitti