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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Klinik Indonesia JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Majalah Obat Tradisional Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan INDONESIAN JOURNAL OF PHARMACY JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Ilmiah Manuntung JFIOnline Jurnal Farmasi Jurnal Kefarmasian Indonesia
Achmad Fudholi
Fakultas Farmasi UGM
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : Jurnal Farmasi

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Optimasi Formula Tablet Floating Nifedipin Menggunakan HPMC K15M, PVP K-30 dan Avicel PH 102 dengan Metode Simplex Lattice Design Aisiyah, Siti; Fudholi, Achmad; Rohman, Abdul
Jurnal Farmasi (Journal of Pharmacy) Vol. 2 No. 1 (2013): Jurnal Farmasi (Journal of Pharmacy), October 2013
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Nifedipine is a drug with a small solubility in water, a consequence, in order to obtain the desired drug release, the solubility of nifedipine should be increased by the addition of PVPK-30.This study was aimed to know the effect of HPMC K15M, PVP K-30 on the release of nifedipin, and Avicel PH 102 on the floating lag time of nifedipine floating tablet, and to find out the proportion of each ingredient to produce the optimum formula of nifedipin floating tablet. The study was conducted using Simplex Lattice Design (SLD) with 3 components i.e. HPMC K15M, PVPK-30 andAvicel PH 102 in order to obtain 14 formulas. The optimization parameter consists of absorption tablet, floating lagtime, C360 and DE360. The four parameters were analyzed using Design Expert7.1.3 software to determine the optimum formula. The optimum formula was obtained by determining the desired target for each parameter. The absorption was selected in maximum target, floating lag time was selected in minimum target, C360 targeted at number 54 and DE360 targeted at number 40. HPMC K15M at the highest concentration affected the smallest release of nifedipin, the highest PVP K-30 concentration affected the most of nifedipin release, where as high concentration Avicel PH 102 had a small affected reduce in floating lag time of nifedipin floating tablet. The composition of the optimum formula is as follows: 80mg HPMC K15M, 97mg PVPK-30 and 45mg Avicel PH 102. The results of tablet absorption, C360 and DE360 did not differ significantly; floating lag time gave significantly different results to obtain from software. The release kinetics of all formulas fit order 1, which indicated that the drug release occurred through a diffusion mechanism.
Co-Authors . Sismindari A. Kharis Nugroho, A. Kharis Abdul Rohman Agus Siswanto Akhmad Kharis Nugroho Amrullah, Hafizh Anitawati, Enggar Ardiningtyas, Bondan Aris Perdana Kusuma, Aris Perdana Basu Swastha Dharmmesta Carolien, Ivonie Daulay, Eliza Hanum Devi, Andika Purnama Dinaryanti, Pratiwi Drastiana, Friska Eka Deddy Irawan Erlianti, Karina Fithria Dyah Ayu Suryanegara, Fithria Dyah Ayu Gede Bayu Suparta Gozali, Mu’min Gunawan Pamudji Widodo Hari Kusnanto Hartati Hartati Herri S. Sastramihardja Heru Sasongko Ika Ratna Hidayati Iwan Dwiprahasto Kencanasari, Tiekha Lannie Hadisoewignyo Lolok, Nike Herpianti Marchaban Marchaban, Marchaban Meilanda, Rastria Muhammad Ridwan Ni Made Dharma Shantini Suena Ningsih, Andriyani Ningsih, Andryani Nining Sugihartini Nugroho, Edy Prasetyo Nurmainah Nurmainah Nurniswati Nurniswati Oviani, Gusti Ayu P., I Gusti Ngurah Agung Windra W. Parina, Ana Bella Purnamasari, Vina Puspandari, Dyah Ayu Puung, Florensia Kurnia R., Wirdah Wati Resti, Adestria Resti, Adestria Rizellia, Rizellia S, Hilda S., Hilda Sahlani, Suci Paramitasari Sampurno Sampurno Samsubar Saleh Saputri, Laras Tri Sarie, Lamlay Sarifudin, Barbara Azalya Satibi Satibi Sirait, Septilina Melati Sismindari . Siti Aisiyah Siti Aminah Sudibyo Martono Sumarni Sumarni Suwaldi . Suwendar Suwendar Suwidjiyo Pramono Swastiandari, Gabriela Larasati T.N. Saifullah Sulaiman, T.N. Saifullah Tri Murti Andayani Trisnawati, Komang Tuko, Eirene Copalcanty Wahyono Wahyono Wawang Anwarudin Zubaydah, Wa Ode Sitti