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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Klinik Indonesia JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Majalah Obat Tradisional Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan INDONESIAN JOURNAL OF PHARMACY JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JFIOnline Jurnal Farmasi Jurnal Kefarmasian Indonesia
Achmad Fudholi
Fakultas Farmasi UGM
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Optimization of chitosan, sodium carboxy methyl celulose and magnesium stearat as mucoadhesive system in captopril tablet Irawan, Eka Deddy; Fudholi, Achmad
INDONESIAN JOURNAL OF PHARMACY Vol 20 No 4, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (375.204 KB) | DOI: 10.14499/indonesianjpharm0iss0pp231-238

Abstract

Captopril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and some types of congestive heart failure. It has been reported that the duration of antihypertensive action after a single oral dose of captopril is only 6–8 h. Captopril is most stable at acidic condition and as the pH increases, it becomes unstable and undergoes a degradation reaction. These indicates a promising potential of the captopril mucoadhesive system as an alternative to the conventional dosage form. The objective of the current study was to find an optimum formula of mucoadhesive tablet for captopril using factorial design. Tablets were evaluated for mucoadhesive strength and drug release profile. The studies were perfomed to establish composition of chitosan, sodium CMC and Mg stearat. Such composition could produce mucoadhesive strength with a zero order release kinetics. A 23 factorial design has been applied to systematically optimize the formula. The amounts of chitosan (XA), sodium CMC (XB), and Mg stearat (XC) were selected as independent variables. Mucoadhesive strength and dissolution efficiency (DE480) were selected as dependent variables. According the contour plot suggested that optimum formula will be reach mucoadhesive strength (26-30 g) and DE480 (≥70 %) chitosan at low to middle level (20-35 mg), sodium CMC at middle to high level (150-200 mg), and Mg stearat at low to middle level (4-6 mg).Key words : mucoadhesive, factorial design, DE480 , chitosan, CMC Na, Mg stearat, contour plot
Studi on the in vitro release of ibuprofen from xanthan gum matrix combined with a crosslinking agent Hadisoewignyo, Lannie; Fudholi, Achmad
Indonesian Journal of Pharmacy Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.107 KB) | DOI: 10.14499/indonesianjpharm0iss0pp133-140

Abstract

Ibuprofen is non-steroidal anti-inflammatory drugs that is often used so frequently in a day that is can cause the patient to forget to take it. Besides it may cause gastro intestinal disturbances, which increase with the frequent of use. Many studies have been undertaken to obtain ibuprofen controlled release systems. Based on this, this study is done to find out the in vitro release kinetic of ibuprofen from xanthan gum matrix combined with a crosslinking agent, that is locust bean gum or calcium sulphate.In this research there were six formulas sustained release ibuprofen tablet that was made by the same compression pressure. Formula I, II and III used matrix combination of xanthan gum and locust bean gum (1:½, 1:1, 1:1½), while formula IV, V and VI used matrix combination of xanthan gum and calcium sulphate (1:½, 1:1, 1:1½). Afterward, the physical and release characteristics of the tablet were examined.The results showed that the compactibility of matrix combination of xanthan gum and locust bean gum was different from the matrix combination of xanthan gum and calcium sulphate. Combination of xanthan gum and locust bean gum and also calcium sulphate as crosslinking agent can influence the physical properties and the release profile of tablet.Key words: ibuprofen, xanthan gum, locust bean gum, calcium sulphate, dissolution, sustained release tablet.
Optimization formula gastroretentive tablet of ranitidine HCl with floating system Sulaiman, T.N. Saifullah; Fudholi, Achmad; Nugroho, A. Kharis
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (387.929 KB) | DOI: 10.14499/indonesianjpharm0iss0pp106-114

Abstract

Ranitidine  HCl  is  an  H-2  receptor  antagonists  for  the  treatment  of  peptic gastric  secretion  with  a  small  bioavailability,  so  that  should  be  developed  in  a sustained  release  dosage  form  are  retained  in  the  stomach.  Ranitidine  HCl floating  tablet  was  formulation  by  effervescent  system.  Simplex  lattice  design was  applied  to  optimize  the  formula  of  ranitidine  HCl  floating  tablet  by varying levels of Methocel K15M 100-185 mg, sodium bicarbonate 15-100 mg, and  citric  acid0-85 mg.  The  Optimum  formula  determined  by  superimposed contour  plot  from  various  parameters:  flowability  of  granules,  physical properties of tablet and drug release using Design-Expert®program. Based on superimposed  contour  plot obtained  optimum  formula  for  the  area  in  the  range of Methocel K15M 100-145 mg, sodium bicarbonate 20-80 mg and citric acid 25-80 mg.Key words: Ranitidine HCl, Gastroretentive, Simplex lattice design 
Co-Authors . Sismindari A. Kharis Nugroho, A. Kharis Abdul Rohman Agus Siswanto Akhmad Kharis Nugroho Amrullah, Hafizh Anitawati, Enggar Ardiningtyas, Bondan Aris Perdana Kusuma, Aris Perdana Basu Swastha Dharmmesta Carolien, Ivonie Daulay, Eliza Hanum Devi, Andika Purnama Dinaryanti, Pratiwi Drastiana, Friska Eka Deddy Irawan Erlianti, Karina Fithria Dyah Ayu Suryanegara, Fithria Dyah Ayu Gede Bayu Suparta Gozali, Mu’min Gunawan Pamudji Widodo Hari Kusnanto Hartati Hartati Herri S. Sastramihardja Heru Sasongko Ika Ratna Hidayati Iwan Dwiprahasto Kencanasari, Tiekha Lannie Hadisoewignyo Lolok, Nike Herpianti Marchaban Marchaban, Marchaban Meilanda, Rastria Muhammad Ridwan Ni Made Dharma Shantini Suena Ningsih, Andriyani Ningsih, Andryani Nining Sugihartini Nugroho, Edy Prasetyo Nurmainah Nurmainah Nurniswati Nurniswati Oviani, Gusti Ayu P., I Gusti Ngurah Agung Windra W. Parina, Ana Bella Purnamasari, Vina Puspandari, Dyah Ayu Puung, Florensia Kurnia R., Wirdah Wati Resti, Adestria Resti, Adestria Rizellia, Rizellia S, Hilda S., Hilda Sahlani, Suci Paramitasari Sampurno Sampurno Samsubar Saleh Saputri, Laras Tri Sarie, Lamlay Sarifudin, Barbara Azalya Satibi Satibi Sirait, Septilina Melati Sismindari . Siti Aisiyah Siti Aminah Sudibyo Martono Sumarni Sumarni Suwaldi . Suwendar Suwendar Suwidjiyo Pramono Swastiandari, Gabriela Larasati T.N. Saifullah Sulaiman, T.N. Saifullah Tri Murti Andayani Trisnawati, Komang Tuko, Eirene Copalcanty Wahyono Wahyono Wawang Anwarudin Zubaydah, Wa Ode Sitti