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All Journal International Journal of Public Health Science (IJPHS) Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional IDJP (Indonesian Journal of Pharmaceutics) Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASI GALENIKA Majalah Farmasetika Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi Indonesian Journal of Biological Pharmacy Journal of Global Pharma Technology Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika ETHOS: Jurnal Penelitian dan Pengabdian kepada Masyarakat Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine

Nyi Mekar Saptarini

Fakultas Farmasi Universitas Padjadjaran

Author-ID : 2695794

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Formulasi Sampo Ekstrak Daun Teh Hijau (Camellia sinensis var. assamica) Lia Suryati; Nyi Mekar Saptarini
Indonesian Journal of Pharmaceutical Science and Technology Vol 3, No 2 (2016)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Sampo digunakan untuk menghilangkan partikel yang tidak diinginkan, seperti minyak dan ketombe. Salah satu tanaman yang dapat digunakan sebagai sampo adalah teh hijau (Camellia sinensis var. assamica). Penelitian ini bertujuan membuat sampo ekstrak daun teh hijau yang stabil dan aman. Tahapan penelitian meliputi ekstraksi, penapisan fitokimia, formulasi sampo, uji stabilitas fisik meliputi organoleptik, pH, bobot jenis, viskositas, dan uji iritasi. Sampo diformulasikan dengan konsentrasi 5, 10, dan 15% ekstrak daun teh hijau dengan dan tanpa PEG-400. Ekstraksi menghasilkan rendemen sebesar 35%. Penapisan fitokimia menunjukkan simplisia dan ekstrak mengandung alkaloid, flavonoid, dan tanin. Sampo ekstrak daun teh hijau berwarna coklat muda yang homogen dengan rentang pH 5,2-7,0, bobot jenis sebesar 0,93-1,10 g/mL, viskositas 1230-3910 cps, tetapi menyebabkan mata merah pada kelinci.

Formulasi Granul Effervescent Sari Kering Lidah Buaya sebagai Makanan Tambahan Muthmaina Wijayati; Nyi Mekar Saptarini; Irma Erika Herawati
Indonesian Journal of Pharmaceutical Science and Technology Vol 1, No 1 (2014)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Aloe vera has high nutrition content, but bitter taste so direct consumption infrequently. The bitter tastes overcome with preparation. The aim of this study is to make effervescent granule of dried aloe gel as food supplement. The steps in this study consist of making of dried aloe gel, phytochemistry screening and formulation of effervescent granule, quality tests, and hedonic test of effervescent granule. Freeze drying produced 7.57% dried aloe gel. Phytochemistry screening showed quinones, flavonoids, and saponins content. Effervescent granule formulated with concentration of dried gel 20% (F1), 25% (F2), and 30% (F3). The result of granule quality tests showed that effervescent granule meet good requirements with moisture content 0.20-0.21%, bulk density 0.5341-0.5384 g/mL, tapped density 0.6154-0.6178 g/mL with Carr index 13.29±0.025%, flow rate 9.61-9.71 g/s, rest angel 27.15-27.79o, pH 5.82-5.8, and F1 as the most favorable formula. Keywords: Aloe vera, dried gel, effervescent granule, food supplement

ANALISIS RASIO PROTEKSI ANTIULSER SARI BUAH PEPINO (Solanum muricatum Aiton) MENGGUNAKAN MENCIT SEBAGAI MODEL HEWAN COBA Nyi Mekar Saptarini; Dadan Suryasaputra; Atep Misbah Saepulhak
Majalah Obat Tradisional Vol 16, No 2 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Peptic ulcer were been caused by an imbalance between the aggressive factors and a number of defense mechanisms. Pepino (Solanum muricatum Aiton) fruit predicted had antiulcer activity. This study is aimed to test the antiulcer activity of pepino fruit juice in Swiss-Webster mice model which induced by 50 µL concentrated acetic acid. The steps in this study consist of making of fruit juice, phytochemical screening, testing of antiulcer activity at 300, 500, dan 800 µL/20 g BW in doses, and data analyzed using ANOVA. The concentration of pepino fruit juice was 2.5 g/mL. Phytochemical screening showed that pepino fruit juice contain alkaloids, flavonoids, and tannins with protection ratio were 6.02, 23.15, and 63.29% at 300, 500, dan 800 µL/20 g BW, respectively.

Pharmaceutical Industrial Waste Regulation in Five Countries in Asia Luthfia Azzahra; Nyi Mekar Saptarini
Indonesian Journal of Pharmaceutics Vol 3, Issue 1, Jan - April 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i1.33383

The pharmaceutical industry produces a various toxic wastes. Generated waste increases the risk of environmental and ecosystem pollution. It is necessary to have proper waste management to prevent waste pollution to the environment. In 1999, WHO published “Guidelines for the Safe Disposal of Unwanted Pharmaceuticals in and after Emergencies”, that contain treatments and safe disposal method, which is appropriate for any country. Many countries had developed and published regulations and guidelines on waste management. This article aimed to review the handling of pharmaceutical industrial waste in five countries in Asia. This review included studies from ProQuest, Crossref, and Google Scholar. The pharmaceutical industries in Indonesia, India, Japan, Thailand, and China has their own state regulations in order to protect the environment. They also had implemented pharmaceutical industrial waste management following their regulation and guidelines. The method used to treat the waste is similar with WHO guideline. Some factors affecting the country regulations are the insufficient of land and waste management facilities, lack of awareness, low penalties, limited infrastructures, lack of waste testing facilities. The challenge in the future to handle pharmaceutical waste are increasing waste volume, decreasing land for waste management, sewer methods may contaminate water, possible air pollution due to incineration, so it is necessary to have more advanced methods in waste management that are safe for the environment and humans.Keywordz: Industry, Pharmaceutical, Waste Regulation, Asia

ANALISIS KADAR TOTAL FITOSTEROL PADA EKSTRAK DAUN SELADA (Lactuca sativa L.)DENGAN METODE KOLORIMETRI Irma Erika Herawati; Nyi Mekar Saptarini
Jurnal Sabdariffarma Vol 9, No 1 (2021): SABDARIFFARMA
Publisher : Prodi Farmasi - Universitas Al Ghifari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53675/jsfar.v2i1.25

Daun selada (Lactuca sativa L.) mengandung fitosterol, yang secara empirik bisa digunakan sebagai anti kolesterol. Fitosterol dapat digunakan dalam mengurangi absorpsi kolesterol di dalam saluran pencernaan, hal ini karena fitosterol memiliki struktur yang mirip dengan kolesterol. Penelitian ini bertujuan untuk mengetahui kadar total fitosterol pada daun selada. Ekstraksi yang dilakukan adalah metode maserasi dengan menggunakan pelarut n-heksan:etanol. Penentuan kadar total kolesterol menggunakan metode kolorimetri, yaitu pembentukan warna hijau dari senyawa sterol dengan pereaksi Liebermann-Burchard. Dari hasil penelitian didapatkan bahwa kadar fitosterol total daun selada sebesar 17,42 mg±0,7841/100g simplisia kering.

Identifikasi Rhodamin B pada Produk Pangan dan Kosmetik yang Beredar di Bandung ALIYA NUR HASANAH; IDA MUSFIROH; NYI MEKAR SAPTARINI; DRIYANTI RAHAYU
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (455.97 KB)

Rhodamine B is a colouring agent for paint industry, textile and paper. It causes irritation at respiration systems and has a carcinogenic effect. At high concentration rhodamine B causes liver damages. Nowadays, it has been reported being added into cosmetics and food product such as lipstick, eye shadow, rouge, food paste, and kerupuk. This research was conducted to determine rhodamine B in the products by using HPLC and spectrophotometry UV-Vis. It was done through sample collection, sample preparation, validation of analytical method, and analysis of rhodamine B using HPLC and spectrophotometry UV-Vis. The results of HPLC and spectrophotometry UV-Vis showed that four samples of kerupuk (57,14%) and four samples of food paste (50%) contained rhodamine B. However, rhodamine B was not found in cosmetics. The results showed the urgency of fast methods to identify rhodamine, thus its content in food products is carefully controlled.

ANALISIS KADAR FLAVONOID TOTAL PADA RIMPANG, BATANG, DAN DAUN BANGLE (Zingiber purpureum Roscoe) Irma Erika Herawati; Nyi Mekar Saptarini; Nurussofiatur Rohmah Urip
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

ABSTRAK Telah dilakukan penelitian analisis kadar flavonoid total pada rimpang, batang, dan daun Bangle (Zingiber purpureum Roscoe) dengan menggunakan pelarut etanol 96% serta etanol 96% : HCl 12N dengan perbandingan (98 : 2) ; (96 : 4) dan (94 : 6). Metode yang digunakan berdasarkan pembentukan senyawa kompleks flavonoid - AlCl3. Hasil penelitian menunjukkan bahwa ketiga bagian tanaman bangle (rimpang, batang, dan daun) mengandung flavonoid. Pelarut etanol 96% menghasilkan kadar flavonoid pada rimpang sebesar 0,00657% ; batang sebesar 0,00662% dan daun sebesar 0,00613%. Pelarut etanol 96% : HCl 12 N (98 : 2) menghasilkan kadar flavonoid pada rimpang, batang dan daun sebesar (0,00632% ; 0,00662% ; dan 0,00575%). Pelarut etanol 96% : HCl 12 N (96 : 4) menghasilkan kadar flavonoid pada rimpang, batang dan daun sebesar (0,00662% ; 0,00667% ; dan 0,00566%) sedangkan pelarut etanol 96% : HCl 12 N (94 : 6) menghasilkan kadar flavonoid total pada rimpang, batang dan daun sebesar (0,00683% ; 0,00665% ; dan 0,00628%). Hasil penelitian menunjukkan kadar flavonoid paling tinggi terdapat pada bagian batang. Kata kunci : Bangle (Zingiber purpureum Roscoe), flavonoid total, spektroskopi UV-Vis

Application of the Mamdani Fuzzy Logic Multi Output Method to Maintain Electrical Conductivity in Hydroponic Media for Lettuce (Lactuca sativa L.) and Bok Choy (Brassica rapa L.) Nyi Mekar Saptarini; Mohamad Nurkamal Fauzan
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Nutrition in hydroponic cultivation affects the electrical conductivity (EC) that must be controlled to fulfill the plant’s requirement. The aim of this study was to determine the application of the Mamdani fuzzy logic with multi output to maintain the EC value, mixed volume in the tank and real time monitoring the current condition of the system. Case studies on lettuce (Lactuca sativa L.) and bok choy (Brassica rapa L.). The controlled system was NodeMCU and Arduino nano with analog pH, EC meter as input and pumps as an actuator. The results show that this application maintains an average EC value of 1.96 mS/cm and an average mixed volume of 53.4%. Plant conditions were sent to Android device in real time monitoring. The comparison data of manual and automatic (Mamdani fuzzy logic) monitoring were similar. Keywords: Lactuca sativa L., Brassica rapa L., Mamdani, multi output, real time monitoring

KADAR FENOLIK TOTAL EKSTRAK TEMUKUNCI (Boesenbergia rotunda L) ASAL LEMBANG JAWA BARAT DENGAN METODE FOLIN-CIOCALTEU: TOTAL PHENOLIC CONTENT OF TEMUKUNCI (Boesenbergia rotunda L) EXTRACT ORIGIN IN WEST JAVA USING FOLIN-CIOCALTEU METHOD Dani Sujana; Nyi Mekar Saptarini; Sri Adi Sumiwi; Jutti Levita
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 3 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i3.436

Metabolit sekunder yang paling melimpah dan berperan penting dalam pertumbuhan, pigmentasi dan reproduksi pada tumbuhan yaitu senyawa fenolik. Senyawa ini telah menjadi fokus utama dalam beberapa penelitian karena efek biologis yang menguntungkan. Lokasi tumbuh tanaman merupakan salah satu yang dapat mempengaruhi kandungan senyawa aktif pada tumbuhan. Lembang, Bandung, Jawa Barat berada di daratan tinggi, memiliki suhu rendah, kondisi tanah yang subur dan sehingga cocok untuk budidaya tanaman herbal, termasuk temukunci. Polifenol dalam ekstrak tumbuhan bereaksi dengan pereaksi redoks spesifik, dalam hal ini yaitu pereaksi F-C dapat membentuk kompleks biru yang dapat diukur dengan spektrofotometri. Dalam penelitian ini dilaporkan bahwa kandungan fenolik total EEBR adalah 18.32± 0.615 atau setara dengan 183,83 mgGAE/100 g.

Perubahan Disintegran Pada Formula Tablet untuk Efisiensi Biaya Produksi KURNIASARI, NADYA GALUH; Saptarini, Nyi Mekar; Destiani, Dika Pramita
Farmaka Vol 19, No 4 (2021): Farmaka (Suplemen)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v19i4.32278

Formula alternatif diperlukan dalam proses pengembangan formula, formula ini dibuat untuk menurunkan biaya produksi tanpa menurunkan kualitas produk. Pada formula tablet yang akan dikembangkan dilakukan penggantian eksipien yaitu disintegran karena konsentrasi disintegran yang digunakan lebih tinggi jika dibandingkan eksipien lainnya dan memiliki harga yang cukup mahal. Disintegran pada formula sebelumnya adalah croscarmellose sodium dengan 5% yang merupakan jenis superdisintegran. Dalam mengganti disintegran diperlukan studi literatur untuk membandingkan kemampuan disintegran tersebut, selain itu juga harus mempertimbangkan harga dari bahan baku. Hasil studi literatur dan perbandingan harga, menunjukkan bahwa sodium starch glikolat dengan konsentrasi 4% merupakan disintegran yang paling tepat untuk menggantikan croscarmellose sodium.Kata kunci: Formula alternatif, disintegran, efisiensi biaya.

Co-Authors Adrian Suparman Aliya Nur Hasanah Anisa Desy Ariyanti ANNISA CLAUDIA MUSEFI CHAIRANI Arni Praditasari Atep Misbah Saepulhak Atep Misbah Saepulhak, Atep Misbah Bactiar, Bagus Muhti CHRISTINE CITRA DEWI Dadan Suryasaputra Dadan Suryasaputra, Dadan Dani Sujana Danni Ramdhani DETI DEWANTISARI Dewi Sarah, Dewi DHITA DWI PRICILIA Diah Lia Aulifa Dika Pramita Destiani, Dika Pramita DINA SOFA ISTIFADA Driyanti Rahayu Febrina Amelia Saputri Hanifa Olgha Rizka Hazna Putri Salsabilla Henry Ng Henry Ida Musfiroh -, Ida Musfiroh Ikhsan Rambia Irma Erika Herawati Irma Erika Herawati Irma Erika Herawati Irma Erika Herawati Irma Erika Herawati Irma Erika Herawati Jutti Levita Karen Low Ka Ling KURNIASARI, NADYA GALUH Laura Natalia Lia Suryati Lia Suryati, Lia Luthfia Azzahra Made Ayu Wardina Maisyarah, Intan Timur Marline Abdassah Bratadiredja Mohamad Nurkamal Fauzan Muthmaina Wijayati Muthmaina Wijayati, Muthmaina Natalia, Laura Nugraha, Aristo Fajar Nurdin, Halwa Aulia Nurfalah, Ani Nurussofiatur Rohmah Urip Priskila Margaretha PUTRI, ARRAUDHA ADINDA Rambia, Ikhsan Resmi Mustarichie Rimadani Pratiwi Rini Hendriani Shelvy Elizabeth Suherman Sri Adi Sumiwi Sri Agung Fitri Kusuma, Sri Agung STEFANNY AGNES SALIM Sukmara, Sendi Vicania Raisa Rahman Yedi Herdiana, Yedi

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