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Dewi, Fitriya Nur Annisa
Biomedical Laboratory, Center For Primate Animal Studies, Institute For Research And Community Service, IPB University, Bogor, Indonesia
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Journal : Gunung Djati Conference Series

 1 
MONYET EKOR PANJANG (Macaca fascicularis) SEBAGAI HEWAN MODEL DAN ETIKA PENGGUNAANNYA Ratni Ernita; Tatang Mitra Setia; Fitriya Nur Annisa Dewi; Huda Shalahudin Darusman
Gunung Djati Conference Series Vol. 6 (2021): Seminar Nasional Biologi (SEMABIO) 6 Tahun 2021
Publisher : UIN Sunan Gunung Djati Bandung

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Abstract

The use of nonhuman primates as animal models in biomedical research has an important role in the development of human health. A close phylogenetic relationship with humans as well as similarities in genetics, behavior and biochemical activities are some of the things that underlie the selection of nonhuman primates as animal models. Cynomolgus macaques (Macaca fascicularis) is one of Indonesia's endemic primates which is widely used in research. Its current status as Appendix II in Convention International Trade in Endangered Species of Wild Fauna and Flora (CITES) defines that the population remains quite large in nature, which allows this species to be used in research, as long as they are sourced from the captive-bred population. Although the use of nonhuman primates in research is unavoidable, it is warranted that potential harm such as distress, discomfort, stress, pain and even death have to be avoided or minimized. Implementation of ethics is therefore required for the care and use of cynomolgus macaques in research, such as by assuring that the 3R principles (replacement, reduction, refinement) are met. Refinement can be achieved by applying the principles of animal welfare known as the Five Freedoms of Animal Welfare (5F). The active implementation of these ethical principles continues to develop along with the development of science and technology, and receives more spotlight in the world of biomedical research globally. Ensuring adequate implementation of ethical principles in research with nonhuman primates in each research institution must be under the oversight of an IACUC (Institutional Animal Care and Use Committee), which will weigh on the harm to animals compared to the benefits to humans. Active implementation of the principles of ethics and animal welfare will result in increasing the quality of research, serves as an assurance to the society, and in compliance to the requirements for good scientific publication.
Co-Authors . Permanawati Agus Wijaya Anita Esfandiari Dedi Fardiaz Deni Noviana Deny Setyo Wibowo Diah Iskandriati Diah Iskandriati Diah Iskandriati Diah Iskandriati DIAH ISKANDRIATI Diah Iskandriati Diny Agustini Sandrasari Dondin Sajuthi Dwi Ramadhani Effendi, Siti Aisyah Rahmalia Eric Hayes Eric Hayes ESTHER ARIFIN Farida Laila Firman Alamsyah Fitria Senja Murtiningrum FITRY TAFZI Gregory K. Wilkerson Harrold Halilintar MR Subu Taopan Hendra Wijaya Hidekazu Shigematsu Hidekazu SHIGEMATSU Huda S Darusman Huda Shalahudin Darusman I Nengah Budiarsa I Nengah Budiarsa Iin Indriawati Iin Kurnia Hasan Basri Irma H Suparto Irma Herawati Suparto Izzatun Niswah Ajrina J. Mark Cline Joko Pamungkas Kartika Sari Kartjito, Nicolas Edward Christanto Lilis Nuraida MOSES AFFANDI Nancy Dewi Yuliana Nishigaki, Toshiaki Nuri Andarwulan NURI ANDARWULAN2 Pamungkas, Joko Permanawati Permanawati Permanawati Permanawati PUSPO EDI GIRIWONOB R.P Agus Lelana Ratni Ernita Retno Wulansari Safrida Safrida Sela S Mariya Sela S. Mariya Sela Septima Mariya Setyo Widodo Shigematsu, Hidekazu Silmi Mariya Silmi Mariya Silmi Mariya Silmi Mariya Silvia Arin Prabandari Slamet Budijanto Solinda, Gamelita Rizkawandi Sri Wahyuni Suryo Saputro Sus Derthi Widhyari Tatang Mitra Setia Teja Kisnanto Toshiaki Nishigaki Toshiaki NISHIGAKI Uus Saepuloh Uus Saepuloh UUS SAEPULOH Villiandra Villiandra Villiandra Villiandra Villiandra Villiandra Warsito P. Taruno Widanti, Berlian Wijaya, Hendra Yasmina A Pramastri Yasmina A. Paramastri Yasmina Arditi Pramastri YASMINA PARAMASTRI Yeni Kurniati Yeni Kurniati