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Dewi, Fitriya Nur Annisa
Biomedical Laboratory, Center For Primate Animal Studies, Institute For Research And Community Service, IPB University, Bogor, Indonesia
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Journal : Microbiology Indonesia

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Dissemination in Pigtailed Macaques after Primary Infection of Dengue-3 Virus JOKO PAMUNGKAS; DIAH ISKANDRIATI; UUS SAEPULOH; MOSES AFFANDI; ESTHER ARIFIN; YASMINA PARAMASTRI; FITRIYA NUR ANISA DEWI; DONDIN SAJUTHI
Microbiology Indonesia Vol. 5 No. 2 (2011): June 2011
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (70.748 KB) | DOI: 10.5454/mi.5.2.7

Abstract

Nonhuman primates (NHPs) play as indispensable animal model in biomedical research for studying a variety of human health issues, diseases and disorders, therapies, and preventive strategies. Since the immunological and physiological responses of NHPs, at some extent, to experimental viral infections are similar to humans, it is possible that studies of dengue infection in NHPs may aid understanding of dengue infection in humans. In this study,we used pigtailed macaques (Macaca nemestrina) as the experimental animal to study dengue-3 (DEN-3) virus infection.We evaluated DEN-3 viral distribution and replication sites after a primary infection in all collected tissues. Sequential localization in tissue of DEN-3 virus was studied in pigtailed macaques euthanized three days post viral inoculation (10 pfu mL ). Pigtailed macaque that was inoculated subcutaneously or intravenously; showed the highest viremia (62.94 pfu mL and 58.62 pfu mL ) detected by one step reverse transcription real time PCR. The virus inoculated in pigtailed macaques by subcutaneous injection was rapidly disseminated from the inoculation site to the lymph nodes, adrenal glands, kidneys, heart, thyroid, liver, prostate gland, and seminal vesicles. Meanwhile, dissemination of dengue virus in pigtailed macaques inoculated intravenously was detected in lymph nodes, thymus, salivary glands, liver, and prostate gland. This study suggested that the above mentioned-tissue specimens are involved or affected by DEN-3 virus replication and the route of infection seemed to have influenced the virus dissemination.  
Co-Authors . Permanawati Agus Wijaya Anita Esfandiari Dedi Fardiaz Deni Noviana Deny Setyo Wibowo Diah Iskandriati Diah Iskandriati DIAH ISKANDRIATI Diah Iskandriati Diah Iskandriati Diah Iskandriati Diny Agustini Sandrasari Dondin Sajuthi Dwi Ramadhani Effendi, Siti Aisyah Rahmalia Eric Hayes Eric Hayes ESTHER ARIFIN Farida Laila Firman Alamsyah Fitria Senja Murtiningrum FITRY TAFZI Gregory K. Wilkerson Harrold Halilintar MR Subu Taopan Hendra Wijaya Hidekazu Shigematsu Hidekazu SHIGEMATSU Huda S Darusman Huda Shalahudin Darusman I Nengah Budiarsa I Nengah Budiarsa Iin Indriawati Iin Kurnia Hasan Basri Irma H Suparto Irma Herawati Suparto Izzatun Niswah Ajrina J. Mark Cline Joko Pamungkas Kartika Sari Kartjito, Nicolas Edward Christanto Lilis Nuraida MOSES AFFANDI Nancy Dewi Yuliana Nishigaki, Toshiaki Nuri Andarwulan NURI ANDARWULAN2 Pamungkas, Joko Permanawati Permanawati Permanawati Permanawati PUSPO EDI GIRIWONOB R.P Agus Lelana Ratni Ernita Retno Wulansari Safrida Safrida Sela S Mariya Sela S. Mariya Sela Septima Mariya Setyo Widodo Shigematsu, Hidekazu Silmi Mariya Silmi Mariya Silmi Mariya Silmi Mariya Silvia Arin Prabandari Slamet Budijanto Solinda, Gamelita Rizkawandi Sus Derthi Widhyari Tatang Mitra Setia Teja Kisnanto Toshiaki Nishigaki Toshiaki NISHIGAKI Uus Saepuloh Uus Saepuloh UUS SAEPULOH Villiandra Villiandra Villiandra Villiandra Villiandra Villiandra Warsito P. Taruno Widanti, Berlian Wijaya, Hendra Yasmina A Pramastri Yasmina A. Paramastri Yasmina Arditi Pramastri YASMINA PARAMASTRI Yeni Kurniati Yeni Kurniati