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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Martabe : Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Jurnal Dunia Farmasi Jurnal Ilmu Kesehatan Jurnal Riset Kefarmasian Indonesia Ahmar Metastasis Health Journal (AMHJ) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Triswanto Sentat
Sekolah Tinggi Ilmu Kesehatan Samarinda
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Energy Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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ANTIDEPRESSANT ACTIVITY TEST OF RED BETEL LEAF ETHANOL EXTRACT (Piper crocatum) ON MALE WHITE MICE (Mus musculus) USING THE FORCED SWIM TEST METHOD Triswanto Sentat; Anita Apriliana; Siti Lili Rizki Sari; Novi Milasari; Ghina Adhila; Rizki Rahmadi Pratama; M. Hasan Andryanto
AL ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 11, No 2 (2025)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v11i2.18542

Abstract

Red betel leaves (Piper crocatum) contain flavonoids, alkaloids, polyphenols, tannins, and which is known for its antidepressant properties. The purpose of this study was to determine the effect of antidepressant activity of ethanol extract of red betel leaves on male white mice (Mus musculus) orally. The method used in testing antidepressants is the Forced Swim Test. Fifteen mice were divided into five groups: a positive control group receiving 3.5 mg/kg BW amitriptyline, a negative control group, and three groups receiving 200, 400, and 800 mg/kg BW of the extract. The antidepressant effect was measured by observing the immobility of mice during swimming. The results of the study using paired sample t-Test analysis showed that there was a difference in immobility before and after, in the 400 mg/kg BW extract and 3.5 mg/kg BW amitriptyline dose groups had significant differences.
Co-Authors Abdul Rahim Adi Prasetiyo Anita Apriliana Armenia, Armenia Azhoma Gumala Eka Kumalasari Eka Putri, Desi Ellen Indraswari Endah Handayani Fitri Handayani Fitri Handayani Fitri Handayani Furqan, Mainal Ghina Adhila Gusnelti, Yessi Henny Lucida Henny Nurhasnawati Heri Wijaya, Heri Husnul Warnida Husnul Warnida Husnul Warnidah Ika Nurjannah, Ika Lukman Nul Hakim M. Hasan Andryanto Nova Syafni Novi Milasari Nurul Fatimah Nurul Fatimah Pangestu, Susiyanto Prima Putra, Deddi Rakhmadhan Niah Reksi Sundu Risa Supriningrum Rizki Permatasari Rizki Rahmadi Pratama Rusdiati Helmidanora Siti Jubaidah, Siti Siti Lili Rizki Sari Sri Endah Handayani Susiyanto Pangestu Syamsiar, Syamsiar Wiwid Verri Yanti Yulistia Budianti Yullia Sukawaty Yunita Rachma Dwinand