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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Andalas Berkala Ilmu Kesehatan Kulit dan Kelamin Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ners Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Bioscientia Medicina : Journal of Biomedicine and Translational Research Scientific Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) International Journal of Health and Pharmaceutical (IJHP) Jurnal Kesehatan Masyarakat Indonesia (JKMI) Prosiding Seminar Nasional Unimus
Rina Gustia
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Scientific Journal

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Subcorneal Pustular Dermatosis Dengan Diabetes Melitus Tipe 2 dan Dislipidemia: Sebuah Laporan Kasus Gustia, Rina; Muchyar, Mutia Sari; Ashar, Miranda; Imaduddin, Ummul Khair; Intan, Shinta Ayu; Oktora, Meta Zulyati
Scientific Journal Vol. 5 No. 1 (2026): SCIENA Volume V No 1, January 2026
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v5i1.331

Abstract

Pendahuluan: Subcorneal pustular dermatosis (SPD), atau penyakit Sneddon–Wilkinson, merupakan dermatosis neutrofilik kronis yang jarang, ditandai dengan pustul superfisial berulang. SPD semakin banyak dilaporkan berhubungan dengan penyakit sistemik, terutama gangguan metabolik seperti diabetes melitus tipe 2 dan dislipidemia, yang dapat berkontribusi terhadap onset dan kekambuhan penyakit. Laporan kasus: Seorang perempuan berusia 36 tahun yang datang dengan keluhan bercak kemerahan berulang disertai pustul superfisial flaksid berwarna kekuningan yang gatal pada daerah perut dan punggung bawah selama dua bulan terakhir. Lesi awalnya membaik dengan kortikosteroid topikal tetapi kambuh kembali dua minggu kemudian dengan cakupan yang lebih luas. Pasien tidak mengeluhkan demam maupun riwayat konsumsi obat sebelumnya. Pasien memiliki penyakit dasar diabetes melitus tipe 2 dan dislipidemia, keduanya dalam kondisi tidak terkontrol dengan baik. Pemeriksaan klinis menunjukkan plak eritematosa multipel dengan pustul superfisial, krusta, erosi, serta makula hiperpigmentasi pada perut dan punggung bawah. Pemeriksaan dermoskopi menunjukkan multiple yellow-white globule di atas dasar eritematosa yang dikelilingi sisik halus. Evaluasi psikologis menunjukkan tingkat kecemasan sedang dan dampak sedang terhadap kualitas hidup.  Kesimpulan: Kasus ini menekankan pentingnya mengevaluasi dan menangani komorbiditas sistemik, karena disfungsi metabolik dapat berkontribusi terhadap inflamasi persisten, kekambuhan berulang, dan respons terapi yang kurang optimal pada Subcorneal Pustular Dermatosis.
A Case of Onychomycosis with Nail Lichen Planus: The Importance of Supportive Examinations in Establishing a Diagnosis Ariani, Tutty; Farhanah, Nindya; Gustia, Rina
Scientific Journal Vol. 5 No. 1 (2026): SCIENA Volume V No 1, January 2026
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v5i1.325

Abstract

Background: Onychomycosis and Nail Lichen Planus (NLP) are two conditions that cause nail damage and may sometimes present with overlapping clinical features, leading to difficulties in achieving an accurate diagnosis. Several ancillary examinations should be considered to avoid misdiagnosis of nail disorders. Case: A 64-year-old female patient presented to the Dermatology, Venereology, and Aesthetic Clinic at Dr. M. Djamil General Hospital Padang with complaints of progressive nail thickening and whitening affecting almost all nails, occasionally accompanied by itching, for the past 6 months. The patient had previously been diagnosed with onychomycosis and had regularly taken fluconazole 150 mg weekly for 6 months, but without improvement. Physical examination was within normal limits. Dermatological and onychoscopic examination revealed subungual hyperkeratosis, longitudinal ridging, onychotrophy, onychoschizia, trachyonychia, onycholysis, yellowish discoloration, melanonychia, and leukonychia, with an OSI score indicating severe involvement and a NALSI score of 100/120. KOH examination demonstrated the presence of hyphae, fungal culture revealed Aspergillus niger, PAS staining confirmed fungal elements, while biopsy results were consistent with NLP. The patient was diagnosed with onychomycosis with concomitant NLP and was treated with pulse itraconazole at a dose of 400 mg/day for one week each month for 2–3 months. Upon completion, treatment for NLP was initiated. Discussion: In this case, the absence of comprehensive ancillary examinations particularly biopsy, initially led to a diagnosis limited only to onychomycosis, without recognition of the coexisting NLP. This highlights the importance of thorough investigations to ensure an accurate and precise diagnosis.
Co-Authors Abdiana Afdal Afdal, Afdal Afifah Alfyanita Agusti Nala Sari Agustin Vira Amelia Rahayu Andrini Ariesti Anisa Persia Anum, Qaira Ariani, Tutty Ashal, Taufik Ashar, Miranda Asri, Ennesta Astria Rima Rara Yuswir Aswiyanti Asri Avit Suchitra Azaria Ramadhani Zulkifli Clarissa Maharani Putri Deasy Archika Alvares Dedy Kurnia Dina Arfiani Rusjdi Dzakiyyah, Adzristi Zahrah Edison Edison Elizabeth Bahar Ennesta Asri Erlina Rustam Farhanah, Nindya Firda Kartika, Hersa Gardenia Akhyar Hafizah Putri Tasyah Hendriati, Hendriati Imaduddin, Ummul Khair Indah Indria Sari Intan, Shinta Ayu Irdawati Izrul Irdawaty Izrul Jefrizal Wirman Julia, Dwi Sabtika Julita Julita Julizar Julizar Kemala Sayuti Linosefa Linosefa Malinda Meinapuri Mardhiati Mardhiati Muchyar, Mutia Sari Mutia Sari Nagara, Adianto Jaya Nellia Fonna Novian Novian Novita Ariani Nurzain, Muflihati Oktora, Meta Zulyati Putra, M Firas Riselo Putri Ariani Rahmatini . Rendra Darma Satria Rendra Darmasatria Rika Desviorita Rikarni Rinal Effendi Rini Gusya Liza, Rini Gusya Riri Prima Yolanda Rizki Dwayana Rizkia Chairani Asri Rudy Afriant Russilawati, Russilawati Sari, Indah Indria sari, Mutia Satya Wydya Yenny Taria, Sari Almira Tutty Ariani Utama, Redha Cipta Vitresia, Havriza Yenni Raflis Yola Fadilla Yosse Rizal Yossy, Vesri Yufaz Aidi Mahesa Zafira, Qory