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Journal : Global Health Management Journal

Potential of garlic (Allium sativum) essence in changing blood lipid profile of hypertension patients with hypercholesterolemia Hadi, Hadi; Hadisaputro, Suharyo; Ramlan, Djamaluddin
Global Health Management Journal Vol 3, No 1 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Abstract

Background: As like hypertension, hypercholesterolemia is a major risk factor for cardiovascular disease and hypertension and its complications are one of the highest causes of death in the world.Aims: This study aims to determine the potential of garlic essence (Allium sativum) mixed with honey in changing blood pressure and lipid profile of blood in the hypertension patients with hypercholesterolemia, and to compare the effectiveness with those who received Simvastatin, the most preferred pharmacological treatment of hyperlipidemia.Methods: This research is a quasy experiment study with a Nonequivalent control group design. There were 22 hypercholesterolemia outpatients purposively selected from local health centers. The respondents were then divided equally to (a) a control group where the patients were provided with generic Simvastatin 10 mg single dose taken once in the afternoon, and (b) an intervention group where the respondents received a non-pharmacological supplement of garlic essence in 2 grams honey. The blood pressure and the blood lipid profile were examined before (Pretest) and at the Day 22 after the treatment (Posttest). The collected data was then analyzed using a T-test to define the significant mean difference between two groups, and a Cohen’s effect was measured to interpret the size of changes.Results: Either the additions of Simvastatin or the provision of garlic essence mixed with honey decreased the blood pressure (systole and diastole) and the cholesterol, triglyceride, and LDL cholesterol, but increased the HDL cholesterol. While significant difference was observed for all parameters at the intervention group, the improvement at the control group for triglyceride was not significant (p value = 0.041). Overall, by the Cohen's effect size effect, we can interpret that the changes was moderate for diastole and systole blood pressure, and also triglyceride and DLD-cholesterol; however the effect size was low for Cholesterol and HDL-cholesterol. Conclusion: The findings show the importance of the garlic essence mixed with honey to be offered as a nutritional supplement for hypertensive patients with hypercholesterolemia.  Keywords: Garlic (Allium sativum) essence, Simvastatin, Hypertension, Hypercholesterolemia, Blood pressure, Blood lipid profile.
Co-Authors Aini, Gina Nur Akhmad Aminuddin Bama, Akhmad Aminuddin Alwi, Luqman Anak Agung Gede Sugianthara Andik Yulianto Andreas, Jonathan Ardiani, Zefania Regina Arif Setiawan Awaludin Awaludin, Awaludin Balqis, Hanifa Amalia Billah, Tafriyadhur Risa Budi Santosa Budi Santosa Candra Kurniawan Candra, Adiska Rani Ditya Cindi Aprilia Dewangga Yudhistira Dhias Fajar Widya Permana Dillah, Wildan Ubay Djamaluddin Ramlan, Djamaluddin Dwi Tiga Putri, Dwi Tiga Efriani Efriani Erni Erni Erry Koriyanti Faizin, Ali Nur Fajar Awang Irawan Giang, Nguyen Tra Guniandi, Beben Handhin, Mega Lilia Harini, Sri Harini HARIYANTO HARIYANTO Hasnur, Hasnur Heny Setyawati Hermawan Istiadi Huda, Abilal Martin Ida Ayu Putu Sri Widnyani Ipang Setiawan Irawan Irawan Iskandar Rizal Pratama, Iskandar Rizal Izzatillah, Fathonah Jaskulski, Karol JEJE, JENNYCA Khairul Saleh Lelono, Mardi Luh Putu Ratna Sundari Ma’dum, Mirza Arif Marchesywan, Franz Rizky Mochammad Dhifansah Ramadhan Hutomo Muawanah, Elok Nur Akhiroh Muhammad Azinar Muhammad Irfan Muhammad Muhibbi Nasuka Nasuka, Nasuka Netty Kurniawati, Netty Nimatul Mamuriyah Novriansyah Novriansyah, Novriansyah Novtriana, Deasti NURLAELA NURLAELA Prama Ramadani Putranto, Prama Ramadani Prasetyo, Victoria Eka Pratama, Rivan Saghita Priambodo, Erwin Nizar Putra, Muhammad Yudistira Oktavian Qolby, Qonita Nur Rahardian, Bayu Raharjo, Syaherdian Juniarto Ramadhan, Ahmad Teguh Ranu Baskora Aji Putra Rifki, Moh Rohmad, Arif Nur Romadhoni, Syahru Rubianto Hadi Safrina, Sri Said Junaidi Setya Rahayu Siti Baitul Mukarromah Sobihin, Sobihin Soegiarto Soegiarto, Soegiarto Sri Sumartiningsih Suharyo Hadisaputro Sunyoto, Tommy Suprap, Suprap Suratman Suratman Susanti, Elly Susanti Sutopo Sutopo TA, Putra Tandiyo Rahayu Taufiq Hidayah Tri Kuat, Tri Ulinnuha, Rizam Ahada Nur Wilastono, Muzaki Wildan Yogaswara, Andre Yudhistira, Dewangga Yulingga Nanda Hanief