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Journal : Global Health Management Journal

Potential of garlic (Allium sativum) essence in changing blood lipid profile of hypertension patients with hypercholesterolemia Hadi, Hadi; Hadisaputro, Suharyo; Ramlan, Djamaluddin
Global Health Management Journal Vol 3, No 1 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Abstract

Background: As like hypertension, hypercholesterolemia is a major risk factor for cardiovascular disease and hypertension and its complications are one of the highest causes of death in the world.Aims: This study aims to determine the potential of garlic essence (Allium sativum) mixed with honey in changing blood pressure and lipid profile of blood in the hypertension patients with hypercholesterolemia, and to compare the effectiveness with those who received Simvastatin, the most preferred pharmacological treatment of hyperlipidemia.Methods: This research is a quasy experiment study with a Nonequivalent control group design. There were 22 hypercholesterolemia outpatients purposively selected from local health centers. The respondents were then divided equally to (a) a control group where the patients were provided with generic Simvastatin 10 mg single dose taken once in the afternoon, and (b) an intervention group where the respondents received a non-pharmacological supplement of garlic essence in 2 grams honey. The blood pressure and the blood lipid profile were examined before (Pretest) and at the Day 22 after the treatment (Posttest). The collected data was then analyzed using a T-test to define the significant mean difference between two groups, and a Cohen’s effect was measured to interpret the size of changes.Results: Either the additions of Simvastatin or the provision of garlic essence mixed with honey decreased the blood pressure (systole and diastole) and the cholesterol, triglyceride, and LDL cholesterol, but increased the HDL cholesterol. While significant difference was observed for all parameters at the intervention group, the improvement at the control group for triglyceride was not significant (p value = 0.041). Overall, by the Cohen's effect size effect, we can interpret that the changes was moderate for diastole and systole blood pressure, and also triglyceride and DLD-cholesterol; however the effect size was low for Cholesterol and HDL-cholesterol. Conclusion: The findings show the importance of the garlic essence mixed with honey to be offered as a nutritional supplement for hypertensive patients with hypercholesterolemia.  Keywords: Garlic (Allium sativum) essence, Simvastatin, Hypertension, Hypercholesterolemia, Blood pressure, Blood lipid profile.
Co-Authors Adikara, Fahmi Surya Affandi, Azhar Kholiq Aini, Gina Nur Akhmad Aminuddin Bama, Akhmad Aminuddin Alwi, Luqman Anak Agung Gede Sugianthara Andik Yulianto Andreas, Jonathan Apit Fathurohman Ardiani, Zefania Regina Arif Setiawan Assaidah, Assaidah Auliya Kurdiati, Lintang Awaludin Awaludin, Awaludin Azzahra, Ayu Kirani Balqis, Hanifa Amalia Billah, Tafriyadhur Risa Budi Santosa Budi Santosa Candra Kurniawan Candra, Adiska Rani Ditya Cindi Aprilia Dewangga Yudhistira Dhias Fajar Widya Permana Dillah, Wildan Ubay Djamaluddin Ramlan, Djamaluddin Efriani Efriani Erni Erni Erry Koriyanti Esti Susiloningsih Faizin, Ali Nur Fajar Awang Irawan Fiber Monado Frinsyah Virgo Giang, Nguyen Tra Guniandi, Beben Handhin, Mega Lilia Harini, Sri Harini HARIYANTO HARIYANTO Hasnur, Hasnur Henny Helmi Hermawan Istiadi Huda, Abilal Martin Ida Ayu Putu Sri Widnyani Indah Lestari, Indah Ipang Setiawan Irawan Irawan Iskandar Rizal Pratama, Iskandar Rizal JEJE, JENNYCA Khairul Saleh Lelono, Mardi Luh Putu Ratna Sundari Ma’dum, Mirza Arif Marchesywan, Franz Rizky Muawanah, Elok Nur Akhiroh Muhammad Azinar Muhammad Irfan Muhammad Muhibbi Nasuka Nasuka, Nasuka Netty Kurniawati, Netty Nimatul Mamuriyah Novianti, Lidia Novriansyah Novriansyah, Novriansyah Novtriana, Deasti Nur Khakim, M. Yusup Nurkhalifah, Fatimah NURLAELA NURLAELA Octavianus Cakra Satya Prama Ramadani Putranto, Prama Ramadani Pratama, Rivan Saghita Qolby, Qonita Nur Rahardian, Bayu Ramadhan, Ahmad Teguh Ranu Baskora Aji Putra Rohmad, Arif Nur Romadhoni, Syahru Rubianto Hadi Safrina, Sri Said Junaidi Sobihin, Sobihin Soegiarto Soegiarto, Soegiarto Suharyo Hadisaputro Sunyoto, Tommy Supardi Supardi Suprap, Suprap Suratman Suratman Susanti, Elly Susanti Sutopo Sutopo Syakuroh, Abdan TA, Putra Tandiyo Rahayu Taufiq Hidayah Tri Kuat, Tri Ulinnuha, Rizam Ahada Nur Wilastono, Muzaki Wildan Yogaswara, Andre Yudhistira, Dewangga