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Journal : Makara Journal of Science

REACTIONS OF CISPLATIN HYDROLYTES WITH THIOLS. 3: REACTIONS OF cis-[Pt(15NH3)2(H2O)2] 2+ WITH GLUTATHIONE Hadi, Hadi
Makara Journal of Science Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

The reaction of cis-[Pt(15NH3)2(H2O)2] 2+ (3) with glutathione (GSH) was investigated in aqueous solution. In this reaction, the ammine in the platinum complex formed was liberated. Surprisingly two chelate rings were observed, six-membered-S,O-chelate ring complex cis-[Pt(15NH3 )2 (SG-S,O) (7) and five-membered-S,N-chelate ring complex cis-[Pt(15NH3 )2 (SG-S,N)] (8). The bis (thiolate) platinum(II) complex, cis-[Pt(15NH3 )2 (SG)2 ] (9) was always present in this reaction in any mole ratio used. The dinuclear sulphur-bridged complex (10), giving a broad peak in 15N NMR, was only present in very tiny amounts.
REACTIONS OF CISPLATIN HYDROLYTES WITH THIOLS. 3: REACTIONS OF cis-[Pt(15NH3)2(H2O)2] 2+ WITH GLUTATHIONE Hadi, Hadi
Makara Journal of Science Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The reaction of cis-[Pt(15NH3)2(H2O)2] 2+ (3) with glutathione (GSH) was investigated in aqueous solution. In this reaction, the ammine in the platinum complex formed was liberated. Surprisingly two chelate rings were observed, six-membered-S,O-chelate ring complex cis-[Pt(15NH3 )2 (SG-S,O) (7) and five-membered-S,N-chelate ring complex cis-[Pt(15NH3 )2 (SG-S,N)] (8). The bis (thiolate) platinum(II) complex, cis-[Pt(15NH3 )2 (SG)2 ] (9) was always present in this reaction in any mole ratio used. The dinuclear sulphur-bridged complex (10), giving a broad peak in 15N NMR, was only present in very tiny amounts.
REACTIONS OF CISPLATIN HYDROLYTES WITH THIOLS. 3: REACTIONS OF cis-[Pt(15NH3)2(H2O)2] 2+ WITH GLUTATHIONE Hadi, Hadi
Makara Journal of Science Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The reaction of cis-[Pt(15NH3)2(H2O)2] 2+ (3) with glutathione (GSH) was investigated in aqueous solution. In this reaction, the ammine in the platinum complex formed was liberated. Surprisingly two chelate rings were observed, six-membered-S,O-chelate ring complex cis-[Pt(15NH3 )2 (SG-S,O) (7) and five-membered-S,N-chelate ring complex cis-[Pt(15NH3 )2 (SG-S,N)] (8). The bis (thiolate) platinum(II) complex, cis-[Pt(15NH3 )2 (SG)2 ] (9) was always present in this reaction in any mole ratio used. The dinuclear sulphur-bridged complex (10), giving a broad peak in 15N NMR, was only present in very tiny amounts.
Co-Authors Adikara, Fahmi Surya Affandi, Azhar Kholiq Aini, Gina Nur Akhmad Aminuddin Bama, Akhmad Aminuddin Alwi, Luqman Anak Agung Gede Sugianthara Andik Yulianto Andreas, Jonathan Apit Fathurohman Ardiani, Zefania Regina Arif Setiawan Assaidah, Assaidah Auliya Kurdiati, Lintang Awaludin Awaludin, Awaludin Azzahra, Ayu Kirani Balqis, Hanifa Amalia Billah, Tafriyadhur Risa Budi Santosa Budi Santosa Candra Kurniawan Candra, Adiska Rani Ditya Cindi Aprilia Dewangga Yudhistira Dhias Fajar Widya Permana Dillah, Wildan Ubay Djamaluddin Ramlan, Djamaluddin Efriani Efriani Erni Erni Erry Koriyanti Esti Susiloningsih Faizin, Ali Nur Fajar Awang Irawan Fiber Monado Frinsyah Virgo Giang, Nguyen Tra Guniandi, Beben Handhin, Mega Lilia Harini, Sri Harini HARIYANTO HARIYANTO Hasnur, Hasnur Henny Helmi Hermawan Istiadi Huda, Abilal Martin Ida Ayu Putu Sri Widnyani Indah Lestari, Indah Ipang Setiawan Irawan Irawan Iskandar Rizal Pratama, Iskandar Rizal JEJE, JENNYCA Khairul Saleh Lelono, Mardi Luh Putu Ratna Sundari Ma’dum, Mirza Arif Marchesywan, Franz Rizky Muawanah, Elok Nur Akhiroh Muhammad Azinar Muhammad Irfan Muhammad Muhibbi Nasuka Nasuka, Nasuka Netty Kurniawati, Netty Nimatul Mamuriyah Novianti, Lidia Novriansyah Novriansyah, Novriansyah Novtriana, Deasti Nur Khakim, M. Yusup Nurkhalifah, Fatimah NURLAELA NURLAELA Octavianus Cakra Satya Prama Ramadani Putranto, Prama Ramadani Pratama, Rivan Saghita Qolby, Qonita Nur Rahardian, Bayu Ramadhan, Ahmad Teguh Ranu Baskora Aji Putra Rohmad, Arif Nur Romadhoni, Syahru Rubianto Hadi Safrina, Sri Said Junaidi Sobihin, Sobihin Soegiarto Soegiarto, Soegiarto Suharyo Hadisaputro Sunyoto, Tommy Supardi Supardi Suprap, Suprap Suratman Suratman Susanti, Elly Susanti Sutopo Sutopo Syakuroh, Abdan TA, Putra Tandiyo Rahayu Taufiq Hidayah Tri Kuat, Tri Ulinnuha, Rizam Ahada Nur Wilastono, Muzaki Wildan Yogaswara, Andre Yudhistira, Dewangga