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Journal : Makara Journal of Science

REACTIONS OF CISPLATIN HYDROLYTES WITH THIOLS. 3: REACTIONS OF cis-[Pt(15NH3)2(H2O)2] 2+ WITH GLUTATHIONE Hadi, Hadi
Makara Journal of Science Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

The reaction of cis-[Pt(15NH3)2(H2O)2] 2+ (3) with glutathione (GSH) was investigated in aqueous solution. In this reaction, the ammine in the platinum complex formed was liberated. Surprisingly two chelate rings were observed, six-membered-S,O-chelate ring complex cis-[Pt(15NH3 )2 (SG-S,O) (7) and five-membered-S,N-chelate ring complex cis-[Pt(15NH3 )2 (SG-S,N)] (8). The bis (thiolate) platinum(II) complex, cis-[Pt(15NH3 )2 (SG)2 ] (9) was always present in this reaction in any mole ratio used. The dinuclear sulphur-bridged complex (10), giving a broad peak in 15N NMR, was only present in very tiny amounts.
REACTIONS OF CISPLATIN HYDROLYTES WITH THIOLS. 3: REACTIONS OF cis-[Pt(15NH3)2(H2O)2] 2+ WITH GLUTATHIONE Hadi, Hadi
Makara Journal of Science Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The reaction of cis-[Pt(15NH3)2(H2O)2] 2+ (3) with glutathione (GSH) was investigated in aqueous solution. In this reaction, the ammine in the platinum complex formed was liberated. Surprisingly two chelate rings were observed, six-membered-S,O-chelate ring complex cis-[Pt(15NH3 )2 (SG-S,O) (7) and five-membered-S,N-chelate ring complex cis-[Pt(15NH3 )2 (SG-S,N)] (8). The bis (thiolate) platinum(II) complex, cis-[Pt(15NH3 )2 (SG)2 ] (9) was always present in this reaction in any mole ratio used. The dinuclear sulphur-bridged complex (10), giving a broad peak in 15N NMR, was only present in very tiny amounts.
REACTIONS OF CISPLATIN HYDROLYTES WITH THIOLS. 3: REACTIONS OF cis-[Pt(15NH3)2(H2O)2] 2+ WITH GLUTATHIONE Hadi, Hadi
Makara Journal of Science Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The reaction of cis-[Pt(15NH3)2(H2O)2] 2+ (3) with glutathione (GSH) was investigated in aqueous solution. In this reaction, the ammine in the platinum complex formed was liberated. Surprisingly two chelate rings were observed, six-membered-S,O-chelate ring complex cis-[Pt(15NH3 )2 (SG-S,O) (7) and five-membered-S,N-chelate ring complex cis-[Pt(15NH3 )2 (SG-S,N)] (8). The bis (thiolate) platinum(II) complex, cis-[Pt(15NH3 )2 (SG)2 ] (9) was always present in this reaction in any mole ratio used. The dinuclear sulphur-bridged complex (10), giving a broad peak in 15N NMR, was only present in very tiny amounts.
Co-Authors Aini, Gina Nur Akhmad Aminuddin Bama, Akhmad Aminuddin Alwi, Luqman Anak Agung Gede Sugianthara Andik Yulianto Andreas, Jonathan Ardiani, Zefania Regina Arif Setiawan Awaludin Awaludin, Awaludin Balqis, Hanifa Amalia Billah, Tafriyadhur Risa Budi Santosa Budi Santosa Candra Kurniawan Candra, Adiska Rani Ditya Cindi Aprilia Dewangga Yudhistira Dhias Fajar Widya Permana Dillah, Wildan Ubay Djamaluddin Ramlan, Djamaluddin Dwi Tiga Putri, Dwi Tiga Efriani Efriani Erni Erni Erry Koriyanti Faizin, Ali Nur Fajar Awang Irawan Giang, Nguyen Tra Guniandi, Beben Handhin, Mega Lilia Harini, Sri Harini HARIYANTO HARIYANTO Hasnur, Hasnur Heny Setyawati Hermawan Istiadi Huda, Abilal Martin Ida Ayu Putu Sri Widnyani Ipang Setiawan Irawan Irawan Iskandar Rizal Pratama, Iskandar Rizal Izzatillah, Fathonah Jaskulski, Karol JEJE, JENNYCA Khairul Saleh Lelono, Mardi Luh Putu Ratna Sundari Ma’dum, Mirza Arif Marchesywan, Franz Rizky Mochammad Dhifansah Ramadhan Hutomo Muawanah, Elok Nur Akhiroh Muhammad Azinar Muhammad Irfan Muhammad Muhibbi Nasuka Nasuka, Nasuka Netty Kurniawati, Netty Nimatul Mamuriyah Novriansyah Novriansyah, Novriansyah Novtriana, Deasti NURLAELA NURLAELA Prama Ramadani Putranto, Prama Ramadani Prasetyo, Victoria Eka Pratama, Rivan Saghita Priambodo, Erwin Nizar Putra, Muhammad Yudistira Oktavian Qolby, Qonita Nur Rahardian, Bayu Raharjo, Syaherdian Juniarto Ramadhan, Ahmad Teguh Ranu Baskora Aji Putra Rifki, Moh Rohmad, Arif Nur Romadhoni, Syahru Rubianto Hadi Safrina, Sri Said Junaidi Setya Rahayu Siti Baitul Mukarromah Sobihin, Sobihin Soegiarto Soegiarto, Soegiarto Sri Sumartiningsih Suharyo Hadisaputro Sunyoto, Tommy Suprap, Suprap Suratman Suratman Susanti, Elly Susanti Sutopo Sutopo TA, Putra Tandiyo Rahayu Taufiq Hidayah Tri Kuat, Tri Ulinnuha, Rizam Ahada Nur Wilastono, Muzaki Wildan Yogaswara, Andre Yudhistira, Dewangga Yulingga Nanda Hanief