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SITTI HAJAR
Universitas Udayana
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Journal : Narra J

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Safety evaluation and effects of cascara pulp Gayo Arabica coffee cream as anti-photoaging in animal model Lestari, Wahyu; Hajar, Sitti
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.204

Abstract

Prolonged sunlight and ultraviolet (UV) exposure causes premature skin aging called photoaging and coffee-derived topical antioxidants may help to reduce this process. Since a significant amount of antioxidant-rich cascara pulp are wasted in coffee processing, this study aimed to evaluate the safety of cascara extract cream of Gayo Arabica coffee pulp (CECGACP) as anti-photoaging in male Wistar rats (Rattus norvegicus) by assessing the skin primary irritation index (PII), skin macroscopic changes and the level of tumor necrosis factor-alpha (TNF-α). Twenty-five rats were randomly divided into five different groups: negative control (base cream only), positive control containing L-ascorbic acid 3%, and three treatment groups treated with cream containing 5%, 7.5% and 10% of CECGACP. The CECGACP was extracted, formulated into cream as a topical treatment and applied on the backs of the rats two times a day, once before the UV exposure and four hours after the exposure. After four weeks, the skins were macroscopically examined, and the TNF-α levels were measured. The PII was assessed after applying the cream 24 hours before UX exposure. Our data suggested that CECGACP was considered safe because there were no erythema and edema formation on the skin of the rats with PII score of 0 (classified as no irritation or negligible). After UV exposure, all rats had visible wrinkles and erythema on the skin in particular in the first week. After administration of CECGACP, both wrinkles and erythema were decreased. The levels of TNF-α varied from 0.15±0.02 ng/mL in the negative control and CECGACP 7.5% rat groups to 0.19±0.03 in the positive control group; however, there was no significant difference among all the groups. Our study suggests that CECGACP is safe to use in Wistar rats and able to reduce the erythema and edema due to UV exposure. However, the application of CECGACP does not provide a significant reduction of TNF-α levels.
Psoriasis vulgaris patient with psoriatic arthritis managed with interleukin-17A inhibitor: Balancing benefits and adverse effects Utama, Wina S.; Lestari, Wahyu; Hajar, Sitti; Sylvawani, Mahriani; Ismida, Fitri D.; Akele, Richard Y.
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.207

Abstract

Psoriasis vulgaris is a significant health problem and up to 30% of the patients are most likely to develop psoriatic arthritis. Secukinumab, an interleukin-17A (IL-17A) inhibitor, is used to treat patients with moderate-to-severe plaques associated with psoriatic arthritis. The aim of this case report was to highlight the efficacy of secukinumab treatment in a patient with both psoriasis vulgaris and psoriatic arthritis focusing the how to balance the benefits and adverse effects. A 36-year-old female came to Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia with chief complaint of itchy and scaly red plaques almost all over the body. The patient also experienced pain in both knees, both ankle joints and index finger as well as thumb in the right hand in the last year. The patient was diagnosed with psoriasis vulgaris and psoriatic arthritis, then treated with phototherapy and 15 mg of oral methotrexate each week for four weeks. Due to no improvement of the initial treatment, the patient received emollient and secukinumab at a dose of 300 mg/week subcutaneously for five weeks. The lesions began to disappear and the joint pain began to relieve. Secukinumab therapy was continued with a dose of 300 mg/month for six months. However, after six months, the patient complained of acnes appeared on the face. Therefore, the maintenance dose of secukinumab was decreased to 150 mg/month. After the reduced maintenance therapy was given, the patient came back with no complained of acnes. The erythematous plaques on trunk, back, arms and legs have subsided, as well as the joint pain. This case highlights that in a moderate-to-severe psoriasis associated with psoriatic arthritis, secukinumab is highly effective. However, since the potential adverse effects, education and regular follow-up are needed to analyze the success of the treatment and to be able to manage the adverse effects.
Co-Authors Abdul, Hayun Ahmad Yusuf Akbar, Erwin Akele, Richard Y. Al Alim, Zul Fadhli Amna, Nuraisa Amrah Amrah, Amrah Andi Makkasau Andini Arsyad, Nur Fajar Asnani Asnani asrizal, cynthia wahyu Baharuddin Semmaila Beddu, Hartina Citra, Ratna Clarissa Namiko, Rifda Daniel Happy Putra Dewi Ismida, Fitri Earlia, Nanda Erma Suryani Sahabuddin Ervi Novitasari Fadjriani, Fadjriani Fitria Fitria Gustiani Herawan Hisanan I Nyoman Sujana Ichwanty Sabir, Ridha Ismida, Fitri D. Kaharuddin Kaharuddin Khatima, Ashlifatul Lahming, Lahming Liza Salawati, Liza Marwan, Andi Maryam, Tjut Muhammad Yani, Muhammad Mulki, Putria Muslim, Siti Chairunnisa MY, Nurfadila Nadira Sabrina Mufti Nasir Nasir, Munawir Natsir, Siti Zahra Mulianti Noer Intan Novitasari, Noer Intan Nuraeman Nurwahida Puang, Datu Putrawan, Muh. Rizah Qudratullah, Qudratullah Ridha Alim, Intan RIDHA ICHWANTY SABIR, RIDHA ICHWANTY RM Agung Pranata Kusuma Atmaja Rum, Eka Prabawati S., Ratnah Sastrawati, Ika Sri Wahyuni Surti, Surti Sylvawani, Mahriani Teuku Romi Imansyah Putra Tita Menawati Liansyah Utama, Wina S. Wahyu Lestari Wahyu Lestari Yuli Artati Yulianti, Wahyunita Zulkifli, Baidillah