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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Biomedika Sari Pediatri Elementary: Jurnal Ilmiah Pendidikan Dasar Chimica et Natura Acta Jurnal Respirologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Respirasi (JR) Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat Narra J Bioscientia Medicina : Journal of Biomedicine and Translational Research JP2N: Jurnal Pengembangan Dan Pengabdian Nusantara
Dewi Anggraini
1) Arifin Achmad General Hospital, Riau Province, Pekanbaru, Indonesia 2) Eka Hospital Pekanbaru, Pekanbaru, Indonesia 3) Department Of Microbiology, Faculty Of Medicine, Universitas Riau, Pekanbaru, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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KONTRIBUSI PROGRAM KKN TERHADAP AKTIVASI LAYANAN POSBANKUMHAM DAN PEMBENTUKAN SISTEM BANTUAN HUKUM TERINTEGRASI DI DESA PULAU GADANG Zafran Nopala Armindra; Fadhia Alya Putri; Nafisa Khansa Luthfiyah; Hawa Gebriella; Talitha Salwa Adriya; Siska Alya Adha; Nurul Mawaddah; Naufal Mulia Muharram; Dewi Anggraini; Wahyu Agung Prasetyo
JP2N : Jurnal Pengembangan Dan Pengabdian Nusantara Vol. 3 No. 2 (2026): JP2N: Januari-April 2026
Publisher : Yayasan Pengembangan Dan Pemberdayaan Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62180/zgvbkg31

Abstract

Posko Bantuan Hukum dan Hak Asasi Manusia (Posbankumham) adalah jalur  yang disediakan oleh pemerintah desa untuk memberikan bantuan kepada masyarakat dalam hal  pendampingan hukum. Namun, di Desa Pulau Gadang layanan ini  sebelumnya tidak berjalan dengan baik meskipun telah tersedia Surat Keputusan (SK) dan organisasi yang telah dibentuk. Program Kuliah Kerja Nyata (KKN) kemudian  berperan  dalam mengaktifkan kembali Posbankumham melalui pendekatan pemberdayaan hukum bagi masyarakat. Intervensi KKN mencakup pembaruan ruang layanan, penyusunan Standar Operasional Prosedur (SOP), digitalisasi layanan melalui pembuatan situs web, pelatihan untuk kepala desa dan hakim desa (peradilan adat) dalam menangani kasus tindak pidana ringan (tipiring), serta penyuluhan kepada masyarakat. Hasil penelitian menunjukkan bahwa pengaktifan Posbankumham meningkatkan kemampuan  masyarakat dalam mengakses layanan hukum, mempercepat  proses penyelesaian konflik, serta mendorong kolaborasi antara sistem peradilan adat dan hukum positif. Model pengabdian KKN ini berhasil menciptakan sistem bantuan hukum desa yang terorganisir, terintegrasi, dan berkelanjutan melalui kolaborasi antara pemerintah desa, aparat penegak hukum desa, dan masyarakat. Temuan penelitian ini menunjukkan bahwa pemberdayaan hukum berbasis KKN memiliki potensi untuk diterapkan  di desa lain sebagai metode efektif dalam  meningkatkan akses keadilan di tingkat masyarakat.
Impact of DENV Genotypic Variation on Vaccine Efficacy and Cross-Neutralizing Antibody Responses: A Meta-Analysis Utari Gusti Yulimdra; Dewi Anggraini; Fauzia Andrini Djojosugito
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1603

Abstract

Background: The development of a broadly protective dengue virus (DENV) vaccine remains a paramount global health priority. Current tetravalent vaccines target the four DENV serotypes. However, intra-serotypic genetic variations, defined as genotypes, present a neglected immunological barrier. Evidence indicates that genotypic divergence critically impairs cross-neutralizing antibody responses, leaving vaccinated individuals vulnerable to circulating heterologous genotypes and severe antibody-dependent enhancement (ADE). This meta-analysis quantifies the impact of DENV genotypic variation on neutralizing antibody efficacy. Methods: A systematic review and meta-analysis adhering to PRISMA guidelines were conducted. Quantitative virological data were extracted from primary studies, focusing on neutralizing antibody titers against homologous versus heterologous DENV genotypes. A DerSimonian-Laird random-effects model calculated the pooled Standardized Mean Difference (SMD) and 95% Confidence Intervals (CI). Heterogeneity was addressed through subgroup analyses (by serotype and host species). A sensitivity analysis employing the Hartung-Knapp-Sidik-Jonkman (HKSJ) adjustment verified robustness. Risk of bias was evaluated utilizing RoB 2 and SYRCLE tools. Results: Ten controlled studies met the inclusion criteria. The pooled analysis revealed a severe, statistically significant reduction in neutralization capacity against heterologous genotypes compared to homologous strains, yielding an overall SMD of -1.52 (95% CI: -1.95 to -1.09, p < 0.001). High initial heterogeneity (I2 = 84.1%) was partially resolved by stratifying by serotype; the DENV-2 subgroup demonstrated the most profound neutralization deficit (SMD = -1.78, I2 = 42.5%). Sensitivity analyses confirmed the stability of the pooled effect. Conclusion: Vaccine-induced neutralizing responses are significantly attenuated against heterologous DENV genotypes. The prevailing serotype-level vaccine paradigm is insufficient for comprehensive global immunity. Next-generation vaccine designs must incorporate conserved, pan-genotypic epitopes to prevent intra-serotypic immune evasion and subsequent ADE-mediated severe disease.
Impact of DENV Genotypic Variation on Vaccine Efficacy and Cross-Neutralizing Antibody Responses: A Meta-Analysis Utari Gusti Yulimdra; Dewi Anggraini; Fauzia Andrini Djojosugito
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1603

Abstract

Background: The development of a broadly protective dengue virus (DENV) vaccine remains a paramount global health priority. Current tetravalent vaccines target the four DENV serotypes. However, intra-serotypic genetic variations, defined as genotypes, present a neglected immunological barrier. Evidence indicates that genotypic divergence critically impairs cross-neutralizing antibody responses, leaving vaccinated individuals vulnerable to circulating heterologous genotypes and severe antibody-dependent enhancement (ADE). This meta-analysis quantifies the impact of DENV genotypic variation on neutralizing antibody efficacy. Methods: A systematic review and meta-analysis adhering to PRISMA guidelines were conducted. Quantitative virological data were extracted from primary studies, focusing on neutralizing antibody titers against homologous versus heterologous DENV genotypes. A DerSimonian-Laird random-effects model calculated the pooled Standardized Mean Difference (SMD) and 95% Confidence Intervals (CI). Heterogeneity was addressed through subgroup analyses (by serotype and host species). A sensitivity analysis employing the Hartung-Knapp-Sidik-Jonkman (HKSJ) adjustment verified robustness. Risk of bias was evaluated utilizing RoB 2 and SYRCLE tools. Results: Ten controlled studies met the inclusion criteria. The pooled analysis revealed a severe, statistically significant reduction in neutralization capacity against heterologous genotypes compared to homologous strains, yielding an overall SMD of -1.52 (95% CI: -1.95 to -1.09, p < 0.001). High initial heterogeneity (I2 = 84.1%) was partially resolved by stratifying by serotype; the DENV-2 subgroup demonstrated the most profound neutralization deficit (SMD = -1.78, I2 = 42.5%). Sensitivity analyses confirmed the stability of the pooled effect. Conclusion: Vaccine-induced neutralizing responses are significantly attenuated against heterologous DENV genotypes. The prevailing serotype-level vaccine paradigm is insufficient for comprehensive global immunity. Next-generation vaccine designs must incorporate conserved, pan-genotypic epitopes to prevent intra-serotypic immune evasion and subsequent ADE-mediated severe disease.
Co-Authors Adrianison Adrianison Afladhanti, Putri M. Aisyah Elliyanti Amalia, Aisyah Sabrina Atya Nasmah Bet, Anwar Citra Ayu Anggreli Daenansya, Raehan Dani Rosdiana Dedi Satriya Putra Dina Fauzia Dino Irawan Effendi, Dasril Eka Zulya Syahputri Ekky Wibisono Erwin Christianto Erwin Christianto Fadhia Alya Putri Fani, Rifia Tiara Farah Mardhiyah Fauzia Andrini Fauzia Andrini Djojosugito Galuh Tiara Akbar Gusti Yulindra, Utari Hanifah, Zulfa N. hanifah, zulfa nur Hawa Gebriella Hidayat, Nopian INDRA YOVI Insan Fitriyani Jazil Karimi Karina " Karina Karina Kasih, Rani Rindang Marlina Tasril Maya Savira Muhamad Afham Muhammad Ihsan Mukhyarjon Nafisa Khansa Luthfiyah Namira, Syafira Nihla Naufal Mulia Muharram Nazardi Oyong Nazardi Oyong Nori Purnama Nur Afrainin Syah Nurfadila Nurfi Pratiwi, Nurfi Nurul Mawaddah Pratiwi, Adelia Putri, Frilianty Putri, Yolanda Julia Perel Rachmaliza Rachmaliza Ridha Restila Rika Wandari Rita Endriani Riza Yefri Riza Yefri, Riza Rosantia Sarassari Ruza Prima Rustam, Ruza Prima Sabella Gustika Vernanda Safari, Dodi Saukhan, Ghiandra NS Shapira, Vanesya Zahrani Sholihin, Uswathun Hasanah Simanjuntak, Arya M. Simatupang, Elvando Tunggul Mauliate Siska Alya Adha Siti Nurkasanah Sony " Sri Indah Indriani Sri Utari Masyitah Sundari Sundari Suprayoga, Tito Suyanto Suyanto Syah, Nur A. Syahputri, Eka Zulya Syam, Shaogi Talitha Salwa Adriya Triani, Zhana Daisya Tuti Restuastuti Utari Gusti Yulimdra Venty Rahman Wahyu Agung Prasetyo Wardana, Rexi Dwi Wijaya, Dewi Yuana Nurulita Zafran Nopala Armindra