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All Journal Journal of Nutrition and Health JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research The Indonesian Biomedical Journal Media Medika Muda Journal of Dedicators Community Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Pengabdian Masyarakat Multidisiplin Diponegoro International Medical Journal (DIMJ)
Meita Hendrianingtyas
Doctoral Program Of Medical And Health Science, Faculty Of Medicine, Universitas Diponegoro Department Of Clinical Pathology, Faculty Of Medicine, Universitas Diponegoro
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Anthropometric Measurements and Inflammatory Marker in Obese Women Kartika Rizky Aulia; Meita Hendrianingtyas; Edward Kurnia Setiawan Limijadi; Dodik Pramono
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 10, No 2 (2022): Juni
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.10.2.88-94

Abstract

Background: Obesity is one of global epidemic health problems and its prevalence is higher among women. Obesity can cause low grade chronic inflammation mechanism in adipose tissue, which is characterized by the increase of proinflammatory cytokines and adipokines. Neutrophil lymphocyte ratio (NLR) is a simple inflammatory marker which can be reliable in evaluating the inflammatory status occurring in obese women. Waist to height ratio (WHtR) and waist to hip ratio (WHR) are anthropometric measurements, have been reported to be associated with obesity and risk of metabolic syndrome.Objective: This study aimed to determine the correlation of WHtR and WHR with NLR in population of obese women.Materials and Methods: This was a cross sectional study enrolling 80 obese women with Body mass index (BMI) > 27 aged 30 - 50 years in National Diponegoro Hospital Semarang, Indonesia. WHtR was determined by dividing waist circumference by height and WHR was determined by dividing waist circumference by hip circumference. NLR was examined manually from automatic hematology analyzer by dividing absolute neutrophil count (ANC) and absolute lymphocyte count (ALC). Spearman correlation test was performed, p<0.05 was considered as statistically significant.Results: There was significant weak positive correlation between WHtR and NLR in obese women (p = 0,046; r = 0,224). There was no significant correlation between WHR and NLR in obese women (p = 0,961; r = 0,006).Conclusion: The present study showed that WHtR is one of better anthropometric measurement because it is associate with NLR as a simple marker of inflammation in obese women. 
Parathyroid Hormone-25(OH)D and Calcium-Phosphorus Ratio as Osteopenia Risk Factors in Women with Central Obesity Meita Hendrianingtyas; Banundari Rachmawati; Ignatius Riwanto; Budi Mulyono; Suhartono Suhartono; Tri Indah Winarni; Lisyani Budipardigdo Suromo
The Indonesian Biomedical Journal Vol 14, No 2 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i2.1816

Abstract

BACKGROUND: Central obesity has a close association with inflammation and the state of bone mass. Osteopenia is an abnormal condition of bone density. Bone mass density is influenced by several factors, such as 25(OH)D, parathyroid hormone (PTH), calcium (Ca) and phosphorus (P). The aim of this study was to evaluate the role of PTH-25(OH)D and Ca-P ratio as risk factors for osteopenia in women with central obesity.METHODS: A cross-sectional study was conducted in September 2020 to March 2021. The total subjects were 130 women aged 25-50 years old with central obesity. The diagnosis of osteopenia was done using dual X-ray absorptiometry (DXA) to measure bone mineral density. Enzyme linked fluorescent assay (ELFA) method was done to measure PTH and 25(OH)D levels, ion selective electrode method to measure Ca, and photometer method to measure P level. The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value and calculated prevalence ratio (PR) for osteopenia risks, followed by logistic regression analysis.RESULTS: The PR of PTH level was 10.18 (95% CI: 1.15–5.85; p=0.01); the PTH-25(OH)D ratio was 5.12 (95% CI: 1.13–23.19; p=0.04); Ca level was 6.0 (95% CI: 1.33–27.14; p=0.02) and Ca-P ratio was 4.89 (95%CI: 1.33–17.97; p=0.02). The PR for PTH together with Ca level was 18.71 (95% CI: 2.17–160.40; p=0.008).CONCLUSION: The PTH-25(OH)D ratio and the Ca-P ratio are risk factors for the incidence of osteopenia in women with central obesity. A high PTH-25(OH)D ratio and a high Ca-P ratio would have a higher risk of developing osteopenia in this population.KEYWORDS: CRP, PTH-25(OH)D, Ca-P, osteopenia, central obesity, women
Relationship between Body Anthropometric Measurement and Parathyroid Hormone in Female Subjects Mabruratussania Maherdika; Meita Hendrianingtyas
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1796

Abstract

The distribution of fat tissue is related to the risk of metabolic diseases. Parathyroid Hormone (PTH) is an essential hormone for calcium homeostasis. According to several types of research, body fat affects PTH levels. Currently, Body Mass Index (BMI) is not the only parameter needed to identify the body fat distribution in accordance with chronic disease risks such as Waist Circumference (WC), Waist to Hip Ratio (WHR), and Waist to Height Ratio (WHtR). The study aimed to determine the relationship between body anthropometric measurement and PTH. A cross-sectional study was performed on a healthy population of 75 healthy female volunteers with a BMI ≥ 23 kg/m2. Waist circumference, WHR, WHtR, and BMI measurements were carried out and followed by the PTH fragment 1-84 (PTH1-84) test. Data were analyzed using the Spearman test with a significance of p<005. There was no significant correlation between PTH and WHR (r=0.057; p=0.628). There was weak correlation between PTH and BMI (r=0.268; p=0.020), WC (r=0.287; p=0.012) and WHtR (r=0.238; p=0.04). Body mass index, WC, and WHtR can be used as anthropometric parameters to determine PTH disorders
Correlation between Inflammatory Markers of Platelet Index and Vitamin D with Body Mass Index Grace Yuni Harviendo; Ariosta Ariosta; Meita Hendrianingtyas
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1816

Abstract

Weight loss is more of a worldwide health problem and a risk factor for chronic disease. The decrease in serum vitamin D levels in body weight leads to more low grade inflammation. This study aims to determine the relationship between the platelet index, namely MPV, P-LCR as a marker of inflammation and vitamin D with body mass index (BMI). This study was a cross-sectional study of 78 women at the Diponegoro National Hospital with overweight (BMI> 23) in July - September 2020. Data analysis was done using Pearson and Spearman tests and significant if p <0.05. Of the 78 research samples, there was a significant relationship between BMI and MPV (r = 0.404; p = 0.000); P-LCR (r = 0.425; p = 0.000) and 25 (OH) D (r = -0.231; p = 0.04). Low vitamin D levels in obesity and low-grade inflammation increase pro-inflammatory cytokines. Increased leptin levels in obesity contribute to platelet hyperreactivity. Increased platelet activity compensates for the platelets so that the MPV and P-CLR values increase. There is a moderate significant positive relationship between MPV, P-CLR and BMI and a weak significant negative relationship between 25 (OH) D and BMI.
Pengaruh Ekstrak Daun Wungu Terhadap Luas Islet Pankreas Tikus Wistar Diabetes Melitus Excelinda, Tifanni; Istiadi, Hermawan; Retnoningrum, Dwi; Hendrianingtyas, Meita
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (355.873 KB) | DOI: 10.36408/mhjcm.v8i1.492

Abstract

Latar Belakang : Diabetes melitus merupakan kumpulan gejala gangguan metabolik dengan prevalensi penyandang yang masih terus meningkat. Faktor lingkungan, gaya hidup, maupun genetik dapat menyebabkan kerusakan sel pankreas maupun resistensi insulin yang kemudian bermanifestasi sebagai diabetes melitus. Daun wungu (Graphytophyllum pictum (L.) Griff) mengandung metabolit aktif seperti flavonoid yang merupakan antioksidan untuk mencegah destruksi dan meregenerasi sel pankreas penderita diabetes melitus. Tujuan : Membuktikan adanya perbedaan ukuran luas islet pankreas tikus Wistar diabetes melitus yang mendapatkan ekstrak daun wungu (Graphtophyllum pictum (L.) Griff) setelah perlakuan dengan kontrol. Metode : Penelitian true experimental dengan menggunakan desain Post-Test Only Control Group Design. Sampel 24 ekor tikus Wistar jantan dengan kriteria tertentu dibagi secara acak menjadi 4 kelompok. Kontrol negatif (K-1) diberikan aloksan dan kelompok perlakuan 1 (K-2), perlakuan 2 (K-3), dan perlakuan 3 (K-4) masing-masing diberikan aloksan dan ekstrak daun wungu 50 mg/kgBB, 100 mg/kgBB, dan 200 mg/kgBB. Glukosa darah diperiksa pada hari ke-4 untuk memastikan tikus sudah diabetes melitus dan dilanjutkan perlakuan selama 14 hari. Terminasi dan pengambilan organ dilakukan pada hari ke-15. Data berupa luas islet pankreas kemudian dianalisis menggunakan uji Kruskal-Wallis dan uji Mann-Whitney. Hasil: Berdasarkan uji Kruskal-Wallis didapatkan perbedaan luas islet pankreas yang bermakna (p = 0,000) antar kelompok. Pada uji Mann-Whitney didapatkan peningkatan luas islet pankreas yang signifikan (p = 0,000) pada seluruh kelompok perlakuan terhadap kontrol negatif. Rerata luas islet pankreas berbanding lurus dengan peningkatan dosis pemberian ekstrak daun wungu. Kesimpulan : Terdapat perbedaan ukuran luas islet pankreas yang signifikan pada seluruh kelompok perlakuan terhadap kontrol negatif. Kata Kunci : Daun wungu; luas islet pankreas; diabetes melitus
Pengaruh Ekstrak Daun Wungu Terhadap Kadar Malondialdehid Darah Pada Tikus Diabetes Militus Elnitiarta, Jasmine; Istiadi, Hermawan; Hendrianingtyas, Meita; Retnoningrum, Dwi
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.426 KB) | DOI: 10.36408/mhjcm.v8i2.494

Abstract

Latar Belakang: Diabetes melitus (DM) merupakan penyakit kronik dengan gejala glukosa darah yang tinggi (hyperglycaemia) dimana terjadi peningkatan biomarker stress oksidatif yaitu MDA. Daun wungu (Graptophyllum pictum (L.) Griff) memiliki alkaloid dan flavonoid yang bersifat antioksidan untuk mengurangi radikal bebas.Tujuan: Mengetahui pengaruh ekstrak daun wungu (Graptophyllum pictum (L.) Griff) terhadap kadar malondialdehid darah pada tikus Wistar yang diinduksi aloksan.Metode: Desain percobaan menggunakan post-test only control group design. Penelitian ini menggunakan tikus wistar jantan sebanyak 24 ekor yang dibagi menjadi 6 tikus setiap kelompok. Kelompok kontrol negatif diberikan aloksan, kelompok perlakuan 1, kelompok perlakuan 2, dan kelompok perlakuan 3 diberikan ekstrak daun wungu dengan dosis 50, 100 dan 200 mg/kgBB peroral kemudian kadar glukosa darah diperiksa untuk memastikan bahwa tikus sudah diabetes melitus. Setelah tikus diabetes melitus, dilakukan tindakan tiap kelompok. Pada hari ke-14 tikus diambil data kadar malondialdehid darahnya. Data diuji dengan uji normalitas Saphiro-Wilk. Pada penelitian ini data terdistribusi normal (p>0.05) sehingga dilakukan uji ANOVA kemudian dilakukan uji post-hoc. Hasil: Didapatkan penurunan kadar MDA darah pada tikus yang diberikan daun wungu. Hasil signifikan didapatkan antara kelompok perlakuan 3 dengan kelompok kontrol negatif dan kelompok perlakuan lainnya. Kesimpulan: Daun wungu dengan berbagai dosis dapat menurunkan kadar malondialdehid darah pada tikus DM.
Visceral Adiposity Index and Insulin Resistance in Diabetes Mellitus Type 2 Hendrianingtyas, Meita; Pradati, Subandhini Arika
Journal of Biomedicine and Translational Research Vol 10, No 3 (2024): December 2024
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v10i3.23505

Abstract

Background: Diabetes mellitus (DM) has been increasing worldwide. Obesity, especially central obesity, is a sign of increased visceral fat in various diseases, especially DM. Individuals with visceral fat compromise insulin resistance and metabolic disorders and develop diabetes. The gold standard for assessing insulin resistance is the hyperinsulinemic-euglycemic clamp (HEC). However, this method is invasive and expensive, so the homeostasis model assessment-insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI) are more straightforward, more practical, and invasive measurement methods. Visceral adiposity index (VAI) was developed as a new indicator of visceral adipose tissue dysfunction that can be used for CT examination as a marker of visceral adiposity.Objective: To determine the correlation between visceral adiposity index and insulin resistance in patients with type 2 diabetes mellitusMethods: The study was conducted as an analytical observational study using a cross-sectional design approach at the Diponegoro National Hospital Semarang from March to April 2022. Data analysis using the Pearson test (meaningful if p < 0.05)Results: From the 70 samples examined, there was a correlation between VAI and HOMA-IR (r=0,480; p=<0,001), VAI and QUICKI (r=-0,475; p=<0,001), and a strong correlation between HOMA-IR and QUICKI (r=-0,892; p=<0,001)Conclusion: There was a moderate positive correlation between VAI and HOMA-IR and a moderate negative correlation between VAI and QUICKI. Meanwhile, the results of the correlation test between HOMA-IR and QUICKI show that there is a robust negative correlation. 
Diagnostic Value of Osteopontin, Lymphocyte-to-Monocyte Ratio, and CA-125 in Ovarian Carcinoma Suspect Surohadi, Natra D.; Triwardhani, Ria; Kustarini, Indranila; Hendrianingtyas, Meita; Rachmawati, Banundari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 1 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i1.2238

Abstract

Osteopontin (OPN) is an important protein in cancer development and progressivity. Lymphocyte-to-Monocyte Ratio (LMR) as a systemic immunity and inflammatory indicator could be an ideal predictor biomarker because of its method’s simplicity and availability. Elevated CA-125 and OPN as well as decreased LMR were reported as signs of ovarian malignancy. Limited studies about OPN and LMR as diagnostic biomarkers, as well as various specificity and sensitivity of CA-125 intrigued the researcher to prove OPN, LMR, and CA-125 as diagnostic biomarkers for ovarian carcinoma. This study aimed to measure the diagnostic value of OPN, LMR, and CA-125 levels against histopathology results for ovarian carcinoma diagnosis. Eighty patients involved with suspected ovarian carcinoma who were referred to Dr. Kariadi Hospital, Semarang. Osteopontin and CA-125 levels were measured using ELISA, and LMR was calculated from absolute lymphocyte and monocyte counts using an automated hematology analyzer. The receiver operating characteristics curve was used to determine the cut-off and 2x2 table. The cut-off values for OPN, LMR, and CA-125 were 124 ng/mL, 3.7 and 45.4 U/mL, respectively. The sensitivity for OPN, LMR, and CA-125 was 67.24%, 62.07% and 60.34%. Specificity for OPN, LMR, and CA-125 were 68.18%, 54.55% and 59.09%. Osteopontin is the best parameter for determining the diagnosis of ovarian carcinoma but it is still not sufficient because OPN cut-off was still within the normal reference value.
Down Syndrome Combined with Robertsonian Translocation (13;14) Carrier Lestari, Esa Loyallita; Utari, Agustini; Winarni, Tri Indah; Hendrianingtyas, Meita
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2205

Abstract

Down Syndrome (DS) is a genetic disorder in the form of adding chromosome 21 due to abnormal cell division. This condition causes a distinctive physical appearance and intellectual impairment. The prevalence of DS is between 10-11 out of 10,000 live births worldwide. A 2-week-old baby presented with complaints of jaundice with the clinical picture of DS. There was a mild increase in fT4 levels, and TSH levels were still within the reference value range. Karyotype examination showed Robertsonian translocation of chromosomes 13 and 14 and several abnormalities, namely trisomy 21.
Difference of thrombocyte profile between obesity and central obesity in women Hadisasmitajaya, Melki; Hendrianingtyas, Meita; Limijadi, Edward Kurnia Setiawan
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 12, No 1 (2023): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.12.1.21-30

Abstract

Background: Obesity considered as a low-grade inflammation. Increased body fat has known to trigger inflammation. Platelet profile is a number of platelet-related parameters that can predict inflammation consisting of: platelet count (PLT), Platelet Larger Cell Ratio (P-LCR), Mean Platelet Volume (MPV). Differences in platelet profiles (PLT, P-LCR, MPV) in women with and without central obesity have only been investigated in a few studies.Objective: To prove differences in platelet profiles in women with and without central obesity.Materials and Methods: A cross-sectional observational study was conducted on 88 women with and without central obesity in RSND during July-September 2021. Data included age, abdominal circumference, hip circumference, PLT, P-LCR, and MPV. PLT, P-LCR, and MPV were measured using Sysmex XS-500i instrument. Statistical analysis was using Mann-Whitney test.Results: Mean of women PLT with and without central obesity were 338.72±71.09x103/uL and 309.09±44.36x103/uL. Difference platelet levels in women with and without central obesity was p=0.022. Median MPV of women with and without central obesity were 10.5 (8.5-11.8)fL and 9.7 (8.5-11.6)fL. Difference MPV values in women with and without central obesity was p=0.000. Median P-LCR of women with and without central obesity were 28.2 (12.3-44.3)% and 21.5 (15.2-37.1)%, respectively. Difference P-LCR value in women with and without central obesity was p=0.002.Conclusion: Platelet profiles (PLT, MPV, P-LCR) can be used as a marker of chronic low-grade inflammation in women with central obesity.Keywords : central obesity; MPV; PLT; P-LCR
Co-Authors Agustini Utari Ainun Nida Dusturia Ajeng Kurnia Wardhani Ardhea Jaludamascena Ariosta Ariosta Aryu Candra Azka Hukmu Irsyada Banundari Rachmawati Budi Mulyono Buwono Puruhito Daniel Yoga Kurniawan Dian Widyaningrum Djuara P Lubis Dodik Pramono Dwi Retnoningrum Edward Kurnia Setiawan Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Eirin Yovita Kurniawan Elnitiarta, Jasmine Emi Setianingsih Erna Setiawati Erna Setiawati Esya Adetia Tanderi Evelyn Meiliani Panji Putri Excelinda, Tifanni Febby Valencia Andreani Fitrianita Reghita Syari Frederica Vania Agustina Hutahaen Grace Yuni Harviendo Hadisasmitajaya, Melki Hermawan Istiadi Hermawan Istiadi Ignatius Riwanto, Ignatius Indranila Kustarini Samsuria Kartika Rizky Aulia Lestari, Esa Loyallita Lisyani B.Suromo Lisyani Budipardigdo Suromo Mabruratussania Maherdika Mabruratussania Maherdika Maharani Maharani Maria Belladonna MARTHA ARDIARIA Matthew Brian Khrisna MI. Tjahjati DM Muhammad Nurul Amin Muhammad Thifan Satyagraha Muji Rahayu Nani Maharani Nyoman Suci Widyastiti Pradati, Subandhini Arika Rahmi Isma Asmara Putri Rebriarina Hapsari Retnoningrum, Dwi Ria Triwardhani Riski Prihatningtias Riyan Riyan S, Kristiani Samsuria, Indranila K Suhartono, Suhartono Surohadi, Natra D. Tanti Ajoe Kesoema Tanti Ajoe Kusuma Theresia Ilyan Tri Indah Winarni Triwardhani, Ria Veronica Prawira Yetty Movieta Nency