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All Journal JURNAL GIZI INDONESIA International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication Indonesian Journal of Cancer Jurnal Sistem Kesehatan Universa Medicina JNKI (Jurnal Ners dan Kebidanan Indonesia) (Indonesian Journal of Nursing and Midwifery) Indonesian Journal of Obstetrics & Gynecology Science JURNAL KESEHATAN PERINTIS Jurnal Kesehatan Jurnal Medikes (Media Informasi Kesehatan) Indonesian Trust Health Journal Indonesian Journal of Cancer Media Dermato-Venereologica Indonesiana Indonesian Trust Health Journal
Yudi Mulyana Hidayat
Department Of Obstetrics And Gynecology, Division Of Oncology, Faculty Of Medicine, Universitas Padjadjaran/ Dr. Hasan Sadikin General Hospital Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Hubungan antara Ekspresi mRNA Gen Epidermal Growth Factor Receptor (EGFR) dengan Penurunan Kadar β-hCG Serum Pasca-evakuasi Mola Hidatidosa Komplit PAULUS, LAURENS DAVID; HIDAYAT, YUDI MULYANA; GANDAMIHARJA, SUPRIADI
Indonesian Journal of Cancer Vol 9, No 3 (2015): Jul - Sept 2015
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (654.467 KB)

Abstract

In 2008, the incidence of hydatidiform mole that occurred in West Java around 1:28. Malignant transformation of Complete Hydatidiform Mole (CHM) is influenced by many factors, among others, is the expression of the epidermal growth factor receptor (EGFR). This study uses Historical Cohort to retrieve CHM patients data and trophoblastic tissue paraffin block in 2007-2012, and perform examination of Polymerase chain reaction.Results of the study: 40 CHM patients, 24 with EGFR (-) and 16 with EGFR (+), at 12 weeks monitoring post evacuation using the Mochizuki regression curve was not obtained persistent mole in the group with EGFR (-), while the group of EGFR (+), all showed an increase in β-hCG levels. Relative risk (RR) of 3.4 in the CHM group with EGFR (+) into a persistent mole compared with EGFR (-) at 6th week and RR of 13.0 in CHM group with EGFR (+) into a persistent mole compared with EGFR (-) at 8th week. The conclusion of this study demonstrate the suitability of the hypothesis that the higher mRNA gene expression of EGFR, the slower decrease in serum levels of β-hCG after CHM evacuation and expression EGFR (+) may be a predictor of the occurrence of persistent mole. Pada 2008, insiden mola hidatidosa (MH) yang terjadi di Jawa Barat sekitar 1:28. Transformasi keganasan dari mola hidatidosa komplit (MHK) dipengaruhi oleh banyak faktor, antara lain ekspresi Epidermal Growth Factor Receptor (EGFR). Penelitian ini menggunakan metode historical cohort dengan mengambil data dan parafin block jaringan trofoblas pasien MHK tahun 2007−2012, dan dilakukan pemeriksaan POLYMERASE CHAIN REACTion. Hasil penelitian menunjukkan dari 40 pasien MHK, 24 di antaranya EGFR (-) dan 16 EGFR (+) pada 12 minggu pascaevakuasi menggunakan kurva regresi Mochizuki. Tidak didapatkan mola persisten pada kelompok EGFR (-), sedangkan kelompok EGFR (+) semuanya menunjukkan peningkatan β-hCG (mola persisten). Risiko relatif (RR) sebesar 3,4 pada EGFR (+) menjadi mola persisten dibandingkan dengan EGFR (-) pada minggu ke-6 dan RR sebesar 13,0 pada EGFR (+) menjadi mola persisten dibandingkan dengan EGFR (-) pada minggu ke-8. Hasil penelitian ini menunjukkan kesesuaian dengan hipotesis bahwa semakin tinggi ekspresi EGFR maka semakin lambat penurunan kadar β-hCG serum pasca-evakuasi MHK. Ekspresi EGFR dapat menjadi prediktor terjadinya mola persisten.
Hubungan antara Karakteristik Klinis Pasien Mola Hidatidosa dengan Performa Reproduksi Pascaevakuasi di Rumah Sakit Hasan Sadikin Bandung Harjito, Vanessa Natasha; Hidayat, Yudi Mulyana; Amelia, Indah
Jurnal Sistem Kesehatan Vol 3, No 1 (2017): Volume 3 Nomor 1 September 2017
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (292.166 KB) | DOI: 10.24198/jsk.v3i1.13958

Abstract

Pada penderita mola hidatidosa terdapat beberapa karakteristik klinis yang dapat memengaruhi performa reproduksi, yaitu gambaran histopatologi proliferasi berlebih, besar uterus≥20minggu, kadarβ–hCG>100.000mIU/mL, dan kista lutein praevakuasi.Banyak penderita mola hidatidosa merasa khawatir kondisinya dapat memengaruhi fungsi reproduksinya di kemudian hari.Penelitian ini bertujuan untuk mengetahui hubungan antara karakteristik klinis pasien mola hidatidosa dengan luaran kehamilan pascaevakuasi di Rumah Sakit Hasan Sadikin Bandung. Penelitan analitik komparatif ini menggunakan desain kohort retrospektif. Subjek penelitian adalah penderita mola hidatidosa di Rumah Sakit Hasan Sadikin Bandung pada periode 1 Januari 2010-31 Desember 2015 yang memenuhi kriteria penerimaan penelitian. Penelitian mencari hubungan antara variabel karakteristik klinis risiko tinggi (gambaran histopatologi proliferasi berlebih, besar uterus, kista lutein, dan kadar β-hCG) dengan variabel luaran kehamilan pascaevakuasi. Analisis data menggunakan uji Eksak Fisher dengan interval kepercayaan 95%.Subjek penelitian berjumlah 51orang, terdapat 28orang berkarakteristik klinis risiko tinggi. Hasil penelitian menunjukkan karakteristik klinis dan luaran kehamilan pada tipe mola komplit dan mola parsial tidak memiliki perbedaan signifikan(p>0,05). Tidak terdapat hubungan yang signifikan antara gambaran histopatologi proliferasi berlebih, besar uterus, kista lutein, dan kadar β-hCG dengan luaran kehamilan pascaevakuasi(p>0,05). Penelitian ini menyimpulkan tidak terdapat hubungan antara karakteristik klinis pasien mola hidatidosa dengan performa reproduksi pascaevakuasi di Rumah Sakit Hasan Sadikin Bandung.Kata kunci: karakteristik klinis risiko rendah, karakteristik klinis risiko tinggi, luaran kehamilan, mola hidatidosa
Hubungan Kadar βHCG Praevakuasi, Gambaran Histopatologi, dan Kista Lutein dengan Performa βHCG pada Penderita Mola Hidatidosa yang Berkembang Menjadi PTG dan Kembali Normal Hidayat, Yudi Mulyana; Gandamihardja, Supriadi; Krisnadi, Sofie Rifayani
Majalah Kedokteran Bandung Vol 46, No 4 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Insidensi penyakit trofoblas di Indonesia maupun negara berkembang masih cukup tinggi dibandingkan dengan negara maju. Hal yang perlu diwaspadai adalah terjadinya penyakit trofoblast gestasional (PTG) pascaevakuasi mola hidatidosa berkisar 10-20%. Beberapa variabel klinis telah diteliti sebagai variabel faktor risiko keganasan seperti kadar β-human chorionic gonadotropin (βHCG) praevakuasi, gambaran histopatologi, dan terdapat kista lutein. Tujuan penelitian ini adalah mengetahui hubungan kadar βHCG praevakuasi, gambaran histopatologi dan kista lutein dengan performa penurunan βHCG pada penderita mola. Metode penelitian yang digunakan adalah case control study pada penderita mola hidatidosa komplet di Rumah Sakit Dr. Hasan Sadikin Bandung selama periode tahun 2007-2011. Hasil penelitian menunjukkan hubungan bermakna kadar βHCG ≥100.000 mIU/mL dengan keganasan pascamola (p<0,05), terdapat hubungan bermakna gambaran histopatologi proliferasi berlebih dengan keganasan pascamola (p<0,05), dan terdapat hubungan bermakna kista lutein positif dengan keganasan pascamola (p<0,05). Simpulan penelitian ini adalah variabel kadar βHCG praevakuasi ≥100.000 mIU/mL, gambaran histopatologi proliferasi berlebih, dan kista lutein positif memiliki korelasi dengan keganasan pascaevakuasi mola. Variabel faktor risiko tersebut  dapat digunakan untuk memilahkan penderita mola hidatidosa komplet risiko tinggi atau risiko rendah untuk kejadian keganasan dan variabel faktor risiko keganasan tersebut berpengaruh pada performa penurunan kurva regresi βHCG.Kata kunci: Gambaran histopatologi, kadar βHCG, kista lutein, mola hidatidosa komplit, PTGRelationship between Pre-Evacuation βHCG Level, Histopathologycal View, Lutein Cysts and βHCG Performance in Patients with Hydatidiform Mole which Developed into Gestational Trophoblastic Disease (GTD) and Back to NormalAbstractThe incidence of trophoblastic diseases in Indonesia and developing countries is relatively high compared to the developed countries. The incidence of gestational trophoblast tumors (GTT) after the evacuation of a hydatidiform mole ranges from 10% to 20%. Several clinical variables have been studied as the risk factors for malignancy, including the pre-evacuation level of beta human chorionic gonadotropin (βHCG), histopathological appearance, and the presence of lutein cysts. The purpose of this study was to determine the relationship between βHCG decline and pre-evacuation βHCG levels, histopathological features, and the lutein cysts status in patients with moles. This study was a case control study of patients with complete hydatidiform mole in Dr. Hasan Sadikin General Hospital during the period of 2007-2011. The results revealed that there was a significant correlation between the level of βHCG ≥100,000 mIU/mL and post-molar malignancy (p<0.05). There was also a significant relationship between the histopathologic feature of excessive post-molar cell proliferation and malignancy (p<0.05) and between the presence of lutein cyst and post-molar malignancy (p<0.05). This study concludes that the pre-evacuation βHCG level ≥100.000 mIU/mL, excessive proliferation, and the presence of lutein cysts are correlated with malignancy after molar evacuation. These risk factors are useful to differentiate whether a complete hydatidiform mole will become malignant or remain benign.Key words: Beta human chorionic gonadotropin levels, histopathologic features, lutein cysts, complete hydatidiform mole, gestational trophoblast tumors DOI: 10.15395/mkb.v46n4.345
Hubungan antara total asupan energi dan komponen makrontrien dengan penambahan berat badan ibu hamil di Kecamatan Pedurungan Kota Semarang Astuti, Yuli; Hidayat, Yudi Mulyana; Rohmawati, Enny
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 9, No 1 (2020)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.9.1.33-41

Abstract

Background: Gestational weight gain (GWG) is physiological change in pregnancy. Inadequate gestational weight gain (IGWG) and excessive gestational weight gain (EGWG) can pose a risk of complication such as gestational hypertention, low birth weight, giant baby, and premature birth. Food intake (energy and macronutrient) play important role in providing pregnancy needs such as fetal and placental growth, and also play role in fat accumulation in some part of mother’s body. Objectives: This study aims to analyze the relationship between energy intake and macronutrient and gestational weight gain of pregnant woman and to know the consumption of food groups.Methods: This study was quantitative study using cohort prospective approach. 73 healthy pregnant women with normal body fat mass who met inclusion and exclusion criteria was weighed twice in a period of 8 weeks. 24 hours food recall in 2 unsecutive days was done between those times. The instruments used for this study were weight scale, stadiometer, and questionnaire. Nutritional analysis used Nutrisurvey and statistic analysis used Chi Square test.Result: There was a relationship between total energy intake and gestational weight gain ( p = 0.031) and there was no relationship between macronutrient component intake (carbohydrate, fat, and protein) and gestational weight gain (p = 0.175, p = 0.97, and p = 0.089 respectively). Respondent characteristic that has corelation with GWG is number of pregnancy. Most pregnant woman experienced EGWG (56.2%) and their food consumption not fulfilled the balance nutrient recommendation guidelines especially less in vegetables and fruits consumption.Conclusion:There is a significant corelation between energy intake and GWG.
Response to Chemotherapy in Patients with Gestational Trophoblastic Neoplasia in A Tertiary Hospital in Indonesia Farisa Raudina; Yudi Mulyana Hidayat; Sylvia Rachmayati
Althea Medical Journal Vol 7, No 3 (2020)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v7n3.1894

Abstract

Background: The incidence of gestational trophoblastic neoplasia (GTN) is high in Indonesia. Based on the FIGO prognostic score, GTN is classified into low-risk and high-risk categories. The high-risk group requires multidrug chemotherapy whereas the low-risk group requires single-drug chemotherapy. Response to chemotherapy would reflect the remission rate. The aim of this study was to describe the response to chemotherapy in GTN patientsMethods: This was a cross-sectional descriptive retrospective study on medical records of patients with GTN treated in Dr. Hasan Sadikin General Hospital during the period of 2016 to 2018. The inclusion criteria were GTN patients who received > 3 cycles of chemotherapy while the exclusion criteria were incomplete, inaccessible, or missing data. Data were collected on patient’s age, parity, history of previous pregnancy, pregnancy-therapy interval, tumor size, number and location of metastases, and history of failed chemotherapy.Results: Of the189 medical records of the GTN patient collected, only 88 met the inclusion criteria, (63.6% low risk and 36.4% high risk). Most patients were responsive to chemotherapy (61.4%), aged<40 years old, multiparity, tumor size >5 cm, had 4 month interval from previous pregnancy <4 months, had a history of molar pregnancy, had no metastases, and no previous failed chemotherapy.Conclusion: The chemotherapy response in gestational trophoblastic neoplasm patients is fairly good with most patients are in the low-risk groups. Specific tumor markers used in early diagnosis of GTN may play a major role.
ANALISIS PERAN FAKTOR PENYEBAB KEMATIAN MATERNAL YANG DAPAT DICEGAH TERHADAP KETERLAMBATAN RUJUKAN DAN PENANGANAN DI KABUPATEN KARAWANG PROVINSI JAWA BARAT Jasmi ati; Firman F Wirakusumah; Hadyana Sukandar; Farid Husin; Yudi Mulyana Hidayat; Unggul Yudatmo
Indonesian Trust Health Journal Vol 2 No 2 (2019): Indonesian Trust Health Journal
Publisher : STIKes Murni Teguh

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (608.472 KB) | DOI: 10.37104/ithj.v2i2.38

Abstract

Maternal mortality rate is an important indicator of public health quality. Most of the causes of maternal mortality are preventable factors such as patients, health workers, health facilities and referral. The purpose of this study was to analyze of the role of factors maternal mortality could have been prevented to delays in referral and treatment. This is a sequential explanatory mixed method research. The first stage is carried out through quantitative cross sectional study with data capture as much as 65 maternal mortality could have been prevented retrieved from 2015’s Maternal Perinatal Audit (AMP) documents in Karawang Regency. The second stage is through qualitative approach with Focused Group Discussion (FGD) and in-depth interviews.The results of quantitative research shows that the majority (52 cases or 80,0%) of maternal mortality could have been prevented with delays in referral and treatment and there is a significant role of patient factors, health workers, health facilities with delays in referral and treatment while the referral factor does not have a significant role. Qualitative research results indicate that maternal mortality is caused by patient factors such as mother’s attitude toward risk, delayed and/or refusing treatment; factors of health workers due to lack of early detection, poor quality of service, lack of skilled professionals and late treatment; health facilities factors due to poor facility; referral factors such as referral refusal, referral inaccuracies and referral delays due to patient’s financial factor and team coordination and cross-sectoral cooperation is also contributing factors. The failure of early detection and decision-making due to lack of capacity of health personnel to recognize and capture high-risk cases and failure to effectively provide information, education and communication (KIE) are factors that cause delays in referral and treatment. Therefore, active participation of society, stakeholders, health professionals and policy makers are required to improve the quality of obstetric care to reduce maternal mortality. Abstrak Kematian maternal menjadi indikator penting derajat kesehatan masyarakat. Sebagian besar penyebab kematian maternal dapat dicegah meliputi faktor pasien, tenaga kesehatan, fasilitas kesehatan dan rujukan. Tujuan penelitian ini adalah menganalisis peran faktor penyebab kematian maternal yang dapat dicegah terhadap keterlambatan rujukan dan penanganan. Desain penelitian menggunakan sequensial eksplanatory mixed method. Tahap pertama secara kuantitatif yaitu cross sectional dengan pengambilan data dari dokumen Audit Maternal Perinatal (AMP) tahun 2015 sebanyak 65 kematian maternal yang dapat dicegah di Kabupaten Karawang. Tahap kedua secara kualitatif melalui Focus Group Discussion (FGD) dan wawancara mendalam. Hasil penelitian kuantitatif menunjukkan sebagian besar kematian maternal yang dapat dicegah mengalami keterlambatan rujukan dan penanganan yaitu 52 kasus (80,0%) dan terdapat peran yang bermakna dari faktor pasien, tenaga kesehatan, fasilitas kesehatan terhadap keterlambatan rujukan dan penanganan sedangkan faktor rujukan tidak terdapat peran yang bermakna. Hasil penelitian kualitatif didapatkan penyebab dari faktor pasien karena karakteristik ibu berisiko, terlambat mencari penanganan dan menolak pengobatan, dari faktor tenaga kesehatan karena kurangnya deteksi dini dan kualitas pelayanan, kurangnya tenaga profesional dan terlambat penanganan, dari faktor fasilitas kesehatan karena kurang fasilitas, dari faktor rujukan karena menolak rujukan, kurang tepatnya rujukan dan keterlambatan rujukan terkait biaya dan koordinasi tim serta kerja sama lintas sektor juga merupakan faktor yang berperan. Keterlambatan deteksi dini dan pengambilan keputusan karena kurangnya kemampuan tenaga kesehatan mengenali dan menjaring kasus risiko tinggi serta tidak efektif memberikan komunikasi informasi dan edukasi (KIE) yang menyebabkan keterlambatan rujukan dan penanganan. Diperlukan peran serta masyarakat, stakeholder, tenaga kesehatan dan pengambil kebijakan dalam meningkatkan kualitas pelayanan kebidanan untuk menurunkan kematian maternal.
Serum Selenium Concentration in Cervical Cancer Patients: Preliminary Study and Literature Review Leri Septiani; Yudi Mulyana Hidayat; Mutakin Mutakin; Rizky Abdulah; Ahmad Faried; Hiroshi Koyama
International Journal of Integrated Health Sciences Vol 4, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.674 KB)

Abstract

Objective: To analyze the role of selenium and glutathione peroxidase (GPx) in cervical cancer.Methods: Serum selenium concentrations and GPx activities of 19 women with cervical cancer along with their healthy counterparts (control group) were obtained. Selenium concentration were measured fluorometrically and GPx activities were measured spectrophotometrically based on the quantity of NADPH used in the reduction of glutathione. Results: The mean of serum selenium concentrations in cervical cancer group was significantly lower than that in the control group, 67.24±15 ng/mL and 77.05±12 ng/mL (p=0.03), respectively. The mean GPx activity in the cervical cancer group was also significantly lower than that in the control group, 128.18±38 ∆mmol NADPH/min/L and 148.9±23 ∆mmol NADPH/min/L (p=0.04), respectively. Multivariate analysis in the cervical cancer patients showed that the Fédération Internationale de Gynécologie et d’Obstétrique (FIGO) staging score (early vs. advanced) was inversely correlated with serum selenium concentration (p=0.027).Conclusions: Serum selenium concentration and GPx activity was significantly lower in the cervical cancer patients. Our results demonstrate that selenium and GPx activity may have an important role in the carcinogenesis of cervical cancer. Keywords: Cervical cancer, glutathione peroxidase activity, selenium DOI: 10.15850/ijihs.v4n2.833
Hubungan antara Karakteristik Klinis Pasien Mola Hidatidosa dengan Performa Reproduksi Pascaevakuasi di Rumah Sakit Hasan Sadikin Bandung Vanessa Natasha Harjito; Yudi Mulyana Hidayat; Indah Amelia
Jurnal Sistem Kesehatan Vol 3, No 1 (2017): Volume 3 Nomor 1 September 2017
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (292.166 KB) | DOI: 10.24198/jsk.v3i1.13958

Abstract

Pada penderita mola hidatidosa terdapat beberapa karakteristik klinis yang dapat memengaruhi performa reproduksi, yaitu gambaran histopatologi proliferasi berlebih, besar uterus≥20minggu, kadarβ–hCG>100.000mIU/mL, dan kista lutein praevakuasi.Banyak penderita mola hidatidosa merasa khawatir kondisinya dapat memengaruhi fungsi reproduksinya di kemudian hari.Penelitian ini bertujuan untuk mengetahui hubungan antara karakteristik klinis pasien mola hidatidosa dengan luaran kehamilan pascaevakuasi di Rumah Sakit Hasan Sadikin Bandung. Penelitan analitik komparatif ini menggunakan desain kohort retrospektif. Subjek penelitian adalah penderita mola hidatidosa di Rumah Sakit Hasan Sadikin Bandung pada periode 1 Januari 2010-31 Desember 2015 yang memenuhi kriteria penerimaan penelitian. Penelitian mencari hubungan antara variabel karakteristik klinis risiko tinggi (gambaran histopatologi proliferasi berlebih, besar uterus, kista lutein, dan kadar β-hCG) dengan variabel luaran kehamilan pascaevakuasi. Analisis data menggunakan uji Eksak Fisher dengan interval kepercayaan 95%.Subjek penelitian berjumlah 51orang, terdapat 28orang berkarakteristik klinis risiko tinggi. Hasil penelitian menunjukkan karakteristik klinis dan luaran kehamilan pada tipe mola komplit dan mola parsial tidak memiliki perbedaan signifikan(p>0,05). Tidak terdapat hubungan yang signifikan antara gambaran histopatologi proliferasi berlebih, besar uterus, kista lutein, dan kadar β-hCG dengan luaran kehamilan pascaevakuasi(p>0,05). Penelitian ini menyimpulkan tidak terdapat hubungan antara karakteristik klinis pasien mola hidatidosa dengan performa reproduksi pascaevakuasi di Rumah Sakit Hasan Sadikin Bandung.Kata kunci: karakteristik klinis risiko rendah, karakteristik klinis risiko tinggi, luaran kehamilan, mola hidatidosa
Mixed Juice Consumption During Labor to the Mother's Blood Lactate Levels Rezah Andriani; Mieke Hemiawati Satari; Yudi Mulyana Hidayat; Farid Husin; Gaga Irawan Nugraha; Hadi Susiarno; Wisnu Cahyadi
Global Medical & Health Communication (GMHC) Vol 6, No 3 (2018)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (245.136 KB) | DOI: 10.29313/gmhc.v6i3.2907

Abstract

Maternal nutritional needs aim to prevent fatigue marked by lactate accumulation. Mix juice is made for the needs of the mother's energy quickly and reduces the accumulation of lactate. The objective of this study was to find out the influence of mix juice during labor to the mother's blood lactate levels. This study used a randomized controlled trial pretest-posttest group design. This research was carried out at the Pelayanan Obstetri Neonatal Emergensi Dasar/PONED (Basic Emergency Obstetric and Neonatal Care/BEONC) Puskesmas (Public Health Center) Garuda, Puter, Pagarsih, Padasuka, and Ibrahim Aji in Bandung city in March–April 2017. The population was all mothers who gave birth in Bandung. Sampling was carried out randomization, the number of samples of 60 people in treatment and control group. The treatment group received mix juice during labor, while the control group was free to eat and drink. The result was analyzed using comparative-numerical categorical analysis test, and the mean difference was analyzed using unpaired t test. The results showed the average increased in blood lactate levels in the treatment group (1.9 mmol/L) was lower than in the control group (4.0 mmol/L). Statistically, there was a significant difference in elevated blood lactate levels after intervention between the treatment and control group. Mothers who did not receive the mix juice in labor have a risk of elevated blood lactate levels 4 times higher than the mothers who received the mix juice. Conclusion, giving mix juice to the labor process affects the prevention of maternal blood lactate levels. KONSUMSI MINUMAN MIX JUICE PADA PERSALINAN UNTUK KADAR LAKTAT DARAH IBUKebutuhan nutrisi ibu bersalin bertujuan mencegah kelelahan yang ditandai dengan akumulasi laktat. Mix juice dibuat untuk memenuhi kebutuhan energi ibu bersalin secara cepat dan mengurangi penumpukan laktat. Penelitian ini bertujuan menganalisis pengaruh pemberian mix juice terhadap kadar laktat darah ibu. Penelitian ini menggunakan desain randomized controlled trial pretest-posttest group. Penelitian dilaksanakan di Puskesmas Pelayanan Obstetri Neonatal Emergensi Dasar (PONED) Garuda, Puter, Pagarsih, Padasuka, dan Ibrahim Aji di Kota Bandung pada Maret–April 2017. Populasi penelitian adalah semua ibu yang akan melahirkan di Kota Bandung. Penarikan sampel dilakukan secara acak yang berjumlah 60 orang pada kelompok perlakuan dan kontrol. Kelompok perlakuan mendapatkan mix juice selama persalinan, sedangkan kelompok kontrol dibebaskan untuk makan dan minum. Hasil dianalisis menggunakan uji analisis komparatif kategorik numerik dan perbedaan rerata dianalisis menggunakan uji t tidak berpasangan. Hasil penelitian didapatkan rerata kenaikan kadar laktat darah pada kelompok perlakuan (1,9 mmol/L) lebih rendah dibanding dengan kelompok kontrol (4,0 mmol/L). Secara statistik terdapat perbedaan bermakna dalam kenaikan kadar laktat darah setelah intervensi antara kelompok perlakuan dan kontrol. Ibu yang tidak mendapatkan mix juice pada persalinan memiliki risiko kenaikan kadar laktat darah 4 kali lebih tinggi dibanding dengan ibu yang mendapatkan mix juice pada persalinan. Simpulan, pemberian mix juice pada proses persalinan berpengaruh terhadap pencegahan peningkatan kadar laktat darah ibu.
Epidermal growth factor polymorphism most prevalent in stage II cervical carcinoma Kevin Dominique Tjandraprawira; Ramdan Panigoro; Yudi Mulyana Hidayat; Herman Susanto; Edhyana Sahiratmadja
Universa Medicina Vol. 33 No. 3 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.192-198

Abstract

Background    Cervical cancer ranks second among female cancers worldwide and is widely associated with human papilloma virus (HPV) infection. However, HPV infection progression is influenced by various host factors. Epidermal growth factor (EGF) is a host factor important for proper epithelial proliferation and development, and may play a role in cervical cancer progression. A functional A61G polymorphism in the EGF gene has been hypothesized to alter EGF concentration in vivo with increasing guanine content associated with greater EGF level. However, a map of A61G polymorphism distribution is not available for any population, including Indonesia. This study aims to determine the distribution of EGF A61G polymorphism among cervical cancer patients at Dr. Hasan Sadikin General Hospital.MethodsA retrospective cross-sectional study was conducted between July-November 2010. Included were 61 cervical cancer patients of various stages at Dr. Hasan Sadikin hospital, who had previously undergone blood sample collection, DNA isolation and finally genotyping for EGF gene using Illumina BeadXpress®. Chi-square test was used to analyse the data. ResultsThe EGF A61G polymorphism was exhibited by 88.5% of patients (as genotypes A/G and G/G). The majority of patients with this polymorphism were of moderate severity (FIGO stage II and III, 42.6% and 38.1% respectively). Patients with the polymorphism but with the lightest severity (FIGO stage I) accounted for 22.2% of the population. ConclusionEGF A61G polymorphism affected the majority of cervical cancer patients and that once stratified, the patients showed intermediate severity in terms of their cancerous growth.
Co-Authors A.W., Gatot Nyarumenteng Ahmad Faried Ali Budi Harsono Ali Budi Harsono Ali Budi Harsono Amillia Siddiq, Amillia Andi Kurniadi, Andi Anwar , Ruswana Aprilina Aprilina Arieff Kustiandi Arifa Rakhmana Abdullah Astri Novianti Benny Hasan Purwara Berland Budiman Deni K. Sunjaya Dimas Erlangga Luftimas Dodi Suardi Edhyana Sahiratmadja Edwin Armawan Elsa Pudji Setyawati Eunike Febe Febriani Farid Husin Farid Husin Farid Husin Farisa Raudina Firman Fuad Wirakusumah Gaga Irawan Nugraha Gatot N. A. Winarno Gatot N. A. Winarno Hadyana Sukandar Halimatussa'adiah , Melly Hanom Husni Syam Harjito, Vanessa Natasha Harsono, Ali Budi Hendra Gunawan Herman Susanto Herry Herman Hiroshi Koyama Huda Toriq Husin, Farid Indah Amelia Indah Amelia Jasmi ati Johanes C Mose Johanes C. Mose Johanes Cornelius Mose Kemala Isnainiasih Mantilidewi Kevin Dominique Tjandraprawira LAURENS DAVID PAULUS LAURENS DAVID PAULUS, LAURENS DAVID Leri Septiani M. Rizkar Arev Sukarsa MARINGAN DIAPARI LUMBAN TOBING Martasari, Bellia Loranthifolia Megantari, Salsa Bila Mieke Hemiawati Satari Mieke Hemiawati Satari Muhammad Nasir Shafiee Mutakin Mutakin Nanan Sekarwana Niken Bayu Argaheni Oki Suwarsa Pati Aji Achdiat Putu Giri Saputro R. M. Sonny Sasotya Radiastomo Samekta Budi Ramdan Panigoro Rasmia Rowawi Reiva Farah Dwiyana Reyshiani Johan Rezah Andriani Rizky Abdulah Rohmawati, Enny Rotinggo, Rico Salima, Siti Siti Salima Sofie R. Krisnadi Steven Ridwan, Steven Supriadi Gandamihardja SUPRIADI GANDAMIHARJA Supriadi Gandamiharja Susiarno, Hadi Syahrul Rauf Sylvia Rachmayati Tono Djuwantono Unggul Yudatmo Vanessa Natasha Harjito Wiryawan Permadi Yopi Wulandhari Yuli Astuti Yusuf Sulaeman Effendi