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All Journal JURNAL GIZI INDONESIA International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication Indonesian Journal of Cancer Jurnal Sistem Kesehatan Universa Medicina JNKI (Jurnal Ners dan Kebidanan Indonesia) (Indonesian Journal of Nursing and Midwifery) Indonesian Journal of Obstetrics & Gynecology Science JURNAL KESEHATAN PERINTIS Jurnal Kesehatan Jurnal Medikes (Media Informasi Kesehatan) Indonesian Trust Health Journal Indonesian Journal of Cancer Media Dermato-Venereologica Indonesiana Indonesian Trust Health Journal

Yudi Mulyana Hidayat

Department Of Obstetrics And Gynecology, Division Of Oncology, Faculty Of Medicine, Universitas Padjadjaran/ Dr. Hasan Sadikin General Hospital Bandung

Author-ID : 281709

Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Perbedaan Kadar Vitamin D pada Wanita Usia Reproduksi Tidak Hamil dan Wanita Hamil Trimester Pertama M. Rizkar Arev Sukarsa; Radiastomo Samekta Budi; Benny Hasan Purwara; Hanom Husni Syam; Johanes Cornelius Mose; Yudi Mulyana Hidayat; R. M. Sonny Sasotya
Indonesian Journal of Obstetrics & Gynecology Science Volume 2 Nomor 1 Maret 2019
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Tujuan: Penelitian ini untuk mengetahui perbedaan kadar vitamin D pada wanita usia reproduksi tidak hamil dan wanita hamil trimester pertama.Metode: Penelitian ini merupakan penelitian analitik observasional dengan metode rancangan Comparative Cross Sectional yaitu membandingkan kadar vitamin D pada dua kelompok yaitu wanita usia reproduksi tidak hamil dan wanita hamil trimester pertama. Subjek penelitian yaitu wanita usia reproduksi (18-35 tahun) tidak hamil dan bertempat tinggal di kota Bandung dengan wanita dengan usia kehamilan trimester pertama yang memenuhi kriteria inklusi penelitian (n=60). Pada kedua kelompok dilakukan pemeriksaan kadar vitamin D kemudian diperiksa dengan metode Electro-chemiluminescence immunoassay (ECLIA). Penelitian ini dilakukan di RSUP Dr. Hasan Sadikin Bandung pada bulan Februari-April 2018.Hasil: Hasil penelitian menunjukkan kadar vitamin D rata-rata pada kelompok wanita usia reproduksi tidak hamil adalah 18,73 (6,93) ng/mL, sementara pada kelompok wanita hamil trimester pertama yaitu 13,87 (4,04) ng/mL. Perbedaan kadar rata-rata vitamin D pada kedua kelompok tersebut bermakna dengan nilai p<0,001Simpulan: Kadar vitamin D pada kelompok wanita hamil trimester pertama lebih rendah dibandingkan dengan kelompok usia reproduksi tidak hamilDifferences of vitamin D Level in Non-Pregnant Reproductive Age Women and First Trimester Pregnant WomenAbstractObjective: This research aims to compare differences in vitamin D levels in the group of non pregnant women of reproductive age and group of first trimester pregnant women.Method: This type of research is an observational analytic study with Comparative Cross Sectional design method that is comparing vitamin D levels in two groups: non pregnant women of reproductive age and first trimester pregnant women. Subjects of the study were women of reproductive age (18-35 years) who were not pregnant and lived in Bandung with women with first trimester gestational age who fulfilled the inclusion criteria (n=60). In both groups examined vitamin D levels and then examined by Electro-chemiluminescence immunoassay (ECLIA) method. This research was conducted at Hasan Sadikin Hospital Bandung in February-April 2018Result: The results showed that the average vitamin D level in the non pregnant women of reproductive age group was 18.73 (6.93) ng/mL, while in the first trimester pregnant women group was 13.87 (4.04) ng/mL. The difference in mean vitamin D levels in both groups was significant with p <0.001Conclusion: Levels of vitamin D in the group of first trimester pregnant women are lower than the group of non pregnant women of reproductive Key words: Vitamin D, women of reproductive age not pregnant, first trimester pregnant women

Perbandingan Nilai Prediktif antara Risk-of-Malignancy Index (RMI) dan Klasifikasi IOTA Simple Rules dalam Prediksi Keganasan pada Kasus Tumor Ovarium di RSUP Dr. Hasan Sadikin Bandung Huda Toriq; Yudi Mulyana Hidayat; Dodi Suardi
Indonesian Journal of Obstetrics & Gynecology Science Volume 4 Nomor 1 Maret 2021
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v4n1.223

Tujuan: Penelitian ini bertujuan untuk mengevaluasi dan membandingkan penerapan dua metode diagnostik yang telah digunakan di RSHS, yaitu skor RMI dan Klasifikasi IOTA Rules untuk memprediksi keganasan suatu tumor ovarium selama periode 2017−2018Metode: Penelitian ini merupakan penelitian komparatif dengan pengambilan data secara retrospektif. Sumber data diperoleh dari rekam medis pasien yang menjalani operasi pengangkatan dan pemeriksaan histopalogis tumor ovarium. Dilakukan pengumpulan informasi mengenai data USG, kadar CA125, skor RMI, klasifikasi IOTA Simple Rules, dan membandingkannya dengan luaran histopatologis.Hasil: 190 kasus tumor ovarium diteliti. 156 kasus (82,1%) memiliki luaran histopatologis ganas dan 34 kasus lainnya (17.9%) jinak. 178 kasus (93,68%) memiliki skor RMI ≥200 dan 12 kasus (6,32%) <200. sebanyak 78 kasus diklasifikasikan sebagai Malignant, 42 kasus Benign, dan 70 kasus lainnya Inconclusive dengan kriteria IOTA Simple Rules. Distribusi CA125 dan Skor RMI pada kedua kelompok luaran histopatologis berbeda secara bermakna (P<0,05). Sensitivitas dan spesifisitas klasifikasi IOTA Simple Rules di RSHS masing-masing 94,23% dan 97,06%, dengan menggabungkan kelompok IOTA inkonklusif dengan kelompok ganas. Penghitungan sensitivitas dan spesifisitas skor RMI memberikan nilai 95,51% dan 14,71% dengan menggunakan cut-off-point skor RMI 200.Kesimpulan: Sensitivitas dan spesifisitas klasifikasi IOTA Simple Rules lebih baik dibandingkan dengan skor RMI dalam memprediksi keganasan suatu tumor ovarium.Predictive Value Comparison of Risk-of-Malignancy Index (RMI) and IOTA Simple Rules in Predicting Ovarian Tumor Malignancy in Dr. Hasan Sadikin Hospital BandungAbstractObjective: This study was done to evaluate and compare the use of RMI score & IOTA Simple Rule which has been routinely used in Hasan Sadikin Hospital to predict ovarian malignancy in 2017-2018Method: This is a comparative study that collects data retrospectively. Data was obtained from medical record of patient who underwent ovarian tumor surgery, including USG report, CA125, RMI score, IOTA Simple Rules, and compared it with histopathological outcome. Result: 190 ovarian tumor cases was studied. 156 cases (82.1%) have malignant histopathological result and the other 34 cases (17.9%) were benign. 178 (93.68%) cases have RMI score ≥ 200 and 12 cases (6.32%) <200. As much 78 cases were classified as malignant, 42 cases (22.11%) were classified benign, and the other 70 cases were classified inconclusive using IOTA Simple Rules. CA125 and RMI Score distribution on both histopathological group differs significantly (P<0.05). IOTA Simple Rules shows sensitivity and specificity of 94.23% and 97.06% respectively, when inconclusive and malignant results were grouped together. RMI Score showed sensitivity and specificity of 95.51% and 14.71% respectively using cut-off point of 200.Conclusion: IOTA Simple Rules performs better than RMI in predicting ovarian tumor malignancy.Key words: Ovarian cancer, IOTA, RMI, USG, CA125

Pengaruh Vaksin BCG dalam Meningkatkan Proses Segresi Seluler pada Lesi Prakanker Serviks Uteri Derajat Rendah Yudi Mulyana Hidayat; Putu Giri Saputro; Dodi Suardi; Gatot N. A. Winarno; Siti Salima; Ali Budi Harsono
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 2 September 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v3n2.82

Tujuan: Penelitian ini adalah untuk menganalisis peranan pemberian vaksin bacille calmette-guerin (BCG) terhadap proses regresi seluler pada lesi prakanker serviks uteri derajat rendahMetode: Penelitian ini merupakan penelitian eksperimental dengan rancangan pretest (IVA dan Histopatologi) - posttest (IVA dan Test HPV DNA) with control design di Poliklinik Rumah Sakit Dr. Hasan Sadikin Bandung pada bulan Desember 2017-Maret 2018. Hasil: Untuk pemeriksaan IVA bulan ke-0 pada kelompok BCG kategori positif sebanyak 9 (100.0%) sedangkan untuk pemeriksaan IVA bulan ke-3 pada kelompok BCG kategori positif sebanyak 3 (33.3%) dan negatif menjadi sebanyak 6 (66.7%), pemeriksaan tes HPV DNA bulan ke 12 pada kelompok BCG kategori positif HPV DNA High Risk tidak ditemukan ( 0 % ). Hasil uji statistik pada kelompok perlakuan diperoleh nilai p<0.05. Untuk pemeriksaan IVA bulan ke-0 pada kelompok plasebo kategori positif sebanyak 9 (100.0%) sedangkan untuk pemeriksaan IVA bulan ke-3 pada kelompok plasebo kategori positif sebanyak 8 (88.9%) dan negatif menjadi sebanyak 1 (11.1%). pemeriksaan tes HPV DNA bulan ke 12 kelompok BCG kategori positif HPV DNA High Risk sebanyak 1 orang ( 11,1%). Hasil uji statistik pada kelompok kontrol diperoleh informasi nilai p>0.05.Kesimpulan: Terdapat peranan pemberian vaksin BCG terhadap regresi seluler lesi prakanker serviks derajat rendah.The effect of Bacille Calmette-Guerin vaccine on regression of cervical intraepithelial neoplasia-1AbstractObjective: The aim of this study was to analyze the role of Baccile Calmete Guerin (BCG) vaccines delivery in low grade precancerous cervical lesions.Methods: The design of the study was a pretest and posttest experimental with control, done at Hasan Sadikin Hospital Bandung Outpatient Clinic during December 2017–March 2018. Result: Patients with positive VIA test in the intervention group in month-0 were 9 patients (100.0%), in month-3 were 3 patients (33.33%) and the other 6 patients (66.7%) changed into negative. Patients with positive VIA test in the control group in month-0 were 9 patients (100.0%), in month 3 were 8 patients (88.9%) and the other 1 patients (11.1%) changed into negative. The result of statistical analysis in the intervention group was p<0.05. The result of statistical analysis in the control group was p>0.05.Conclusion: : there is a role of BCG vaccine in low grade precancerous cervical lesions.Key words: BCG vaccine, VIA test, Low grade cervical precancerous lesions.

Perbandingan Fungsi Berkemih pada 3 Hari dan 5 Hari Katerisasi Urin Pascaoperasi Histerektomi Radikal pada Wanita Penderita Keganasan Serviks Stadium Awal Astri Novianti; Benny Hasan Purwara; Yudi Mulyana Hidayat; Sofie Rifayani Krisnadi; Maringan Diapari Lumban Tobing; Edwin Armawan
Indonesian Journal of Obstetrics & Gynecology Science Volume 1 Nomor 2 September 2018
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

AbstrakTujuan: Menganalisis perbandingan fungsi berkemih pada pemakaian kateter urin selama 3 hari dan 5 hari pasca operasi histerektomi radikal.Metode: Non-inferiority randomized controlled trial. Subjek penelitian adalah penderita kanker serviks di Rumah Sakit Hasan Sadikin Bandung yang dilakukan operasi histerektomi radikal. Dilakukan penilaian fungsi berkemih dan kejadian infeksi saluran kemih sebelum dan setelah operasi hari ke−3 (kelompok intervensi) dan hari ke−5 (kelompok kontrol). Hasil: Pascaoperasi terjadi penurunan fungsi sensorik 8,5% pada kelompok intervensi dan 13,5% pada kelompok kontrol dan penurunan fungsi motorik 87,5% pada kelompok intervensi dan 150% pada kelompok kontrol. Kejadian infeksi saluran kemih meningkat 6,7% pada kelompok kontrol. Kesimpulan: Penggunaan kateter urin selama 3 hari pasca histerektomi radikal tidak lebih buruk dari 5 hari dan dapat digunakan sebagai manajemen pada penderita kanker serviks pasca histerektomi radikal. The Comparison of 3 Days and 5 Days Catheterization Following Radical Hysterectomy in Women with Early Stage Cervical Cancer: A Non-Inferiority Randomized Controlled TrialAbstractObjective: To compare the urinary function after radical hysterectomy with catheter usage for 3 days and 5 days. Method: A non-inferiority randomized controlled trial. Subjects were women diagnosed with cervical cancer that underwent radical hysterectomy in Hasan Sadikin Hospital Bandung. The study conducted by comparing urinary function and urinary tract infection in 3 days catheterization and 5 days catheterization after radical hysterectomy. Result: Post operation, there was decreased 8,5% sensory function in intervention group and 13,5% in control group and decreased 87,5% motoric function in intervention group and 150% in control group. The urinary tract infection increased about 6,7% in control group. Conclusion:3-days urethral catheterization following radical hysterectomy is non inferior to 5 days urethral catheterization and could be used for management of women with early stage cervical cancer after radical hysterectomy. Key words: Urinary dysfunction after radical hysterectomy, 3 and 5 days catheterization after radical hysterectomy, urinary tract infection

Akurasi Spesivisitas dan Sensitivitas Angka RMI 2 Skor pada Penderita Tumor Ganas Ovarium di RSUP Dr. Hasan Sadikin Bandung Periode 2017−2018 Arieff Kustiandi; Yudi Mulyana Hidayat; R.M Sonny Sasotya; Andi Kurniadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 2 September 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v3n2.207

Tujuan: Penelitian ini bertujuan untuk mengetahui spesifitas dan sensitivitas skor RMI 2 dalam menentukan keganasan ovarium. Kadar CA 125 dan skor RMI 2 diukur dari hasil pemeriksaan histopatologi digunakan sebagai pemeriksaan gold standard. Penelitian ini dilakukan pada periode Januari 2017−Desember 2018.Metode: Penelitian ini menggunakan metode observasional analitik dengan rancangan cross sectional. Data kategorik diuji dengan uji chi-square atau uji Exact Fisher. Data numerik digunakan uji-t tidak berpasangan atau uji Mann Whitney. Sumber data diperoleh dari rekam medis pasien di Poli Ginekologi Onkologi RSUP Dr. Hasan Sadikin Bandung berdasarkan angka skor RMI 2 pada penderita suspek tumor ganas ovarium.Hasil: Sampel berjumlah 172 dengan 31 berkategori jinak dan 141 berkategori ganas berdasarkan hasil histopatologi. Hasil penelitian menunjukkan nilai median CA 125 kelompok ganas dibanding kelompok jinak (437, 05 vs 212,14) bermakna secara statistik p = 0,001 (nilai p<0,05). Cut of point skor RMI 2 adalah >200 dengan sensitivitas 95,74% dan spesifisitas 16,12%.Kesimpulan: Skor RMI 2 adalah metode yang digunakan untuk memprediksi tumor ganas ovarium. Hal ini sangat berguna digunakan dengan kombinasi CA 125 dengan hasil pemeriksaan ultrasonografi (USG) dan status menopause atau dikenal dengan Risk Malignancy Index (RMI skor 2 cut off point >200 ) dengan sensitivitas 95,74%, spesifisitas 16,12%dan akurasi 81,39 %. Skor RMI 2 mempunyai sensitivitas yang tinggi, tetapi mempunyai spesivisitas yang rendah, sehingga membutuhkan penelitian lebih lanjut.Accuracy of Specificity and Sensitivity of RMI 2 Score Numbers in Ovarium Fanner Tumors in RSUP Dr. Hasan Sadikin Bandung Period 2017-2018AbstractObjective: This study aims to determine the specificity and sensitivity of RMI 2 score in ovarian malignancy. The CA 125 level and the RMI 2 score were measured and adjusted by histopathology examination as gold standard. This research was conducted in period January 2017−December 2018.Methods: This research used observational analitic research method with cross sectional design. Categorical data were tested by chi-square test or Fisher's Exact test. Numerical data are used unpaired t-test or Mann Whitney test. The source of data from medical records of patients in Gynecology Oncology Clinic Dr. Hasan Sadikin Bandung based on the RMI 2 score with suspected ovarian malignant tumors.Result: Samples were 172 with 31 benign categories and 141 malignant categories based on the results of histopathology. The results showed a median value of CA 125 of the malignant group compared to the benign group (437, 05 vs. 212.14) statistically significant p = 0.001 (p value <0.05). The RMI 2 score cut off point > 200 with a sensitivity of 95.74% and specificity of 16.12%. Conclusion: This study is an RMI 2 score is a useful way as a predictor of ovarian malignancy. This is very useful to use with a combination of CA 125 with the results of ultrasonography (USG) and menopausal status or known as the Risk Malignancy Index (RMI score 2 cut off point> 200) with a sensitivity of 95.74%, specificity 16.12% and accuracy 81 , 39%. RMI 2 score has high sensitivity, but has low specificity, so it needs further research.Key words: CA 125, RMI 2 score, ovarian malignancy

Evaluasi Program Deteksi Dini Kanker Serviks dengan Metode See and Treat di Kabupaten Karawang Berland Budiman; Yudi Mulyana Hidayat; Ali Budi Harsono
Indonesian Journal of Obstetrics & Gynecology Science Volume 2 Nomor 1 Maret 2019
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

AbstrakTujuan: Kanker serviks merupakan jenis kanker terbanyak nomor dua di kalangan perempuan di Indonesia setelah kanker payudara. Kanker serviks dikenal dengan “silent killer” karena perkembangannya yang sulit dideteksi. Metode see and treat dengan pemeriksaan Inspeksi Visual Asam Asetat (IVA) dan tindakan segera jika ditemukan IVA positif menggunakan krioterapi merupakan upaya untuk menurunkan angka kejadian dan mortalitas yang disebabkan kanker serviks. Tujuan penelitian ini adalah untuk melakukan evaluasi pelaksanaan program deteksi dini kanker serviks di Kabupaten Karawang dari dimulainya pelaksanaan program pilot project dari tahun 2007 hingga sekarang. Metode: Desain penelitian menggunakan metode mixed method. Rancangan penelitian kuantitatif dengan metode potong lintang dan rancangan penelitian kualitatif dengan melakukan wawancara dengan panduan open-ended question.Hasil: Dari hasil penelitian variabel yang paling berpengaruh terhadap komponen input adalah sumber daya manusia dan dukungan pemerintah berupa pendanaan, pada komponen proses adalah variabel pelaksanaan dan monitoring evaluasi, sedangkan pada variabel output sasaran target program masih jauh dari yang diharapkan. Kesimpulan: Dapat disimpulkan bahwa program deteksi dini kanker serviks dengan metode see and treat di Kabupaten karawang masih kurang optimal. Dibutuhkan sumber daya manusia yang baik secara kualitas dan kuantitas, ketersediaan sarana dan prasarana, dukungan pemerintah yang optimal, dan sosialisasi masyarakat untuk menunjang keberhasilan program.Evaluation of Early Detection of Cervical Cancer with See and Treat Method in Karawang RegencyAbstractObjective: Cervical cancer is the second most common cancer among women in Indonesia after breast cancer. Cervical cancer is known as the “silent killer” because its development is difficult to detect. The see and treat method with IVA examination and immediate action if a positive IVA was found using cryotherapy is an attempt to reduce the incidence and mortality caused by cervical cancer. The purpose of this research is to explore the implementation of early detection program of cervical cancer in Kabupaten Karawang from the beginning of pilot project implementation from year 2007 until now.Method: The research design used mixed method. The design of quantitative research with cross sectional method and qualitative research design by conducting an interview with open-ended question guide. Result: From the results of research, the most influential variables on the input components are human resources and government support in the form of funding, the component of the process is the implementation and evaluation variables evaluation, while the target output variable target program is still far from expected. Conclusion: It can be concluded that early detection program of cervical cancer with see and treat method in Karawang district is not optimal. Good human resources needed in quality and quantity, availability of facilities and infrastructure, optimal government support, and socialization of the community to support the success of the program.Key words: Cervical cancer, program evaluation, see and treat

Perbandingan Kepadatan Mineral Tulang Antar Pemakai Kontrasepsi Hormonal Progestin dan Kontrasepsi Non Hormonal pada Wanita Usia Subur Aprilina Aprilina; Wiryawan Permadi; Elsa Pudji Setyawati; Farid Husin; Johanes C. Mose; Yudi Mulyana Hidayat
Jurnal Kesehatan Vol 11, No 1 (2020): Jurnal Kesehatan
Publisher : Politeknik Kesehatan Tanjung Karang

The decrease of bone mineral density will result in reducing bone strength tend to bone brittle so osteoporosis occurred. Osteoporosis affects 44 million people in the United States, 80% are women. It was assumed that progestin contraceptive acceptors decreased bone mineral density and increased the risk of osteoporotic fractures. The study used a comparative analytical method by using a cross-sectional study. The population was all acceptors progestin hormonal contraceptives (implants or injections) and acceptors of non-hormonal contraception (IUD or MOW) who came to the Public health center of Sekip Palembang and public health center of Basuki Rahmat in Palembang. The total sample was 200 respondents. The sample used purposive sampling, by using a consecutive sampling technique. The results were analyzed by using the Mann Whitney test and two ways ANOVA test directions with post hoc test and profile analysis. The results showed a significant difference in bone mineral density between the acceptors of progestin hormonal contraceptives and the acceptors of non- hormonal contraceptives to eligible women with ρ-value=0.001. There was a significant difference between acceptor of progestin hormonal contraceptives and non- hormonal contraceptives to eligible women referred to the duration of use, p-value of 1-2 years old was p-value=0.109, >2-3 years, p-value 0.039, and ≥3 years, p-value=0.033. Conclusion: there are differences in bone mineral density between acceptors of progestin hormonal contraceptives and acceptors of non-hormonal contraceptives to eligible women.

Mobile Phone Text Messaging Cross Platform Intervention for Cervical Cancer Screening: Changes in Knowledge and Attitude in Rural Areas Pre-Post Intervention Niken Bayu Argaheni; Firman F Wirakusumah; Maringan D.L. Tobing; Herry Herman; Deni K. Sunjaya; Yudi Mulyana Hidayat
JNKI (Jurnal Ners dan Kebidanan Indonesia) (Indonesian Journal of Nursing and Midwifery) Vol 8, No 2 (2020)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/jnki.2020.8(2).123-133

The key to the success of cervical cancer control programs is screening followed by adequate treatment. The socio-economic status gap and the low level of education lead to limited awareness and understanding of women of childbearing age. Increasing the capacity of knowledge of women of childbearing age through health education either directly or indirectly is important. Therefore, there is need to develop health education by utilizing the rapidly growing media today such as through the application of cross platform messages on smartphones. This study aims to analyze the effect of the application of health education on detection of cervical cancer through the application of cross-platform messages to increase knowledge and attitude of Women in Childbearing Age. A quasi-experimental research of pre-posttest design with control groups conducted consisting of 72 subjects of Women in Childbearing Age. Fogg's Behavior Model was the conceptual framework that guided the development of the cross-platform messaging intervention. A series of checklist from expert panel conducted to inform the development of the cross-platform messaging intervention. The messages are delivered for a 7-day period in the morning. Data collection using a checklist instrument. Univariable analysis through Rasch and bivariable modeling using numerical categorical comparative test, difference using T test. Findings revealed a significant increase in participants’ knowledge and attitude of cervical cancer screening. Women of Childbearing Age whose health education through cross-platform application has a 3.5 times probability of knowledge and good attitude compared to women of childbearing age who are not getting health education through cross-platform applications. Health education through cross-platform messaging services can be a cheap and effective method to improve the knowledge and attitude of women of childbearing age, as well as reaching individuals who have never done early detection of cervical cancer.

Pengaruh Penerapan Aplikasi Sahabat Ibu Hamil (ASIH) terhadap Penurunan Keluhan Trimester I Kehamilan Yopi Wulandhari; Nanan Sekarwana; Yudi Mulyana Hidayat
JURNAL KESEHATAN PERINTIS Vol 6 No 2 (2019): DESEMBER 2019 : Jurnal Kesehatan Perintis (Perintis's Health Journal)
Publisher : LPPM UNIVERSITAS PERINTIS INDONESIA

Peningkatan status kesehatan ibu pada saat kehamilan dapat dilakukan dengan meningkatkan akses kesehatan dan pemanfaatan teknologi sistem informasi. Perkembangan teknologi yang berkembang pesat saat ini adalah smartphone. Dengan demikian dibuatlah sebuah Aplikasi Sahabat Ibu Hamil (ASIH) yang berisikan informasi dan panduan penatalaksanaan seputar keluhan selama kehamilan. Diharapkan dengan aplikasi ini dapat meningkatkan status kesehatan. Penelitian ini bertujuan untuk menganalisis pengaruh penerapan Aplikasi Sahabat Ibu Hamil (ASIH) terhadap penurunan keluhan Trimester I kehamilan. Penelitian ini menggunakan rancangan quasi eksperimen dengan pretest posttest control group design. Subjek penelitian yaitu ibu hamil trimester I di wilayah kerja Puskesmas Ibrahin Adjie Bandung berjumlah 60 orang, yang terbagi ke dalam 2 kelompok yaitu 30 orang kontrol dan 30 kelompok intervensi. Pengambilan sampel dengan consecutive sampling. Pengujian statistik untuk menjawab hipotesis penelitian menggunakan uji Chi Kuadrat dengan kemaknaan hasil uji ditentukan berdasarkan nilai p<0,05. Hasil penelitian menunjukkan bahwa penurunan keluhan pada kelompok ASIH terdapat perbedaan yang bermakna pada keluhan mual muntah, konstipasi dan mudah lelah dengan p<0,005, sedangkan pada kelompok Konvensional keluhan mual muntah dan mudah lelah mengalami penurunan yang bermakna namun keluhan konstipasi tidak menunjukkan perbedaan yang bermakna. Sementara hasil perbandingkan penurunan keluhan kedua kelompok diperoleh bahwa terdapat perbedaan yang bermakna dengan nilai p=0,002 pada keluhan mual muntah dengan RR (IK 95%) sebesar 1,9 yang artinya ASIH berpengaruh 1,9 kali menurunkan keluhan mual muntah dibandingkan dengan metode konvensional. Namun keluhan konstipasi dan mudah lelah tidak menunjukkan perbedaan yang bermakna. Simpulan: Aplikasi Sahabat Ibu Hamil (ASIH) berpengaruh terhadap penurunan keluhan trimester I kehamilan.

Hubungan antara Ekspresi mRNA Gen Epidermal Growth Factor Receptor (EGFR) dengan Penurunan Kadar ?-hCG Serum Pasca-evakuasi Mola Hidatidosa Komplit LAURENS DAVID PAULUS; YUDI MULYANA HIDAYAT; SUPRIADI GANDAMIHARJA
Indonesian Journal of Cancer Vol 9, No 3 (2015): Jul - Sept 2015
Publisher : National Cancer Center - Dharmais Cancer Hospital

In 2008, the incidence of hydatidiform mole that occurred in West Java around 1:28. Malignant transformation of Complete Hydatidiform Mole (CHM) is influenced by many factors, among others, is the expression of the epidermal growth factor receptor (EGFR). This study uses Historical Cohort to retrieve CHM patients data and trophoblastic tissue paraffin block in 2007-2012, and perform examination of Polymerase chain reaction.Results of the study: 40 CHM patients, 24 with EGFR (-) and 16 with EGFR (+), at 12 weeks monitoring post evacuation using the Mochizuki regression curve was not obtained persistent mole in the group with EGFR (-), while the group of EGFR (+), all showed an increase in ?-hCG levels. Relative risk (RR) of 3.4 in the CHM group with EGFR (+) into a persistent mole compared with EGFR (-) at 6th week and RR of 13.0 in CHM group with EGFR (+) into a persistent mole compared with EGFR (-) at 8th week. The conclusion of this study demonstrate the suitability of the hypothesis that the higher mRNA gene expression of EGFR, the slower decrease in serum levels of ?-hCG after CHM evacuation and expression EGFR (+) may be a predictor of the occurrence of persistent mole.Pada 2008, insiden mola hidatidosa (MH) yang terjadi di Jawa Barat sekitar 1:28. Transformasi keganasan dari mola hidatidosa komplit (MHK) dipengaruhi oleh banyak faktor, antara lain ekspresi Epidermal Growth Factor Receptor (EGFR). Penelitian ini menggunakan metode historical cohort dengan mengambil data dan parafin block jaringan trofoblas pasien MHK tahun 2007?2012, dan dilakukan pemeriksaan POLYMERASE CHAIN REACTion. Hasil penelitian menunjukkan dari 40 pasien MHK, 24 di antaranya EGFR (-) dan 16 EGFR (+) pada 12 minggu pascaevakuasi menggunakan kurva regresi Mochizuki. Tidak didapatkan mola persisten pada kelompok EGFR (-), sedangkan kelompok EGFR (+) semuanya menunjukkan peningkatan ?-hCG (mola persisten). Risiko relatif (RR) sebesar 3,4 pada EGFR (+) menjadi mola persisten dibandingkan dengan EGFR (-) pada minggu ke-6 dan RR sebesar 13,0 pada EGFR (+) menjadi mola persisten dibandingkan dengan EGFR (-) pada minggu ke-8. Hasil penelitian ini menunjukkan kesesuaian dengan hipotesis bahwa semakin tinggi ekspresi EGFR maka semakin lambat penurunan kadar ?-hCG serum pasca-evakuasi MHK. Ekspresi EGFR dapat menjadi prediktor terjadinya mola persisten.

Co-Authors A.W., Gatot Nyarumenteng Ahmad Faried Ali Budi Harsono Ali Budi Harsono Ali Budi Harsono Amillia Siddiq, Amillia Andi Kurniadi, Andi Anwar , Ruswana Aprilina Aprilina Arieff Kustiandi Arifa Rakhmana Abdullah Astri Novianti Benny Hasan Purwara Berland Budiman Deni K. Sunjaya Dimas Erlangga Luftimas Dodi Suardi Edhyana Sahiratmadja Edwin Armawan Elsa Pudji Setyawati Eunike Febe Febriani Farid Husin Farid Husin Farid Husin Farisa Raudina Firman Fuad Wirakusumah Gaga Irawan Nugraha Gatot N. A. Winarno Gatot N. A. Winarno Hadyana Sukandar Halimatussa'adiah , Melly Hanom Husni Syam Harjito, Vanessa Natasha Harsono, Ali Budi Hendra Gunawan Herman Susanto Herry Herman Hiroshi Koyama Huda Toriq Husin, Farid Indah Amelia Indah Amelia Jasmi ati Johanes C Mose Johanes C. Mose Johanes Cornelius Mose Kemala Isnainiasih Mantilidewi Kevin Dominique Tjandraprawira LAURENS DAVID PAULUS LAURENS DAVID PAULUS, LAURENS DAVID Leri Septiani M. Rizkar Arev Sukarsa MARINGAN DIAPARI LUMBAN TOBING Martasari, Bellia Loranthifolia Megantari, Salsa Bila Mieke Hemiawati Satari Mieke Hemiawati Satari Muhammad Nasir Shafiee Mutakin Mutakin Nanan Sekarwana Niken Bayu Argaheni Oki Suwarsa Pati Aji Achdiat Putu Giri Saputro R. M. Sonny Sasotya Radiastomo Samekta Budi Ramdan Panigoro Rasmia Rowawi Reiva Farah Dwiyana Reyshiani Johan Rezah Andriani Rizky Abdulah Rohmawati, Enny Rotinggo, Rico Salima, Siti Siti Salima Sofie R. Krisnadi Steven Ridwan, Steven Supriadi Gandamihardja Supriadi Gandamiharja SUPRIADI GANDAMIHARJA Susiarno, Hadi Syahrul Rauf Sylvia Rachmayati Tono Djuwantono Unggul Yudatmo Vanessa Natasha Harjito Wiryawan Permadi Yopi Wulandhari Yuli Astuti Yusuf Sulaeman Effendi

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