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All Journal Jurnal Pengolahan Hasil Perikanan Indonesia Journal of Food and Pharmaceutical Science Saintek Perikanan : Indonesian Journal of Fisheries Science and Technology Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Teknosains Jurnal Teknologi Pertanian agriTECH INDONESIAN JOURNAL OF PHARMACY Industria: Jurnal Teknologi dan Manajemen Agroindustri Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology Indonesian Food and Nutrition Progress Jurnal Perikanan Universitas Gadjah Mada Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Veterinary Sciences) Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Dinasti International Journal of Education Management and Social Science Journal of Multidisciplinary Applied Natural Science Analisa: Journal of Social Science and Religion Estungkara: Jurnal Pengabdian Pendidikan Sejarah Paradigma: Jurnal Kajian Budaya Journal of Food and Pharmaceutical Sciences Journal of Fisheries & Marine
Amir Husni
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Journal : Journal of Multidisciplinary Applied Natural Science

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In Vitro Anti-Acne Activity and Bioactive Compound Analysis of Sargassum cristaefolium Ethanolic Extract from Teluk Awur Jepara Kristiani, Theresia Adven Dea; Husni, Amir; Isnansetyo, Alim
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.262

Abstract

Acne is a prevalent skin disorder, particularly among adolescents, causing significant physical and psychological impacts. Ongoing efforts are dedicated to acne treatment by developing therapeutic agents with enhanced effectiveness while minimizing side effects. In this study, we aimed to assess the potential of Sargassum cristaefolium sourced from Teluk Awur Jepara, extracted using ethanol, in combating acne through its in vitro antibacterial and antioxidant attributes. Utilizing the disk diffusion method, our findings demonstrated the extract's efficacy against Cutibacterium acne, Staphylococcus epidermidis, and Staphylococcus aureus. The minimum inhibitory concentration and minimum bactericidal concentration were determined to be 50 and >100 mg mL-1 against C. acnes, 25 and 100 mg mL-1 against S. epidermidis, and 25 and 100 mg mL-1 against S. aureus, respectively. Additionally, bacteriolytic assays confirmed the extract's ability to partially lyse bacterial cells, particularly S. aureus and S. epidermidis at 2× MIC, while C. acne exhibited partial lysis until the 6th hour, followed by an increase in absorbance, possibly due to cellular debris aggregation or bacterial persistence due to incomplete lysis. Furthermore, the extract exhibited notable free radical scavenging properties against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), with IC50 values of 645.35 ± 9.52 and 574 ± 33.52 µg mL-1, respectively. The S. cristaefolium ethanol extract exhibited a total phenol content of 14.17 ± 0.39 mg GAE g-1 and a sulfate content of 10.99 ± 0.45%. Liquid chromatography-mass spectrometry (LC-MS) analysis identified bioactive compounds, including carotenoids, terpenoids, steroids, flavonoids, chromenols, and fatty acids, all of which demonstrate substantial potential as antioxidants and antibacterial agents against acne-causing bacteria. Therefore, ethanolic extract of S. cristaefolium demonstrates potential as an anti-acne treatment due to its antibacterial and antioxidant properties.
Co-Authors Ade Octavia Adi Saputra, Muhamad Agung Endro Nugroho Agung Endro Nugroho Agung Giri Samudra Akhmad Awaludin Agustiar Al-Fairusy, Muhajir ALIM ISNANSETYO Alim Isnansetyo Almira Islamei Pratiwi Alvika Hayyu Chandra Permana, Alvika Hayyu Chandra Amelia Hana Amir Mugozin Anandita Perwita Kurniawan Andi Hakim Annisa Ajeng Maharani Anny Wahyuni Antarif Kusuma Brata Atah, Said Azizi, Wirdatul Auliya Bambang Retno Aji Bekti Wulan Sari Bekti Wulan Sari Bustami Abubakar Claude Mona Airin Deffy R. Putra Dewi Ariani Donghwa Chung Dwi Retno Wulandari Ekantari, Nurfitri Endang Sri Rahayu Ervika Rahayu Novita Herwati Fatimah, Aden Nurin Fitriaty, Fitriaty Gandhi E. Julianto Ginting, Rini Febriyanta Br Hadi Sunliensyar, Hafiful Hanum, Maulida Selma Hermansyah Hermansyah Il Shik Shin Imam Arda Perdana Imas Faturrohmah Indriani, Rizka Indun Dewi Puspita Indun Dewi Puspita Ivana M. Diharningrum Iwan Y.B. Lelana Iwan Y.B. Lelana Iwan Yusuf B. Lelana Iwan Yusuf Bambang Lelana Iwan Yusuf Bambang Lelana Iwan Yusuf Bambang Lelana Komala Putu Tara Hradaya Kristiani, Theresia Adven Dea Kun Cahyaningrum Latif Sahubawa Leihitu, Irsyad Lupi Purnomosari Maknun, Fazidatul Lu’luil Maria Madalena Maulida Selma Hanum Mohamad Gazali Muhammad Nursid Mustofa Meihan, Andre N. Nurjanah Nasruddin AS, Nasruddin AS Nurfitri Ekantari Nurfitri Ekantari Nurul Binti Isnaini Nurul Binti Isnaini Obdulia P. Nugrahani Pingkan Mayestika Afgatiani Pris Larasati Pudji Astuti PUDJI ASTUTI Pudji Astuti Punky Kusuma Damayanti Putra, Hemi Adi Radipta Lailatussifa Rafiie, Said Achmad Kabiru Ramadhan, Kurnia Fajar Rani Laksanawati Reza Idria Riky Paskandani, Riky Rina Syafitri, Rina Risa Ummami Rizka Indriani Rizqi Wahyu Herdianto Ruhamah Ruhamah Rusyda Nurshitaningrum Sadzali, Asyhadi Mufsi Said Achmad Kabiru Rafiie Said Atah Sanusi Ismail Sarmin Sarmin Siti A. Budhiyanti Siti Ari Budhiyanti Sovia Indah Nurkhanifah Subaryono Subaryono Subaryono Subaryono, Subaryono Suhardani, Mila Novalita Sunandar, Husna Vannisa Taswir Taswir Tazwir Tazwir Triyanto Triyanto Ustadi Ustadi Ustadi Ustadi Ustadi Ustadi Ustadi Ustadi Ustadi, Ustadi Uswatun Hasanah Yudi Pranoto Yusuf Kalingga Murda Zuriat, Zuriat