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All Journal Jurnal Pengolahan Hasil Perikanan Indonesia Journal of Food and Pharmaceutical Science Saintek Perikanan : Indonesian Journal of Fisheries Science and Technology Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Teknosains Jurnal Teknologi Pertanian agriTECH INDONESIAN JOURNAL OF PHARMACY Industria: Jurnal Teknologi dan Manajemen Agroindustri Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology Indonesian Food and Nutrition Progress Jurnal Perikanan Universitas Gadjah Mada Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Veterinary Sciences) Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Dinasti International Journal of Education Management and Social Science Journal of Multidisciplinary Applied Natural Science Analisa: Journal of Social Science and Religion Estungkara: Jurnal Pengabdian Pendidikan Sejarah Paradigma: Jurnal Kajian Budaya Journal of Food and Pharmaceutical Sciences Journal of Fisheries & Marine
Amir Husni
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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Inhibitory Activity of Sargassum hystrix Extract and Its Methanolic Fractions on Inhibiting α-Glucosidase Activity Azizi, Wirdatul Auliya; Ekantari, Nurfitri; Husni, Amir
Indonesian Journal of Pharmacy Vol 30 No 1, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1190.167 KB) | DOI: 10.14499/indonesianjpharm30iss1pp36

Abstract

Seaweed has a great potential in the pharmaceutical field, one of them as antidiabetic. The purposed of this study was to know the inhibitory activity of Sargassum hystrix extract and its methanol fraction in inhibiting α-glucosidase activity. S. hystrix was extracted using methanol, then partitioned using chloroform, ethyl acetate, and methanol. Methanol fraction then separated by column chromatography to obtain the compound. The crude extract, the partitioned methanol fraction, and the column chromatography fraction were tested for its activity on inhibiting the α-glucosidase. The compounds of active fraction were analyzed using gas chromatography-mass spectrometry (GC-MS). The inhibitory activity (IC50) of the crude extracts and the partitioned methanol fraction were 0.35±0.05 and 0.02±0.00 (mg/mL), respectively. The column chromategraphy fractions that had an inhibitory activity to α-glucosidase were M2 (23.46±1.63%), M3 (30.88±4.53%), M4 (73.64±3.47%), and M7 (53.48±1.56%). GC-MS showed that the suspected compound which had inhibiting α-glucosidase in methanol fraction were 9-Octadecenoic acid, 1-Heptadecanecarboxylic acid,9,12-Octadecadienoic acid (Z, Z), and Octadecanoic acid methyl ester.
Co-Authors Ade Octavia Adi Saputra, Muhamad Agung Endro Nugroho Agung Endro Nugroho Agung Giri Samudra Akhmad Awaludin Agustiar Al-Fairusy, Muhajir ALIM ISNANSETYO Alim Isnansetyo Almira Islamei Pratiwi Alvika Hayyu Chandra Permana, Alvika Hayyu Chandra Amelia Hana Amir Mugozin Anandita Perwita Kurniawan Andi Hakim Annisa Ajeng Maharani Anny Wahyuni Antarif Kusuma Brata Atah, Said Azizi, Wirdatul Auliya Bambang Retno Aji Bekti Wulan Sari Bekti Wulan Sari Bustami Abubakar Claude Mona Airin Deffy R. Putra Dewi Ariani Donghwa Chung Dwi Retno Wulandari Ekantari, Nurfitri Endang Sri Rahayu Ervika Rahayu Novita Herwati Fatimah, Aden Nurin Fitriaty, Fitriaty Gandhi E. Julianto Ginting, Rini Febriyanta Br Hadi Sunliensyar, Hafiful Hanum, Maulida Selma Hermansyah Hermansyah Il Shik Shin Imam Arda Perdana Imas Faturrohmah Indriani, Rizka Indun Dewi Puspita Indun Dewi Puspita Ivana M. Diharningrum Iwan Y.B. Lelana Iwan Y.B. Lelana Iwan Yusuf B. Lelana Iwan Yusuf Bambang Lelana Iwan Yusuf Bambang Lelana Iwan Yusuf Bambang Lelana Komala Putu Tara Hradaya Kristiani, Theresia Adven Dea Kun Cahyaningrum Latif Sahubawa Leihitu, Irsyad Lupi Purnomosari Maknun, Fazidatul Lu’luil Maria Madalena Maulida Selma Hanum Mohamad Gazali Muhammad Nursid Mustofa Meihan, Andre N. Nurjanah Nasruddin AS, Nasruddin AS Nurfitri Ekantari Nurfitri Ekantari Nurul Binti Isnaini Nurul Binti Isnaini Obdulia P. Nugrahani Pingkan Mayestika Afgatiani Pris Larasati Pudji Astuti PUDJI ASTUTI Pudji Astuti Punky Kusuma Damayanti Putra, Hemi Adi Radipta Lailatussifa Rafiie, Said Achmad Kabiru Ramadhan, Kurnia Fajar Rani Laksanawati Reza Idria Riky Paskandani, Riky Rina Syafitri, Rina Risa Ummami Rizka Indriani Rizqi Wahyu Herdianto Ruhamah Ruhamah Rusyda Nurshitaningrum Sadzali, Asyhadi Mufsi Said Achmad Kabiru Rafiie Said Atah Sanusi Ismail Sarmin Sarmin Siti A. Budhiyanti Siti Ari Budhiyanti Sovia Indah Nurkhanifah Subaryono Subaryono Subaryono Subaryono, Subaryono Suhardani, Mila Novalita Sunandar, Husna Vannisa Taswir Taswir Tazwir Tazwir Triyanto Triyanto Ustadi Ustadi Ustadi Ustadi Ustadi Ustadi Ustadi Ustadi Ustadi, Ustadi Uswatun Hasanah Yudi Pranoto Yusuf Kalingga Murda Zuriat, Zuriat