Article Per Year (5 Year)
p-Index From 2021 - 2026
3.484
P-Index
This Author published in this journals
All Journal International Journal of Evaluation and Research in Education (IJERE) Atom Indonesia Journal Jurnal Penelitian Fisika dan Aplikasinya (JPFA) Jurnal Pendidikan Sains Jurnal Pendidikan IPA Indonesia Jurnal Pembelajaran Fisika Jurnal Pendidikan Fisika FKIP UM Metro Journal of Engineering and Technological Sciences JFA (Jurnal Fisika dan Aplikasinya) Berkala Ilmiah Pendidikan Fisika Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan JPSE (Journal of Physical Science and Engineering) Science and Technology Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) JPF : JURNAL PENDIDIKAN FISIKA COMPTON: Jurnal Ilmiah Pendidikan Fisika Jurnal Pengabdian Kepada Masyarakat (Mediteg) Dedikasi: Jurnal Pengabdian Masyarakat Jurnal Pengabdian kepada Masyarakat Nusantara Community Empowerment LOSARI: Jurnal Pengabdian Kepada Masyarakat Jurnal Ekonomi Bisnis, Manajemen dan Akuntansi (JEBMA) AbdiTechno (Jurnal Pengabdian Masyarakat) International Journal of Community Service Implementation ABDI KAMI: Jurnal Pengabdian Kepada Masyarakat
Sunaryono
Universitas Negeri Malang
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Physics Public Health Social Sciences Transportation Other

Published : 41 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Science and Technology Indonesia

 1 
Novel Self-Nanoemulsifying Drug Delivery System of Single Bulb Garlic: Stability, Toxicity, and Antiinflammation in 3T3-L1 Cells Dewi Sekar Miasih; Yuslinda Annisa; Sri Rahayu Lestari; Hendra Susanto; Sunaryono
Science and Technology Indonesia Vol. 7 No. 4 (2022): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1699.595 KB) | DOI: 10.26554/sti.2022.7.4.417-426

Abstract

Single bulb garlic (SBG) has the potential as an immunomodulator; however, it has low solubility and bioavailability. A lipid-based delivery system, that is, the self-nanoemulsifying drug delivery system (SNEDDS), offers a novel opportunity in drug delivery. SBG can be a suitable candidate for SNEDDS development. This research aims to describe the physical stability, toxicity test of the SNEDDS, and SNEDDS SBG potential as antiinflammation in 3T3-L1 cells. The SNEDDS is made with various ratios of concentrations of carrier oil, surfactants, and cosurfactants, namely, 0.50: 3.45: 0.96, and added with SBG extract (SBGE) of 20 mg/mL. The results of the response test of SNEDDS SBGE formulation indicate an average and standard deviation of emulsification time of 16.38±3.01 (second), pH 7.21±0.08, and transmittance of 98.40±0.23(%). The average nanoemulsion size is 14.333±0.416 nm, polydispersion index of 0.213±0.056, and zeta potential of -14.67±0.72 mV. The results of the physical stability test indicate no segregation, deposition, cracking, or creaming in all nanoemulsion samples and SNEDDS SBG. The MTT test in a dose of 62.5, 125, 250, 500, 100, 2000, and 4000 µg/mL suggests that the highest viability of the 3T3-L1 cells is at a dose of 2000 µg/mL, which is 97.83%±1.55%. Therefore, SNEDDS SBGE can be a potential candidate for oral preparation by increasing bioavailability and reducing toxicity in the 3T3-L1 cells. An antiinflammatory test on the TNF-???? and IL-1???? expressions influences the 3T3-L1 cells. the SNEDDS of SBGE has the potential to reduce the expression of TNF-???? and IL-1???? and increase IL-10 expression in the methylglyoxal-induced 3T3-L1 cells.
Co-Authors A. Okazawa A. Taufiq Abdul Hamid Hasbullah Achmad Hamdan Adam, Dian Awaluddin Adim Firmansah Agung Witjoro Ahmad Hanfan, Ahmad Ahmad Taufiq Akhmad Jufriadi Amin Mustajab Andy Choerullah Anita Listanti Annisa Avrilia Annisa Firly Aprilia Putri Apriani, Feriansyah Apriani, Tia Arfienda Miawa Tyassilva Arif Hidayat Aripriharta - Arrika Wifqotu Lailin Nafisah Aryansyah Pratama Asmarita, Yulmaisi Dwi B. Anggit Wicaksono Basri, Nur Akhyar Choirunnisa, Fadhillah Chokchai Yuenyong Christina Martha Chusna, Nadiya Miftachul D. Darminto Darminto Darminto Dewi Sekar Miasih Diyana, T. N. Doni Andra E.G.R Putra Endang Purwaningsih Endang Purwaningsih Era Budi Prayekti Futri Yuliana H N Ulya Hadi, Sholihul Hariyanto, Yuanita Amalia Helmi Muhammad Hendra Susanto Heriyanto Heriyanto Heru Wahyu Herwanto I Dewa Putu Nyeneng I. Watanabe Irawan, Ivan Danar Aditya Kartini Herlina Kesaulya, Noke Kormil Saputra Kusuma Wardhani Mas'udah Kusuma Wardhani Mas'udah Leonardus Hendra Aha Lia Yuliati Mahben Jalil Markus Diantoro Mokh Sholihul Hadi Muh. Iqbal Saman Muhammad Baqir Zaini Muhardjito Muhardjito Muhiban Syabani Munzil Munzil N. Hidayat N. Kojima Nadhira, Anissa Chairani Alfin Najmi, M. Ikhwan Nandang Mufti Nik Ahmad Nizam Nik Malek Novi Arianti Nurdin Nurdin Nurul Hidayat Parno Parno Ramadhani, I Gusti Ayu Isnaini Fatha Rasyid, Fauziah Rifqi Al Ihsan S E I Suryani S W Himmah S. Pratapa Samsul Hidayat Sanusi, Dirga Kaso Satia Nur Maharani Sentot Kusairi Sholihul Hadi Siti Maryam Solehudin Solehudin Sri Rahayu Lestari ST. Ulfawanti Intan Subadra Supriana, Edi Supriyono Koes Handayanto Sutopo Sutopo Thathit Suprayogi Tomy Suganda Tomy Suganda Widya Elyani Yuda Prima Hardianto Yuliana, Erma Surya Yuliana, Futri Yunan Amza Muhammad Yuslinda Annisa Z Nurdiana Zulfi Farida Alfianti