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Profil Kejadian Efek Samping Obat Tuberkulosis Lini Pertama Aprilia, Devi Ratna; hendra, Godeliva adriani; Aditya, Martanty
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 3 No. 1 (2025): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v3i1.54

Penyakit infeksi merupakan penyakit yang disebabkan oleh adanya bakteri patogen di dalam tubuh manusia. Tuberkulosis paru merupakan penyakit menular yang disebabkan langsung oleh Mycobacterium tuberculosis, terutama menyerang pada paru-paru. Penelitin ini adalah untuk mecegah timbulnya resisten oat akibat kejadian putus obat serta edukasi efek samping yang timbul untuk meningkatkan kepatuhan pada pasien serta untuk melihat efek samping obat tuberkulosis lini pertama. Metode penelitian ini dilakukan secara observasional dengan pendekatan cross sectional dan pengambilan data secara retrospektif. Pengambilan data dilakukan terhadap pasien yang terkonfirmasi TBC dengan lini pertama dengan populasi seluruh pasien TBC dengan lini pertama yang dirawat secara rawat jalan dan sampel sebanyak 88 berdasarkan kriteria inklusi. Hasil dari peneilitian menunjukkan bahwa karakteristik seperti usia, jenis kelamin, fase intensif dan fase lanjutan tidak ada hubungan dengan kejadian efek samping terbukti dengan hasil p-value yang lebih dari 0,05. Kesimpulan dari penelitian ini adalah efek samping yang muncul pada pasien tbc lini pertama adalah Mual, muntah, pusing, kencing berwarna merah, pusing, nafsu makan berkurang, kesemutan, nyeri otot, nyeri sendi, telapak kaki berkeringat dan diare.

End User’s Computing Satisfaction Untuk Sistem Informasi Obat Bahan Alam Pada Tenaga Vokasi Farmasi Sebagai Pengguna Di Kota Semarang Ratu, Modestus; Suwarni, Sri; Wulandari, A. Ratna; Aditya, Martanty; Santoso, Arif
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p196-202

The use of herbal medicine is a method of treatment that utilizes plants, either empirically by the community or with the help of information from healthcare professionals. This research aims to evaluate the level of satisfaction and the strength of the relationship between the dimensions of satisfaction using the End User’s Computing Satisfaction method by Pharmacy Vocational Personnel towards the Natural Herbal Medicine Information System (SI-OBAL) in Semarang City. This research is a non-experimental study with the EUCS method, which is qualitatively quantified prospectively. The instrument used was a questionnaire that has been tested by experts and through validation and reliability testing. The data was analyzed using frequency statistics to describe the characteristics of the respondents and the percentage of each dimension, which includes end-user satisfaction with technological aspects such as content, accuracy, format, timeliness, and ease of use of the system. The results of the study show that the overall level of satisfaction of Pharmacy Vocational Personnel with the Natural Herbal Medicine Information System (SI-OBAL) is 84.19%, which is categorized as very satisfied. This indicates that SI-OBAL has successfully met the needs and satisfaction of Pharmacy Vocational Personnel in Semarang City.

Korelasi Karakteristik Pasien dengan Biaya Perawatan Pasien Stroke Iskemik Geriatri Nugraha, Dhanang Prawira; Aditya, Martanty
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.44-51

Background Ischemic stroke is a degenerative condition that primarily affects the elderly and has high treatment expenses. There is no data on how much it costs to treat stroke patients in Indonesia, and there are many factors that influence the cost of ischemic stroke treatment, particularly in geriatric patients. Methods This study was conducted from October to December 2018 using a cross-sectional technique. In this study, 53 patients who met the exclusion and inclusion criteria were employed as samples. The patient's characteristics, such as age, gender, length of stay, number of comorbidities, and drug quantities, are the independent variables in this study. The cost of treatment is the dependent variable. Data was acquired utilizing data collecting sheets from hospital information systems and medical records. The Spearman test and the eta test were conducted with 95 percent confidence to determine the correlation between patient characteristics and treatment costs, and the value of R was used to determine the strength of the correlation between variables. Results According to the findings, the average cost of treatment for geriatric ischemic stroke patients was Rp 5,144,083 Rp 4,423,794. The length of stay (p-value 0.05; R=0.756), the number of comorbidities (p-value 0.05; R=0.44), and the number of drugs (p-value 0.05; R=0.60) all had a significant correlation with the cost of treatment. Conclusions The factors that significantly affect the cost of hospitalisation for geriatric ischemic stroke patients are the length of stay, number of comorbidities, and number of drugs.

Correlation Between Drug-Related Problems and the Treatment Cost for Geriatric Ischemic Stroke Patients in Tulungagung nugraha, dhanang prawira; aditya, martanty
Jurnal Ekonomi Kesehatan Indonesia Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Ischemic stroke was one of the diseases that frequently occurred in geriatric patients, while hemorrhagic stroke had a higher prevalence. Geriatric patients who experienced a stroke were not exempt from drug-related problems (DRP) due to the complexity of treatment and comorbid factors they encountered. This study aimed to determine the correlation between DRP and the cost of care for ischemic stroke patients, particularly in the geriatric population. The study design was cross-sectional, with data collected retrospectively, and the sample comprised 53 geriatric stroke patients who met the inclusion and exclusion criteria. DRP was assessed using the PCNE 6.2 criteria, and the cost data included expenses for medications, medical devices, laboratory tests, visit fees, accommodation, diagnostic electromedical procedures, radiology, nutrition, and insurance. The independent variable in this study was DRP, while the dependent variable was the cost of care. The analysis used in this study was Spearman's correlation and was presented with a correlation coefficient (R). The results showed a significant correlation between DRP and care costs (p-value < 0.05), with a correlation coefficient 0.501. The study concluded with the assertion that an increase in DRP is associated with elevated costs of care for geriatric ischemic stroke patients.

The Association of Respondent Characteristics with Hyperglycemia among Obesity at the Outpatient Clinic Aditya, Martanty; Nugraha, Dhanang Prawira; Zita, Hestyana; Yanuar, Michael Resta Surya; Afthoni, Muhammad Hilmi
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 2 (2025): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i2.7515

The prevalence of obesity continues to increase and has become one of the significant risk factors for insulin resistance. This condition contributes to the rising prevalence of diabetes mellitus and various metabolic disorders. This study aimed to investigate the association between risk factors andblood glucose levels in individuals with obesity. The respondents were individuals with obesity who had existing medical records and subsequently registered at the outpatient clinic of IHC Lavalette Hospital, Malang. This research employed an observational study design with a cross-sectional method. Sampling was conducted using purposive sampling based on inclusion criteria, resulting in 121 respondents. Data were collected through interviews and medical records and analysed using Fisher exact test. The results showed that certain risk factors were significantly associated with the occurrence of hyperglycemia, including male (OR = 8.376; 95% CI: 1.619–83.695), age 51–75 years (OR = 10.283; 95% CI: 1.979– 102.917), and not taking OADs (OR = 8.426; 95% CI: 1.855–52.901). No significant associations were observed for employment status, marital status, family history of diabetes mellitus, sleep habits, or class I and II obesity. Results related to comorbidity and several odds ratio estimates had wide confidence intervals, reflecting uncertainty due to the small number of cases. Further studies with larger sample sizes are warranted.

Exploring Prescription Patterns and Patient Characteristics in Antiepileptic Therapy: A Retrospective Observational Study: Menjelajahi Pola Resep dan Karakteristik Pasien dalam Terapi Antiepilepsi: Studi Observasional Retrospektif Martanty Aditya; Godeliva Adriani Hendra; Putera Maitreya
Academia Open Vol. 8 No. 2 (2023): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.8.2023.7268

This retrospective observational study aimed to provide an overview of prescribed antiepileptic therapy utilization and patient profiles. Conducted at a Neurology Polyclinic, data from December 2022 to January 2023 were analyzed descriptively. Among 35 eligible patients, the majority were male (68.57%), aged 15-25 years (48.57%), with long-standing epilepsy (54.28%), and absence of recent seizures (54.28%) and comorbidities (62.85%). Monotherapy was employed for 51.43%, while 48.57% received combination therapy. Phenytoin emerged as the most frequently prescribed monotherapy (25.71%), and valproic acid combined with phenytoin was the prominent combination (14.28%). This study highlights the prevalence of phenytoin and valproic acid usage, suggesting the need for further investigation into their efficacy and implications for epilepsy management. Highlights: Diverse Prescription Patterns: The study reveals a range of antiepileptic therapy prescriptions, with phenytoin and valproic acid being the predominant choices in both single and combination forms. Patient Profiles and Demographics: The analysis focuses on male-dominated respondents aged 15-25 years, emphasizing the importance of understanding patient characteristics for tailored epilepsy management strategies. Implications for Treatment Strategies: The findings underscore the significance of evaluating the efficacy and clinical implications of commonly prescribed antiepileptic drugs, guiding clinicians in optimizing epilepsy treatment regimens. Keywords: Antiepileptic therapy, Prescription patterns, Patient characteristics, Epilepsy management, Combination therapy.

Pengaruh Artificial Intelligence (AI) dalam Visualisasi Materi untuk Meningkatkan Minat Belajar dan Pemahaman Mahasiswa Farmasi Fibe Yulinda Cesa; Meylinda Widyasari; Martanty Aditya; Hendry Setiawan
JUKEJ : Jurnal Kesehatan Jompa Vol 5 No 2 (2026): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol5.Iss2.2629

Metode pembelajaran konvensional di tingkat Universitas kerap kurang mampu membangkitkan minat dan pemahaman mahasiswa secara optimal. Penelitian ini bertujuan untuk meningkatkan pemahaman dan minat belajar mahasiswa melalui kolaborasi teknik mnemonic dengan pemanfaatan AI (ChatGPT, Image Generator 2.0, dan Gemini) dalam proses perkuliahan. Penelitian melibatkan 47 mahasiswa yang terbagi dalam dua kelompok, yaitu kelas A dan kelas B. Data dikumpulkan menggunakan kuesioner tervalidasi serta pretest dan posttest, kemudian dianalisis dengan uji Paired Sample T-test dan Independent Sample T-test. Hasil kuesioner menunjukkan bahwa sebagian besar responden merasakan kontribusi positif dari integrasi AI dan mnemonic dalam meningkatkan konsentrasi dan kemampuan mengingat materi. Uji Paired Sample T-test pada kedua kelas menghasilkan nilai p < 0,05, yang mengindikasikan adanya peningkatan hasil belajar yang signifikan antara pretest dan post-test. Sementara itu, uji Independent Sample T-test menghasilkan nilai p = 0,954, yang menunjukkan bahwa peningkatan yang terjadi pada kelas A dan kelas B tidak berbeda secara signifikan, sehingga kedua metode perlakuan memberikan efek yang setara. Temuan ini mengimplikasikan bahwa integrasi teknik mnemonic dan AI dapat menjadi alternatif metode pembelajaran inovatif yang efektif dan konsisten dalam meningkatkan capaian belajar mahasiswa, terlepas dari perbedaan komposisi kelompok.

Aplikasi Metode Biologi Molekuler pada Model Embrio Ikan Zebra (Danio rerio) dalam Pengembangan Obat Kardiovaskular Fibe Yulinda Cesa; Martanty Aditya; Devilke Yandriyani; Reflinda Sindy Puspita; Rizal Bing Garumal Indianta
JUKEJ : Jurnal Kesehatan Jompa Vol 5 No 2 (2026): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol5.Iss2.2698

Cardiovascular diseases remain a leading cause of global mortality and morbidity for 6.9 million deaths in 2021 due to conditions like stroke and ischemic heart disease. The high cost of long-term treatment often leads to decreased medication adherence, spurring the development of new, more affordable yet effective drugs. To minimize risk, animal models are crucial in drug development before human trials. Therapy for cardiovascular diseases continues to evolve due to high costs and poor adherence. Zebrafish have emerged as a promising animal model due to their genetic similarity to humans, allowing for the testing of more efficient and affordable novel drugs. This study reviewed articles on cardiovascular disease in zebrafish embryos from MDPI, PubMed, Science Direct, and Springer Link databases, using specific keywords. Inclusion criteria included quantitative research articles in English or Indonesian, open-access, and published between 2015-2025. Following the PRISMA process (identification, screening, eligibility), 14 relevant journals were selected from 5.680 initial articles and subsequently analyzed using JBI Critical Appraisal Tools for further discussion. The findings indicate that various molecular techniques, such as immunostaining, PCR, and western blotting, enable cardiovascular disease research in zebrafish embryos. This model offers speed, accuracy, and cost-efficiency due to its transparent and replicable nature. Despite requiring specialized skills due to their small size, zebrafish embryos present a promising alternative for developing new cardiovascular drugs.

The Association Between Haloperidol and Clozapine and The Risk of Hyperglycaemia in Patients with Schizophrenia Martanty Aditya; Godeliva Adriani Hendra; Rina Setyowati
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 1 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i1.105

First- and second-generation antipsychotics such as haloperidol and clozapine are treatment options for schizophrenia; however, both have the potential for metabolic side effects, including hyperglycemia. This study aimed to analyse the association between using haloperidol or clozapine, either alone or together, and the occurrence of hyperglycemia in patients with schizophrenia. The research used an observational design with a cross-sectional study and retrospective data from 154 medical records of schizophrenia patients. The study was conducted at Dr. Radjiman Wediodiningrat Psychiatric Hospital outpatient clinic, Lawang, from January to March 2025. Data were analysed using the chi-square test and odds ratio with RStudio 2024. The results showed that most patients received clozapine alone or with other medications (70.78%). A significant association was found between clozapine use and male sex (p = 0.014) as well as the 17–40 age group (p = 0.001). Haloperidol use was linked to an increased risk of elevated creatinine levels (p = 0.026). However, there was no significant link between the type of therapy and the risk of hyperglycemia (OR = 1.243; 95% CI: 0.097–66.819). Levels of SGOT (p = 0.913), SGPT (p = 0.258), and urea (p = 1.000) stayed within normal limits in both treatment groups. In summary, clozapine may carry a slightly higher but statistically insignificant risk of causing hyperglycemia. Overall, treatment with haloperidol or clozapine appears safe concerning liver and kidney function, as indicated by normal SGOT, SGPT, and urea levels.

The Association Between Haloperidol and Clozapine and The Risk of Hyperglycaemia in Patients with Schizophrenia Martanty Aditya; Godeliva Adriani Hendra; Rina Setyowati
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 1 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i1.105

First- and second-generation antipsychotics such as haloperidol and clozapine are treatment options for schizophrenia; however, both have the potential for metabolic side effects, including hyperglycemia. This study aimed to analyse the association between using haloperidol or clozapine, either alone or together, and the occurrence of hyperglycemia in patients with schizophrenia. The research used an observational design with a cross-sectional study and retrospective data from 154 medical records of schizophrenia patients. The study was conducted at Dr. Radjiman Wediodiningrat Psychiatric Hospital outpatient clinic, Lawang, from January to March 2025. Data were analysed using the chi-square test and odds ratio with RStudio 2024. The results showed that most patients received clozapine alone or with other medications (70.78%). A significant association was found between clozapine use and male sex (p = 0.014) as well as the 17–40 age group (p = 0.001). Haloperidol use was linked to an increased risk of elevated creatinine levels (p = 0.026). However, there was no significant link between the type of therapy and the risk of hyperglycemia (OR = 1.243; 95% CI: 0.097–66.819). Levels of SGOT (p = 0.913), SGPT (p = 0.258), and urea (p = 1.000) stayed within normal limits in both treatment groups. In summary, clozapine may carry a slightly higher but statistically insignificant risk of causing hyperglycemia. Overall, treatment with haloperidol or clozapine appears safe concerning liver and kidney function, as indicated by normal SGOT, SGPT, and urea levels.

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