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All Journal Jurnal Kedokteran Brawijaya Jurnal Kesehatan Andalas Indonesian Journal of Tropical and Infectious Disease MNJ (Malang Neurology Journal) Paediatrica Indonesiana Majalah Kesehatan FKUB Indonesian Journal of Chemistry Jurnal Respirologi Indonesia ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Narra J Pediatric Sciences Journal
Agustin Iskandar
Departemen Patologi Klinik Dan Kedokteran Laboratorium, Fakultas Kedokteran, Universitas Brawijaya / RSUD Dr Saiful Anwar, Malang
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Jurnal Kedokteran Brawijaya

 1 
EFEK KOMBINASI KLOROKUIN DAN N-ACETYL CYSTEINETERHADAP JUMLAH TROMBOSIT MENCIT GALUR BALB/C YANG DIINFEKSI Plasmodium berghei Mulyastuti, Yuanita; Widijanti, Anik; Ali, Mulyohadi; Iskandar, Agustin; Fitri, Loeki Enggar
Jurnal Kedokteran Brawijaya Vol 20, No 1 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.731 KB) | DOI: 10.21776/ub.jkb.2004.020.01.8

Abstract

Malaria is the most important of the parasitic diseases of humans. In Indonesia, about more than 70 million people live in area which is endemic to malaria, about 15 million new case ofmalaria occurred every year. In malaria immune response forms free radical which assist to eliminate the cause of disease but  also destroys endothelial cells at various organ. This oxidative damage plays an important role in the development of malarial thrombocytopenia. The aim of this research was to investigate the effect of Choroquine combine with N-Acetyl cysteine on the degree of parasitemia and platelets amount during malaria infection. Combination of Chloroquine and N-Acetyl cysteine have been tested by using experimental research method in male Balb/c mice which was infected by Plasmodium berghei. Measurement of the degree ofparasitemia was done everyday and the amount of the platelet as one of the nonspecific cellular immunity parameter at malaria was calculated once in three days. Treatment group were divided to eight groups, group of chloroquine(0,05 mg/gr), group of N-Acetylcysteine with dose 0,25 mg/gr, 0,5 mg/gr, and 1 mg/gr and also combination group of chloroquine and N-Acetyl cysteine with constant dose of chloroquine(0,05 mg/gr) and various dose of N-Acetyl cysteine(0,25 mg/gr, 0,5 mg/gr, and 1 mg/gr). One group consistedof infected mice without treatment as control group.
EFEK KOMBINASI ARTEMISININ DAN N-acetylcysteineTERHADAP KADAR Malondialdehyde(MDA) OTAK DAN PARU MENCIT GALUR Balb/c YANG DIINFEKSI Plasmodium berghei Fitri, Loeki Enggar; Iskandar, Agustin; Permatasari, Nur; Gunawan, Joko Agus; Indrawan, Khadafi
Jurnal Kedokteran Brawijaya Vol 24, No 2 (2008)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (94.577 KB) | DOI: 10.21776/ub.jkb.2008.024.02.4

Abstract

Cerebral and lung damage during malaria infection is believed to be caused by free radicals activitiesthat are produced during immunology process. The free radicals react with lipid component of cellular membrane which generates malondialdehyde (MDA) as its end-product. The aim of the research was to determine whether combination of artemisinin and NAC was moreeffective in decreasing cerebral and lung MDA level compared to artemisinin mono-therapy . The researchwas post-test-control-only design using 5 groups consisted of group A (negative control group), group B mice which infected with P.berghei without therapy (positive control group), group C mice which infected with P.berghei and received artemisinin mono-therapy (0.04 mg/g BW for 7 days), group D mice which infected with P.berghei and received artemisinin in combination with NAC (1 mg/g BW for 7 days) and group E mice which infected with P.berghei and received artemisinin in combination with NAC (1 mg/g BW for 3 days and tapered into ½ mg/g BW for 4 days). On the 3rd, 5th,and 7thday, 3 mice from each group were scarified and assayed for MDA level. On the 3rd day, a decreasing trend of cerebral and lung MDA level wasobserved on all treatment groups. On the 5thday, a decreasing trend of cerebral and lung MDA level wasobserved in group that received artemisinin and NAC whereas group’s that received artemisinin mono-therapy increased. Cerebral and lung MDA level of groupthat received artemisinin mono-therapy was significantly different with group that received combination of artemisinin and NAC in constant dose (p = 0.014) and with group that received combination artemisinin  and NAC in tapering dose (p = 0.004).
Co-Authors Aditya Sri Listyoko Agustina Tri Endharti Aina Angelina Akmaly, Triyana Dian Dhuha Alim, Fathi Nabila Amalia, Najwa Anik Widijanti Aprilia, Andrea Aris Widayati Aryati Aryati Aryati Aryati Aryati Aryati Beti Ernawati Dewi Carla Pramudita Susanto Catur Suci Sutrisnani Corebima, Brigitta IRV Deasy Ayuningtyas Tandio Dewi, Rose Khasana Dian Nugrahenny Dina Fauziah Edi Widjajanto Eko Sulistijono Eko Sulistijono Ery Olivianto Fran Siska Hambiah Hari Oki Hambiah Hari Oki Hamid, Aulia A. Hardi Darmawan Hartanti, Khoirunisah Dwi Herdiman T. Pohan Ihda Dian Kusuma Indriana, Kristin Jahono, Maxie Felix Joko Agus Gunawan Karima, Karima Kautsarani, Intan Khadafi Indrawan Kristin Indriana Leonard Nainggolan Lindayanti Sumali Loeki Enggar Fitri Ludytajati, Ferine Maisaroh, Luluk Mayashita, Dearikha Karina Mirza, Sarah Zoraya Mufidatun Hasanah Muhammad Anshory Muhammad Anshory, Muhammad Mulyohadi Ali Mustika Dewi Nada Putri Pranidya Norwahyuni, Yuyun Novi Khila Firani Novi Kurnianingsih Nur Permatasari Nur Samsu Prameswari, Asri Pranidya, Nada Putri Pratama, Gusti Rajendra Yoga Putri Wulan Akbar Rahajuningsih Dharma Rambe, Annisa Fadhila Aurelia Rianto Setiabudy Riskawati, Yhusi Karina Rosari, M Angelina de Sanjaya, Hayyu Rafina Saptadi Yuliarto Seskoati Prayitnaningsih Settrin Chenderawasi Siska, Fran Sudjari Sudjari Suhendro Suhendro Syahfitri, Rininta Syahrul Chilmi Tri Wahju Astuti, Tri Wahju Triwahju Astuti Wafi, Muhammad Wihastuti TA Yeni Ayu Prihastuti Yeni Ayu Prihastuti Yuanita Mulyastuti Yuniasih, Kristina