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All Journal Biogenesis: Jurnal Ilmiah Biologi Jurnal Kesehatan Prosiding Seminar Biologi INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Journal of Pharmaceutical and Medicinal Sciences JFIOnline ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar Sociality: Journal of Public Health Service Jurnal Sains dan Kesehatan
Isriany Ismail
Universitas Islam Negeri Alauddin Makassar
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Quality and Release Profile of Captopril from Mucoadhesive Gastroretentive Tablet by Using Matrix Sodium Carboxymethyl Cellulose and Carbopol 934P Isriany Ismail; M. Asrah Hidayah Usman; Nur Ida
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.14028

Abstract

Captopril have good absorption in gastric pH and ionized on intestinal pH. It is necessary to keep the drug in the form of molecules in the area of the absoption. The mucoadhesive gastroretensive drug delivery system provides the possibility of controlled release in stomach in a certain amount of time. Research has been conducted to assess the quality and profile of captopril release in of a mucoadhesive gastroretensive tablet. Mucoadhesive tablets (MK) were made in 5 formulas by wet granulation method using carbopol 934P and sodium carboxymethyl cellulose as matrix with ratio 10: 0 (MK1), 0: 10 (MK2), 5: 5 (MK3), 7: 3 (MK4), and 3: 7 (MK5). The parameters which was evaluate were characteristics of granules and tablets and kinetics model of captopril release from tablets in 0,01 N HCl medium. Mucoadhesive tablets had different characteristics for each formula. Mucoadhesive tablets that had good quality and release profile were shown by MK4 and MK5 formula. They had controlled drug release profiles accorded to the Korsmeyer-Peppas and Higuchi kinetics models, respectively.
Potential of Sweet Orange Peels (Citrus sinensis) Essential Oil as Sunscreen Isriany Ismail; Fatma Dewi; Ferawati Ferawati; Nursalam Hamzah
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.20720

Abstract

Telah dilakukan penelitian tentang uji efektifitas minyak atsiri kulit buah jeruk manis (Citrus sinensis) sebagai tabir surya secara spektrofotometer UV-VIS. Penelitian ini bertujuan untuk menentukan potensi dari minyak atsiri kulit jeruk manis sebagai tabir surya yang ditentukan dengan nilai SPF, transmisi eritema dan transmisi pigmentasi. Minyak atsiri jeruk diperoleh dengan mengekstraksi kulit buah jeruk manis dengan metode pengepresan/pemerasan. Pengujian dilakukan menggunakan metode spektrofotometri UV pada panjang gelombang 290 – 400 nm terhadap konsentrasi minyak atsiri 20, 40, 60, 80, 100, dan 120 bpj. Hasil analisis menunjukkan bahwa minyak atsiri kulit buah jeruk manis (Citrus sinensis) mengabsorbsi sinar UV B hingga UV A dengan nilai SPF 1,094 hingga 1,380. Persen eritema dan pigmentasi pada konsentrasi 120 bpj berturut-turut adalah 66,98% dan 65,54%.
Effects of Enhancment Span-60 of Vernonia amygdalina Leaves Extract-loaded Niosomes Pratiwi, Afrianty; Syahrana, Nur Azizah; Ismail, Isriany; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.45956

Abstract

Introdiction: Niosomes are a promising drug carrier because of their bilayer structure and the fact that they are produced by the self-association of nonionic surfactants and cholesterol in an aqueous phase. Niosomes are non-toxic, biodegradable, and compatible with human cells. Aims: This research aimed to create niosomes from V. amygdalina leaves and investigate how span 60 addition affects niosome properties. Methods: Extraction V. amygdalina using maceration, niosomes synthesized using a thin-film hydration process, and characterization performed by SEM, particle size, polydispersity index, zeta potential, and FTIR. Conclusion: V. amygdalina succesfully to loaded into niosomes. Span-60 with various concentration affected of characterization of niosomes. Increased span-60 increasing particle size, polydispersity index, and %EE.
Studi Pustaka: Pengaruh Metode Ekstraksi Terhadap Kualitas Gelatin dari Ikan dengan Pretreatment Asam dan Basa Jaya, Adrian; Ismail, Isriany; Arsul, Muhammad Ikhlas
Jurnal Farmasi UIN Alauddin Makassar Vol 12 No 1 (2024): Jurnal Farmasi Edisi Mei
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jfuinam.v12i1.38150

Abstract

Pendahuluan: Gelatin ikan merupakan gelatin alternatif yang bersifat multifungsi yang diperoleh dari hidrolisis kolagen dari bagian ikan meliputi sisik, kulit maupun tulang dengan metode ekstraksi tertentu. Tujuan: Untuk mendapatkan informasi dari berbagai sumber literatur mengenai pengaruh metode ekstraksi gelatin ikan terhadap kualitas gelatin dalam upaya mengembangkan metode yang paling efisien dalam produksi gelatin ikan. Metode: Penulisan artikel ini adalah literature review yaitu sebuah pencarian literatur baik international maupun nasional yang dilakukan dengan menggunakan database pubmed, sciencedirect, dan google schoolar. Penelusuran dan analisis artikel menggunakan metode PICO (Population, Intervention, Comparison, Outcome). Hasil: Terdapt 28 artikel yang memenuhi kriteria untuk selanjutnya dilakukan analisis dengan melihat metode ekstraksi gelatin dan karakteristik gelatin. Kesimpulan: Semakin tinggi suhu ekstraksi, semakin rendah nilai Gel strength dan kadar abu dari gelatin yang dihasilkan. Semakin tinggi suhu ekstrkasi maka semakin tinggi nilai viskositas. Pada hasil analisis diperoleh bahwa pH optimum diperoleh pada ekstraksi gelatin berada pada kisaran 4,5-6,5.
Edukasi Kosmetik Sehat dan Halal Pada Anak Usia Sekolah Syarif, Alwiyah Nur; Maddeppungeng, Nurul Muhlisah; Syahrana, Nur Azizah; Ismail, Isriany
SAMATA JOURNAL OF PUBLIC HEALTH SCIENCE Volume 1, Issue 1, March-August 2022
Publisher : Program Studi Kesehatan Masyarakat UIN Alauddin Makassar

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Abstract

Orang yang berada di kelompok usia remaja sudah sangat memperhatikan penampilan mereka. Banyaknya kosmetik yang beredar dipasaran, jika tidak diketahui kriterianya keamanannya dapat mengakibatkan iritasi pada kulit. Studi ini bertujuan untuk menilai pengetahuan dan kebiasaan siswa mengenai penggunaan kosmetik yang sehat dan halal melalui pemberian direct socialization. Studi ini dilakukan di Madrasah Aliah Negeri 2 Model dengan memperioritaskan kehadiran siswi kelas XII dan guru perempuan yaitu sebanyak 53 peserta. Kajian ini dibagi menjadi tiga tahapan. Pada tahapan pertama, para siswi menerima informasi umum tentang kegiatan dan daftar hadir. Tahap kedua peserta kemudian diukur tingkat pengetahuan dan perilaku melalui pengisian kuesioner. Pada tahapan ketiga, diadakan penyuluhan kesehatan dengan topik yang tercakup dalam pertanyaan angket. Para fasilitator mengevaluasi hasil kegiatan dengan pembagian post-test pada tahap akhir kegiatan ini. Studi ini menyimpulkan terdapat perubahan pengetahuan sebelum dan sesudah diberikan penyuluhan penggunaan kosmetik yang aman, sehat dan halal. Kegiatan ini secara tidak langsung memberikan pengetahuan tentang pencegahan timbulnya dermatitis kontak alergi banyak terjadi pada remaja, terutama pada wajah.
Pengaruh Perbandingan Konsentrasi Polimer terhadap Karakteristik dan Laju Pelepasan Patch Transdermal Nifedipin: The Effect of Comparison Polymer Concentrations on the Characteristics and Release Rate of the Transdermal Nifedipin Patch Nur Azizah Syahrana; Surya Ningsi; Haeria Haeria; Isriany Ismail
Jurnal Sains dan Kesehatan Vol. 3 No. 1 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

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Abstract

Nifedipine is a dihydropyridine anti-hypertensive drug as a calcium channel blocker with low oral biovaibility and a short half-life resulting in frequent repeated daily use of the drug when given orally in conventional dosage forms. The matrix system transdermal patch is an option that allows controlled delivery of the drug through the skin and provides patient comfort. The purpose of this study was to determine the effect of polymer deposition on the material and the in-vitro release rate of nifedipine transdermal patches with the polymer ratio of Ethyl Cellulose (EC) and Hydroxy Propyl Methyl Cellulose (HPMC) used, namely F1 (7:3), F2 (8:2) and F3 (9:1). The results of the nifedipine patch test on organoleptic examination are round, characteristic odor, yellow color and smooth surface texture. In vitro release showed that the best polymer was found in Formula 2 EC: HPMC (8:2) with good characteristics and the highest flux value was 1.307 (µg.cm-2 min-1).
Potential of Thibbun Nabawi Habbatusauda (Nigella sativa); Review of the Active Pharmacological Timoquinone Mardan, Mardan; Ismail, Isriany; Rauf, Afrisusnawati
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 2 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

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Abstract

Habbatusauda or Black Seed or Black Cumin (Nigella sativa) has been widely mentioned in various Islamic studies, including its potential as a "cure for all diseases except death. The hadith can be interpreted as improving immunity and enhancing memory (physical and cognitive aspects). Scientifically, the high content of thymoquinone and DHA in Black Seed plays a major role as an immunomodulator and brain nutrition. Black Seed contains both hydrophilic and lipophilic compounds. Amino acids, proteins, carbohydrates, essential oils, fixed oils, sterols, alkaloids, saponins and crude fiber, and minerals, thymoquinone, p-cymene, longifoline thujene, carvacrol, cubebene, pinene, limonene, pinene, sabinene are the ingredients. Timoquinone is present at a concentration of 3.5-8.7 mg/g in oil. Black Seed Oil is also high in DHA (3%). The content of the active compound Timoquinone is most responsible for its wide range of effects.
Peningkatan Kadar Ketoprofen Terdisolusi melalui Pembentukan Dispersi Padat menggunakan Polivinil Alkohol (PVA): The Increasing of Dissolved Ketoprofen Concentration through Solid Dispersion Formation using Polyvinyl Alcohol (PVA) Sultan, Asriana; Ida, Nur; Ismail, Isriany
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (80.773 KB) | DOI: 10.22487/j24428744.2019.v5.i1.12096

Abstract

Ketoprofen is included in the Class II of Biopharmaceutical Classification System (BCS) which has low solubility. Low solubility will affect the dissolution rate and the dissolved concentration, so the absorption and bioavailability are low as well. Several studies have been conducted to improve the solubility and the dissolution of drugs from these group, such as by solid dispersion system. This study aims to determine the effect of polyvinyl alcohol (PVA) on the dissolved concentration of ketoprofen in solid dispersion and in physical mixture, and to decidethe optimum formula.Solid dispersion and physical mixture of ketoprofen - PVA were formulated with the ratio of 1:1, 1:2 and 1:4, and then compared with the standard ketoprofen. Evaluation of solid dispersion was performed by the intervention test of PVA as a matrix on the maximum wavelength of standard ketoprofen using a UV-Vis spectrophotometer and the dissolution test in artificial gastric fluid media without pepsin using a basket stirrer at pH ± 1,2, the temperature of 37 ± 0.5ºC, and device speed of 50 rpm. The sample was collected at 10, 20, 30, 45, and 60 minutes. The amount of dissolved ketoprofen was determined by a UV-Vis spectrophotometer at a wavelength of 260 nm. The results showed that there was no shifting on maximum wavelength point in both solid dispersions and physical mixtures. The dissolved ketoprofen concentration that was represented in solid dispersion was greater than in physical mixture and standard ketoprofen. The highest dissolved ketoprofen concentration was indicated in solid dispersion formula with the ratio of 1:1.
The Determination of Tartrazine and Sodium Benzoate Levels in Several Jelly Brands in Jeneponto Regency Using UV-Vis Spectrophotometry Dhuha, Nur Syamsi; Doloking, Haeria; Khaerani; Leboe, Dwi Wayuni; Ismail, isriany
Jurnal Farmasi UIN Alauddin Makassar Vol 13 No 2 (2025): Jurnal Farmasi Edisi Desember
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jfuinam.v13i2.63247

Abstract

Pendahuluan: Jajanan jelly merupakan produk pangan yang banyak dikonsumsi oleh anak-anak dan umumnya mengandung bahan tambahan pangan berupa pewarna sintetis dan pengawet. Tartrazin sebagai pewarna kuning sintetis serta natrium benzoat sebagai pengawet sering digunakan untuk meningkatkan daya tarik dan memperpanjang masa simpan produk. Namun, penggunaan yang melebihi batas maksimum dapat menimbulkan risiko kesehatan. Tujuan: Menentukan kadar tartrazin dan natrium benzoat pada beberapa merek jajanan jelly yang dijual di Pasar Tradisional Bontoramba, Kabupaten Jeneponto, menggunakan metode spektrofotometri UV-Vis. Metode: (1) Produk jelly memiliki komposisi tartrazin dan natrium benzoat, (2) beredar aktif di Pasar Bontoramba, dan (3) berasal dari produsen berbeda. Tartrazin dan natrium benzoat diekstraksi menggunakan teknik ekstraksi cair-cair, kemudian diukur secara kuantitatif menggunakan spektrofotometri UV-Vis. Konsentrasi masing-masing analit dihitung berdasarkan kurva kalibrasi. Hasil: Kadar tartrazin diperoleh mulai dari di bawah batas deteksi hingga 1,08 mg/L, sedangkan kadar natrium benzoat berada pada kisaran 0,89–2,39 mg/L. Seluruh sampel menunjukkan kadar yang masih berada dalam batas aman menurut regulasi BPOM (300 mg/kg untuk tartrazin dan 600 mg/kg untuk natrium benzoat). Kesimpulan: Kadar tartrazin dan natrium benzoat pada seluruh sampel jajanan jelly yang dianalisis masih berada jauh di bawah batas maksimum penggunaan bahan tambahan pangan, sehingga dinyatakan aman dikonsumsi berdasarkan dua parameter tersebut. Pemantauan rutin tetap diperlukan untuk memastikan kepatuhan produsen terhadap standar keamanan pangan.  Kata Kunci: Tartrazin, Natrium Benzoat, Jelly, Spektrofotometri UV-Vis, Bahan Tambahan Pangan, Keamanan Pangan.
Co-Authors Afrisusnawati Rauf Alifia Putri Febrianti Andi Armisman Edy Paturusi Andi Dian Aulia Sandi Andi Dian Aulia Sandi Armisman Paturusi Asriana Sultan Aswandi Aswandi Dhuha, Nur Syamsi Doloking, Haeria Dwi Wahyuni Dwi Wahyuni Leboe Dwi Wahyuni Leboe Elly Wahyudin Fatma Dewi Ferawati Ferawati Fitriani Fajri Ahmad Gemy Nastity Handayany Hadiq, Shabran Haeria Haeria Haeria Haeria Haruna, Nadyah Hasriani Hasriani Ilham Aridani Irna Umar Jaya, Adrian Juliandri Juliandri Karnila Amir Tahir Khaerani Latifah Rahman Leboe, Dwi Wayuni Lisa Fitriani M. Asrah Hidayah Usman Maddeppungeng, Nurul Muhlisah Mardan Muh Ihsan Muh Ikhlas Arsul Naswina Putrianti Nur Azizah Syahrana Nur Ida Nur Syamsi Dhuha Nurfadilah Absa Nurhidayah Wahid Nursalam Hamzah Nurshalati Tahar Nurwinda Eka Syaputri Pratiwi, Afrianty Rauf, Afrisusnawati Rizal Rizal St Rahmah Akbar Surya Ningsi Surya Ningsi Syamsuri Syakri Syarif, Alwiyah Nur Watri Ratnasari Zakiah Anugerah Hamzah