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All Journal HAYATI Journal of Biosciences Archive of Community Health Buletin Udayana Mengabdi E-Jurnal Medika Udayana Majalah Ilmiah Fisioterapi Indonesia Indonesian Journal of Cancer Syntax Literate: Jurnal Ilmiah Indonesia Media Kesehatan Politeknik Kesehatan Makassar ISM (Intisari Sains Medis) : Jurnal Kedokteran Open Access Indonesian Journal of Medical Reviews Indonesian Journal of Cancer Journal of Global Pharma Technology Physical Therapy Journal of Indonesia Kinesiology and Physiotherapy Comprehensive Indonesian Journal of Biomedicine and Clinical Sciences

I Gusti Ayu Artini

Bagian Farmakologi Fakultas Kedokteran, Universitas Udayana

Author-ID : 2927136

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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PILATES EXERCISE LEBIH EFEKTIF DARIDAPA CORE EXERCISE DALAM MENURUNKAN NYERI PUNGGUNG BAWAH NON SPESIFIK PADA PENJAHIT DI KOTA DENPASAR Ida Ayu Citra Ratnasari; Nila Wahyuni; I Gusti Ayu Artini
Majalah Ilmiah Fisioterapi Indonesia Vol 5 No 1 (2017): Majalah Ilmiah Fisioterapi Indonesia
Publisher : Bachelor of Physiotherapy and Physiotherapy Profession Study Program, Faculty of Medicine, Udayana University in collaboration with Indonesian Physiotherapy Association (IPA)

ABSTRACT Low back pain bothers people both in their work life and social life. The aim of this research is to find out the effectiveness of Pilates exercise and Core exercise in decreasing the non-specific low back pain for tailors in Denpasar city. The research used experimental with pre and post two group design plan. The sample of the research was 24 people which were divided into two groups. Group treatment 1 was given Pilates Exercises and Group treatment 2 was given Core Exercise. The results of data analysis using a paired sample t-test for group one p = 0.000, for group two with p = 0.007. The results of data analysis using a Mann Whitney U-test which showed significant difference with result value of p = 0.000 (p < 0.05). From these results it can be concluded that the Pilates exercise is more effective in reducing non-specific low back pain than Core exercise. Keywords: Low back pain, Pilates exercise, Core exercise,

Peranan Nanopartikel Dalam Penatalaksanaan Kanker di Era Targeting Therapy I Gusti Ayu Artini
Indonesian Journal of Cancer Vol 7, No 3 (2013): Jul - Sep 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Hingga saat ini kanker masih menjadi masalah kesehatan di berbagai negara di dunia dan merupakan penyebab kematian kedua di dunia. Pemanfaatan nanopartikel dalam penatalaksanaan kanker bertujuan untuk meningkatkan bioavailabilitas dan distribusi obat, serta memperbaiki targeting dan release obat ke sel tumor, sehingga diharapkan dapat meningkatkan efikasi dan mengurangi efek samping. Nanopartikel merupakan semua bentuk material biologis dan sintetik yang dimensinya < 1 ?m. Nanopartikel dalam penatalaksanaan kanker dikembangkan sebagai drug delivery vehicle (carrier), contrast agent (imaging), diagnostic device, platform untuk theranostic agents, antioksidan, in vivo tumor targeting dengan spesifisitas dan afinitas yang tinggi, serta sebagai probe pada riset preklinik untuk studi molekuler penyakit. Berbagai permasalahan yang mungkin timbul dalam penggunaan nanopartikel adalah opsonisasi permukaan nanopartikel, uptake dan retensi nanopartikel di organ RES (hepar, lien), kesulitan targeting dan penetrasi pada tumor, serta toksisitas nanopartikel.Kata kunci: nanopartikel, targeting, drug-delivery vehicle

Uji Proliferasi dan Ekspresi P53 Ekstrak Etanol Minyak Buah Merah terhadap Sel Kanker Serviks SiHa AGUNG WIWIEK INDRAYANI; IDA AYU IKA WAHYUNIARI; GUSTI AYU ARTINI
Indonesian Journal of Cancer Vol 6, No 4 (2012): Oct - Dec 2012
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v6i4.288

Buah merah (Pandanus conoideus Lam.) secara empiris telah digunakan untuk pengobatan kanker. Buah merah mengandung -carotene dan ?-tocopherol, yang merupakan sumber antioksidan. Penelitian ini bertujuan untuk mengetahui efek antiproliferasi dan ekspresi tumor suppressor gene p53 ekstrak etanol minyak buah merah (EEMBM) pada sel kanker serviks SiHa.Uji proliferasi dan uji ekspresi p53 dilakukan secara in vitro. Uji proliferasi menggunakan enam variasi dosis EEMBM dan dievaluasi dengan metode tryphan blue staining setelah inkubasi selama 24, 48, dan 72 jam. Uji ekspresi tumor supresor gene p53 menggunakan tiga variasi dosis EEMBM dan dievaluasi dengan metode imunohsitokimia setelah inkubasi selama 24 jam.Hasil penelitian menunjukkan bahwa persentase penghambatan proliferasi sel kanker servikss SiHa oleh EEMBM pada dosis tertinggi (0,125 ?g/mL) setelah inkubasi selama 24, 48, dan 72 jam berturut-turut adalah 97,97%; 100,0%; dan 100,0%. Bila dibandingkan dengan kontrol positif (doksorubisin), persentase penghambatan sel kanker pada dosis tertinggi setelah inkubasi 24, 48, dan 72 jam berturut-turut adalah 85,31%; 94,43%; dan 99,82%. Terdapat perbedaan bermakna pada persentase penghambatan proliferasi sel kanker serviks SiHa antar kelompok uji pada masing-masing waktu inkubasi (p<0,001). EEMBM juga meningkatkan ekspresi tumor suppressor gene p53 pada dosis 0,06250; 0,03125; dan 0,01562 ?g/mL berturut-turut sebesar 43,69%; 61,99%; dan 18,14%. Bila dibandingkan dengan kontrol positif, ekspresi p53 pada tiga variasi dosis (3,75; 1,875; 0,9375 ?g/mL) berturut-turut sebesar 42,63%; 41,88%; dan 35,94%. Terdapat perbedaan bermakna pada ekspresi p53 antar-kelompok uji (p<0,001).Kesimpulannya, ekstrak etanol minyak buah merah memiliki efek antiproliferasi dan dapat meningkatkan ekspresi tumor suppressor gene p53 pada sel kanker serviks SiHa in vitro.Kata kunci: Ekstrak etanol minyak buah merah, efek antiproliferasi, ekspresi tumor suppressor gene p53, sel kanker serviks SiHa

Analisis tingkat pengetahuan mahasiswa program studi pendidikan dokter tahun ajaran 2017-2018 Universitas Udayana tentang prescribing error Nabila Putri Rachmawati; Desak Ketut Ernawati; I Gusti Ayu Artini
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Introduction: Prescribing Errors is a failure in the treatment process leading to or potentially harmful to the patient, this error most often occurs although it can be prevented. The incidence of prescribing errors continues to increase from year to year, but data in Indonesia that discusses the level of knowledge of medical students about prescribing errors is still small. The purpose of this study is to determine the level of knowledge of medical student study program 2017-2018 academic year at Udayana University Denpasar about prescribing errors.Method: This research is a descriptive cross sectional study conducted at the Medical Faculty Udayana University Sudirman Campus Denpasar. Data obtained in the form of primary data questionnaire. Data were analyzed using software computer.Result: The results showed that the most gender are women of 68 students (66%). The largest proportion of age is 19-20 years old number of 52 students (52%). Groups of semesters 1, 3, 5 and 7 obatined a similar proportion of 25 students (25%). The level of students' knowledge of prescribing case study is classified into moderate category with mean 3,7-7,1 of 67 students (67%). The number of correct answers in identifying type of error from 3 prescriptions is in the case of the first prescription, the 3rd semester student who is able to identify the prescribing error, with the type of mistake that is wrong dose as many as 14 students (35,9%) with p value = 0,066 and wrong dosage form as 21 students (39,6%) with p value = 0.000. In the case of the second prescriptions, 7th semester students were able to identify the prescribing error, with the type of mistake that is wrong dose as many as 13 students (41,9%) with p value = 0,005 and wrong dosage form as 22 students (36,7%) with p value = 0.000. In the case of the third prescriptions, the 3rd semester students were able to identify the prescribing error, with the type of mistake that is the wrong indication of the drug as many as 15 students (62,5%) p value = 0.000.Conclusion: In this research, it can be concluded that the knowledge level of the majority students is in moderate levelabout 67 (67%). While the remaining respondents good knowledge level as much as 7 (7%) and bad knowledge is as much as 26 (26%).

Drug prescription pattern of hypertension patients at primary healthcare facilities in West Denpasar Kartiga Silvaraju; I Gusti Ayu Artini
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: In the treatment of hypertension, investigating and monitoring the prescription patterns of antihypertensive medications time by time is essential to assess the adherence to treatment guidelines. Inappropriate prescribing negatively impacts on health and economy of individual and the society.Aim: The study aims to know the antihypertensive prescribing pattern of hypertension patients at primary healthcare facilities.Method: This studyis a descriptive study with cross sectional design as well as concern to the drug prescribing pattern of hypertension in both 1st and 2nd West Denpasar primary healthcare (PHC), Bali as many as 54 samples from January-December 2016.Result: Mean age is between 60-69 years old, and female were more prone to hypertension than male.Conclusion: The study revealed that the prescription of antihypertensive medication in West Denpasar primary healthcare was related to JNC guidelines, except monotherapy of diuretics.

AKTIVITAS FISIK BERHUBUNGAN DENGAN KESEIMBANGAN STATIS DAN DINAMIS LANSIA-SEBUAH STUDI POTONG LINTANG Ni Komang Artini Yanti; Anak Ayu Nyoman Trisna Narta Dewi; I Nyoman Adi Putra; I Gusti Ayu Artini
Majalah Ilmiah Fisioterapi Indonesia Vol 11 No 1 (2023): Majalah Ilmiah Fisioterapi Indonesia
Publisher : Bachelor and Profession of Physiotherapy Study Program, Faculty of Medicine, Udayana University in collaboration with Indonesian Physiotherapy Association (IPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MIFI.2023.v11.i01.p04

Pendahuluan: Keseimbangan memiliki peranan penting dalam melakukan kegiatan sehari-hari. Menurunnya kontrol neuromukuler, perubahan sendi, serta sistem lainnya menyebabkan kemampuan lansia untuk memjaga keseimbangan tubuh menurun, sehingga risiko jatuh pada lansia meningkat. Aktivitas fisik diperlukan untuk kualitas hidup lansia yang baik, jika selama bertahun-tahun lansia mengalami penurunan tingkat aktivitas fisik, akan dapat berdampak negatif pada kesehatan lansia termasuk gangguan keseimbangan statis dan dinamis. Tujuan penelitian ini yaitu untuk mengetahui hubungan antara aktivitas fisik terhadap keseimbangan statis dan dinamis lansia di Banjar Taman Griya Desa Adat Jimbaran. Metode: Penelitian ini menggunakan jenis penelitian observasional analitik dengan desain cross-sectional yang menggunakan teknik simple random sampling, dengan jumlah sampel yaitu 41 lansia yang sesuai dengan kriteria inklusi, eksklusi dan drop out yang telah ditentukan. Data dikumpulkan dengan mengukur aktivitas fisik menggunakan GPAQ, keseimbangan statis menggunakan Functional Reach Test dan keseimbangan dinamis dengan Time Up and Go Test. Hasil: Hasil uji analisis non parametrik spearman rho dari aktivitas fisik dengan keseimbangan statis yaitu nilai p=0,000 (p<0,05) dan r=0,665, sedangkan hasil uji analisis non parametrik spearman rho dari aktivitas fisik dengan keseimbangan dinamis didapatkan nilai p=0,000 (p<0,05) dan r=0,716. Simpulan: Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat hubungan antara aktivitas fisik terhadap keseimbangan statis dan dinamis lansia di Banjar Taman Griya Desa Adat Jimbaran.

Role of PPAR-Α Signaling Pathway on the Protection of Antituberculosis-Induced Liver Damage by Purple Sweet Potato Extract i gusti ayu artini
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.922 KB)

Background: Peroxisome proliferator activated receptor-α (PPAR-α) participates in protecting the liver from many cases of liver damage. It is involved in reducing lipid accumulation, oxidative stress and inflammation. Purple sweet potato extract is one of herbal extract that posses hepatoprotector activity related to its antioxidant and antiinflammatory action. Its hepatoprotective effect on isoniazid and rifampicin induced hepatic injury has not been established yet, as well as its effect on PPAR-α expression and activation in the liver. The aim of this research was to investigate the hepatoprotective effect of purple sweet potato extract on hepatic injury induced by isoniazid and rifampicin, as well as the effect of purple sweet potato on PPAR-α expression and activation in the liver. Methods: The study design was randomized post test only control group design. We included male Wistar rats, age 8-12 weeks, weight 180-220 gram (divided into 3 groups: control, intervention and normal group). The extraction was performed with masseration technique. PPAR-α expression was measured with ELISA; activated PPAR-α was detected using immunohistochemistry; ALT level was measured with spectrophotometry. Data were analyzed using One Way Anova test, continued with Post Hoc test. Results: The result represented that PPAR-α expression in intervention group was significantly higher than control (1.344±0.249 vs. 0.587±0.306; p

Pregnane-X-Receptor Genotype and Hepatotoxic Incidence on Tuberculosis Patients Receiving Antituberculosis in Bali i gusti ayu artini
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Drug-induced liver injury might lead to serious illness. One of the drugs that potentially toxic to the liver is antituberculosis. Many factors could influence antituberculosis-induced liver injury, including genetic variation. One of such genetic variation is polymorphism of pregnane-x-receptor (PXR) gene. PXR plays a crucial role in the regulation of many drug metabolizing enzymes and drug transporters. The association between PXR polymorphism and hepatotoxic incidence in several studies showed the inconsistent result. Therefore, it’s very important to study the PXR genotype pattern and its relation with hepatotoxic incidence among tuberculosis patients who received antituberculosis treatment. This study aimed to investigate the incidence of hepatotoxic according to PXR genotype pattern among tuberculosis patients who received antituberculosis treatment in Bali. Methods: This study was a cross-sectional study. About 65 subjects were enrolled in this study, selected from tuberculosis patients who attended the pulmonary outpatient clinic of Sanglah Hospital, Bali Indonesia and received the antituberculosis drug. Identification of PXR genotype was performed using PCR/RFLP technique with MboI restriction enzyme. Results: The proportion of wild type and mutant genotype of PXR were 72.3% and 27.7%, respectively. There was no significant difference in the proportion of hepatotoxic between wild type and mutant genotype of PXR. Conclusion: There was no significant difference in the proportion of hepatotoxic between wild type and mutant genotype of PXR on tuberculosis patients who received antituberculosis in Bali.

Developing Animal Model for Analysing Liver Toxicity of Isoniazid and Rifampicin Combination I Gusti Ayu Artini
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Liver toxicity often results from drug administration, such as antituberculosis. The prevalence of liver toxicity in tuberculosis patients remained high in the last decade. Liver toxicity induced by isoniazid (INH) and rifampicin (RIF) combination might have different features and mechanisms with liver toxicity induced by other substances or drugs (acetaminophen, carbontetrachloride, d-galactosamine, ethanol or dimethylnitrosamine). The goal of this study was to investigate the toxic dose and duration of administration of combined isoniazid and rifampicin that contributed to the hepatic injury in rats. Methods: A combination of INH-RIF contained 100 mg of INH and 100 mg of RIF. The induction of INH-RIF was given for 28 consecutive days. Twenty rats were divided into five groups: control, group 1 (dose 50 mg), group 2 (dose 100 mg), group 3 (dose 200 mg), group 4 (dose 400 mg),and group 5 (dose 800 mg). At the end of induction, serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured, and liver histopathology was evaluated. Data were analyzed with one-way Anova test. Results: Serum AST and ALT levels were significantly higher in groups 1 and 2 compared to control (p<0.001). Post-hoc analysis revealed that 50 mg and 100 mg dose significantly increased the serum AST and ALT. Conclusion: There were significant differences in serum AST and ALT, as well as histopathological scores, among rats induced by INH and RIF combination.Keywords: Isoniazid; Rifampicin; Liver; Animal.

Core Exercise Sama Baiknya dengan Balance Exercise Dalam Meningkatkan Keseimbangan Dinamis Pemain Futsal Fatimah S, Sitti; Winaya, I Made Nico; Artini, I Gusti Ayu
Media Kesehatan Politeknik Kesehatan Makassar Vol 17, No 2 (2022): Media Kesehatan
Publisher : Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/medkes.v17i2.2817

Futsal merupakan permainan yang membutuhkan keseimbangan dinamis yang baik karena pemain dituntut memiliki kemampuan permainan yang mencakup offence- defence, skill/ability, power balance, dan stamina/endurance. Keseimbangan dinamis dapat ditingkatkan dengan Core exercise dan Balance Exercise. Tujuan penelitian ini adalah untuk mengetahui efektivitas Core exercise dan Balance Exercise dalam keseimbangan dinamis pemain futsal. Desain yang digunakan pada penelitian ini adalah pre and post test group design. Subyek: 18 subyek sehat berusia 11-12 tahun, terbagi secara acak menjadi 2 kelompok. Kelompok I mendapatkan perlakuan Core exercise dan Kelompok II mendapat perlakuan Balance Exercise. Pelatihan dilakukan 3 kali seminggu selama 4 minggu. Keseimbangan dinamis diukur dengan menggunakan Y Balance Test sebelum dan sesudah pelatihan. Analisis menggunakan Paired Samples T-test dan Wilcoxon Signed Rank Test. Mann-Whitney U- Test (jangkauan kanan) dan Independent Samples Test (jangkauan kiri). Terdapat peningkatan bermakna pada kelompok I jangkauan kanan nilai p = 0,004 dan jangkauan kir inilai p = 0,008. Pada kelompok II juga terdapat peningkatan bermakna yaitu jangkauan kanan nilai p = 0,000 dan jangkauan kiri nilai p = 0,001. Nilai selisih rerata peningkatan keseimbangan antara kedua kelompok tidak ada perbedaan yang bermakna didapatkan nilai jangkauan kanan p = 0,200 dan nilai jangkauan kiri p = 0,747. Simpulan: Core exercise dan Balance Exercise sama baiknya dalam meningkatkan keseimbangan dinamis pada anak-anak Klub Futsal Muhammadiyah. Kata Kunci :Core exercise, Balance Exercise, Keseimbangan Dinamis

Co-Authors Agung Nova Mahendra Agung Wiwiek Indrayani Anak Agung Gede Eka Septian Utama Ari Wibawa Arina Papita Simanungkalit Cokorda Istri Ajeng Prameswari Desak Ketut Ernawati Desak Made Wihandani Dewi, Anak Ayu Nyoman Trisna Narta Dharmajayanti, Ida Ayu Laksmi Diksha, I Gusti Ngurah Ariestha Satya Dinda Paramaningtyas Sudibya Fatimah S, Sitti Febrina, Jessica Gede Denny Wiradarma Gede Parta Kinandana Grudug, Kadek Agastya Widya Sedana I Dewa Gede Alit Kamayoga I Gusti Ayu Agung Anindya Maharani I Gusti Ayu Eka Arirahmayanti I Gusti Made Aman I Gusti Made Gde Surya Chandra Trapika I Kadek Dwi Putra Diatmika I Made Jawi I MADE MULIARTA . I Made Niko Winaya I Nyoman Adi Putra I Wayan Adi Pranata I Wayan Juli Sumadi I.A.A. Widhiartini Ida Ayu Citra Ratnasari Ida Ayu Eka Pradnya Paramita Dewi Paramita Dewi Ida Ayu Ika Wahyuniari Kadek Meitri Ariyantini Kadek Novi Anggreni Kartiga Silvaraju M Widnyana Made Aditya Prawira Arthawan Made Ayu Nadine Indira Surya Made Cindy Widya Murthi Made Hendra Satria Nugraha Made Satria Ambarsika Made Virgo Baharirama Marcella, Marzha Nabila Putri Rachmawati Negara, Anak Agung Gede Angga Puspa Ni Komang Artini Yanti Ni Komang Ayu Juni Antari Ni Luh Nopi Andayani Ni Made Linawati Ni Putu Devi Purnamayanti Ni Wayan Mira Resdiani Ni Wayan Tianing Nila Wahyuni Pande Putu Karina Candra Putu Aditya Mahardika Putu Ayu Sita Saraswati Putu Ayunia Laksmita Putu Diah Saraswati Rahayu Putu Yunita Primasari Rizki Mega Aprilia Saputri, Desi Mevlana Theresia Fitri Hakna Sihombing Trapika, I Gusti Made Gde Surya Chandra Winaya, I Made Nico Wuga, Kristina Supartin Monika

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