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All Journal HAYATI Journal of Biosciences Archive of Community Health Buletin Udayana Mengabdi E-Jurnal Medika Udayana Majalah Ilmiah Fisioterapi Indonesia Indonesian Journal of Cancer Syntax Literate: Jurnal Ilmiah Indonesia Media Kesehatan Politeknik Kesehatan Makassar ISM (Intisari Sains Medis) : Jurnal Kedokteran Open Access Indonesian Journal of Medical Reviews Indonesian Journal of Cancer Journal of Global Pharma Technology Kinesiology and Physiotherapy Comprehensive Indonesian Journal of Biomedicine and Clinical Sciences
I Gusti Ayu Artini
Bagian Farmakologi Fakultas Kedokteran, Universitas Udayana
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) TERHADAP Staphylococcus aureus ATCC 43300 Wuga, Kristina Supartin Monika; Jawi, I Made; Artini, I Gusti Ayu; Widhiartini, Ida Ayu Alit
E-Jurnal Medika Udayana Vol 13 No 6 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i06.P03

Abstract

Background: Kelor leaves (Moringa oleifera L.) have active compounds such as flavonoid, alkaloid, phenol, tanin, and saponin. The content of these compounds is stated to have antibacterial activity. the development of an alternative treatment of natural ingredients is needed to treat infections caused by Staphylococcus aureus bacteria, one of which is Moringa leaves (Moringa oleifera L.). Objective: To analyze the antibacterial activity from ethanol extract of moringa leaf in inhibiting of Staphylococcus aureus growth at concentrations of 25%, 50%, and 100%. Methods: The method used is a true experimental posttest-only control group in vitro. The samples of this study were divided into five groups: the positive control group (vancomycin) and the negative control group (96% ethanol solvent), with concentrations of 25%, 50%, and 100%. Result: The results proved that the extract of ethanol from moringa leaves without dilution (100% of concentration) showed about zone of inhibition against Staphylococcus aureus ATCC 43300 bacteria with an inhibition diameter of 8.4 mm and the positive control vancomycin has an inhibition zone diameter of 17.4 mm. Conclusion: Moringa leaf ethanol extract showed inhibition against bacterial growth in vitro at a concentration of 100%. Keywords: Antibacterial activity, Moringa oleifera L, Staphylococcus aureus
Aktivitas Antibakteri Ekstrak Etanol Bunga Kamboja Merah (Plumeria rubra L.) terhadap Pertumbuhan Bakteri Methicillin-resistant Staphylococcus aureus (MRSA) Diksha, I Gusti Ngurah Ariestha Satya; Artini, I Gusti Ayu; Trapika, I Gusti Made Gde Surya Chandra; Widhiartini, Ida Ayu Alit
E-Jurnal Medika Udayana Vol 13 No 5 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i05.P13

Abstract

Introduction: MRSA is an antibacterial resistance problem that requires serious treatment. The limitations of antibacterials make it difficult to treat infections. The development of alternative antibacterial is needed. Objectives: This study shows the antibacterial effect of ethanol extract of Plumeria rubra L. flowers against MRSA bacteria. Methods: This research is a true experimental research with the only post-test control group design. The Kirby-Bauer test method was used to evaluate the antibacterial activity of ethanol extract of Plumeria rubra L. flowers with concentrations of 20%, 40%, and 60% in triplicate. The test bacteria used MRSA ATCC 33591 bacteria. Antibacterial activity was assessed from the diameter of the inhibition zone formed in bacterial cultures on agar media. Results: The inhibition zone were not formed after ethanolic extract of Plumeria rubra L. flowers at various concentrations. These were not antibacterial activity shown from Plumeria rubra L. flowers extract at concentrations of 20%, 40%, and 60%. Conclusions: The ethanolic extract of Plumeria rubra L. flowers does not show antibacterial activity against MRSA bacteria. Keywords: Red frangipani flowers (Plumeria rubra L.), antibacterial activity, MRSA.
INDEKS MASSA TUBUH BERHUBUNGAN DENGAN KECEPATAN DAN KELINCAHAN ATLET Dharmajayanti, Ida Ayu Laksmi; Negara, Anak Agung Gede Angga Puspa; Artini, I Gusti Ayu
Kinetic and Physiotherapy Comprehensive Vol 2 No 3 (2023): Volume 2 No. 3 December 2023
Publisher : PT. Kesehatan Gerak Fungsi Tubuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62004/kpc.v2i3.32

Abstract

Background: Athletes are prepared to adapt their body composition to the their sports. Biomotor components such as agility and speed are certainly one of important components to support the performance of an athlete. It is necessary to know more about the suitability of body composition needed for each sport that can improve performance in athletes. This study aimed to determine the relationship between BMI, speed, and agility among athletes. Methods: This study used a literature review design to discuss the relationship between BMI, speed, and agility among athletes based on secondary data from published literature on Google Scholar and PubMed. The inclusion criteria used include: journals describing correlation between the body mass index, speed, and agility among athletes, journals published between 2015-2023. The exclusion criteria used include: excluding other articles if there are duplicates, excluding abstracts, theses, and dissertations. Results: Based on the results of a review of five studies that discussed body mass index on speed and agility in athletes, it was found that four journals stated that there were significant relationships between BMI, agility, and speed, but there was one journal which found an insignificant relationship between BMI and agility for male athletes but it was significant for female athletes. Conclusion: Agility and speed in athletes have a relationship with each BMI category. Athletes who were in the underweight BMI category would have better agility and speed compared to athletes who were in the overweight.
Synergistic Antifungal Effects of Gardenia augusta and Averrhoa bilimbi Leaf Extracts Against Candida albicans: Implications for the Treatment of Oral Candidiasis In Vitro Study Pande Putu Karina Candra; I Made Jawi; I Gusti Ayu Artini; I Gusti Made Gde Surya Chandra Trapika
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 6 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i6.682

Abstract

Oral candidiasis, commonly known as thrush, is a frequent fungal infection caused by Candida albicans that can lead to painful canker sores and more severe complications. Conventional treatments may have side effects, necessitating the exploration of alternative therapies. This study investigated the antifungal effects of Gardenia augusta and Averrhoa bilimbi leaf extracts against C. albicans in vitro. A post-test-only control group design was employed. Ethanolic extracts of G. augusta and A. bilimbi leaves were prepared. The antifungal activity of individual extracts and their combination (1:1 ratio) was evaluated against C. albicans using the agar well diffusion method. Ketoconazole (2%) served as the positive control, and 96% ethanol was the negative control. The diameter of inhibition zones was measured, and data were analyzed using SPSS version 26.0. Both G. augusta and A. bilimbi leaf extracts demonstrated significant antifungal activity against C. albicans, evidenced by clear inhibition zones. The combination of extracts exhibited a synergistic effect, producing a larger inhibition zone than either individual extract. In conclusion, G. augusta and A. bilimbi leaf extracts hold promise as potential alternative therapies for oral candidiasis. Their synergistic effect suggests a potential for enhanced efficacy in treating canker sores caused by C. albicans. Further research is warranted to explore their clinical application.
The role of flaxseed (Linum usitatissimum) in improving plasma lipid profiles: a literature review Marcella, Marzha; Desak Made Wihandani; I Gusti Ayu Artini
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.16550

Abstract

Several major risk factors contribute to cardiovascular diseases. One of these is dyslipidemia, an imbalance of plasma lipids such as total cholesterol (TC), low-density lipoprotein (LDL), triglycerides (TG), and high-density lipoprotein (HDL). While medications to lower lipids are widely used to improve lipid profiles, they have some limitations. Flaxseed is rich in ɑ-linolenic acid, phytosterols, and lignans, which can improve lipid profiles. This study aimed to review the potential effects of flaxseed on lipid metabolism. Data was gathered from research databases such as Google Scholar, PubMed, Science Direct, and Springer for the past 5 yr. About 1,527 scientific articles were found, but after eliminating duplicates and screening of title and abstract, only 45 full-text articles were assessed, with 16 selected. The result showed that ɑ-linolenic acid, phytosterols, lignans, and fibers in flaxseed improve TC, LDL, TG, and HDL through various mechanisms. In conclusion, flaxseed shows promise as a natural therapy for dyslipidemia, improving TC, LDL, VLDL, and TG levels, though HDL effects vary. Disparities are linked to demographics, form, dosage, and duration, highlighting the need for standardized research.
Penggunaan Obat Antivirus Bagi Penderita COVID – 19 di RS Universitas Udayana Tahun 2022 – 2023 Grudug, Kadek Agastya Widya Sedana; Jawi, I Made; Artini, I Gusti Ayu
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i12.55251

Abstract

COVID-19, yang disebabkan oleh virus SARS-CoV-2, pertama kali ditemukan di Wuhan, Cina, dan menjadi ancaman kesehatan global sejak awal 2020. Penelitian mengenai penggunaan obat antivirus di RS Universitas Udayana pada 2022-2023 penting untuk memberikan gambaran lengkap tentang terapi COVID-19. Penelitian ini dilakukan untuk mengetahui penggunaan obat antivirus pada penderita COVID – 19 di RS Universitas Udayana pada tahun 2022 – 2023 Penelitian ini merupakan penelitian deskriptif dengan pendekatan potong lintang (cross – sectional) untuk mengetahui gambaran penggunaan obat antivirus bagi penderita COVID – 19 di RS Universitas Udayana pada tahun 2022 - 2023. Data dikumpulkan secara retrospektif dengan melihat rekam medis pasien COVID – 19 pada tahun 2022 - 2023 di RS Universitas Udayana setelah mendapatkan izin dari pihak – pihak yang bersangkutan. Kemudian data diolah dengan software IBM SPSS 26. Hasil penelitian menunjukan dari total 101 pasien COVID-19, mayoritas adalah laki-laki dengan persentase 50,5%, dan kelompok usia 19-35 tahun merupakan yang paling banyak terpapar; sekitar 63,4% pasien memiliki komorbid, dan mayoritas pasien mengalami derajat keparahan rendah (73,3%); dalam penanganan, Favipiravir adalah obat antivirus yang paling sering digunakan. Dari total 101 pasien COVID-19, laki-laki lebih dominan dan kelompok usia dewasa muda hingga paruh baya, terutama 19-35 tahun, adalah yang paling banyak terinfeksi. Sebagian besar pasien memiliki komorbid, yang memperburuk kondisi mereka. Meskipun mayoritas pasien mengalami derajat keparahan rendah, Favipiravir merupakan obat antivirus utama yang digunakan dalam terapi,
The Effect of Stevia (Stevia rebaudiana Bertoni) Leaf Extract Cream on Transforming Growth Factor-β1 Levels and Collagen Amount in the Skin of Male Wistar Rats (Rattus norvegicus) Exposed to Ultraviolet B Febrina, Jessica; Muliarta, I Made; Wahyuniari, Ida Ayu Ika; Sumadi, I Wayan Juli; Linawati, Ni Made; Artini, I Gusti Ayu
HAYATI Journal of Biosciences Vol. 33 No. 2 (2026): March 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.2.435-444

Abstract

Ultraviolet B (UVB) exposure is a major cause of skin aging, leading to collagen degradation and wrinkles due to free radical damage. Stevia (Stevia rebaudiana Bertoni) has antioxidant properties that may counteract this by preserving Transforming Growth Factor-β1 (TGF-β1), essential for collagen synthesis. This study evaluated the effects of stevia leaf extract cream on TGF-β1 and collagen levels in male Wistar rats. Thirty rats were divided into five groups: K0 (no UVB, no cream), K1 (base cream), P1 (2.5% stevia cream), P2 (5% stevia cream), and P3 (10% stevia cream). Groups K1, P1, P2, and P3 were exposed to a cumulative UVB exposure of 840 mJ/cm2 over four weeks. The TGF-β1 levels measured by ELISA did not differ significantly among groups (p>0.05). However, collagen levels, assessed using Picro Sirius Red staining, varied significantly (p<0.05). The K1 exhibited significantly lower collagen compared to K0 (p=0.003), whereas the P2 group effectively prevented collagen degradation compared to K1 (K1: 65.87% vs. P2: 77.92%; p = 0.005). While stevia leaf extract cream did not prevent TGF-β1 reduction, it demonstrated a clear protective effect against UVB-induced collagen loss. Among the tested concentrations, 5% stevia leaf extract cream was the most effective in preserving dermal Collagen, highlighting its potential as a topical agent for preventing photoaging and maintaining skin structural integrity.
Co-Authors Agung Nova Mahendra Agung Wiwiek Indrayani Ari Wibawa Arina Papita Simanungkalit Desak Ketut Ernawati Desak Made Wihandani Dewi, Anak Ayu Nyoman Trisna Narta Dharmajayanti, Ida Ayu Laksmi Diksha, I Gusti Ngurah Ariestha Satya Dinda Paramaningtyas Sudibya Fatimah S, Sitti Febrina, Jessica Gede Denny Wiradarma Grudug, Kadek Agastya Widya Sedana I Gusti Ayu Eka Arirahmayanti I Gusti Made Aman I Gusti Made Gde Surya Chandra Trapika I Kadek Dwi Putra Diatmika I Made Jawi I MADE MULIARTA . I Nyoman Adi Putra I Wayan Adi Pranata I Wayan Juli Sumadi I.A.A. Widhiartini Ida Ayu Citra Ratnasari Ida Ayu Ika Wahyuniari Kadek Meitri Ariyantini Kartiga Silvaraju Made Aditya Prawira Arthawan Made Ayu Nadine Indira Surya Made Cindy Widya Murthi Made Satria Ambarsika Made Virgo Baharirama Marcella, Marzha Nabila Putri Rachmawati Negara, Anak Agung Gede Angga Puspa Ni Komang Artini Yanti Ni Komang Ayu Juni Antari Ni Luh Nopi Andayani Ni Made Linawati Ni Putu Devi Purnamayanti Ni Wayan Mira Resdiani Ni Wayan Tianing Nila Wahyuni Pande Putu Karina Candra Paramita, Ida Ayu Pradnya Putu Aditya Mahardika Putu Ayunia Laksmita Putu Diah Saraswati Rahayu Putu Yunita Primasari Rizki Mega Aprilia Theresia Fitri Hakna Sihombing Trapika, I Gusti Made Gde Surya Chandra Winaya, I Made Nico Wuga, Kristina Supartin Monika