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All Journal HAYATI Journal of Biosciences Jurnal Farmasi Klinik Indonesia JOPS (Journal Of Pharmacy and Science) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Sainstech Farma: Jurnal Ilmu Kefarmasian Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Eduvest - Journal of Universal Studies Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan Indonesian Journal of Jamu
Mahdi Jufri
Department Of Pharmaceutics And Pharmaceutical Technology, Faculty Of Pharmacy, University Of Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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ANALISIS INTERAKSI OBAT ANTIDIABETIK ORAL PADA PASIEN RAWAT JALAN DI RUMAH SAKIT X DEPOK Purnasari, Santi; Jufri, Mahdi; Sari, Dini Permata
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 4, No 1 (2008)
Publisher : Indonesian Research Gateway

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Oral antidiabetic medications has been used over 40 years to control blood glucosa level. Type 2 diabetes mellitus usually complicate with several chronic disease that cause diabetic therapy usually combined with other medications.  This increase the possibility of drug interaction. The present research was done to reveal the prescribing pattern and drug interaction problem in a hospital (Hospital X) at Depok. Data was collected from 307 prescriptions contain oral antidiabetic which were prescribe during January 2005-May 2006. Result showed that the most prescribe oral antidiabetic medication was glimepiride (45,89%). Drug interaction occurred in 41,69% prescriptions. Using statistical analysis Chi square it was revealed that there is significant correlation between the number of medication in one prescription with the number of drug interaction found.  ABSTRAK Obat antidiabetik oral telah digunakan selama 40 tahun terakhir untuk mengontrol kadar glukosa darah. Pada pasien diabetes melitus tipe 2 umumnya disertai dengan beberapa penyakit menahun, sehingga dalam terapi diabetes biasanya dikombinasikan dengan obat-obat lain. Hal ini meningkatkan terjadinya interaksi obat yang merugikan pasien. Penelitian ini bertujuan untuk mengetahui gambaran peresepan dan masalah interaksi obat di Rumah Sakit X Depok. Data diambil dari 307 resep obat antidiabetik oral selama bulan Januari 2005-Mei 2006. Obat golongan sulfonilurea yang paling banyak diresepkan adalah glimepirid (45,89%). Sebanyak 41,69% resep obat antidiabetik oral memiliki interaksi. Dengan menggunakan uji stastistik Kai Kuadrat diketahui adanya hubungan yang bermakna antara jumlah obat dalam satu resep yang mengandung obat antidiabetik oral dengan jumlah interaksi obat yang teridentifikasi.
Formulasi Nanopartikel Verapamil Hidroklorida dari Kitosan dan Natrium Tripolifosfat dengan Metode Gelasi Ionik Iswandana, Raditya; Anwar, Effionora; Jufri, Mahdi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 4 (2013)
Publisher : Indonesian Research Gateway

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Nanopraticles can be prepared by several methods and the ionic gelation method is the easiest one. Verapamil hydrochloride is a drug which used as antiarrhythmic, antiangina, and antihypertension therapy. Nevertheless, bioavailability of orally administered verapamil is very low, only about 10 to 23%. Therefore, verapamil hydrochloride was prepared as nanoparticles dosage form to increase its  bioavailability. The purpose of the present study was to optimize ionic gelation method of chitosan and sodium tripolyphosphate to obtain the best nanoparticles formulation. Nanoparticles were obtained from four different methods (formula A, B, C and D). Particle size distribution, zeta potential, entrapment efficiency, morphology, and fourier transform infra red spectrum of each nanoparticles formula were characterized. The chosen formula was formula D which has 62.8 nm of size, 59.15% of entrapment efficiency, ±25.46 mV of zeta potential, spherical shape, and the ionic interaction was confirmed by FT-IR spectrum. The result showed that chitosan-tripolyphosphate succesfully produce the verapamil hydrochloride nanoparticles by ionic gelation method.Keywords: chitosan, ionic gelation, nanoparticles, sodium tripolyphosphate, verapamil hydrochloride
Instant Powder Formulation for Anti Anemia and Optimization Exctraction Condition of Moringa pterygosperma Gaertn Leaves Using MAE Anggraeni, Yosita; Jufri, Mahdi Jufri; Munim, Abdul
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
Publisher : Indonesian Research Gateway

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Iron supplement containing ferrous sulfate is commonly used for anaemia. Unfortunately, it has bad taste, can cause nausea, and made adverse effects if taken in large doses for long periods. It is necessary to ????ind an alternative source of raw materials, including those from plants. Moringa pterigospera Gaertn leaves was selected because it contains iron and other nutritions. The purpose of this work was to make instant powder formula for anti anaemia using Moringa leaves extract as an alternative for ferous suphate iron suplementation. The extraction was performed by Microwave Assisted Extraction method. Optimization of extraction condition was performed by creating some variations in solvent composition (0- 70% ethanol), microwave power (450 to 900 watts) and extraction time (3 to10 min). Iron content was determined by Atomic Absorption Spectrophotometer at wave length of 248 nm. Instant powder formula was made in 3 concentrations of sodium CMC as suspending agent. Results of the study showed that the most optimal extraction condition which resulted the highest iron content (2.4 mg/g extracts) achieved with 900 watts microwave power, 10 min extraction time and aqua demineralisata. According to 30 panelists of hedonic test, formula which used 5% w/w of sodium CMC got the highest scores. Its powder form had 2.31% of loss on drying and 7.74 g/sec of ????low rate for powder form and pH of 5.78, viscosity of 15.98 cps for reconstituted form.
Uji Akvitas dan Keamanan Hair Tonic Ekstrak Daun Kembang Sepatu pada Pertumbuhan Rambut Kelinci Febriani, Amelia; Elya, Berna; Jufri, Mahdi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 1 (2016)
Publisher : Indonesian Research Gateway

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ABSTRACT :Hair loss affects one’s self image and emotional well-being. It is a very real and serious aesthetic concern for everyone. Leaves and flowers of Hibiscus are traditionally known to potentiate hair growth promotion. In this study we determine the hair growth promotion activity of hibiscus leaves using 2.5%, 5% and 10% of hibiscus leaf extract in the form of hair tonic. We also assessed the physical stability and safety of the hair tonic. Hair growth promotion activity assay was carried out by applying hair tonic on the rabbit’s back and measured hair length, hair thickness, hair weight and hair density. Physical stability assessment was performed at low (4°C ± 2°C), room (25°C ± 2°C) and high (40°C ± 2°C) temperature as well as the cycling test. Safety test was done by eye irritation test with HET-CAM and skin irritation test with patch test method. The results showed that hair tonic contains 10% of leaf extract have hair growth activity promotion better than the minoxidil 2%. Physical stability test showed extract of hibiscus leaf hair tonic has good physical stability. Results of safety test showed that there’s no skin irritation occurred while eye irritation test showed positive eyes iritation. Keywords: hibiscus leave, hair growth, hair tonic, HET-CAM, patch test  ABSTRAK: Kerontokan rambut yang sering diakhiri kebotakan merupakan problema estetis yang sangat dikhawatirkan setiap orang. Daun dan bunga kembang sepatu telah diakui memiliki aktivitas pertumbuhan rambut berdasarkan penggunaan tradisional. Pada penelitian ini, 2,5%, 5% dan 10%  ekstrak daun kembang sepatu diformulasikan dalam bentuk hair tonic karena penggunaannya lebih mudah dan tidak lengket seperti sediaan semisolid. Tujuan penelitian ini adalah untuk mengetahui aktivitas pertumbuhan rambut ektrak etanol daun kembang sepatu  stabilitas fisik dan keamanannya. Uji aktivitas pertumbuhan rambut dilakukan dengan mengoleskan sediaan hair tonic pada punggung kelinci dan diukur panjang rambut, ketebalan rambut (diameter rambut), kelebatan rambut (bobot rambut) dan kepadatan rambut (densitas rambut). Uji stabilitas fisik dilakukan pada penyimpanan suhu rendah (4oC±2oC), suhu ruang (25oC±2oC) dan suhu tinggi (40oC±2oC) serta  cycling test. Uji keamanan dilakukan dengan uji iritasi mata dengan metode HET-CAM dan uji iritasi kulit dengan metode patch test. Hasil menunjukkan bahwa sediaan hair tonic ekstrak daun kembang sepatu 10% memiliki aktivitas pertumbuhan rambut yang lebih baik dibandingkan kontrol positif minoksidil 2%. Hasil uji stabilitas fisik menunjukkan sediaan hair tonic ekstrak daun kembang sepatu memiliki stabilitas fisik yang baik. Dari hasil uji keamanan iritasi kulit  tidak terjadi iritasi, sedangkan hasil uji iritasi mata menunjukkan sediaan mengiritasi mata.Kata Kunci: daun kembang sepatu, pertumbuhan rambut, hair tonic, HET-CAM, patch test 
Co-Authors Abdul Munim Abiyoga Pradata Ahmad Fauzantoro Andre Fahriz Perdana Harahap Andri Pramesyanti Pramono Anggraeni, Yosita Anggraini, Nadia Bunga Anisa Amalia Anna U. H. Rochjana Asnimar Binu Asnimar Binu, Asnimar Ayup Milladi Azhari, Andre Alwi Basra Ahmad Amru Berna Elya Effionora Anwar Elis Apriyanti Elis Apriyanti, Elis Fadlina Chany Saputri Fajriati Zulfa Febriani, Amelia Firli, Akhmad Ridwan Fitria, Wahda Halimah Anggi Rahmani Henry . Henry, Henry Heri setiawan Ika Maruya Kusuma Joshita Djajadisastra Joshita Djajadisastra JOSHITA DJAJADISASTRA Joshita Djajadisastra Joshita Djajadisastra, Joshita Julia Rahmawati Julia Rahmawati, Julia Kori Yati Kori Yati Ledy Maya Ledy Maya, Ledy Lusi Dwita Lusi Putri Dwita Makhdalena Makhdalena Makhdalena Makhdalena, Makhdalena Mardiastuti Mardiastuti Mardiastuti Wahid Meiskha Bahar Misri Gozan Muhammad Yusuf Arya Ramadhan Mun’im, Abdul Nasihin Saud Irsyad Oktania Sandra Puspita Perdanastuti, Hidayah Sunar Purnasari, Santi Purwaningsih, Erni Putri Margaining Utami Putri Margaining Utami, Putri Margaining Raditya Iswandana Ratu A. D. Sartika Retnosari Andrajati Retnosari Andrajati Retnosari Andrajati Rosmala Dewi Rosmala Dewi Akhmad Ridwan Firli SANDRA AULIA MARDIKASARI Sari, Dini Permata Sa’diah , Siti Septia Andini Sheila Azelya Fernanda Siti Sa’diah Suci Syafitri Utami Tanfidz Alishlah, Tanfidz Umi Cahyaningsih Vardhani, Afifah Wahda Fitria Yohanna Aristanti Yudhi Nugraha