Article Per Year (5 Year)
p-Index From 2021 - 2026
2.844
P-Index
This Author published in this journals
All Journal BALI MEDICAL JOURNAL (BMJ) Medicina Buletin Udayana Mengabdi E-Jurnal Medika Udayana Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Universa Medicina Paediatrica Indonesiana ISM (Intisari Sains Medis) : Jurnal Kedokteran ANIMA Indonesian Psychological Journal Journal of Global Pharma Technology Physical Therapy Journal of Indonesia
I Made Sudarmaja
Bagian Parasitologi Fakultas Kedokteran Universitas Udayana
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

Published : 54 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 54 Documents
Search

 2   3   4   5   6 
In-vivo antimalarial activity of Holothuria scabra simplicia in Plasmodium berghei-infected mice Sri Laksemi, Dewa Ayu Agus; Asri Damayanti, Putu Ayu; Sudarmaja, I Made; Tunas, I Ketut; Ratna Sundari, Luh Putu; Rustini, Ni Luh; Budi Apsari, Putu Indah
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.195-201

Abstract

BACKGROUNDMalaria remains one of the major causes of death worldwide. Holothuria scabra has a high nutritional content and many biological effects. The development of alternative anti-malarial drugs is necessary, considering that resistance to the newest anti-malarial drugs has been reported. This research study aimed to determine the anti-malarial effects of Holothuria scabra in mice infected with Plasmodium berghei. METHODSThis was a post-test only control group study conducted on 24 Balb/c mice. Peter’s four-day suppressive test was employed to ascertain the claimed anti-plasmodial effect of the simplicia. Following inoculation with P. berghei, all 24 mice were infected and randomized into 4 groups, namely 3 treatment groups and 1 control group. The control group was given carboxymethyl cellulose, two of the treatment groups were given doses of 10 and 100 mg/kg BW Holothuria scabra, respectively, using Peter’s four-day suppressive test, while the remaining treatment group received a dose of 100 mg/kgBW using the prophylactic method. Data were analyzed using One way ANOVA. RESULTSThe results showed by using both the four-day suppressive test and the prophylactic method, that Holothuria scabra has antimalarial activity. Holothuria scabra at a dose of 100 mg/kg BW was significantly effective in decreasing the percentage of parasitemia (p=0.000) and tended to inhibit the growth of Plasmodium berghei in mice (p=0.054). CONCLUSIONThis study demonstrated that Holothuria scabra possesses anti-plasmodial activity in mice. Hence, the sea cucumber could serve as a potential source of a newer antimalarial agent.
Light physical activity and vitamin D improve sperm quality of male Rattus norvegicus exposed to cigarette smoke Amaral, Meriana Barreto; Satriyasa, Bagus Komang; Yasa, I Wayan Putu Sutirta; Sudarmaja, I Made; Jawi, I Made; Manuaba, Ida Bagus Putra; Linawati, Ni Made; Widiyanti, I Gusti Ayu
Physical Therapy Journal of Indonesia Vol. 6 No. 1 (2025): January-June 2025
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v6i1.261

Abstract

Background: Male infertility is a significant global health issue, with rising prevalence linked to environmental factors such as secondhand smoke, which impairs sperm quality. This study aimed to examine how light physical activity and vitamin D supplementation improved sperm quality in rats exposed to cigarette smoke. Methods: This study used a randomized experimental design with 38 rats, divided into two groups. The control group was exposed to cigarette smoke and received vitamin D at 18 IU/kg body weight (BW) daily. The treatment group was exposed to cigarette smoke, received the same vitamin D dose, and underwent light physical activity. The 35-day research period involved the analysis of evaluated parameters. Differences between these parameters were assessed using an independent t-test, with statistical significance set at a P-value < 0.05. Results: Compared to the control group (p-values< 0.001), the treatment group, receiving light physical activity and vitamin D supplementation, exhibited significantly lower malondialdehyde (MDA) levels (0.96 ± 0.14 nmol/mL), higher vitamin D receptor expression (2.44 ± 0.58 cells/HPF), and increased testosterone levels (4.33 ± 0.76 ng/dL). Sperm quality was also significantly improved in the treatment group, showing higher sperm count (2.24 ± 0.81 × 10⁶/mL), motility (4.20 ± 0.23%), viability (3.07 ± 0.39%), and normal morphology (5.34 ± 0.17%) (p-values< 0.001). Conclusion: Light physical activity and vitamin D supplementation improved sperm quality in cigarette smoke-exposed male rats, correlating with reduced MDA and elevated vitamin D receptor expression and testosterone. Further clinical trials are warranted to explore human applications.
Serum DNase1, sTNFR1 and sTNFR2 as Risk Factors for Lupus Nephritis in Systemic Lupus Erythematosus Patients Manuaba, Ida Ayu Ratih Wulansari; Suryana, Ketut; Bakta, I Made; Sudarmaja, I Made
The Indonesian Biomedical Journal Vol 16, No 3 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i3.3052

Abstract

BACKGROUND: Early detection and management of lupus nephritis (LN) in systemic lupus erythematosus (SLE) are essential to prevent irreversible kidney damage and improve patient outcomes; therefore, identifying reliable biomarkers to predict LN is paramount. However, there are still relatively few studies examining the potential biomarkers for LN in SLE patients. This study was conducted to investigate serum deoxyribonuclease I (DNase), soluble tumor necrosing factor 1 (sTNFR1) and soluble tumor necrosing factor 2 (sTNFR2) as a risk factor for LN in SLE patients.METHODS: A case-control study involving SLE patients aged 20-60 years was conducted. Blood was withdrawn from each subject for the measurement of serum level of DNase1, sTNFR1, and sTNFR2 that was performed using enzyme-linked immunoassay (ELISA) methods. Data was then analyzed using Chi-Square test and logistic regression tests.RESULTS: A total of 22 patients with LN and 22 without LN were included. The cut-off value for DNase1, sTNFR1, and sTNFR2 were 5.05 ng/mL, 6.52 ng/mL, and 7.02 ng/mL, respectively. The risk factors of LN in SLE patients were the low level of serum DNase1 (aOR=6.64; 95%CI: 1.25-35.29; p=0.026), low level of serum sTNFR1 (aOR=8.12; 95% CI: 1.56-42.10; p=0.013), and low level of serum sTNFR2 (aOR=5.57; 95%CI: 1.03-30.11; p=0.046).CONCLUSION: Serum DNase1 lower than 5.05 ng/mL, sTNFR1 lower than 6.52 ng/mL, and sTNFR2 lower than 7.02 ng/mL were risk factors for lupus nephritis in SLE patients. Hence, serum DNase1, sTNFR1 and sTNFR2 could be used as risk factors predictors for LN in SLE patients.KEYWORDS: DNase1, sTNFR1, sTNFR2, SLE, lupus nephritis
Role Playing Method Decreases Communication Anxiety of Medical Students Wulanyani, Ni Made Swasti; Sudarmaja, I Made; Surijah, Edwin Adrianta
ANIMA Indonesian Psychological Journal Vol 23 No 4 (2008): ANIMA Indonesian Psychological Journal (Vol. 23, No. 4, 2008)
Publisher : Faculty of Psychology, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/aipj.v23i4.4370

Abstract

As a professional in public health services, a physician should be acquainted with commu- nication skills when interacting with all kinds of human character. An effective communication could be implemented to collect information as a prerequisite to make an accurate diagnosis and satisfy the patient as well. Anxiety haunting inexperienced students in facing real patients could block one’s real communication potential. The aim of this study was to assess whether the role playing method could decrease the anxiety scale of the subjects. Subjects (N = 70) were first semester medical students. The Communication Anxiety Scale were delivered before and after they conduct the role play. Data were analysed with t test. Results show a significant decline in anxiety scale (p < 0.001). The role playing method is able to decrease communication anxiety through simulation (training in a near-real situa- tion, stimulating imagination and verbal potentials). Sebagai profesional dalam bidang layanan kesehatan masyarakat, seorang dokter dituntut memiliki keterampilan komunikasi saat berhadapan dengan karakter manusia yang beragam. Komu- nikasi efektif dapat digunakan untuk menggali informasi demi tertegakkannya diagnosis yang akurat dan juga memuaskan pasien. Kecemasan yang timbul pada para mahasiswa yang belum berpenga- laman dapat menghambat kemampuan komunikasi yang sesungguhnya. Tujuan studi ini adalah me- nilai apakah metode bermain peran dapat menurunkan tingkat kecemasan para subjek. Subjek (N = 70) adalah mahasiswa semester 1 fakultas kedokteran. Skala Kecemasan Komunikasi disajikan se- belum dan setelah subjek melakukan permainan peran. Data dianalisis dengan t test. Hasil menun- jukkan bahwa tingkat kecemasan menurun secara signifikan (p < 0.001). Metode bermain peran telah berhasil menurunkan tingkat kecemasan komunikasi karena memberikan kesempatan berlatih dalam situasi yang mendekati kenyataan, merangsang imajinasi dan kemampuan verbal
Co-Authors A.A Indah Suadnyani A.A Indah Suadnyani Abdulhadi FA Adiputra, I Komang Hotra Agilan Sethupathy Amaral, Meriana Barreto Amelia, Irene Anak Agung Ayu Mirah Adi Ariwati, Ni Luh Ayu Surasmiati, Ni Made Bagus Komang Satriyasa Cokorda Agung Wahyu Purnamasidhi Daondy Friarsa Soeharto Dewa Ayu Agus Sri Laksemi Dewa Ayu Agus Sri Laksmi Divya Nirmala, Putu Ayu Edwin Adrianta Surijah Eka Sutyawan, I Wayan I Gusti Agung Ayu Chintya Cahyarini I Gusti Agung Dwi Putri Anjani I Gusti Ayu Prapti Adnyani I Gusti Ayu Prapti Adnyani I Gusti Kamasan Arijana I Kadek Swastika I Ketut Tunas I Made Bakta I Made Jawi I NYOMAN MANTIK ASTAWA I Putu Dema Prasetya I Putu Dodik Supartha I Wayan Ardyan Sudharta Putra I Wayan Putu Sutirta Yasa I Wayan Sugiritama Ida Ayu Dewi Wiryantini Ida Ayu Ide Larassanthi Pratiwi Ida Ayu Sintya Pratiwi Ida Bagus Putra Manuaba Ivy Cerelia Valerie Kadek Adit Wiryadana Kadek Yuda Dira Pratama Ketut Suryana Ketut Teddy Bayu Pradinata kumara, i made bagus bayu L. Ariwati Luh Ariwati Luh Putu Ratna Sundari Lusi Martha Indrayani Made Lady Adelaida Made Martha Pradnyana Made Sushmita Dharmasuari Maretta Rosabella Purnamasari Maretta Rosabella Purnamasari Maria Krishnandita N.L Ariwati N.L.P.E. Diarthini Ni Luh Ariwati Ni Luh Ariwati Ni Luh Jayanti Wulan Sari Ni Luh Komang Sumi Arcani Ni Luh Putu Eka Diarthini Ni Luh Putu Eka Diarthini, Ni Luh Putu Eka Ni Luh Rustini Ni Made Laksmi Utari Ni Made Linawati Ni Made Suasti Wulanyani Ni Nyoman Agustianingsih Ni Putu Akopita Devi Ni Putu Tamara Bidari Suweta Nurulhuda Binti Embong P.A.A. Damayanti Pandango, Ivana Griselarosa Koni Pratisthita Sukadana, I Made Ananda Prajna Putu Ari Paramitha Widiani Putu Ayu Asri Damayanti Putu Ayu Larasati Putu Bagus Onicha Baskaranatha Putu Diah Saraswati Rahayu Putu Indah Budi Apsari REFAYANTI, NI MADE ERNITA Saraswati Devi, Ni Made Kumbha Mella Shabrina Inderjit Sri Laksemi, Dewa Ayu Agus SugengO Juwono Mardihusodo Widiyanti, I Gusti Ayu Wulansari Manuaba, Ida Ayu Ratih Wulanyani Wulanyani