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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Keperawatan Indonesia ILMU KELAUTAN: Indonesian Journal of Marine Sciences Jurnal Natur Indonesia Microbiology Indonesia Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Sains Dasar Jurnal Keolahragaan Seminar Nasional Teknik Kimia Kejuangan Indonesian Journal of Cancer Jurnal Perlindungan Tanaman Indonesia Scientiae Educatia: Jurnal Pendidikan Sains Jurnal Penelitian Karet Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology Jurnal Gizi Klinik Indonesia Biosfer: Jurnal Pendidikan Biologi Jurnal Biologi Tropis BAREKENG: Jurnal Ilmu Matematika dan Terapan Bioma : Jurnal Biologi Indonesia Jurnal Perikanan Universitas Gadjah Mada Jurnal Keperawatan Muhammadiyah Jurnal Penelitian Arkeologi Papua dan Papua Barat JOSSAE (Journal of Sport Science and Education) Proceeding Biology Education Conference Berita Kedokteran Masyarakat Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Folia Medica Indonesiana
Ferry Fredy Karwur
Universitas Kristen Satya Wacana
Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Transportation Other

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Review article: uric acid homeostasis and disturbances Karwur, Ferry Fredy; Pujiastuti, Dwi Rahayu
Folia Medica Indonesiana Vol. 53, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

This review examined the homeostasis of uric acid in human body and analyzed recent studies of the affecting major variables. Normal uric acid concentration in male is 3.5-7.2 mg/dL and in female is 2.6-6 mg/dL. Daily turnover of normal uric acid ranges from 498-1392 mg/day, miscible pool is 767-1650 mg, reabsorption is 8064 mg/day, renal excretion is 262-620 mg/day and intestine 186-313 mg/day. The dynamics of uric acid is influenced by factors of food, drink, age, history of disease, and genetic. High purine dietary consumption increases blood uric acid by 1-2 mg/dL, 213-290 g/day fructose drinks increases 0.52-1.7 mg/dL, 1.5 g/kgBW sucrose increases 0.61 mg/dL, and 10-20 ml/kgBW beer increases 0.50-0.92 mg/dL. The ABCG2 gene plays a role in bringing uric acid out of the body by 114.31-162.73 mg/dL, SLC2A9 of 5.43-20.17 mg/dL, and SLC22A12 of 5.77-6.71 mg/dL. The data described the homeostasis of uric acid and the magnitude of the impact of environmental (consumption of food, beverages, and lifestyle) and genetic factors. Understanding uric acid homeostasis and its disturbances is important in managing diseases as a consequence of hyperuricemia and hypouryscemia
Co-Authors A. B. Susanto Albina Eva Yolanda Anggreni Beatris Liunokas Angkit Kinasih Angreni B Liunokas Antonius Budi Susanto Binerd Anthon Im Toy Dalengkade, Mario Nikolaus Desi Desi Dispanstiani Abidin Dwi I Prayitmo Ferdy S Rondonuwu Ferdy S. Rondonuwu Ferdy S. Rondonuwu Ferdy Semuel Rondonuwu Fiktor I. Boleu Frity Lisa Taroreh Frity Lisa Taroreh Handung Nuryadi Haryono Semangun Iqna Kamila Abfa Jerry F Langkun Jubhar C Mangimbulude Jubhar C. Mangimbulude Jubhar C. Mangimbulude Jubhar Mangimbulude Junet F. da Costa Junet. F. da Costa Kristiani Desimina Tauho Kukuh Pambuka Putra Leenawaty Limantara Leviano Leviano Lodu, Widiyasri M. Rio Syahputra Martanto Martosupono Martanto Martosupono Monika Rahardjo Naely K Wusqy NAELY K. WUSQY Naely Kurnia Wusqy Nur Auliani Lestariningrum, Nur Auliani Nurul Wahidatul Hidayati Ocky K Radjasa Ocky Karna Radjasa Permatasari, Mayang Januarti Prameshwari, Deshinta R.I.N.K Retno Triandhini Rambu L.N.K. Retno Triandhini Renny Indrawati, Renny Retno Triandhini Ria Novianti Ronaldo Lomi Djara Rosiana Eva Rayanti Rully Toar Tumanduk Sabrina Aprilisa Martha Siswahyudianto Sonya Titin Nge Venti Agustina Widiyasri Lodu Windu Merdekawati Wiwik Astuti Wiwik Astuti