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All Journal Jurnal Ilmu Dasar e-Journal Pustaka Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Program Kreativitas Mahasiswa - Penelitian Indonesian Journal of Pharmaceutical Science and Technology STOMATOGNATIC- Jurnal Kedokteran Gigi Journal of Agromedicine and Medical Sciences Global Medical and Health Communication CHEMPUBLISH JOURNAL Jurnal Bioteknologi & Biosains Indonesia (JBBI) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Journal of Tropical Ethnobiology BERNAS: Jurnal Pengabdian Kepada Masyarakat Borneo Journal of Pharmacy Journal of Bio-molecule Research And Engineering Journal of Agropharmacy Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Evi Umayah Ulfa
Fakultas Farmasi Universitas Jember
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Toxicity of Ceremai (Phyllanthus Acidus) and Zodia (Evodia Suaveolens) Leaf Extracts on Mortality of Aedes Aegypti Larvae Imtiyaz, Andi Hilman; Armiyanti, Yunita; Ulfa, Evi Umayah; Rohmah, Etik Ainun
Journal of Agromedicine and Medical Sciences Vol 10 No 3 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i3.48674

Abstract

Aedes aegypti is the vector that carries Dengue Hemorrhagic Fever (DHF). Various strategies have been implemented to control the spread of the Aedes aegypti, one of which is using temephos larvicide. The use of temephos causes Aedes aegypti resistance and environmental pollution. Therefore, it is necessary to develop a bio-larvicide using ceremai leaf (Phyllanthus acidus) and zodia leaf (Evodia suaveolens). This study aimed to determine the toxicity of ceremai leaf and zodia leaf extracts on the mortality of Aedes aegypti larvae. This type of research is a pure experiment using a Completely Randomized Design. The research sample was third instar Aedes aegypti larvae. There were 7 groups consisting of 1 negative control (aquadest and tween20), 1 positive control (temephos 0.008%) and 5 treatment groups (ceremai leaf extract and zodia leaf extract). Larval mortality data were observed after 24 hours of exposure. The results of the Kruskal Wallis test showed that there was a difference in mortality between groups with a value of p : 0.020 (p < 0.05). Zodia leaf extract at 0.2% has the highest toxicity to the mortality of Aedes aegypti larvae. The probit test results of zodia leaf extract showed LC50 and LC90 values of 0.075% and 0.121% within 24 hours of exposure. Zodia leaf ethanol extract has effectiveness as larvicide of Aedes aegypti. Keywords: Aedes aegypti, larvicide, extract, ceremai, zodia
In Silico Design Gene Encoding CYP71AV1 for Expression in Escherichia coli Ulfa, Evi Umayah
Journal of Bio-Molecule Research and Engineering Vol 1 No 1 (2022)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbiome.v1i1.35856

Abstract

Cytochrome P450 monooxygenase (CYP71AV1) is a crucial enzyme in the artemisinin biosynthesis pathway. This enzyme oxidized Amorpha 4,11 diene to produce artemisinic acid. This study aimed to in silico design high-level expression of CYP71AV1 in the E.coli system. In silico techniques are highly suitable for designing protein recombinant production before entering the laboratory. The amino acid sequence of CYP71AV1 was back-translated to the DNA sequence and adapt to E.coli codon usage by using Gene Designer. The DNA sequence of optimized CYP71AV1 was analyzed using Rare Codon Analysis to assess the expression efficiency in E.coli. The protein solubility prediction was determined using the SoDoPe tool. The optimized CYP71AV1 was determined to have a CAI 0.81, a GC content of 53.08 %, CFD with low frequency, and no negative cis or repeat elements. The result of the probability of solubility of CYP71AV1 was 0.6207 when expressed in E.coli. The MBP fusion partner can be used to increase the solubility of CYP71AV1. The in silico results showed the possibility of high-level protein expression of optimized CYP71AV1 in the E.coli system.
Optimization study on palm fat base (HAMIN®) and purified water proportion in diphenhydramine hydrochloride cream formulation Winarti, Lina; Gazzali, Amirah Mohd; Arafika, Whendy Waliya; Ameliana, Lidya; Ulfa, Evi Umayah; Nurahmanto, Dwi; Paramayuda, Farukh
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.30790

Abstract

HAMIN® is a self-emulsifying base composed of a mixture of hydrogenated palm kernel oil and hydrogenated palm kernel stearin. This formulation not only enhances the aesthetic quality of products but also simplifies the manufacturing process, as it eliminates the need for additional emulsifying agents to form a stable cream. Due to these properties, HAMIN® is considered highly suitable for the development of both pharmaceutical and cosmetic formulations. Despite its potential applications, no prior research has investigated the optimal ratio of HAMIN® palm fat base to distilled water distilled waterrequired to achieve desirable physical characteristics and drug release properties in cream formulations. Therefore, this study aims to determine the optimum composition of HAMIN® palm fat base and distilled water for the formulation of diphenhydramine hydrochloride cream. The optimization process was conducted using the simplex lattice design (SLD) method, a statistical approach commonly employed to evaluate and optimize multicomponent formulations. The experimental results demonstrated that increasing the concentration of HAMIN® palm fat base had a dominant effect on enhancing the pH, viscosity, adhesion, and stability of the cream. Conversely, a higher concentration of distilled water significantly improved spreadability, extrudability, and drug release flux. These findings indicate that the selection of base composition plays a crucial role in determining the overall performance of the cream formulation. The optimal formulation, as determined through SLD analysis, consisted of 41.667% HAMIN® palm fat base and 48.333% distilled water, achieving a desirability index of 0.649. This composition represents the most balanced formulation in terms of physical stability and drug release, making it a promising candidate for further pharmaceutical and cosmetic applications.
Aktivitas Sitotoksik Ekstrak n-Heksana, Diklorometana, dan Metanol Daun Beluntas (Pluchea indica Less.) terhadap Sel Kanker Leher Rahim (HeLa) Puspitasari, Endah; Agustina, Bayu; ., Nuri; Ulfa, Evi Umayah
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.810

Abstract

Eksplorasi agen kemopreventif kanker masih terus dikembangkan, terutama yang berasal dari bahan alam. Hal ini didasari oleh keinginan untuk menekan angka kematian akibat kanker dan mengurangi efek samping yang ditimbulkan oleh terapi kanker yang saat ini digunakan. Penelitian ini ditujukan untuk mengetahui aktivitas sitotoksik daun beluntas (Pluchea indica Less.) terhadap sel kanker leher rahim yang merupakan kanker ginekologi peringkat pertama yang menyerang wanita. Aktivitas sitotoksik dilakukan terhadap ekstrak n-heksana, diklorometana, dan metanol daun beluntas terhadap sel HeLa dengan metode perhitungan langsung menggunakan bantuan perwarna trypan blue. Nilai IC50 dari ketiga ekstrak daun beluntas berturut turut adalah 18,06 μg/ml, 74,56 μg/ml, dan 31,21 μg/ml. Ketiganya memberikan perbedaan yang signifikan. Ketiga ekstrak yang diuji memiliki aktivitas sitotoksik dan dapat dikembangkan sebagai kandidat agen kemopreventif kanker. Namun masih perlu diteliti lebih lanjut bagaimana mekanisme aksi yang menjadi perantara aktivitas sitotoksik tersebut.
Skrining Fitokimia dan Evaluasi Antibakteri Ekstrak NADES (Natural Deep Eutectic Solvents) Daun Iler (Coleus atropurpureus L. Benth) terhadap Bakteri Penyebab Folikulitis Ulfa, Evi Umayah; Pratama P., M. Reynaldi Archan; Dianasari, Dewi
Journal of Agropharmacy Vol. 1 No. 1 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The iler plant (Coleus atropurpureus) can be used as an efficacious medicinal plant. The chemical contents of the iler plant include essential oils, alkaloid, polyphenols, tannins and flavonoids. This content can be used as an antibacterial. This study aims to determine the antibacterial activity of iler leaves (Coleus atropurpureus) against bacterial folliculitis (Staphylococcusaureus). The NADES combination used is choline chloride:sorbitol with a ratio of 1:1, 2:1, and 3:1. The extraction method uses the UAE method and the antibacterial activity test uses the well diffusion method. The positive control used was Ciprofloxacin. The diameter of the inhibition zone for S. aureus bacteria is in a ratio of 1:1 (4,53 mm), 2:1 (6,29 mm), and 3:1 (8,12). The results of the phytochemical screening test obtained showed that the NADES extract of Iler leaves was positive for containing alkaloids, flavonoids, polyphenols and tannins.
Optimization of Gel Cream Containing HAMIN™ and HPMC K100M as Bases for Topical Delivery of Diclofenac Sodium Winarti, Lina; Gazzali, Amirah Mohd; Mufidah, Fania Mufti; Faramayuda, Fahrauk; Ulfa, Evi Umayah; Nurahmanto, Dwi; Afthoni, Muhammad Hilmi; Pratiwi, Liza; Wijianto, Bambang
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.10417

Abstract

Diclofenac sodium, a widely used NSAID, has limited skin permeability, which reduces its topical efficacy; therefore, a gel-cream formulation combining the rapid absorption of gels with the emollient properties of creams is proposed to enhance drug penetration and patient comfort. To further improve delivery, HAMIN™, a novel natural palm oil–based base with excellent biocompatibility and lipid-enhancing properties, will be combined with HPMC K100M. This thickener stabilises viscosity and prolongs skin contact time, supporting better absorption. This study aimed to develop and optimise a topical gel cream for diclofenac sodium using HAMIN™ and HPMC K100M to achieve ideal physical properties and improved skin penetration. The formulation was statistically optimised using a Simplex Lattice Design (SLD), with HAMIN™ (X₁) and HPMC K100M (X₂) as independent variables, and pH (Y₁), spreadability (Y₂), viscosity (Y₃), extrudability (Y₄), release flux (Y₅), and permeation flux (Y₆) as dependent responses. Optimisation with Design Expert version 13 yielded the ideal composition of 16.84% HAMIN™ and 1.16% HPMC K100M, resulting in predicted values of pH 5.07, spreadability 7 cm, viscosity 4502.25 mPas, extrudability 78.98 N/s, release flux 70.61 µg/cm²√min, and permeation flux 0.4868 µg/cm²/min, with a desirability score of 0.829. Despite a slightly lower release flux, the optimised HAMIN™ and HPMC K100M-based gel cream demonstrated superior skin permeation compared to a commercial emulgel for up to 300 minutes. The incorporation of HAMIN™, a natural palm oil base, offers a novel and effective strategy to enhance the topical delivery of diclofenac sodium via a statistically optimised gel cream formulation.
Penentuan Kandungan Fenolik Total dan Model Klasifikasi Serbuk Rimpang Jahe Emprit (Zingiber officinale var. Amarum Roscoe) di Dataran Sedang dan Tinggi Harinditha Pramana Putra; Evi Umayah Ulfa; Lestyo Wulandari
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 20 No. 02 Desember 2023
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v0i0.16275

Abstract

Jahe emprit (Zingiber officinale var. Amarum Roscoe) merupakan salah satu varietas jahe di Indonesia yang dimanfaatkan sebagai obat anti inflamasi, obat nyeri sendi, tonikum, serta obat batuk. Salah satu senyawa yang mempengaruhi khasiat dari jahe emprit adalah senyawa golongan fenol. Penelitian ini bertujuan menentukan kandungan fenolik total dan menentukan model klasifikasi menggunakan spketroskopi NIR dan kemometrik pada jahe emprit yang di tanam di dataran sedang dan dataran tinggi. Penentuan model klasifikasi menggunakan analisis multivariat LDA (Linear Discriminant Analysis), SVM (Support Vector Machines), dan SIMCA (Soft Independent ModeIIing of CIass AnaIyze), dan SVM (Support Vector Machines). Selanjutnya dilakukan validasi LOOCV (Leave-one-out cross-vaIidation) dan validasi eksternal. Penentuan fenolik total menggunakan spektroskopi uv-vis dengan reagen folin. Hasil rata-rata dari kandungan fenolik total pada dataran sedang adalah (23,592 ± 6,705) mg GAE/g serbuk, dan pada dataran tinggi adalah (13,382 ± 1,2700) mg GAE/g serbuk. Model klasifikasi LDA, SVM, dan SIMCA menghasilkan %akurasi sebesar 100%. Hasil validasi LOOCV model LDA dan SIMCA adalah 100%, dan SVM sebesar 60%. Hasil validasi eksternal model LDA dan SIMCA memiliki akurasi sebesar 100%. Setelah itu aplikasi pada sampel nyata pada model LDA dan SIMCA masing-masing memiliki akurasi sebesar 100%.
Implementasi Sistem Monitoring Kualitas Fisik Air Berbasis IoT dalam Mendukung Pengelolaan Air Bersih di Desa Sukogidri Kabupaten Jember Ulfa, Evi Umayah; Kaloko, Bambang Sri; Rosyidi, Viddy Agustian; Retnani, Windi Eka Yulia; Rintyarna, Bagus Setya
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 2 (2026)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v7i2.17426

Abstract

Distribusi dan akses air bersih masih menjadi tantangan di wilayah pedesaan, termasuk di Desa Sukogidri, Kabupaten Jember. Meskipun desa Sukogidri telah memiliki Sistem Penyediaan Air Minum Desa (SPAM) melalui dana PAMSIMAS, namun belum tersedia sistem yang dapat melakukan pemantauan kualitas fisik air secara kontinu dan real-time sesuai Permenkes No 37 Tahun 2017. Kegiatan pengabdian masyarakat ini bertujuan untuk mengimplementasikan sistem monitoring kualitas air berbasis Internet of Things (IoT) yang dilengkapi dengan sensor suhu, pH, kekeruhan, konduktivitas, dan oksigen terlarut (DO), serta terhubung dengan aplikasi Thingview sebagai platform pemantauan data. Sistem ini dipasang di menara air SPAM Desa Sukogidri. Hasil kegiatan menunjukkan bahwa teknologi ini mampu memantau kualitas air secara efektif, memberikan data secara langsung, serta meningkatkan kapasitas pengurus SPAM melalui pelatihan teknis yang diberikan. Implementasi teknologi ini tidak hanya meningkatkan efektivitas pengelolaan sumber daya air, tetapi juga mendukung upaya peningkatan penyediaan air bersih di masyarakat desa.
Artikel Uji toksisitas akut oral xilooligosakarida dari hidrolisis xilan jerami menggunakan enzim rekombinan Endo-β-1,4-D-Xylanase : Studi Toksisitas Xilooligosakarida Vergian, Putra; stri Ratnadewi, Anak Agung I; Riandy, Cahyaningtyas Tetta; Rukmana, Riesma; Ulfa, Evi Umayah; Siswoyo, Tri Agus; Syafriadi, Mei
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal (January - June)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.49759

Abstract

Xylooligosaccharides (XOS) are recognized as prebiotics that stimulate the proliferation of probiotic bacteria and enhance short-chain fatty acid (SCFA) production. Compared to other prebiotics, XOS offer notable advantages, including thermal stability and tolerance to a broad pH range. Building on these attributes, this study aimed to evaluate the potential toxicity of XOS derived from rice straw xylan hydrolyzed using recombinant endo-β-1,4-D-xylanase expressed in Saccharomyces cerevisiae. Acute oral toxicity was assessed in male Wistar rats at a single dose of 2000 mg/kg body weight, with observations conducted over a 14-day period. Parameters evaluated included body weight, clinical signs, hematological and biochemical indices, as well as macroscopic and histopathological alterations. Signs of toxicity were observed as changes in stool consistency within the first 4 to 24 hours, while mortality occurred in three male rats. Although body weight showed a tendency to increase, particularly in males, the estimated LD₅₀ value ranged between >500 and 2000 mg/kg body weight, classifying XOS as moderately toxic. Moreover, histopathological examination revealed pathological alterations in the kidneys and liver, while serum biochemical analysis indicated metabolic changes that remained within normal limits. Overall, these findings suggest that XOS possess promising prebiotic potential; however, further studies are required to confirm their long-term safety for application in food products.
Co-Authors Agustina, Bayu Agustina, Bayu Ajeng Maharani Sri Pananjung Ajeng Maharani Sri Pananjung, Ajeng Maharani Ameliana, Lidya Arafika, Whendy Waliya Auralia Putri Pratama Bagus Setya Rintyarna Bambang Sri Kaloko Bambang WIJIANTO Baroroh, Rizqy Kiromin Debi Listiayana Dedi Irawanto Desi Sandra Sari Dhani Wijaya, Dhani Diana Holidah Dianasari, Dewi Dwi Nurahmanto Ema Rachmawati Ema Rachmawati Endah Puspitasari Esti Utarti ESTIKA YUNINDARWATI Fahrauk Faramayuda, Fahrauk Ferani Cendrianti Gazzali, Amirah Mohd Harinditha Pramana Putra Hidayatul Ulyah Imtiyaz, Andi Hilman Indah Yulia Ningsih Izzay Afkarina Jacinda Na’ilahafitra Kartika Senjarini Lestyo Wulandari Lina Winarti Liza Pratiwi M Mirza Nuryady, M Mirza Maharany, Dinda Mei Syafriadi Mochammad Amrun Hidayat Mufidah, Fania Mufti Ni Nyoman Tri Puspaningsih Novanda asri I, Novanda asri Nuri . Pananjung A.S, Pananjung Paramayuda, Farukh Pratama P., M. Reynaldi Archan Putri Eka Maryani Ramadhan, Andika Dewi Riandy, Cahyaningtyas Tetta Rini Riyanti Rismatul Khoiroh Rizki Rica Rachim Fadilah Putri Rohmah, Etik Ainun Rukmana, Riesma Sattya Arimurti Shinta Cholifatu Rohma stri Ratnadewi, Anak Agung I Tri Agus Siswoyo Umar Dian Prambudi Kusuma Vergian, Putra Viddy Agustian Rosyidi Windi Eka Yulia Retnani Yuniar Wahyu Rahmawati Yuniatin Hasanah Yunita Armiyanti