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All Journal e-Journal Pustaka Kesehatan Althea Medical Journal Jurnal Kesehatan Andalas Folia Medica Indonesiana Journal of Agromedicine and Medical Sciences Mutiara Medika: Jurnal Kedokteran dan Kesehatan MNJ (Malang Neurology Journal) Majalah Kedokteran Andalas Jurnal Respirasi (JR) Jurnal Kesmas Untika Luwuk: Public Health Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berita Kedokteran Masyarakat Jember Medical Journal (JMJ)
Cholis Abrori, Cholis
Department Of Pharmacology, Faculty Of Medicine, University Of Jember, Indonesia
Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Mesenchymal Stem Cell Therapy to Reduce the Neurological Deficit of Chronic Ischemic Stroke Patients: A Systematic Review nita, surya; Narwanto, Muhammad Ihwan; Yuli Hermansyah; Cholis Abrori; Novan Krisno Adji
Jember Medical Journal Vol. 3 No. 2 (2024): .
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jembermedicaljournal.v3i2.943

Abstract

Current ischemic and hemorrhagic stroke treatments are limited by a narrow golden period and lack of regenerative benefits, so stem cell therapy emerges as an ideal candidate for functional recovery in stroke patients. Stem cell therapy, still being studied, is expected to repair ischemic areas damaged by stroke to restore their physiological functions and reduce neurological deficits in chronic stroke patients. This study aimed to determine the therapeutic efficacy of MSCs in reducing neurological deficits in chronic ischemic stroke patients. We conducted a systematic review. We searched PubMed, Cochrane Library, Science Direct, and Springer Link from inception until December 2022 for cohort studies dealing with mesenchymal stem cell therapy for patients with ischemic stroke. The citation-searching method in this study collected 1,038 articles using the advanced searching method and 8 articles using the citation-searching method, bringing the total number of articles to 1,046. The exclusion criteria used were articles with systematic reviews and meta-analyses and articles that were not accessible in full text. Based on the results of a systematic review study conducted, the conclusion that can be drawn is that MSCs therapy has proven effective in reducing neurological deficits in chronic ischemic stroke patients in terms of the decreased NIHSS score. 
EFFICACY OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION AS UPPER EXTREMITY MOTOR REHABILITATION THERAPY AFTER STROKE: A SYSTEMATIC REVIEW Purwandhono, Azham; Adji, Novan Krisno; Abrori, Cholis; Fatmawati, Heni; Habibi, Ali
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.12

Abstract

Background: The most frequent impairment following a stroke is the hemiparesis of the opposite-side upper extremity. Repetitive Transcranial Magnetic Stimulation (rTMS) is popular in research studies on upper extremity motor rehabilitation after stroke. Information regarding the onset of therapy, duration of therapy, and the type of rTMS in post-stroke upper extremity motor rehabilitation therapy is still spread in various journals, therefore researchers are interested in making this systematic review. Objective: This study aimed to assess the efficacy of rTMS for upper extremity motor rehabilitation after stroke, and had specific aims to compare different treatment timings and durations, as well as evaluating the effectiveness of high-frequency versus low-frequency rTMS. Methods: Literature search was conducted with multiple electronic databases, such as PubMed, ScienceDirect, Cochrane Library, and LinkSpringer. The boolean operator method will be used for the keywords and the synonyms were searched using the Medical Subject Heading (MeSH) database. Critical appraisal and Risk of biases were assessed for each study using The Joanna Briggs Institute (JBI) Critical Appraisal Tools. Data analysis in this systematic review are using descriptive analysis. Results: The included studies consisted of two types of rTMS with varying onset and duration of the therapy. The duration of rTMS therapy consists of 5-18 sessions. In the Upper Extremity Fugl-Meyer Assessment (UE-FMA) based study, High-Frequency (HF) rTMS had significant overall results when compared to sham, whereas Low-Frequency (LF) rTMS therapy still showed contradictory results. HF-rTMS therapy can be performed in acute, subacute, and chronic stroke phases. The duration of HF-rTMS therapy can be done with 5 or 10 sessions, but it still needs further research in order to determine the number of sessions that have the best efficacy. Conclusion: This study show HF-rTMS has better efficacy compared to LF-rTMS for upper extremity motor rehabilitation therapy after stroke.
Perbandingan Peningkatan Kadar Malondialdehid (MDA) Serum setelah Olahraga Pagi dan Malam Hari pada Orang Tidak Terlatih Mushab, Mushab; Hairrudin, Hairrudin; Abrori, Cholis
Jurnal Kesehatan Andalas Vol. 9 No. 2 (2020): Online June 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i2.1312

Abstract

Olahraga mampu meningkatkan kadar radikal bebas dalam tubuh melalui beberapa mekanisme yaitu peningkatan aktivitas mitokondria, NADPH, dan XO serta inflamasi pada sel otot rangka yang mengakibatkan stimulasi aktivitas fagosit. Olahraga yang dilakukan pada malam hari memiliki beberapa mekanisme tambahan sehingga berpotensi menyebabkan peningkatan kadar radikal bebas lebih tinggi, yaitu faktor pencetus radikal bebas yang meningkat pada malam hari. Salah satu indikator untuk mengetahui kadar radikal bebas dalam tubuh yaitu malondialdehid (MDA). Tujuan: Menentukan perbandingan antara peningkatan kadar MDA serum setelah olahraga pada dan malam hari pada orang tidak terlatih. Penelitian ini merupakan uji klinis dengan pre dan post-test group design. Metode: Sampel berjumlah  20 mahasiswa Fakultas Kedokteran Universitas Jember yang tidak terlatih, masing-masing berperan ganda sebagai kelompok pagi (Kp) dan kelompok malam (Km) sehingga jumlah total sampel sebesar 40. Olahraga yang dilakukan berupa sepeda statis dengan intensitas 70-80% dari heart rate maksimal. Setelah satu minggu dilakukan croosing-over, yaitu sampel Kp dijadikan Km begitu pula sebaliknya. Pengukuran kadar MDA dilakukan sebelum dan setelah olahraga menggunakan metode TBARS. Peningkatan kadar MDA merupakan selisih dari kadar MDA setelah dan sebelum olahraga. Hasil: Peningkatan kadar MDA setelah olahraga pada pagi dan malam hari adalah 0,29±0,87 nmol/mL dan 1,13±1,2 nmol/mL. Hasil uji statistik menunjukkan ada perbedaan yang signifikan p=0,021 (p<0,05). Simpulan: Peningkatan kadar MDA setelah olahraga pada malam hari lebih tinggi dibandingkan dengan peningkatan kadar MDA setelah olahraga pada pagi hari pada orang yang tidak terlatih.Kata kunci: malondialdehid, olahraga, radikal bebas, TBARS
Bacterial contamination of tomatoes sellers in eight traditional markets of Jember Regency, East Java, Indonesia Laili, Nikmatul; Suswati, Enny; Abrori, Cholis; Mufida, Diana Chusna; Hermansyah, Bagus; Putri, Elvia Rahmi Marga
BKM Public Health and Community Medicine Vol 40 No 04 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v40i04.9307

Abstract

Purpose: Foodborne diseases are a significant threat to public health and is often associated with pathogenic microorganisms entering the body due to consuming contaminated food. One of the factors causing foodborne diseases was the contamination of pathogenic bacteria in vegetables consumed raw, one of which is tomatoes. This study was conducted to determine the correlation between traders' personal hygiene behavior and bacterial contamination of tomatoes in the traditional Jember Regency market. Methods: This study used analytical observational research with a cross-sectional research design, conducted in the Laboratory of Microbiology, Faculty of Medicine, University of Jember. The large sample size of this study was 40 traders. Personal hygiene behavior of traders was obtained from direct observation with observation sheets in eight selected traditional markets in Jember Regency. Results: Tomato samples were contaminated with bacteria with the highest bacterial colony >2.5 x 108 CFU/g and the lowest 4.6 x 105 CFU/g. The types of bacteria found in this study were Vibrio parahaemolyticus (15%), Shigella sp. (62.5%), Salmonella sp. (72.5%), Vibrio cholerae (82.5%), Escherichia coli (90%), and Staphylococcus aureus (92.5%). The bivariate test results showed no significant correlation between personal hygiene, sanitation, supporting facilities, and traders' characteristics with bacterial contamination of tomatoes sold in eight Jember traditional markets. Conclusion: This study concludes that there is no significant correlation between traders' personal hygiene behavior and bacterial contamination in tomatoes sold in eight traditional markets of Jember Regency. Consumers should wash tomatoes well or process them first before consumption.
Potential of shallot peels as a daily antioxidant supplement against cigarette smoke-induced lung damage Helianti, Dina; Dewi, Rosita; Munawaroh, Ayu; Rachmania, Sheilla; Maulana, Aditha Satria; Abrori, Cholis; Sumadi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art10

Abstract

Background: Cigarette smoking damages the alveoli through oxidative stress. Shallot peels containing flavonoids, especially quercetin, potentially serve as a daily antioxidant supplement to impede lung tissue damage induced by cigarette smoke. However, the maximum effective dose is yet to be determined. Objective: This research was designed to establish the maximum effective dose of shallot peel infusion (SPI) to prevent oxidative stress and histopathological lung damage induced by cigarette smoke. Methods: This experimental laboratory was a posttest-only control group design. A total of 24 male Rattus norvegicus Wistar strain, were allocated into 6 groups: a control group and 5 SPI-treated groups. All rats were exposed to 2 cigarettes/day and were treated for 28 days with aquabidest and different doses of SPI (0 mg/kgBW, 125 mg/kgBW, 250 mg/kgBW, 500 mg/kgBW, 1,000 mg/kgBW, and 2,000 mg/kgBW). The level of oxidative stress in serum was measured malondialdehyde (MDA) level with ELISA, and histopathological lung damage was estimated using the lung histopathological damage scoring method assessing inflammatory cells, alveolus lumen and inter-alveoli junction.Results: The quadratic regression analysis revealed the maximum effective dose of SPI to prevent oxidative stress and lung damage were 1,435 mg/kgBW and 1,206 mg/kgBW, respectively. In the histopathological examination of the lungs, the administration of SPI up to a dose of 1206 mg/kg BW prevents the inflammatory process caused by cigarette smoke, which is indicated by the number of inflammatory cells, the thickness of the alveolar septum, and the increasingly normal shape of the alveolar lumen.Conclusion: SPI doses of less than 1,206 mg/kgBW are safe and effective daily antioxidant supplements in rats exposed to cigarette smoke and have the potential to be further studied for application in humans.
Co-Authors Adji, Novan Krisno Afifatun Hasanah Angga Mardro Raharjo Angga Mardro Raharjo, Angga Mardro Arifa Mustika Athoillah, Nabil Atina Robbiatul Azizah Azham Purwandhono Bagus Hermansyah Chikita R Hanifati Cicih Komariah Desie Dwi Wisudanti Deti Rosalina Diana Chusna Mufida Dimas Zabirrurohman Putra Dina Helianti Dini Agustina Dion Krismashogi Dharmawan Dwisaraswati, Salma Aulia Dwita Aryadina Rachmawati Elly Nurus Sakinah, Elly Nurus ENNY SUSWATI Erma Sulistyaningsih Farida Yan Pratiwi Kurnia Fath Arina Fahma Fauqi Amalia Habibi, Ali Hairrudin Hairrudin Heni Fatmawati Ida Srisurani Wiji Astuti Ika Rahmawati Sutejo Indi Kamilia Fitri Inke Kusumastuti Jasmine Fachrunnisa Justina Evy Tyaswati Khana Nurfadhila Komang Yunita Wiryaning Putri Laili, Elisa Fadia Laili, Nikmatul Laksmi Indreswari Lucky Tiya M. Ali Shodikin M. Ihwan Narwanto M.S. Irham Rozaq Maulana, Aditha Satria Mauliya Sri Sukmawati Wahyudi Miftakhul Huda Moh. Lutfi Hasbullah Muhamad Hasan Muhammad Hasan Munawaroh, Ayu Mushab Mushab Mushab, Mushab Natasha Amelia Nita, Surya Novan Krisno Adji Nurlaila Ayu Purwaningsih Nyoman Defriyana Suwandi Olyvia Yulyani Khaerul Putri Pipiet Wulandari Pralampita, Pulong Wijang Prayoga Adinawer Sirait Putri, Elvia Rahmi Marga Rahami, Nahla Ahmad Rena Normasari Rezza Putri Mahartika Rosita Dewi Rumastika, Nindya Shinta septa surya wahyudi, septa surya Sheilla Rachmania, Sheilla Sheillavi Fauziah Alex Saddamiah Sumadi Supangat Supangat Tsintani Nur Aristiana Wibsono, Sony Wiwien Sugih Utami Yedi Murdanu Yovita Karina Pandan Putri Yudha Nurdian Yuli Hermansyah Yuli Hermansyah, Yuli Yunita Armiyanti Zahrah Febianti