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Journal : INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES

FLOUXETINE IMPROVED INTRAVAGINAL EJACULATORY LATENCY TIME THROUGH DECREASED LEVELS OF INTERFERON-GAMMA AND INCREASED LEVELS OF SEROTONIN IN PATIENT WITH PREMATURE EJACULATION I M., Nyandra; W, Pangkahila; A. A., Raka-Sudewi; I N. A., Bagiada
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 6 No 2 (2012): Indonesian Journal of Biomedical Sciences
Publisher : Udayana University

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Abstract

Pathophysiology of premature ejaculation (PE) is very complex because it is associated with many factors, which can be grouped into biological factors and psychological factors. Various diseases have been found correlate between psychological factors and biological factors through cytokines, one of which is IFN-g (IFN-g). IFN-g affect indolamine dioxygenase enzyme (IDO) and decrease levels of serotonin. Low levels of serotonin leads to PE. The purpose of this study was to prove the relationship of serotonin and IFN-g in pathophysiology of PE. This study was designed as a pretest-posttest double-blind cross-over control group design. Patients with PE were divided into 2 groups: control group and treatment group. Treatment group received flouxetine 20 mg for 30 days. Then the control and treatment groups were crossed after passing a 14-days washout period. Previously as a control group to treatment group and received flouxetine 20 mg per day for 30 days. Before and after treatment in each group was examined the levels of serotonin and IFN-g. Of the 26 subjects, each group there was 13 subjects. Flouxetine 20 mg per day for 30 days increased serotonin levels were significantly (p < 0.05), and decreased levels of IFN-g were significantly (p < 0.05). Increased levels of serotonin and decreased levels of IFN-g was significantly associated with improvements (intravaginal ejaculatory latency time) ejaculation in PE patient. From these results it can be concluded that PE occurs because decreased levels of serotonin. Decreased levels of serotonin are associated with increased levels of IFN-g. Keywords: PE, Serotonin, IFN-g.
Co-Authors Adnorita Fandah Oktariani Agus Donny Susanto Agus Dony Susanto Agustin, Ni Putu Diah Putri Alemita Asteti Pullu Amanda Tizza Ayunadha P Anak Agung Gde Agung Angga Atmaja Andrianto, Nurrahman ASTUTI, PUTU WIDYA Bagiada I N. A. Bambang Hadi Kartiko Cahayantari, Luh Diah Rosa Candra Puspitasari Dermawan Waruwu Dewa Ayu Eka Yuni Artini Dewa Ayu Puspa Dewi Dewi, I Dewa Ayu Sri Warma Franning Deisi Badu Hardy, Dedy Kastama Hildegardis Debby I Gede Widhiantara I Gusti Ngurah Manik Nugraha I Made Gde Sudyadnyana Sandhika I Made Wisnu Adhi Putra I Nyoman Purnawan I Nyoman Suarjana I Putu Dedy Kastama Hardy Ida Bagus Agung Yogeswara Karisma, Putu Agus Sukma Kurniati, Made Lestari, KM. Herliena Made Agus Sugianto Made Trisna Murthi Martini, Ketut Martini, Ni Ketut Maya Rizky Rahmayani Ni Ketut Martini Ni Luh Arik Setiawati Ni Luh Putu Seri Wardani Ni Luh Putu Yusi Haryathi Ni Made Diana Erfiani Ni Made Kurniati Ni Putu Diana Suartari Ni Putu Ulan Yunda Dewi Ni Putu Widya Astuti Ni Wayan Dewi Martini Nurain Labaco Nurata, I Wayan Nyoman Suarjana Nyoman Trisna Aryanata Pambayun, Mahogany Adjeng Pangkahila W Paramarta, Nyoman Bayu Putri, Fina Aryani Putri, Kadek Fina Aryani Putu Angga Wiradana Putu Chrisma Dewi Putu Eka Sudaryatma Putu Sri Armayani Raka-Sudewi A. A. Rinda Dian Pratiwi Rostriana, Angelina Adventa Sanah, Isnaini Nur Ulfa Seprianus Jowa Setyo Budi Kurniawan Suarjana , Nyoman Sudani, Ni Wayan Sumadewi, Ni Luh Utari Sumadewi, Utari Suryasa, Wayan Wayan Suryasa Yudha, Ari Natalia Yudha, Ni Luh Gde Ari Natalia Zul Adhayani Arda