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All Journal Indonesian Journal of Cancer The Indonesian Journal of Public Health Public Health of Indonesia Medicinus : Jurnal Kedokteran Journal of Epidemiology and Public Health Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Narra J Cermin Dunia Kedokteran Indonesian Journal of Cancer The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)

Andree Kurniawan

Bagian Penyakit Dalam, Fakultas Kedokteran Universitas Pelita Harapan Siloam General Hospital

Author-ID : 301723

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 69 Documents Claim Missing Document

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Articles

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Tuberkulosis Payudara Primer sebagai Diagnosis Banding Massa Payudara Nata Pratama Hardjo Lugito; Edy Gunawan; Margaret Chandra; Andree Kurniawan; Darti Isbandiarti
Cermin Dunia Kedokteran Vol 43, No 1 (2016): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v43i1.10

Dilaporkan kasus seorang pasien perempuan berusia 40 tahun dengan TB payudara primer, suatu bentuk TB ekstra-paru yang jarang dijumpai. Keluhan berupa benjolan payudara kanan sejak 2 minggu dan pembesaran kelenjar getah bening aksila kanan. Ultrasonografi menemukan abses dan pembesaran kelenjar getah bening. Biopsi abses menemukan gambaran infeksi Mycobacterium tuberculosis. Setelah pengobatan anti-TB selama 6 bulan, abses membaik. Gambaran klinis TB payudara bervariasi dan memiliki kemiripan dengan beberapa penyakit lainnya. TB payudara merupakan salah satu diagnosis alternatif massa payudara di daerah dengan insidens TB tinggi.

Sarcopenic Obesity in Cancer Patients: Focus on Pathogenesis Wilson Matthew Raffaello; Andree Kurniawan
Indonesian Journal of Cancer Vol 14, No 3 (2020): September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Sarcopenic obesity is an emerging problem in cancer patients. However, this is often difficult to diagnose without the measurement of body composition. Sarcopenic obesity is associated with increased mortality, chemo-toxicity, and other complications in cancer patients. Until now, there is scarce information about sarcopenic obesity in the cancer population.Method: We identified 1955 articles related to sarcopenic obesity in adult cancer patients using PubMed, PubMed Central, and Cochrane Library databases from January 1, 1989, until January 1, 2020. Firstly, we screened the titles and abstracts which mentioned sarcopenic and obesity, especially in pathogenesis. 29 articles could proceed to the next step; then, they were screened for the full text. All steps were reviewed by two authors.Results: At last, they were 9 articles included. Sarcopenic obesity is defined as the coexistence of sarcopenia and obesity, an increase in fat mass in the body. Sarcopenic obesity carried cumulative risks from each of the two individual body compositions. CT-scan offers the highest available precision in determining body composition parameters, especially in the cancer population. Multiple causes and interactions between hormonal changes, aging, disuse, neuronal, poor nutrition, physical inactivity, and low-grade inflammation played roles. Sarcopenic obesity is associated with chemotherapy toxicity. High protein intake should be initiated to ensure adequate protein intake. Resistance training is beneficial in improving muscle mass and strength by focusing on strength training, flexibility, and balance.Conclusions: Sarcopenic obesity is an emerging problem but is often neglected. Further research needs to be conducted especially in explaining the pathogenesis of sarcopenic obesity. The combination of physical exercise and diet modification is the best management to improve sarcopenia obesity in cancer patients.

Patogenesis, Diagnosis, dan Penatalaksanaan Tromboemboli Vena pada kanker Andree Kurniawan
Indonesian Journal of Cancer Vol 7, No 3 (2013): Jul - Sep 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Tromboemboli vena sering terjadi pada pasien kanker. Kejadian tromboemboli vena memiliki morbiditas dan mortalitas yang bermakna pada pasien kanker. Studi terbaru menunjukkan pemahaman yang lebih baik terkait faktor risiko klinis dan biomarker biologis yang dapat menjelaskan patogenesisnya menjadi lebih mudah dimengerti. Model prediksi risiko telah dihasilkan untuk menstratifikasi faktor risiko tromboemboli vena multipel pada pasien kanker. Profilaksis terjadinya trombosis dengan unfractioned heparin atau low-molecular-weight heparin (LMWHs) telah diperlihatkan aman dan efektif pada pasien risiko tinggi. Tata laksana tromboemboli vena pada kanker memerlukan antikoagulan jangka panjang dengan LMWH atau antikoagulan oral.Kata kunci: kanker, tromboemboli vena

Diffuse Large B Cell Lymphoma, Bilateral Lower Extremity Lymphedema, and Ulcerated Inguinal Lymph Node NATA PRATAMA HARDJO LUGITO; ANDREE KURNIAWAN; THEO AUDI YANTO
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : National Cancer Center - Dharmais Cancer Hospital

Lymphedema (LE) is a chronic medical condition characterized by lymphatic fluid retention, resulting in tissue swelling. There are two general classifications of LE; primary and secondary which are based on two mechanisms; lymphatic obstruction and lymphatic interruption. The most common cause of LE in the developing world is secondary to an infection known as filariasis. Cancer including Hodgkin and non-Hodgkin lymphomas; and its treatment are some causes of secondary LE. LE also could maintain the persistence of an occult localization of lymphoma. This case illustration describes a female, 57 year-old with stage II lymphedema of both legs, bilateral inguinal lymphadenopathies that were biopsied. The filarial blood examination was negative. Biopsies showed diffuse large B-cell lymphoma.

Penatalaksanaan Perdarahan pada Kanker ANDREE KURNIAWAN
Indonesian Journal of Cancer Vol 7, No 4 (2013): Oct - Dec 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v7i4.313

Perdarahan pada pasien kanker dapat bermanifestasi dengan berbagai cara. Komplikasi perdarahan meningkatkan perawatan dan mortalitas pasien kanker. Berbagai faktor dapat berkontribusi untuk terjadinya komplikasi perdarahan pada kanker. Kemungkinan penyebab, baik terkait penyakit maupun terapi kanker yang menyebabkan supresi sumsum tulang, dapat terjadi pada kanker solid maupun hematologi. Karena banyak etiologi yang dapat menjadi penyebab, pendekatan diagnostik yang komprehensif diperlukan untuk manajemen pasien kanker. Anamnesis yang sistematik, pemeriksaan fisik yang teliti, dan pemeriksaan laboratorium yang cost efektif diperlukan untuk tata laksana pasien dengan kanker. Akhirnya, pendekatan interdisiplin meliputi terapi lokal dan sistemik diperlukan untuk penatalaksanaan pasien kanker yang mengalami perdarahan.Kata Kunci: kanker, perdarahan

Nutritional Status and Quality of Life in Breast Cancer Patients in Karawaci General Hospital ANDREE KURNIAWAN; NATA PRATAMA HARDJO LUGITO
Indonesian Journal of Cancer Vol 10, No 1 (2016): Jan - Mar 2016
Publisher : National Cancer Center - Dharmais Cancer Hospital

ABSTRACTCancer is related to a deterioration of nutritional status and quality of life (Qol), but the extent of these conditions in patients with breast cancer has not been studied well. Malnutrition is prevalent among cancer patients and maybe correlated with altered quality of life. The aim of this study is to evaluate the association of QoL and nutritional status after breast cancer diagnosed. Nutritional status was evaluated with Patient Generated Subjective Global Assessment and QoL using Short form 36 (SF-36) and also with the specific module for breast cancer patients. A consecutive sampleof twenty two patients diagnosed with breast cancer was evaluated. The associations of QoL with stadium and nutrition status were evaluated using T-test analysis. The mean of body mass index was 21.3 kg/m2. Fifty percent patient have menopause. Most patients were stage II (77.3%), the others stage III (18.2%) and stage I (4.5%). Sixty eight point two percent had risk of malnutrition. The stadium of tumor was significantly related to physical functioning (p < 0.000), physical limitation (p < 0.024), emotional limitation (p < 0.013), well-being (p < 0.020), health changes (p < 0.010). Thestatus of nutrition was significantly related to physical functioning (p < 0.001), loss of energy (p < 0.010) and general health (p <0.005). For Conclusion, the status of nutrition breast cancer patients were related to QoL especially physical functioning, loss of energy and general health after they were diagnosed.ABSTRAKKanker sangat terkait dengan perburukan status nutrisi dan kualitas hidup. Namun demikian, belum banyak studi yang yang melaporkan masalah nutrisi dan kulitas hidup pada kanker payudara. Malnutrisi sering ditemukan pada kanker dan mungkin terkait dengan perubahan kulaitas hidup. Tujuan penelitian ini adalah untuk mengevaluasi hubungan antara kualitas hidup dengan status nutrisi setelah kanker payudara terdiagnosis. Evaluasi status nutrisi dilakukan dengan Patient Generated Subjective Global Assessment dan kualitas hidup dengan Short form 36 (SF-36) sertakarakteristik pada kanker payudara. Sampel diambil dengan teknik konsekutif terhadap 22 pasien yang terdiagnosis kanker payudara. Hubungan kualitas hidup dengan stadium kanker dan status nutrisi dinilai menggunakan analisis T-test. Indeks massa tubuh rata-rata adalah 21,3 kg/m2. Lima puluh pasien telah menopause. Terbanyak adalah stadium 2 (77,3%), stadium 3 (18,2%), dan stadium 1 (4,5%). Enam puluh dua koma dua persen berisiko malnutrisi. Stadium tumor secara bermakna berhubungan dengan fungsi fisik (p <0,000), keterbatasan fisik (p<0,024), keterbatasan emosi(p<0,013), rasa nyaman (p<0,020), dan perubahan kesehatan (p<0,000). Status nutrisi berhubungan secara bermakna dengan fungsi fisik (p<0,001), kehilangan energi (p<0,010), dan kesehatan secara umum (p<0,005). Simpulan, status nutrisi pasien kanker payudara berhubungan dengan kualitas hidup, terutama fungsi fisik, kehilangan energi, status kesehatan umum setelah mereka terdiagnosis.

Tuberculosis Infection Could Mimic Malignant Lymphoma In F-18 FDG PET: A Case Report Ryan Yudistiro; Ivana Dewi Mulyanto; Febby Hutomo; Daniel Chung; Andree Kurniawan; Fajar L. Gultom; Ralph Girson Gunarsa
Indonesian Journal of Cancer Vol 14, No 4 (2020): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Lymphoma and tuberculosis in several cases share similar clinical features that are difficult to differentiate. Lymphadenopathy, fever, malaise, weight loss, and respiratory symptoms are clinical features that could be found in both lymphoma and tuberculosis. Positron Emission Tomography/Computed Tomography Fluorodeoxyglucose (F-18 FDG PET) is a pivotal modality for imaging patients with cancer. Several non-malignant diseases like tuberculosis infection show high FDG uptake and lead to low specificity of F-18 FDG PET.Case Presentation: This case report describes a 55-year-old male patient with a history of Diffuse Large B-cell Lymphoma (DLBCL) who was suspected of having a recurrent disease. The patient has had a 6-month remission period after 6 cycles of R-CHOP regimen chemotherapy. He denied any known history of tuberculosis infection and HIV. F-18 FDG PET was performed to assess the extent of suspected lymphoma recurrent disease. F-18 FDG PET demonstrated multiple hypermetabolic bilateral neck region, mediastinum, and bilateral axilla lymphadenopathies. There were also multiple high FDG uptakes in the liver, mesocolon, and bones. The patient was suspected of having a lymphoma recurrent disease based on these findings. He underwent an excisional biopsy in the neck and was found to have lymphadenitis granulomatous disease from tuberculosis. Based on the histopathology finding, the patient received anti-tuberculosis drugs for 12 months and showed relief of signs and symptoms. F-18 FDG PET for anti-tuberculosis treatment evaluation revealed a complete metabolic response.Conclusion: Tuberculosis should be one of the differential diagnoses when a lymphoma recurrent disease is suspected. Clinical features, laboratory results, and imaging findings sometimes show similarities between lymphoma and tuberculosis. Histopathology evaluation is mandatory to confirm the diagnosis.

Unusual Metastases of Hepatocellular Carcinoma to the Heart ANDREE KURNIAWAN; NATA PRATAMA HARDJO LUGITO
Indonesian Journal of Cancer Vol 10, No 4 (2016): October - December 2016
Publisher : National Cancer Center - Dharmais Cancer Hospital

ABSTRACTHepatocellular carcinoma (HCC) is the sixth most prevalent cancer worldwide. Metastasis of HCC to the heart is rare with prevalence on autopsy of less than 6%. There is still limited study evaluated the metastasis of hepatocellular carcinoma to the heart. The aim of this study is to know the prevalence and characteristic of metastasis of HCC to theheart in Indonesia. This retrospective study was conducted in secondary referral hospital in Tangerang county, Indonesia. We evaluated from medical record included baseline characteristic, survival and treatment of HCC and echocardiogram data for diagnosing metastasis to the heart from 2013-2015. There were 5 HCC patients recorded in thelast 3 years. All patients were male with median age 56(53-61) years old. Four patients were diagnosed using transthoracic echocardiograph and the rest using multi sliced CT scan. All patients were having continuous thrombus from inferior cava vein until right atrial. For the conclusion Hepatocellular carcinoma were reported as the cause ofintra-heart metastases in Indonesia. All patients were in late stage.ABSTRAKKarsinoma hepatoselular adalah kanker keenam terbanyak di seluruh dunia. Metastasis karsinoma hepatoselular ke jantung jarang, prevalensi yang ditemukan pada otopsi kurang dari 6 persen. Masih amat jarang studi yang mengevaluasi metastasis karsinoma hepatoselular ke jantung. Tujuan dari studi ini adalah ingin mengetahui prevalensi dankarakteristik metastasis karsinoma hepatoselular ke Jantung di Indonesia. Studi retrospektif ini dilakukan di rumah sakit rujukan tipe B di daerah Tangerang, Indonesia. Kami mengevaluasi dari rekam medis, meliputi karaktersitik dasar, kesintasan, dan terapi karsinoma hepatoselular; serta data ekokardiografi untuk mendiagnosis metastasis ke jantung dari 2013-2015. Terdapat 5 pasien hepatoselular karsinoma pada 3 tahun terakhir. Semua pasien laki-laki dengan usia median 56 (53-61) tahun. Empat pasien terdiagnosis menggunakan ekokardiografi trans torakal dan sisanya menggunakan CT scan. Semua pasien memiliki trombus kontinu dari vena cava inferior hingga atrium kanan. Sebagai simpulan, karsinoma hepatoselular dilaporkan sebagai penyebab metastasis ke jantung di Indonesia. Semua pasien datang pada stadium lanjut.

Koagulasi Intravaskuler Diseminata pada Kanker ANDREE KURNIAWAN; NATA PRATAMA HARDJO LUGITO
Indonesian Journal of Cancer Vol 9, No 3 (2015): Jul - Sept 2015
Publisher : National Cancer Center - Dharmais Cancer Hospital

Disseminated Intravascular Coagulation is one of thrombosis manifestation other than venous thromboembolism, which onset is acute and has slight different clinical manifestation that tends to be chronic. Pathogenesis of the DIC in hematology malignancy is caused by the activation of fibrinolytic pathway by tumor cells. In solid tumor the pathogenesis is mainly because of the activation of cogulation factor by tissue factor expressed by tumor cells. Thediagnosis of DIC in cancer still needs further validation from the international society of thrombosis and hemostasisand Japanese society hematology criteria in cancer subjects. The principle of therapy for DIC in cancer patients is management of the cancer itself as the underlying etiology with the target is remission. The uses of anticoagulant therapy needs further clinical trial in the future. Coagulation factor and platelet transfusion can be given if there is significant bleeding.Koagulasi intravaskuler diseminata (KID) adalah manifestasi trombosis lain selain tromboemboli vena yang bersifat akut. Pada pasien kanker gambarannya sedikit berbeda, yaitu cenderung bersifat kronik, tergantung pada jenis kankernya. Patogenesis KID pada keganasan hematologi adalah akibat fibrinolisis yang meningkat. Sedangkan pada tumor solid terjadi akibat aktivasi faktor koagulasi oleh faktor jaringan yang diekspresikan oleh sel kanker. Diagnosis KID pada kanker masih memerlukan validasi kriteria dari perhimpunan trombosis hemostasis internasional dan Jepang pada kelompok pasien kanker. Prinsip terapi KID pada kanker adalah tata laksana kanker yang menjadi penyebab, dengan target remisi penyakit. Pemberian antikoagulan memerlukan uji klinis menggunakan populasi pasien kanker. Transfusi faktor koagulasi dan atau trombosit hanya diberikan apabila terdapat perdarahan yang bermakna.

Sarcopenia in Cancer Patients Andree Kurniawan
Indonesian Journal of Cancer Vol 13, No 3 (2019): September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Sarcopenia in cancer patients, especially in advanced stage, recently known as an emerging problem. Firstly, sarcopenia is found in elderly patients. The diagnosis of sarcopenia needs evaluation of muscle composition and function and physical activity. Sarcopenia will give negative impacts such as increased mortality, chemo-toxicity, and decreased quality of life. Here, we review the current evidence describing the definition, impact, risk factors, mechanisms, diagnosis and treatment of sarcopenia in cancer patients.Method: We identified 48 studies and/or review articles evaluating sarcopenia in cancer patients by searching PubMed and EMBASE databases. Results: Sarcopenia is reported across all stages and types of cancers. There is a new definition of sarcopenia that is reported in 2019 paper. The risk factors or causes of sarcopenia in cancer are complex depending on the clinical settings of each patient. SARC-F questionnaire can be used to screen cancer patients in clinical settings. The diagnostic evaluation and cut-off measurement of sarcopenia especially in cancer varied across studies. The loss of muscle mass that happens during chemotherapy will make a poor prognosis. Sarcopenia can worsen chemotherapy toxicity. Combination exercise with adequate dietary supplementation, adequate energy, and protein are important in the management of sarcopenia in cancer patients.Conclusions: Patients with cancer belong to a population at risk of developing sarcopenia before and after chemotherapy. Sarcopenia diagnosis needs the evaluation of muscle mass and muscle strength or physical performance. Physical activity exercise is the best strategy to reduce sarcopenia in cancer patients.

Co-Authors Achmad Fauzi ACHMAD FAUZI Agatha, Cindy Monika Agatha, Lisa Agung, Fransisca Handy Allen Widysanto Andhika Rachman Andri Sanityoso Sulaiman Angelina, Stella Anurantha, Jonathan Juniard Argo, Teresa Mika Ari Fahrial Syam Armen Armen Arshita Auliana Audrey Hamdoyo Billy Susanto Ceva W. Pitoyo Chandra, Margaret Chintya Marcella Cindy Sidarta Claudia Jodhinata Cucunawangsih Cucunawangsih, Cucunawangsih Daniel Chung Darien Alfa Cipta Darti Isbandiarti Devina Adella Halim Devina Adella Halim Dewi Purnamasari Diah Martina, Diah Edy Gunawan Edy Gunawan, Edy Elizabeth Marcella Euphemia Seto Euphemia Seto, Euphemia Evangelista, Nadya Nathalia Fajar L. Gultom Febby Hutomo Felix Wijovi Felix Wijovi Fidelia Octaviani Halim, Devina Adella Hamdoyo, Audrey Hariyanto, Timotius I. Hartoyo, Vinson Heriyanto, Rivaldo Steven Heryadi, Nadia Khoirunnisa Imanuelly, Michelle Indrawan, Michele Isbandiarti, Darti Ivana Dewi Mulyanto Jane Olivia Lorens Jeremia Imanuel Siregar Jodhinata, Claudia Johan Wibowo Johan Wibowo Jonathan Juniard Anurantha Jovita Jovita Khie Chen Liem, Jean Andrina Lorens, Jane Olivia Lucas, Brian Lugito, Nata P H Marcella, Chintya Marcella, Elizabeth Marcellus Simadibrata Marcellus Simadibrata Margaret Chandra Margaret Merlyn Tjiang, Margaret Merlyn Maria, Eva Michael Susanto Michael Susanto Michael, Rafael Jonathan Michele Indrawan Michelle Imanuelly Monica, Moryella Nadia Ayu Mulansari, Nadia Ayu Nadia Khoirunnisa Heryadi Nadya Nathalia Evangelista NATA LUGITO, NATA Nata P H Lugito Nata P Hardjo Lugito, Nata P Nata Pratama Nata Pratama Hardjo Lugito Novia Lauren Sieto Nugroho Prayogo Octaviani, Fidelia Orlin, Sisilia Patricia Budimulia Prima Yuriandro Rahmat Cahyanur Ralph Girson Gunarsa Resa Setiadinata Resti Mulya Sari Rivaldo Steven Heriyanto Rivami, Dwi Savitri Rizki Yaruntradhani Rizki, Saraswati Anindita Ryan Yudistiro Saraswati Anindita Rizki Saraswati Anindita Rizki Setiadinata, Resa Sharfina, Ratuafni Sidarta, Cindy Sieto, Novia Lauren Sinaga, Terry Devita Siregar, Jeremia Imanuel Sisilia Orlin Soputri, Christin Stella Angelina Stevent Sumantri Stevent Sumantri, Stevent Sugianto, Jeremy Octavian Susanti - Susanto, Billy Tan, Christine Tanuwijaya, Nathania Victoria Stevina Terry Devita Sinaga THEO AUDI YANTO, THEO AUDI Timotius Ivan Hariyanto Veli Sungono Vinson Hartoyo Wijaya, Indra Wijovi, Felix Wilson Matthew Raffaello Winata, Sharleen Wong, Clarinda Wonsono, Beverley Yohanes Deo Fau

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