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All Journal Indonesian Journal of Cancer The Indonesian Journal of Public Health Public Health of Indonesia Medicinus : Jurnal Kedokteran Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Narra J Cermin Dunia Kedokteran Indonesian Journal of Cancer The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Andree Kurniawan
Bagian Penyakit Dalam, Fakultas Kedokteran Universitas Pelita Harapan Siloam General Hospital
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Hemofilia Susanto, Michael; Kurniawan, Andree
Medicinus Vol. 6 No. 1 (2016): October 2016 - January 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i1.1140

Abstract

Hemophilia A and B are X-linked recessive diseases that are caused by gene mutations in factors VIII adan IX of the blood clotting cycle. Hemophilia C is an autosomal recessive disease caused by a mutation in factor XI, and acquired hemophilia is largely is an autoimmune process. Hemophilia A and B cannot be distinguished clinically, and severe cases can cause bleeding in the joints and lead to chronic hemophilic arthropathy. The main treatment of hemophilia is infusions of factor VIII and IX, and DDAVP in less severe cases. The main complication that can rise from the use of clotting factors is the appearance of specific inhibitor antibodies that can neutralize the work of the factors. Severe cases of hemophilia A and B by itself carries a poor prognosis, but proper treatment throught the use of clotting factors can give a very good prognosis
Heart Involvement in Systemic Lupus Erythematosus Kurniawan, Andree; Lugito, Nata Pratama Hardjo
Medicinus Vol. 6 No. 2 (2017): February 2017 - May 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i2.1143

Abstract

Pericardial effusion is considered as one of criteria to diagnose systemic lupus erythematosus (SLE) based on American Rheumatism Association (ARA) criteria. There is limited data about the incidence and characteristic pericardial effusion in SLE patients in our country. The aim of this study is to report and assess the incidence of and characteristic heart involvement in SLE. This is cross-sectional study conducted in secondary referral hospital in Tangerang county, west part of Jakarta, capital city of Indonesia. We evaluated from medical record and echocardiogram data from 2013-2015 patients diagnosed with SLE according to ARA criteria. From 33 SLE medical records reviewed, we found 13 patients (40%) with pericardial effusions. All patients were in active stage. Clinical assessment and transthoracic echocardiogram were used to diagnose pericardial effusions. Eighty percent pericardial effusion positive patients had minimal effusion. The others had moderate effusion. No tamponade patients were recorded. Ninety six percent patients were female with median age 24(13-51) years old. Three patients were reported having pulmonary arterial hypertension. One patient had thrombus in left ventricle. All patients had clinical symptoms of cardiac such as heart failure and chest pain. For the conclusion, the incidence of pericardial effusion in SLE patient was 40 percent. Eighty percent patients had minimal effusion. All patients had cardiac symptoms related.
Disseminated Intravascular Coagulation Lorens, Jane Olivia; Kurniawan, Andree
Medicinus Vol. 6 No. 2 (2017): February 2017 - May 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i2.1146

Abstract

Disseminated Intravascular Coagulation (DIC) is an acquired pathological syndrome, featured by a hypercoagulable state, bleeding symptoms, and multiple organ failure. Based by these very distinct features, DIC is classified into four types namely Bleeding type, Organ failure type, Massive bleeding type, and Asymptomatic type. Diagnosing DIC is a challenge to the health practitioner, considering that DIC is a multifactorial syndrome, which always is a complication of some underlying diseases. To diagnose DIC, it is necessary to do a comprehensive evaluation of clinical symptoms and laboratory results. The necessary laboratory results include platelets count, fibrin degradation products (FDPs), fibrinogen, and PT-aPTT.
Prevalensi Infeksi Clostridium difficile Pada Pasien Neutropenia dengan Kanker Kurniawan, Andree
Medicinus Vol. 5 No. 2 (2016): February 2016 - May 2016
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v5i2.1164

Abstract

Clostridium difficile (C. difficile) infection mostly found in immunocompromised patient. Most of the patients with neutropenia had hematologic malignancy and come with multiple risk factors for C. difficile infection. The aim of this study is to know the prevalence and characteristic of C. difficile infections in cancer neutropenia patients. This cross-sectional study was done in secondary referral hospital in suburban Karawaci, Tangerang, Banten, Indonesia from June 2014 until Mei 2015. Adult cancer patients hospitalized with neutrophil count less than 1500 106 cell/L were included. All patients were checked for antigen and toxin C. difficile in faeces. From 25 patients were evaluated for C. difficile infection in neutropenia. C. difficile antigen only found in one patient or 4% sample.Key words: C. difficile, cancer, neutropenia
PENDEKATAN DIAGNOSTIK TERHADAP LEUKEMIA AKUT Hartoyo, Vinson; Kurniawan, Andree
Medicinus Vol. 4 No. 8 (2015): February 2015 - May 2015
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v4i8.1184

Abstract

Leukemia akut merupakan jenis kanker yang paling sering ditemukan pada anak-anak, dengan angka kejadian sekitar 30 persen dari keseluruhan kasus keganasan pada anak-anak, dengan leukemia limfoblastik akut (LLA) memiliki angka kejadian lima kali lebih sering daripada leukemia mieloblastik akut (LMA). Meskipun tata laksana dan regimen pengobatan untuk leukemia limfoblastik akut sudah lebih maju, angka harapan hidup pasien masih cukup rendah terutama pada kelompok pasien dengan usia awitan yang lebih tua (berkisar pada angka 40% pada kelompok umur lebih tua). Dilaporkan sebuah kasus pada seorang anak perempuan berusia 17 tahun yang datang dengan pendarahan dari hidung, telinga, gusi dan saluran cerna (melena dan hematemesis) sejak 3 hari sebelum masuk rumah sakit. Pemeriksaan darah dan apus darah tepi menunjukkan pansitopenia dengan hitung jenis 26% dominan limfosit, dan dengan persentase retikulosit 0.26% yang menunjukkan adanya kegagalan fungsi sumsum tulang. Pasien ini direncanakan untuk menjalani biopsi sumsum tulang sebelum akhirnya meninggal pada hari ketiga perawatan.
EMBOLI PARU Octaviani, Fidelia; Kurniawan, Andree
Medicinus Vol. 4 No. 9 (2015): June 2015 - September 2015
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v4i9.1191

Abstract

Emboli paru merupakan salah satu kegawatdaruratan pada bidang kardiovaskular yang cukup sering terjadi dengan berbagai manifestasi klinis dari keadaan yang asimptomatik hingga keadaan yang mengancam nyawa. Insidensi terjadinya emboli paru pada populasi mencapai 23 per 100,000 penduduk dengan tingkat mortalitas mecapai 15%. Emboli paru dapat disebabkan oleh tromboemboli vena, emboli udara, lemak, cairan amnion, fragmen tumor, dan sepsis. Pemeriksaan ventilation-perfusion scintigraphy masih menjadi baku emas untuk menegakkan diagnosis emboli paru. Sedangkan pemeriksaan lain dapat dilakukan untuk membantu klinisi mendiagnosis kejadian emboli paru. Tatalaksana pada emboli paru akut harus dilakukan dengan segera dengan menggunakan antikoagulan seperti unfractioned heparin, LMWH atau vitamin K antagonis, dilanjutkan dengan trombolitik atau embolektomi apabila trombolitik tidak dapat dilakukan. 
Risk Factors of Non-Typhoidal Salmonella Bacteremia Versus Typhoidal Salmonella Bacteremia in Patients from a General Hospital in Karawaci, Tangerang, Indonesia: A Five-Year Review Lugito, Nata; Cucunawangsih, Cucunawangsih; Kurniawan, Andree; Purnamasari, Dewi
Medicinus Vol. 9 No. 1 (2019): October:2019
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i6.2593

Abstract

Salmonella infections including Non-typhoidal Salmonella (NTS) and enteric fever are important global public health problem, causing approximately 94 million human cases of gastroenteritis with 150,000 deaths annually around the globe. The aim of this study was to determine risk factors for NTS bacteremia patients compared to Typhoidal patients in Indonesia, area with high incidence of enteric fever. This retrospective descriptive study was conducted in Siloam Hospital in Karawaci, Indonesia, from January 2011 to December 2015. Logistic regression model was used to determine independent predictors of NTS bacteremia including demographic and epidemiologic characteristics, clinical presentations, and laboratory results. Out of 129 positive isolates for Salmonella with complete medical records, 18 (13.9%) were positive for NTS. Patients with NTS bacteremia were more likely to belong in the age group below 5 or above 60 year-old, more frequent to have anemia and abnormal leucocyte count. The susceptibility patterns against antimicrobial of NTS bacteremia and Typhoidal bacteremia were similar. In logistic regression analysis, age below 5 or above 60 year-old, hemoglobin level below 12 g/dL and leucocyte count below 4,000/µL or above 12,000/µL were independent risk factors for NTS bacteremia.
Management of Autoimmune Hemolytic Anemia in the Midst of Coronavirus Disease 2019 Pandemic: A Case Report Kurniawan, Andree; Halim, Devina Adella
Medicinus Vol. 9 No. 2 (2020): February : 2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i7.2761

Abstract

Introduction : The novel coronavirus disease 2019 (COVID-19) has become a pandemic involving all people and can be severe and life-threatening in a certain population such as those with comorbidity. Autoimmune hemolytic anemia (AIHA) is an autoimmune hematologic disease characterized with antibodies production that binds to red cell surface antigens. In this pandemic, several concerns have been raised by autoimmune disease clinicians and patients regarding the use of immunosuppressive drugs. In this case report, we illustrate the problems of autoimmune hemolytic anemia patient when she got active case.Case Illustration : A 28 years old lady was admitted to the hospital owing to fatigue and tiredness during exercise for two weeks. She had been diagnosed with autoimmune hemolytic anemia before and did not comply with the treatment. This patient has been reevaluated of having AIHA from the symptoms of fatigue, enlarged spleen, low hemoglobin, increased reticulocytes, signs of hemolytic in blood smear examination, increased indirect bilirubin, LDH and the Combs’ test result was given positive. She received methylprednisolone 2 mg/kg of body weight intravenously, washed packed red cells (PRC), calcium and proton pump inhibitor. She was discharged at the seventh day since admission and she was prescribed oral methylprednisolone equal to 1 mg/kg body weight.Conclusion : This is an educated case of non-compliance of AIHA that should be given high dose steroid and blood transfusion during hospitalization amid the COVID-19 pandemic. The recommendation of treatment for AIHA was still the same as before the pandemic occured.
Correlation Between The Knowledge On Health Effects Of Smoking And Motivation On Smoking Cessation In Ex-Smokers Of Lung Department Patients, Siloam General Hospital, Lippo Village. Wong, Clarinda; Lucas, Brian; Sungono, Veli; Kurniawan, Andree; Widysanto, Allen
Medicinus Vol. 10 No. 1 (2020): October:2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i2.3435

Abstract

Introduction: Data from WHO showed that deaths caused by tobacco reaches approximately ± 6 million deaths annually. There are many information about the danger of smoking which spreading from various sources. The level of  knowledge about the danger of smoking can be associated with motivation to stop smoking. Therefore, motivation toward smoking cessation arises if someone knows the benefits that can be taken, through an adequate knowledge.Aim: To determine the relationship between the level of knowledge on the health effects of  smoking with motivation to stop smoking in ex-smokers of lung department patients at Siloam General Hospital, Lippo Village.Methodology: This is a cross-sectional study, analyzing 138 ex-smokers of Siloam General Hospital’s lung department patients using consecutive sampling techniques.Results: the results showed 73.2% of people have good knowledge about the danger of smoking and 26.8% are not. Then, 58% of people have high motivation to stop smoking and 42% have low motivation. The results of statistical test using Chi Square showed a significant relationship between the level of knowledge and the motivation to quit smoking (OR = 4.293 [95% CI: 1,921-9,594], P<.001). The results of the multivariate logistic regression test showed educational factors (P=0.014), and the frequency of smoking (P=0.007) also influence the motivation to stop smoking.Conclusion : There’s a significant relation between knowledge about the danger of smoking and the motivation to quit smoking.
A Systematic Review of Coronavirus Disease 2019 with Respiratory Distress Syndrome in Adult: Focus on Risk Factors, Mechanism, Diagnosis, and Treatment Jodhinata, Claudia; Kurniawan, Andree; Halim, Devina Adella
Medicinus Vol. 10 No. 1 (2020): October:2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i2.3442

Abstract

Context: Coronavirus disease 2019 (COVID-19) is a newly discovered disease, caused by SARS-CoV-2 and currently has become a pandemic. Acute respiratory distress syndrome (ARDS) is the most common complication in COVID-19. There were numerous conflicting results among articles related to it. The aim of this study is to ascertain the most compelling evidence about ARDS in COVID-19.Evidence Acquisition: This systematic review was registered in PROSPERO (CRD42020180379). A systematic search was conducted in PubMed, PubMed central, and Google Scholar on April 16, 2020. Two reviewers independently searched and selected the articles. The risk of bias was evaluated using the Newcastle-Ottawa Quality assessment tool.Results: A total of 1,647 articles were screened, 9 articles were included. Patients were classified as having various degrees of ARDS, the diagnosis of COVID-19 was confirmed by PCR nasopharyngeal swab.  Risk factors of ARDS in COVID-19 reported were older age, male gender, and pre-existing medical conditions. Cytokine storm was thought to play a role in the mechanism of ARDS. The main treatment for COVID-19 was supportive and symptomatic. To date, there is no antiviral treatment recommended for COVID-19 and the given treatment for ARDS in COVID-19 was similar to other pneumonia-induced ARDS. No additional therapy specific for ARDS in COVID-19 has been proposed.Conclusion: Our synthesis of the literature showed that there was no good evidence in the mechanism and treatment of ARDS. Further translation research in the mechanism of ARDS and continuing with clinical trials evaluating drug efficacy for ARDS in COVID-19 is needed.
Co-Authors Achmad Fauzi ACHMAD FAUZI Agatha, Cindy Monika Agatha, Lisa Agung, Fransisca Handy Allen Widysanto Andhika Rachman Andri Sanityoso Sulaiman Angelina, Stella Anurantha, Jonathan Juniard Argo, Teresa Mika Ari Fahrial Syam Armen Armen Arshita Auliana Audrey Hamdoyo Billy Susanto Ceva W. Pitoyo Chandra, Margaret Chintya Marcella Cindy Sidarta Claudia Jodhinata Cucunawangsih Cucunawangsih, Cucunawangsih Daniel Chung Darien Alfa Cipta Darti Isbandiarti Devina Adella Halim Devina Adella Halim Dewi Purnamasari Diah Martina, Diah Edy Gunawan Edy Gunawan, Edy Elizabeth Marcella Erico, Adelbertus Euphemia Seto Euphemia Seto, Euphemia Evangelista, Nadya Nathalia Fajar L. Gultom Febby Hutomo Felix Wijovi Felix Wijovi Fidelia Octaviani Halim, Devina Adella Hamdoyo, Audrey Hariyanto, Timotius I. Hartoyo, Vinson Heriyanto, Rivaldo Steven Heryadi, Nadia Khoirunnisa Imanuelly, Michelle Indrawan, Michele Isbandiarti, Darti Ivana Dewi Mulyanto Jane Olivia Lorens Jeremia Imanuel Siregar Jodhinata, Claudia Johan Wibowo Johan Wibowo Jonathan Juniard Anurantha Jorisal, Patricia Jorizal, Patricia Jovita Jovita Khie Chen Liem, Jean Andrina Lorens, Jane Olivia Lucas, Brian Lugito, Nata P H Mangkuliguna, Gladys Marcella, Chintya Marcella, Elizabeth Marcellus Simadibrata Marcellus Simadibrata Margaret Chandra Margaret Merlyn Tjiang, Margaret Merlyn Maria, Eva Michael Susanto Michael Susanto Michael, Rafael Jonathan Michele Indrawan Michelle Imanuelly Mira Yuniarti Monica, Moryella Nadia Ayu Mulansari, Nadia Ayu Nadia Khoirunnisa Heryadi Nadya Nathalia Evangelista NATA LUGITO, NATA Nata P H Lugito Nata P Hardjo Lugito, Nata P Nata Pratama Nata Pratama Hardjo Lugito Novia Lauren Sieto Nugroho Prayogo Octaviani, Fidelia Orlin, Sisilia Pardede, Ingrid Maria Patricia Budimulia Prima Yuriandro Rahmat Cahyanur Ralph Girson Gunarsa Resa Setiadinata Resti Mulya Sari Rivaldo Steven Heriyanto Rivami, Dwi Savitri Rizki Yaruntradhani Rizki, Saraswati Anindita Rusli Muljadi, Rusli Ryan Yudistiro Saraswati Anindita Rizki Saraswati Anindita Rizki Setiadinata, Resa Setiawan, Hardianto Sharfina, Ratuafni Sidarta, Cindy Sieto, Novia Lauren Sinaga, Terry Devita Siregar, Jeremia Imanuel Sisilia Orlin Soputri, Christin Stella Angelina Stevent Sumantri Stevent Sumantri, Stevent Sugianto, Jeremy Octavian Susanti - Susanto, Billy Sutanto, Ratna Syahputra, Rheza Maulana Tan, Christine Tanuwijaya, Nathania Victoria Stevina Tarigan, Vera Nevyta Terry Devita Sinaga THEO AUDI YANTO, THEO AUDI Timotius Ivan Hariyanto Veli Sungono Vinson Hartoyo Violetta, Olivia Wijaya, Indra Wijovi, Felix Wilson Matthew Raffaello Winata, Sharleen Wong, Clarinda Wonsono, Beverley Yohanes Deo Fau