Article Per Year (5 Year)
p-Index From 2021 - 2026
2.696
P-Index
This Author published in this journals
All Journal JBIO: jurnal biosains (the journal of biosciences) Current Biochemistry Jurnal Pedagogik Olahraga Best Journal (Biology Education, Sains and Technology) Journal of Telenursing (JOTING) AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Jurnal Kesehatan Tambusai FORTE JOURNAL The Journal of Society Medicine (JSOCMED) Edubiotik : Jurnal Pendidikan, Biologi dan Terapan
Harahap, Armansyah Maulana
Universitas Negeri Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 17 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 17 Documents
Search

 1   2 
Examined study of the impact of ethanol extract from Sirih China (Peperomia pellucida L.) ointment on the histological appearance of the epidermis and the duration of burn healing in mice (Mus musculus) Harahap, Armansyah Maulana; Salamah, Salamah; Rambe, Robiatun; Elanda, Yurike; Khairunnisa, Nur Aini; Priawan, Indra
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 1 (2025): Juni 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i1.10460

Abstract

Burns are a condition where there is damage to the epidermis layer down to the dermis layer. The skin structure sustains damage from the epithelium to the basal layer of the dermis. You can use the herbal Chinese pepper (Peperomia pellucida L.) for burn treatment. This study aims to evaluate the impact of administering Chinese betel leaf ointment, with variations in concentration and formula, on the duration of burn wound healing and the diameter of wound closure. Methods There were 30 Mus musculus mice in this study. Divided them into five groups: a regular group without burns, a positive control group that received gentamicin, treatment group 1 that received a low concentration 5% ethanol extract of Chinese betel leaf (EECB) ointment, a treatment group 2 that received a low concentration 10% EECB ointment, and a treatment group 3 that received a high concentration 15% EECB ointment. Results demonstrate wound closure activity by measuring the diameter of burn wounds treated with a 15% concentration of Chinese pepper ointment on the 18th day and a 15% concentration closed the burn wound. Histopathological differences were seen in the K3 group, where collagen density scored +3 (±0.06). We found a very weak positive correlation (0.000) between histopathology (collagen) and wound diameter and a strong negative correlation (-0.0527) between the histopathological parameter (collagen) and the duration of burn wound healing. Conclusion. The research concludes that the effectiveness of administering Chinese betel leaf ointment with a concentration of 15% was obtained
IDENTIFIKASI SENYAWA BIOAKTIF EKSTRAK ETANOL KULIT MELINJO (Gnetum gnemon) DENGAN METODE GC-MS Armansyah Maulana Harahap; Indra Priawan
FORTE JOURNAL Vol 4 No 2 (2024): Edisi Juli 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v4i2.948

Abstract

Melinjo (Gnetum gnemon) merupakan tanaman yang banyak tumbuh di Asia Tenggara dan banyak digunakan sebagai makanan. Pemanfaatan lain dari melinjo ialah sebagai obat yang memiliki banyak khasiat dikarenakan melinjo kaya akan resveratrol, saponin, stilbenoid, isovitexin, dan gnetin. Kulit melinjo memiliki manfaat yang mirip dengan bagian tanaman melinjo lainnya yaitu sebagai antiinflamasi, antioksidan, dan antimikroba. Namun, pada pemanfaatannya kulit melinjo merupakan bagian yang jarang digunakan dan sering dibuang. Penelitian ini bertujuan untuk mengidentifikasi senyawa bioaktif dari ekstrak etanol kulit melinjo dengan menggunakan metode GC-MS (Gas Chromatograph Mass Spectrometry). Kulit melinjo dikumpukan dari Desa Bunut, Kisaran Sumatera Utara, kemudian dilakukan ekstraksi dengan metode maserasi dan dianalisis untuk identifikasi senyawa boaktif dengan menggunakan metode GC-MS. Hasil identifikasi didapatkan GC-MS, ditemukan 11 senyawa bioaktif yang teridentifikasi dengan aktivitas biologis sebagai antiinflamasi, antioksidan, antifibrotic, laksatif osmotik pada konstipasi dan sebagai pengobatan pada PCOS. Adapun 1,2,3,4,5,6- Cyclohexaneherol (51.20%), Sorbitol (8.73%), dan Hexadecanoic Acid, Methyl Ester (7,48%) merupakan senyawa yang paling tinggi kandungannya pada ekstrak etnaol kulit melinjo.
IN SILICO STUDY OF ACTIVE COMPOUNDS IN Halosi (Bidens pilosa) AS ANDROGEN INHIBITORS IN PROSTATE CANCER Harahap, Armansyah Maulana; Priawan, Indra; Siregar, Sarah Rahmayani
Current Biochemistry Vol. 12 No. 1 (2025)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.12.1.1

Abstract

Prostate cancer is a disease that affects men's prostate gland cells and can spread to other parts of the body, mostly bones and lymph nodes. It is the third most common type of cancer in men in Indonesia and the second most common type of cancer in men worldwide. Ini adalah studi in silico tentang aktivitas chemical compounds in the leaves of the halosi plant (Bidens pilosa) to inhibit the Androgen receptor (1E3G) in the treatment of prostate cancer. Androgen receptor (AR) is a receptor protein that plays an important role in the development of prostate cancer cells. Molecular docking method using Chemdraw 3D, AutoDockTools 1.5.6., BIOVIA Discovery Studio 2021, and Ligandscout were used to conduct tests. Hasil menunjukkan bahwa bahan Bidens pilosa memiliki rendahnya ∆G free bond energy sebesar -10.26 KKal/mol and interaction with with several amino acid residues similar to Oxymetholone, a natural ligand. Therefore, it can be concluded that andrographolid compounds from halosi plant are the most able to inhibit Andorgen receptors
PENATALAKSANAAN KARSINOMA NASOFARING DENGAN BANTUAN ALDH1 A1 SEBAGAI BIOMARKER DALAM PENENTUAN STADIUM Harahap, Armansyah Maulana
BEST Journal (Biology Education, Sains and Technology) Vol 6, No 2 (2023): September 2023
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v6i2.7474

Abstract

ALDH tersebar di seluruh tubuh, mengkatalisis oksidasi aldehida dan berfungsi dalam detoksifikasi seluler, metabolisme dan pensinyalan asam retinoat / retinoic acid (RA) dan perlindungan dari spesies oksigen reaktif / reactive oxygen species (ROS). ALDH diregulasi oleh senyawa asam retinoat termasuk retinoid dan jalur potensial onkogenik seperti WNT/β-catenin dan MUC1-C/ERK. ALDH kemudian mengoksidasi aldehida yang berpartisipasi dalam mekanisme pensinyalan atau menginduksi kerusakan seluler atau DNA, meminimalkan produksi ROS dan pensinyalan asam retinoat. Mekanisme regulasi ini bergabung untuk menghasilkan efek yang dimediasi ALDH pada diferensiasi dan proliferasi sel, tumorigenesis, stemness dan resistensi terhadap terapi. Metode Penelitian ini menggunakan analisis deskriptif terstruktur dengan kajian telaah literatur. Data artikel baik original article, research article, Review article maupun case report dikumpulkan untuk dianalisa sesuai dengan tujuan dari judul dan penulisan artikel ini. ALDH1 dianggap sebagai penanda / marker CSC, yang dapat menginduksi kanker dengan mempertahankan karakteristik CSC dan memodifikasi metabolisme. Tingkat ekspresi ALDH1 merupakan marker yang membedakan sel punca normal dari sel punca kanker. Studi penelitian klinis telah menemukan bahwa rasio prognostik dari famili gen ALDH1 dapat digunakan sebagai prediktor kuat yang buruk dari berbagai kanker solid. Sebagai prediktor kuat, ALDH1 juga terlibat dalam menurunkan resistensi obat pada kanker padat. Meski masih kontroversial, tidak dapat dipungkiri bahwa sel kanker dengan aktivitas ALDH tinggi dan karakteristik mirip sel punca lainnya terkait erat dengan resistensi obat dan rekurensi tumor. Keseimpulan menyatakan bahwa kadar ALDH1A1 yang tinggi memiliki korelasi terhadap kenaikan stadium pada kejadian karsinoma nasofaring, dimana semakin tinggi ALDH1A1 maka polanya menuju ke stadium IV.  
POTENSI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN BANDOTAN (AGERATUM CONYZOIDES L) TERHADAP BAKTERI STAPHYLOCOCCUS EPIDERMIDIS DAN ESCHERICIA COLI: POTENSI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN BANDOTAN (AGERATUM CONYZOIDES L) TERHADAP BAKTERI STAPHYLOCOCCUS EPIDERMIDIS DAN ESCHERICIA COLI Nur Aini Khairunnisa; Amanda Rahayu, Nurul; Husein, Saddam; Maulana Harahap, Armansyah; Pangondian, Aswan; Athaillah
FORTE JOURNAL Vol 5 No 2 (2025): Edisi Juli 2025
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v5i2.1878

Abstract

Bandotan (Ageratum conyzoides L.) is a herbaceous plants that belonging to Asteraceae family which contained a diverse range of secondary metabolites including alkaloids, flavonoids, tannins, glycosides, and saponins. The diversity of its bioactive compounds confers Bandotan as natural ingredient with considerable pharmacological potential, particularly as an antioxidant, antibacterial, and insecticidal agent. The present study aimed to evaluate the antibacterial potential of the Ethanolic Extract of Ageratum conyzoides (EEAC)  Leaves against Staphylococcus epidermidis and Escherichia coli. Diffusion methode using in this study with various concentration from 31.25 until 500 ppm. The results showed that the Minimum Inhibitory Concentration (MIC) for both bacteria was at 31.25 ppm and the inhibition zone was at 10.3 for E. coli and 12.4 for S. epidermidis with 500 ppm concentration. In Minimum Bactericidal Concentration (MBC) test, it is known that EEAC has the highest potential to eradicate E. coli and S. epidermidis. According to this, EEAC has the strong potential effect againts both bacterial strains.
Antidiabetic Effects of Moringa oleifera Leaf Extract on Blood Glucose Levels in Alloxan-Induced Diabetic Rats (Rattus norvegicus): A Systematic Literature Review Harahap , Armansyah Maulana; Ginting, Muhammad Aldi Rivai; Putri, Yulia; Sari, Herviani; Priawan, Indra
Journal of Society Medicine Vol. 4 No. 12 (2025): December
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i12.267

Abstract

Introduction: This systematic literature review, guided by PRISMA guidelines, evaluates the effectiveness of Moringa oleifera leaf extracts in reducing blood glucose levels in alloxan-induced diabetic rats. Method: Literature was searched in PubMed and Google Scholar using keywords including “Moringa oleifera,” “leaf extract,” “alloxan-induced diabetes,” and “blood glucose.” From 472 identified articles, 9 studies met inclusion criteria and were analyzed. Results: Nearly all studies reported significant reductions in blood glucose levels following administration of Moringa oleifera leaf extracts at effective doses ranging from 200–800 mg/kg body weight over 14–28 days. Key mechanisms include protection of pancreatic β-cells from oxidative stress, enhanced insulin secretion, and improved insulin sensitivity. Both aqueous and ethanolic extracts exhibited antihyperglycemic effects, with aqueous extracts demonstrating faster onset and ethanolic extracts providing more sustained outcomes. Conclusion: These findings support the potential of Moringa oleifera leaf extracts as a natural antidiabetic agent in preclinical models. However, further research is required to standardize extraction methods, dosages, and molecular mechanisms to facilitate clinical translation in humans.
Integrated network pharmacology and molecular docking analysis of Aerva sanguinolenta n-hexane extract against breast cancer Harahap, Armansyah Maulana; Agustini, Kurnia; Ningsih, Sri; Bahtiar, Anton
Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Vol. 10 No. 02 (2025): Edubiotik : Jurnal Pendidikan, Biologi dan Terapan
Publisher : Biology Education Department, Universitas Insan Budi Utomo, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33503/ebio.v10i02.1609

Abstract

Breast cancer, particularly the estrogen receptor-positive (ER-positive) subtype, remains a significant global health challenge. Although Aerva sanguinolenta (AS) has shown Anti-cancer potential, its comprehensive mechanistic effects on breast cancer are still largely unknown. This study aims to uncover the pharmacological effects of AS bioactive compounds on breast cancer using an integrated network pharmacology and molecular docking approach. Bioactive compounds in AS were identified through GC-MS. Compound-target and breast cancer gene interactions were obtained from various databases, followed by protein-protein interaction, Gene Ontology, and KEGG pathway analyses. Molecular docking studies were then used to confirm key interactions. We found that 4 of 103 AS compounds met strict screening criteria, identifying 712 potential gene targets, 33 of which were directly related to breast cancer, including hormonal (ESR1) and apoptosis (AURKA) pathways. Further analysis and molecular docking confirmed the strong binding affinity of Bakuchiol and Afzelin compounds to their main targets, which are involved in critical biological processes such as estrogen receptor signaling, cell cycle regulation, and pathways related to cell proliferation and breast cancer development. In conclusion, this study provides a comprehensive understanding of the potential mechanisms of AS bioactive compounds Afzelin and Bakuchiol against breast cancer, demonstrating their therapeutic potential through Network Pharmacology and docking scores.
Co-Authors alfira, alfira Amanda Rahayu, Nurul Anton Bahtiar Athaillah Doloksaribu, Bernike Elanda, Yurike Endang Sulistyarini Gultom Farah dhiba Ginting, Muhammad Aldi Rivai Indra Priawan Keumalasari, Dina Khairunnisa, Nur Aini kurnia agustini Mansoor Abdul Hamid Nila Zusmita Wasni Nila Zusmita Wasnia Nur Aini Khairunnisa Nuraiza Meutia Oslida Martony Priawan, Indra Pulungan, Ahmad Shafwan S Rambe, Robiatun Saddam Husein, Saddam salamah salamah Sarah Rahmayani Siregar Sari, Herviani Silalahi, Ali Affan Sri Ningsih Wahyuni, Arlinda Sari Yetty Machrina Yulia Putri