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Irawan Fajar Kusuma
Bagian Ilmu Kesehatan Masyarakat Fakultas Kedokteran Universitas Jember
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HUBUNGAN PENGETAHUAN IBU TENTANG STIMULASI DINI DENGAN PERKEMBANGAN MOTORIK PADA ANAK USIA 6-24 BULAN DI KECAMATAN MAYANG KABUPATEN JEMBER Irawan Fajar Kusuma; Ramzi Syamlan; Ayu Yoniko
Jurnal Ilmu Kesehatan Masyarakat Vol 9 No 1 (2013)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Jember

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Abstract

More than two third of toddler in some developing countries suffer from declining of their childhood development. In Indonesia, in 2003, Department of Health has conducted childhood development in 30 provinces and reported that 45,12 % of infant has suffered from growth and development disorder. One of factors that influence the development is early stimulation especially from people close to the toddler (mother and other family).The aim of this study is to analyze the relationship between mother’s knowledge about early stimulation and motoric development of toddlers. This is an observational study of case control design. To obtain the samples, the technique is non probability sampling with consecutive sampling. Motoric development of toddlers from 6 – 24 month old are observed by KPSP form. Data are analyzed using bivariate analysis of Marginal Homogeneity test and Conditional Regressiona Logistic (Confidence Interval 95%). The result shows that mother’s knowledge on early stimulation have significant effect to the motoric development of toddlers. The odds ratio shows 4,950 means that the lack of knowledge of the mother on early stimulation may increase the risk of motoric development disorder about nearly 5 times. It can be conclude that there is significant relationship between mother’s knowledge on early stimulation and motoric development disorder. Mother who is in the closest position of toddlers should be educated with this knowledge of education.
INTERVENSI PENDIDIKAN KESEHATAN KOMUNITAS MENGENAI TUBERCULOSIS PARU PADA PAGUYUBAN PARU DESA PLEREAN, SUMBERJAMBE, JEMBER Irawan Fajar Kusuma; Ragil Ismi Hartanti
Jurnal Ilmu Kesehatan Masyarakat Vol 3 No 2 (2007)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Jember

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Abstract

Pulmonary TB is a chronic infectious disease and one of the most important health problems in the world, especially in developing countries such as Indonesia. Anti TB drugs resistance and how easy it spread because the lack of information and knowledge are the major constrains in TB eradication. Many efforts has been taken to  overcome this problems, however, its incidence and prevalence is still high. Health community education, including the spreading of pulmonary TB and how to recognize the clinical manifestations, is one of the effort to overcome this problem. The aim of this study was to know the effect of health community education about pulmonary TB to Paguyuban Paru Group at Plerean, Subdistrict Sumber Jambe, Jember. This is a quasi experimental study, using pre test and post test after a health community education has been given. By paired sample test, the result showed significant difference (p<0,05) in the knowledge about pulmonary TB among the member of Paguyuban Paru at Plerean, Subdistrict Sumber Jambe, Jember, before and after health community education has been given. The conclusión of this study is that health community education effectively increase the knowledge about pulmonary TB and, next, can compress the incidence of pulmonary TB in Indonesia   Key words : pulmonary TB, community, health education
Predictors Factors of Mortality Hepatocelullar Carcinoma Patients RSD dr. Soebandi Jember 2018-2020 Roan Pratama Putra; Irawan Fajar Kusuma; Adelia Handoko
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.25275

Abstract

Liver cancer, predominantly Hepatocellular Carcinoma (HCC), is a tumor that originates from hepatocytes and is clinically progressive. In Indonesia, according to the Ministry of Health in 2019, liver cancer is the second most common cancer in men, amounting to 12.4 per 100,000 population with an average death rate of 7.6 per 100,000 population. There are very few studies on HCC in RSD dr. Soebandi Jember. This study aims to determine the characteristics and factors that can be predictors of death in HCC patients. This study uses an observational analytic research type with a case-control research design. The data of this study used secondary data from the medical records of HCC patients at RSD dr. Soebandi Jember, as well as primary data in the form of telephone interviews. The results of this study with a total of 72 samples showed that there was a significant difference between liver cirrhosis and HCC patient mortality within 90 days (p = 0.005), and could be used as a predictor of HCC mortality (OR = 17.15; 95% CI = 1.532-192.017). Keywords: HCC, predictors of death, HCC mortality
Empowerment and Partnership Programs in Healthy Community Movements Through Integrated Development Posts (IDP) of Non-Communicable Disease (NCD) Tantut Susanto; Erwin Nur Rif'ah; Irawan Fajar Kusuma; Suyani Indriastuti
Warta Pengabdian Vol 16 No 2 (2022): Warta Pengabdian
Publisher : LP2M Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/wrtp.v16i2.27270

Abstract

Optimizing the role of the community in the Healthy Community Movement (HCM) through the facilitation of health cadres at the Integrated Development Post (IDP) of non-communicable diseases (NCDs) to become an effective solution of health promotion program using empowerment and partnerships in the community as a form of active participation in health. The purpose of this community service was to increase community empowerment and partnerships in overcoming NCDs problems through HCM to reduce hypertension in Glagahwero Village, Panti District, Jember Regency. The activities were carried out for 3 months (August - November 2020) in the form of education and health counseling about HCM and hypertension, anti-hypertensive exercise, hypertension diet, empowerment of family cooking in the management of family salt consumption, and IDP of NCDs. The fostered village service activities involved 70 target groups. The results were found that the community was able to do HCM to control blood pressure by doing anti-hypertensive exercises once a week, mothers were able to prepare a low-salt menu in their families, and IDP of NCDs activities were carried out once a month. The further impact was a decrease in mean systolic blood pressure (130.5 ± 22.5 mmHg Vs. 122.3 ± 18.3 mmHg; p = <0.001) and diastolic (81.83 ± 10.4 mmHg Vs. 79.4 ± 9.1 mmHg; p = 0.015), decreased body weight (60.6 ± 12.1 kg Vs. 59.7 ± 12 kg; p <0.001), and decreased abdominal circumference (88.5 ± 14.2 cm Vs 82.7 ± 14.1 cm; p <0.001) after 3 months of community service development. Thus, it can be concluded that the partnership and empowerment of the community in HCM is able to prevent PTM, so it is suggested that IDP of NCDs activities need to be carried out in a sustainable manner in the community.
Association of parental feeding styles and the nutritional status of children ages 2 to 5 years in Jember, East Java, Indonesia Marchianti, Ancah Caesarina Novi; Rachmawati, Dwita Aryadina; Astuti, Ida Srisurani Wiji; Raharjo, Angga Mardro; Kusuma, Irawan Fajar; Sudarmanto, Yohanes; Hakiim, Arsyzilma; Nurmaida, Eny
Public Health and Preventive Medicine Archive Vol. 12 No. 1 (2024)
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53638/phpma.2024.v12.i1.p07

Abstract

Background and purpose: There is a great deal of mythical erroneous information regarding children's nutrition that can affect styles of parental feeding. If it is left uncontrolled, it may influence the nutritional status that led to malnutrition. The purpose of this study is to determine association between styles of parental feeding and nutritional status of children ages of 2 to 5 years old.  Methods: This was a cross-sectional study, conducted in November-December 2023 in Jember, East Java, Indonesia. Samples were 244 mothers who were selected purposively and satisfied the inclusion and exclusion criteria. Data was collected with interview which include parents’ and children’s characteristics, the feeding practices using a validated structured questionnaire (FPSQ-28), and children nutritional status. Descriptive analysis followed by correlation analysis were performed. Results: Most parents earn more than IDR 2,000,000 and work as self-employed, whereas more than half of the respondents, both fathers and mothers, had at least a high school education, and the majority of height in both were 150-170 cm with normal body mass index. There is a weak positive association between the styles of parental feeding with the body weight for age (r=0.183; p=0.040) while no significant association with body weight for height (r=0.08; p=0.216). Conclusion: Styles of parental feeding affected children's feeding and nutritional status, particularly when it comes to chronic conditions and in order to maintain children's nutrition or balanced nutrition, it is necessary to conduct education and evaluation of parental feeding styles.    
Increased of Spleen White Pulp Diameter Post Dbl2β-Pfemp1 Recombinant Protein Injection in Wistar Rats: Pre-Clinical Study for Malaria Vaccine Development Sulistyaningsih, Erma; Sa’diyah, Nindya Audatus; Kusuma, Irawan Fajar; Dewi, Rosita; Rachmania, Sheilla
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 18 No 1 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v18i1.7451

Abstract

Malaria is a major infectious disease worldwide, and vaccination is essential for disease control. The Plasmodium falciparum Erythrocyte Membrane Protein-1 (PfEMP1) is a potential malaria vaccine candidate due to its involvement in pathogenesis. Injection of DBL2β-PfEMP1 recombinant protein in animal models induces IgG and CD4+ production and inhibits binding with host endothelial receptors. This study aimed to analyze the spleen immune response by measuring the white pulp diameter. The experimental study used Wistar rats (Rattus norvegicus) that were divided into four groups, a control group and three treatment groups, which were injected with 100, 150, and 200 μg of DBL2β-PfEMP1 protein. Injection was done thrice with three-week intervals (days 0, 21, and 42). On day 56, rats were euthanized, and spleens were prepared for histology examination. The white pulp diameter increased along with increasing the dose of protein. The ANOVA test showed a significant difference between groups (p=0.001). The posthoc Bonferroni test showed a significant difference between the control and the 150 and 200 μg groups and the 100 μg and 200 μg groups. In conclusion, the DBL2β-PfEMP1 recombinant protein injection increased the spleen white pulp diameter in Wistar rats, and the 200 μg dose resulted in the highest increase.
Efektivitas Penyuluhan Risiko Preeklampsia Pada Ibu Hamil di Patrang Kabupaten Jember Nurmaida, Eny; Rachmawati, Dwita Aryadina; Rachmania, Sheilla; Putri, Elvia Rahmi Marga; Hakiim, Arsyzilma; Marchianti, Ancah Caesarina Novi; Astuti, Ida Srisurani Wiji; Raharjo, Angga Mardro; Sudarmanto, Yohanes; Kusuma, Irawan Fajar
Jember Medical Journal Vol. 3 No. 1 (2024)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jembermedicaljournal.v3i1.936

Abstract

Angka kematian ibu di Kabupaten Jember dan Jawa Timur masih tinggi.  Terjadipeningkatan kasus kematian ibu pada tahun 2018-2021. Preeklamsia merupakan salah satu penyebab utama kematian ibu hamil. Tindakan preventif seperti edukasi pada ibu hamil mengenai pentingnya pemeriksaan kehamilan pada kehamilan risiko tinggi perlu dilakukan agar tidak terjadi komplikasi. Tujuan penelitian ini adalah untuk mengetahui efektivitas penyuluhan risiko preeklamsia pada ibu hamil di Kecamatan Patrang Kabupaten Jember. Jenis penelitian ini adalah penelitian pra-eksperimental dengan desain penelitian one group pretest-posttest. Instrumen penelitian berupa kuesioner yang berisi 22 pertanyaan mengenai pengetahuan, faktor risiko, gejala dan komplikasi preeklamsia. Besar sampel sebanyak 30 responden (quota sampling). Uji normalitas data menggunakan uji Shapiro Wilk dan uji hipotesis menggunakan uji Wilcoxon Signed Rank. Nilai Sig uji Saphiro Wilk diperoleh 0,033 yang berarti data tidak berdistribusi normal. Dari hasil uji hipotesis diperoleh nilai Asymp. (2-tailed) 0,000 yang menunjukkan terdapat perbedaan yang signifikan antara nilai pretest responden sebelum diberikan penyuluhan dan posttest responden setelah diberikan penyuluhan.
Optimized Expression Condition of CIDRα-PfEMP1 Recombinant Protein Production in Escherichia coli BL21(DE3): A Step to Develop Malaria Vaccine Candidate Setyoadji, Winnie Almira; Sulistyaningsih, Erma; Kusuma, Irawan Fajar
Research Journal of Life Science Vol 8, No 1 (2021)
Publisher : Direktorat Riset dan Pengabdian Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.rjls.2021.008.01.3

Abstract

Malaria is still an essential epidemiological disease worldwide, including in Indonesia. Several approaches are performed to control the disease, as well as vaccine development. The Cysteine-rich interdomain region α of Plasmodium falciparum erythrocyte membrane protein 1 (CIDRα-PfEMP1) is a pivotal domain in the malaria pathogenesis make it a malaria vaccine candidate. The development of the malaria vaccine is performed using recombinant technology. Recombinant protein production is an important step. The study aimed to determine the optimized condition for CIDRα-PfEMP1 recombinant protein expression in Escherichia coli BL21(DE3) expression system. Serial IPTG concentrations from 0.05, 0.1, 0.3, and 0.5 mM and two different incubation periods of 4 h and 8 h were optimized. The recombinant protein expression was visualized in SDS-PAGE, measured using the Bradford protein assay, and calculated using software Image J. SDS-PAGE visualization showed a 27 kDa band expressed CIDRα-PfEMP1 recombinant protein. The optimized condition for CIDRα-PfEMP1 recombinant protein expression was at 0.03 mM IPTG concentration and 8 h incubation period.
Optimized Purification of CIDRα-PfEMP1 Plasmodium falciparum Recombinant Protein with Affinity Chromatography Alami, Eqiel Navadz Akthar; Sulistyaningsih, Erma; Kusuma, Irawan Fajar; Rachmania, Sheilla
Jurnal ILMU DASAR Vol 23 No 2 (2022)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jid.v23i2.24127

Abstract

Interaction of Cysteine-rich Interdomain Region (CIDR)α-Plasmodium falciparum Erythrocyte Membrane Protein (PfEMP1) and Endothelial Cell Receptors especially CD36 on host cells is main malaria pathogenesis, makes this domain as a malaria vaccine candidate. Recently, the development of the malaria vaccine is conducted by recombinant technology, and the purification of the CIDRα-PfEMP1 recombinant protein is a pivotal step. This study aimed to determine an optimal condition to purify the CIDRα-PfEMP1 recombinant protein by affinity chromatography through imidazole and NaCl concentration. The purified recombinant protein was visualized using SDS-PAGE and its concentration was measured using Image J software and Bradford Assay. The data were analyzed using SPSS 26 software, and the Paired T-Test analysis was conducted to compare the concentration of purified recombinant protein from two different methods. The result showed that thetarget band of purified recombinant protein was 27 kDa. The thickest target protein band was observed in purified recombinant protein using 140 mM imidazole and 300 mM NaCl. The recombinant protein concentration using Image J software was 0.025 µg/µL, while the Bradford Assay was 0.56 µg/µL. The Paired T-Test analysis has a significance value of 0.010 (p<0.05), meaning there was a significant difference between the concentration measurement using Image J software and Bradford Assay. In conclusion, the optimized condition to purify the CIDRα-PfEMP1 recombinant protein by affinity chromatography was using 140 mM imidazole and 300 mM NaCl. It is suggested to measure the purified CIDRα-PfEMP1 recombinant protein concentration using the Bradford Assay method due to its convenience and sensitivity.
THE IMPACT OF CHRONIC PESTICIDE ON INCIDENCE OF GASTRIC CANCER: SYSTEMATIC REVIEW AND META-ANALYSIS Khoiruddin, Mukhammad Arif Hadi; Tartila, Jasmine; Utami, Wiwien Sugih; Kusuma, Irawan Fajar
HEARTY Vol 12 No 3 (2024): AGUSTUS
Publisher : Fakultas Ilmu Kesehatan, Universitas Ibn Khaldun, Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/hearty.v12i3.14515

Abstract

Indonesia as an agricultural country relies heavily on its corps as the main sector of nation’s development. On daily basis, many farmers use pesticide to increase corps productivity. However, pesticides were known to induce malignancy, one of them being gastric cancer; the fourth most mortal cancer in the world, with less than 12 month life expectancy on advanced stage, thereby making it a global health problem. This research used systematic review and meta-analysis methods to examine pesticide exposure variables on gastric cancer cases. Three journals were found, and meta-analysis results showed that there was a significant increase in the risk of gastric cancer in respondents who experienced pesticide exposure, especially with prolonged exposure with an odds ratio of 1.47 (more than two years). However, this review cannot explain the toxicity dose of pesticides and the nutritional status of respondents which can increase the incidence of gastric cancer due to the lack of research on related variables.
Co-Authors Adelia Handoko Adhitya Wicaksono Aisya, Meutia Citra Alami, Eqiel Navadz Akthar Ancah Caesarina Novi Marchianti Andriani, Made Prasanti Angga Mardro Raharjo Angga Mardro Raharjo, Angga Mardro Aprilia, Annisa Nadya Aris Prasetyo Arsyzilma Hakiim Ayu Yoniko Ayu Yoniko Christiari Bagus Hermansyah Dini Agustina Dwita Aryadina Rachmawati Erma Sulistyaningsih Erwin Nur Rif'ah Ghaiska Najma Amnur Ida Srisurani Wiji Astuti Jauhar Firdaus Khoiruddin, Mukhammad Arif Hadi Kholifaturrohmah, Sakinatus Sariroh Kholifaturrohmy, Muhammad Rizqi Khulaida Fatila Hayati Leersia Yusi Ratnawati Luthfiyyah, Nur Atikah M. Ali Shodikin Marchianti, Ancah C N Muhammad Hasan Muhammad Hasan Muhammad Hasan Nurmaida, Eny Pradewi, Ranny Tandria Putra, Muhamad Dwi Eka Putri, Elvia Rahmi Marga Ragil Ismi Hartanti Rahma, Nafisah Hani Asyifah Ramzi Syamlan Rizka Kusumaningsih Roan Pratama Putra Rosita Dewi Sa’diyah, Nindya Audatus Setyoadji, Winnie Almira Sheilla Rachmania, Sheilla Sillehu, Sahrir Sudarmanto, Yohanes Sulistyaningsih , Erma Suyani Indriastuti Tantut Susanto Tartila, Jasmine Wiwien Sugih Utami Yunita Armiyanti Zahniar, Zahniar